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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Oxidative stress in granulosa cells contributes to poor oocytequality and IVF-ET outcomes in women with polycystic ovarysyndrome显示文摘The increased levels of intraceHular reactive oxygen species (ROS) in granulosa cells (GCs) may allectthe pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared the in vitrofertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factorinfertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group hadsignificantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factorgroup (P 〈 0.05); however, the number of retrieved oocytes was not significantly different between the two groups(P 〉 0.05). PCOS group had slightly lower fertilization, cleavage, grade IflI embryo, clinical pregnancy, andimplantation rates and higher miscarriage rate than the tubal factor group (P 〉 0.05). We further found asignificantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P 〈 0.05). The increasedROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneio-donium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increasedROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality andreduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involvedin the mechanism of ROS production in GCs of women with PCOS. | Qiaohong Lai Wenpei Xiang Qing Li Hanwang Zhang Yufeng Li Guijin Zhu Chengliang Xiong Lei Jin | 2018 | Frontiers of Medicine2018，12，5： | 26 |
| 3 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 4 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 5 | Bifurcations of Rough Heteroclinic Loops with Three Saddle Points | JIN Yin Lai ZHU De Ming Department of Mathematics. Linyi Teachers University. Shandong 276005. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China Department of Mathematics. East China Normal University. Shanghai 200062. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 13 |
| 6 | Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats显示文摘Glucocorticoid (GC ) 导致了骨质疏松症(GIO ) 被损害骨头形成描绘,它能被 tanshinol 减轻,从鼠尾草植物 miltiorrhiza Bunge 孤立的水的多酚。在这研究,我们调查了位于成骨以及使用 tanshinol 防碍 GIO 的可能性的导致 GC 的调整下面的分子的机制。4 个月的女 SD 老鼠是口头上地管理的提取的水(反对) ,泼尼松(GC, 5 | Ya-jun YANG Zhu ZHU Dong-tao WANG Xin-le ZHANG Yu-yu LIU Wen-xiu LAI Yu-lin MO Jin LI Yan-long LIANG Zhuo-qing HU Yong-jie YU Liao CUI | 2018 | Acta Pharmacologica Sinica2018，39，4： | 11 |
| 7 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 8 | Impact of hepatitis C virus genotype 3 on liver disease progression in a Chinese national cohort显示文摘Background:Hepatitis C virus(HCV)genotype 3,particularly subtype 3b,is increasing in prevalence and distribution in China.This study evaluated the prevalence,regional distribution,clinical characteristics,host factors,treatment outcomes,and disease progression of patients with HCV genotype 3 in China.Methods:A 5-year follow-up was preceded by a cross-sectional study.Treatment choices were at the discretion of treating physicians.Estimated infection time to overall-disease-progression(defined by≥1 of:newly diagnosed cirrhosis;cirrhosis at baseline,Child-Turcotte-Pugh score increased 2 points or more;progression from compensated cirrhosis to decompensated cirrhosis;hepatocellular carcinoma;liver transplantation;or death)was calculated using the Kaplan-Meier method.Cox regression analyses were conducted to evaluate the risk factors for disease progression.Results:The cross-sectional study enrolled 997 patients,including 91 with HCV genotype 3 infection.Among them,subtype 3b(57.1%)was more dominant than subtype 3a(38.5%).Five hundred and twelve patients were included into the follow-up phase.Among patients analyzed for estimated infection time to overall-disease-progression,52/304(17.1%)patients with HCV genotype 1 and 4/41(9.8%)with HCV genotype 3(4/26 with genotype 3b,0/13 with genotype 3a,and 0/2 with undefined subtype of genotype 3)experienced overall-disease-progression.Patients with HCV genotype 3 were younger than those with genotype 1(mean age:39.5±8.7 vs.46.9±13.6 years)and demonstrated more rapid disease progression(mean estimated infection time to overall-disease-progression 27.1 vs.35.6 years).Conclusions:HCV genotype 3,specifically subtype 3b,is associated with more rapid progression of liver disease.Further analysis to compare HCV subtype 3a and 3b is needed in high prevalence regions. | Nan Wu Hui-Ying Rao Wei-Bo Yang Zhi-Liang Gao Rui-Feng Yang Ran Fei Ying-Hui Gao Qian Jin Lai Wei | 2020 | Chinese Medical Journal2020，，3： | 10 |
| 9 | Long-term eficacy of plasma-derived hepatitis B vaccine among Chinese children:a 12-year folow-up study显示文摘INTRODUCTIONToevaluatelongtermeficacyofaplasmaderivedhepatitisBvaccineandprovideevidencefordecisionmakingonthevaccineboost... | LIAO Su Su 1, LI Rong Cheng 2, LI Hui 1, YANG Jin Ye 2, ZENG Xian Jia 1, GONG Jian 2, WANG Shu Sheng 2, LI Yan Ping 2 and ZHANG Kong Lai 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 9 |
| 10 | Characterizing the optimal operation of photocatalytic degradation of BDE-209 by nano-sized TiO_2显示文摘Brominated flame retardants have been widely used in industry.There is a rapid growing public concern for their availabilities in the environment.Advanced oxidation process(AOP) is a promising and efficient technology which may be used to remove emerging chemicals such as brominated flame retardants.This study aims at investigating optimal operational conditions for the removal of BDE-209 using nano-scaled titanium(IV) oxide.The residual PBDE congeners after photocatalytical degradation of BDE-209 by TiO 2 were analysed by gas chromatography-mass spectrometry(GC-MS).It was found that the degradability of BDE-209 by TiO 2 was attributed to its photocatalytic activity but not the small size of the particles.The half-life of removing BDE-209 by TiO 2 was 3.05 days under visible light.Tetra-and penta-BDEs were the major degraded products of BDE-209.Optimum conditions for photocatalytical degradation of BDE-209 was found to be at pH 12(93% ± 1%),5,10,20 mg/L(93.0% ± 1.70%,91.6% ± 3.21%,91.9% ± 0.952%,respectively),respectively of humic acid and in the form of anatase/rutile TiO 2(82% ± 3%).Hence,the efficiency of removing BDE-209 can be maximized while being cost effective at the said operating conditions. | Ka Lai Chow Yu Bon Man Jin Shu Zheng Yan Liang Nora Fung Yee Tam Ming Hung Wong | 2012 | Journal of Environmental Sciences2012，24，9： | 8 |
| 11 | Cyclovirobuxinum D Alleviates Cardiac Hypertrophy in Hyperthyroid Rats by Preventing Apoptosis of Cardiac Cells and Inhibiting the p38 Mitogen-Activated Protein Kinase Signaling Pathway显示文摘Objective: To investigate the underlying mechanisms of cyclovirobuxinum D(Cvb-D) on alleviating cardiac hypertrophy in rats. Methods: Sprague-Dawley rats were randomly divided into 5 groups: control group; levothyroxine-induced cardiac hypertrophy group(model); levothyroxine-induced cardiac hypertrophy + Cvb-D group(Cvb-D); levothyroxine-induced cardiac hypertrophy + captopril group(captopril); levothyroxine-induced cardiac hypertrophy + SB203580 group(SB203580), n=10 for each group. Rats were daily administered the respective drugs continuously for14 days by gastric gavage. A rat model of cardiac hypertrophy was established by intraperitoneal injection of levothyroxine to investigate whether Cvb-D protects against cardiac hypertrophy by inhibiting the p38 mitogen-activated protein kinase(MAPK) signaling pathway and preventing apoptosis of cardiac cells. Results: Treatment with Cvb-D significantly deceased left ventricle hypertrophy, improved the histopathology, hemodynamic conditions, and cardiac function in rats with cardiac hypertrophy. Compared with the normal control group, in rats with cardiac hypertrophy, expression of bax in the heart and phospho-p38 MAPK protein levels were significantly up-regulated(P<0.01 or 0.05), whereas the bcl-2 protein level was downregulated(P<0.01). In contrast, Cvb-D treatment reversed the changes in bax and phospho-p38 MAPK protein levels but increased the bcl-2 protein level(P<0.01 or 0.05), and these effects were similar to those of captopril and SB203580(a specific p38 MAPK inhibitor) treatment. Furthermore, both Cvb-D, captopril and SB203580 reduced m RNA expression of p38α, p38β, c-fos, and c-jun m RNA, and Cvb-D had a stronger effect(P<0.01). Conclusion: These results demonstrate that Cvb-D protects against cardiac hypertrophy, which is possibly mediated by prevention of cardiac cell apoptosis and inhibition of the p38 MAPK signaling pathway. | WU Jun-biao ZHOU Yuan LIANG Chun-ling ZHANG Xiao-jun LAI Jie-mei YE Shu-fang OUYANG Hui LIN Jin ZHOU Jiu-yao | 2017 | Chinese Journal of Integrative Medicine2017，23，10： | 8 |
| 12 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 13 | Hepatitis G virus infection in patients with chronic non-A-E hepatitis显示文摘HepatitisGvirusinfectioninpatientswithchronicnonAEhepatitisCHANGJinHong,WEILai,DUShaoCai,WANGHao,SUNYanandTAOQiMinSubjec... | CHANG Jin Hong, WEI Lai, DU Shao Cai, WANG Hao, SUN Yan and TAO Qi Min | 1997 | World Journal of Gastroenterology1997，3，3： | 7 |
| 14 | Surgical outcome and patient satisfaction after Z-epicanthoplasty and blepharoplasty显示文摘AIM: To evaluate surgical outcomes of modified Z-epicanthoplasty with blepharoplasty that we previously reported from the patient's perspective using patient-reported outcome measures(PROMs) and patient satisfaction scores.METHODS: A total of patients(n=180) who underwent the surgery between January 2013 and June 2016 were randomly selected. Standardized patient satisfaction forms(total score, 40) and validated PROMs questionnaires(total score, 12) were sent to patients for completion. PROMs assesses the severity of scarring, pain and asymmetry, as well as functional and appearance issues.RESULTS: All patients were female, ranging from 18 to 35 years old(mean=24). The response rate was 73.3%(n=132). The majority of patients reported good or excellent outcomes based on PROM analysis. Patients reported minimum or non-visible scarring at both the double eyelid surgical scar(85.6%) and the inner canthus(80.3%). Issues concerning function and appearance were minimal as 80.3% reported satisfaction with both domains. Notably, the majority of patients reported either a high or very high satisfaction rate to yield a mean score of 104 out of 120(P<0.05).CONCLUSION: Integration of our modified Z-epicanthoplasty with blepharoplasty produces good outcomes based on PROM results, which shows a positive linear relationship with patient satisfaction scores. | Jing-Yi Zhao Xiao-Shuang Guo Guo-Dong Song Xian-Lei Zong Xiao-Nan Yang Le Du Chen-Zhi Lai Zuo-Liang Qi Xiao-Lei Jin | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 7 |
| 15 | Changes in Soil Organic Carbon Dynamics in a Native C4 Plant-Dominated Tidal Marsh Following Spartina alterniflora Invasion显示文摘Invasion of an exotic C_4 plant Spartina alterniflora has been shown to increase soil organic carbon(SOC) concentrations in native C_3 plant-dominated coastal wetlands of China. However, little is known about the effects of S. alterniflora invasion on SOC concentrations and fractions in tidal marshes dominated by native C_4 plants. In this study, a field experiment was conducted in a tidal marsh dominated by the native C_4 plant Cyperus malaccensis in the Minjiang River estuary, China. Concentrations of SOC and liable SOC fractions, dissolved organic carbon(DOC), microbial biomass carbon(MBC), and easily oxidizable carbon(EOC),were measured in the top 50-cm soils of the C. malaccensis community, as well as those of three S. alterniflora communities with an invasion duration of 0–4 years(SA-4), 4–8 years(SA-8), and 8–12 years(SA-12), respectively. Results showed that both SOC stocks in the 50-cm soils and mean SOC concentrations in the surface soils(0–10 cm) of the C. malaccensis community increased with the duration of S. alterniflora invasion, whereas SOC concentrations in the 10–50-cm soils decreased slightly during the initial period of S. alterniflora invasion, before increasing again. The pattern of changes in labile SOC fractions(DOC, MBC, and EOC) with invasion duration was generally similar to that of SOC, while the ratios of labile SOC fractions to total SOC(DOC:SOC, MBC:SOC, and EOC:SOC) decreased significantly with the duration of S. alterniflora invasion. The findings of this study suggest that invasion of the exotic C_4 plant S. alterniflora into a marsh dominated by the native C_4 plant C. malaccensis would enhance SOC sequestration owing to the greater amount of biomass and lower proportion of labile SOC fractions present in the S. alterniflora communities. | jin baoshi lai derrick yuk fo gao dengzhou tong chuan zeng congsheng | 2017 | Pedosphere2017，27，5： | 7 |
| 16 | HBcrAg Identifies Patients Failing to Achieve HBeAg Seroconversion Treated with Pegylated Interferon Alfa-2b显示文摘 | Hui Ma Rui-Feng Yang Xiao-He Li Qian Jin Lai Wei | 2016 | Chinese Medical Journal2016，，18： | 7 |
| 17 | MEASUREMENT OF ANODIC OVERVOLTAGE BY AMODIFIED CURRENT INTERRUPTION METHOD IN CRYOLITE-ALUMINA MELTS显示文摘1INTRODUCTIONIntheelectrolyticproductionofaluminium,thecelconsistsofacarbonanodeandanaluminiummetalcathode.Thedominantpotent... | Yang, Jianhong Lai, Yanqing Xiao, Jin Li, Jie Liu, Yexiang Thonstad, J. | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 7 |
| 18 | Immunotoxicity of Acrylamide in Female BALB/c Mice显示文摘Objective To investigate the immunotoxicity of acrylamide(ACR) in female BALB/c mice. Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weight-based cluster included five groups(10 mice per group): negative control, positive control(cyclophosphamide), low, intermediate, and high dose ACR groups, and all the groups were administered ACR by gavage for 30 days. At the end of the study, the immunotoxicological effects of the ACR were evaluated through immunopathology, humoral immunity, cellular immunity, and non-specific immunity. Results The terminal body weight, spleen and thymus weights, lymphocyte counts in the ACR-H group were decreased, pathological changes were observed in lymph glands, thymus and spleen. %T cells in blood lymphocytes were significantly increased in all ACR-treated groups, and a significant reduction of % natural killer(NK) cells and increase of %Th cells were observed in the ACR-H group. interleukin-6(IL-6), Concanavalin A(ConA)-induced splenocyte proliferation and serum half hemolysis value(HC50) were also significantly suppressed in the ACR-H group. Conclusion ACR elicited an inhibitory effect on cellular and humoral immunity of mice after 30 day feeding. | FANG Jin LIANG Chun Lai JIA Xu Dong LI Ning | 2014 | Biomedical and Environmental Sciences2014，27，6： | 6 |
| 19 | Validated preoperative computed tomography risk estimation for postoperative hepatocellular carcinoma recurrence显示文摘AIM To develop and validate a risk estimation of tumor recurrence following curative resection of operable hepatocellular carcinoma(HCC).METHODS Data for 128 patients with operable HCC(according to Barcelona Clinic Liver Cancer imaging criteria) who underwent preoperative computed tomography(CT) evaluation at our hospital from May 1, 2013 through May 30, 2014 were included in this study. Follow-up data were obtained from hospital medical records. Follow-up data through May 30, 2016 were used to retrospectively analyze preoperative multiphasic CT findings, surgical histopathology results, and serum α-fetoprotein and thymidine kinase-1 levels. The χ~2 test, independent t-test, and Mann-Whitney U test were used to analyze data. A P-value of < 0.05 was considered statistically significant.RESULTS During the follow-up period, 38 of 128 patients(29.7%) had a postoperative HCC recurrence. Microvascular invasion(MVI) was associated with HCC recurrence(χ~2 = 13.253, P < 0.001). Despite postoperative antiviral therapy and chemotherapy, 22 of 44 patients with MVI experienced recurrence after surgical resection. The presence of MVI was 57.9% sensitive, 75.6% specific and 70.3% accurate in predicting postoperative recurrence. Of 84 tumors without MVI, univariate analysis confirmed that tumor margins, tumor margin grade, and tumor capsule detection on multiphasic CT were associated with HCC recurrence(P < 0.05). Univariate analyses showed no difference between groups with respect to hepatic capsular invasion, Ki-67 proliferation marker value, Edmondson-Steiner grade, largest tumor diameter, necrosis, arterial phase enhanced ratio, portovenous phase enhanced ratio, peritumoral enhancement, or serum α-fetoprotein level.CONCLUSION Non-smooth tumor margins, incomplete tumor capsules and missing tumor capsules correlated with postoperative HCC recurrence. HCC recurrence following curative resection may be predicted using CT. | Wei Zhang Shao-Lv Lai Jie Chen Dong Xie Fei-Xiang Wu Guan-Qiao Jin Dan-Ke Su | 2017 | World Journal of Gastroenterology2017，23，35： | 6 |
| 20 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
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