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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 4 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 2 |
| 5 | Identification of a New Rice Blast Resistance Gene, Pid3, by Genomewide Comparison of Paired Nucleotide-Binding Site-Leucine-Rich Repeat Genes and Their Pseudogene Alleles Between the Two Sequenced Rice Genomes显示文摘 | Shang Junjun Tao Yong Chen Xuewei Zou Yan Lei Cailin Wang Jing Li Xiaobing Zhao Xianfeng Zhang Meijun Lu Zhike Xu Jichen Cheng Zhukuan Wan Jianmin Zhu Lihuang | 2009 | Genetics2009，，4： | 1 |
| 6 | Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance显示文摘The bioaccumulation of mercury(Hg)in aquatic ecosystem poses a potential health risk to human being and aquatic organism.Bioaccumulations by plankton represent a crucial process of Hg transfer from water to aquatic food chain.However,the current understanding of major factors affecting Hg accumulation by plankton is inadequate.In this study,a data set of 89 aquatic ecosystems worldwide,including inland water,nearshore water and open sea,was established.Key factors influencing plankton Hg bioaccumulation(i.e.,plankton species,cell sizes and biomasses)were discussed.The results indicated that total Hg(THg)and methylmercury(MeHg)concentrations in plankton in inland waters were significantly higher than those in nearshore waters and open seas.Bioaccumulation factors for the logarithm of THg and MeHg of phytoplankton were 2.4–6.0 and 2.6–6.7 L/kg,respectively,in all aquatic ecosystems.They could be further biomagnified by a factor of 2.1–15.1 and 5.3–28.2 from phytoplankton to zooplankton.Higher MeHg concentrations were observed with the increases of cell size for both phyto-and zooplankton.A contrasting trend was observed between the plankton biomasses and BAF_(MeHg),with a positive relationship for zooplankton and a negative relationship for phytoplankton.Plankton physiologic traits impose constraints on the rates of nutrients and contaminants obtaining process from water.Nowadays,many aquatic ecosystems are facing rapid shifts in nutrient compositions.We suggested that these potential influences on the growth and composition of plankton should be incorporated in future aquatic Hg modeling and ecological risk assessments. | Zhike Li Jie Chi Zhenyu Wu Yiyan Zhang Yiran Liu Lanlan Huang Yiren Lu Minhaz Uddin Wei Zhang Xuejun Wang Yan Lin Yindong Tong | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 1 |
| 7 | Polargraphic determina-tion of fluoride using the adsorption wave of the Ce ( Ⅲ )-alizarin complexone-fluoride complex 显示文摘 | Lu Guanghan He Zhike | 1991 | Talanta1991，38，9： | 1 |
| 8 | High efficient ultraviolet photocatalytic activity of BiFeO3 nanoparticles synthesized by a chemical coprecipitation process显示文摘 | Zhike Liu Yajun Qi Chaojing Lu | 2010 | Mater Electron2010，，21： | 1 |
| 9 | Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification显示文摘 | Minjia Tan Hao Luo Sangkyu Lee Fulai Jin Jeong Soo Yang Emilie Montellier Thierry Buchou Zhongyi Cheng Sophie Rousseaux Nisha Rajagopal Zhike Lu Zhen Ye Qin Zhu Joanna Wysocka Yang Ye Saadi Khochbin Bing Ren Yingming Zhao | 2011 | Cell2011，，： | 1 |
| 10 | m^(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration显示文摘Neutrophil migration into the site of infection is necessary for antibacterial innate defense,whereas impaired neutrophil migration may result in excessive inflammation and even sepsis.The neutrophil migration directed by extracellular signals such as chemokines has been extensively studied,yet the intrinsic mechanism for determining neutrophil ability to migrate needs further investigation.N6-methyladenosine(m^(6)A)RNA modification is important in immunity and inflammation,and our preliminary data indicate downregulation of RNA m^(6)A demethylase alkB homolog 5(ALKBH5)in neutrophils during bacterial infection.Whether m^(6)A modification and ALKBH5 might intrinsically modulate neutrophil innate response remain unknown.Here we report that ALKBH5 is required for antibacterial innate defense by enhancing intrinsic ability of neutrophil migration.We found that deficiency of ALKBH5 increased mortality of mice with polymicrobial sepsis induced by cecal ligation and puncture(CLP),and Alkbh5-deficient CLP mice exhibited higher bacterial burden and massive proinflammatory cytokine production in the peritoneal cavity and blood because of less neutrophil migration.Alkbh5-deficient neutrophils had lower CXCR2 expression,thus exhibiting impaired migration toward chemokine CXCL2.Mechanistically,ALKBH5-mediated m^(6)A demethylation empowered neutrophils with high migration capability through altering the RNA decay,consequently regulating protein expression of its targets,neutrophil migration-related molecules,including increased expression of neutrophil migration-promoting CXCR2 and NLRP12,but decreased expression of neutrophil migration-suppressive PTGER4,TNC,and WNK1.Our findings reveal a previously unknown role of ALKBH5 in imprinting migrationpromoting transcriptome signatures in neutrophils and intrinsically promoting neutrophil migration for antibacterial defense,highlighting the potential application of targeting neutrophil m^(6)A modification in controlling bacterial infections. | Yang Liu Renjie Song Lu Zhao Zhike Lu Yini Li Xinyi Zhan Fengjiao Lu Jiang Yang Yamei Niu Xuetao Cao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
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