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| 1 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 2 | Survival of people living with HIV after treatment with Traditional Chinese Medicine in Henan province of China: a retrospective cohortstudy显示文摘OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results. | Yantao Jin Zhibin Liu Xiumin Chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 8 |
| 3 | Tolerance of nestin^+ cholinergic neurons in the basal forebrain against colchicine-induced cytotoxicity显示文摘In the present study we injected colchicine into the lateral ventricle of Sprague-Dawley rats to investigate the effects of colchicine on the number of different-type neurons in the basal forebrain and to search for neurons resistant to injury.After colchicine injection,the number of nestin+ cholinergic neurons was decreased at 1 day,but increased at 3 days and peaked at 14-28 days.The quantity of nestin-cholinergic neurons,parvalbumin-positive neurons and choline acetyl transferase-positive neurons decreased gradually.Our results indicate that nestin+ cholinergic neurons possess better tolerance to colchicine-induced neurotoxicity. | Jing Yu Kaihua Guo Dongpei Li Jinhai Duan Juntao Zou Junhua Yang Zhibin Yao | 2011 | Neural Regeneration Research2011，6，24： | 4 |
| 4 | Labeled box-particle CPHD filter for multiple extended targets tracking显示文摘In multiple extended targets tracking, replacing traditional multiple measurements with a rectangular region of the nonzero volume in the state space inspired by the box-particle idea is exactly suitable to deal with extended targets, without distinguishing the measurements originating from the true targets or clutter.Based on our recent work on extended box-particle probability hypothesis density(ET-BP-PHD) filter, we propose the extended labeled box-particle cardinalized probability hypothesis density(ET-LBP-CPHD) filter, which relaxes the Poisson assumptions of the extended target probability hypothesis density(PHD) filter in target numbers, and propagates not only the intensity function but also cardinality distribution. Moreover, it provides the identity of individual target by adding labels to box-particles. The proposed filter can improve the precision of estimating target number meanwhile achieve targets' tracks. The effectiveness and reliability of the proposed algorithm are verified by the simulation results. | ZOU Zhibin SONG Liping CHENG Xuan | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 3 |
| 5 | A novel glucose biosensor based on immobilization of glucose oxidase in chitosan on a glassy carbon electrode modified with gold-platinum alloy nanoparticles/muhiwall carbon nanotubes 显示文摘 | KANG Xinhuang MAI Zhibin ZOU Xiaoyong | 2007 | Anal Biochem2007，369，： | 1 |
| 6 | Changes of antioxidative enzymes and cell membrane osmosis in tomato colonized by arbuscular mycorrhizae under NaCl stress显示文摘 | ZhongQun He ChaoXing He ZhiBin Zhang ZhiRong Zou HuaiSong Wang | 2007 | Colloids and Surfaces B: Biointerfaces2007，，2： | 1 |
| 7 | A novel glucose biosensor based on immobilization of glucose oxidase in chitosan on a glassy carbon electrode modified with gold-platinum alloy nanoparticles/ multiwall carbon nanotubes显示文摘 | Xinhuang Kang Zhibin Mai Xiaoyong Zou | 2007 | Analytical Biochemistry2007，，369： | 1 |
| 8 | Glucose Biosensors Based on Platinum Nanoparticles-Deposited Carbon Nanotubes in Sol-Gel Chitosan/Silica Hybrid显示文摘 | Kang Xinhuang Mai Zhibin Zou Xiaoyong Cai Peixiang and Mo Jinyuan | 2008 | Talanta2008，74，4： | 1 |
| 9 | Glucose biosensors based on platinum nanoparticles- deposited carbon nanotubes in sol-gel ehitosan/silica hybrid显示文摘 | Xinhuang Kang Zhibin Mai Xiaoyong Zou | 2008 | Talanta2008，，74： | 1 |
| 10 | A sensitive nonenzymatic glucose sensor in alkaline media with a copper nanocluster/multiwall carbon nanotube-modified glassy carbon electrode显示文摘 | Xinhuang Kang Zhibin Mai Xiaoyong Zou Peixiang Cai Jinyuan Mo | 2007 | Analytical Biochemistry2007，，1： | 1 |
| 11 | Fiber Supercapacitors Utilizing Pen Ink for Flexible/Wearable Energy Storage显示文摘 | Yongping Fu Xin Cai Hongwei Wu Zhibin Lv Shaocong Hou Ming Peng Xiao Yu Dechun Zou | 2012 | Adv Mater2012，，42： | 1 |
| 12 | Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Aβ1 - 15 reduces Aβburden and behavioral impairment without Aβ-specific T cell response 显示文摘 | Juntao Zou Zhibin Yao Ge Zhang | 2008 | Neurological Sciences2008，272，： | 1 |
| 13 | A novel glucose biosensor based on immobilization of glucose oxidase in chitosan on a glassy carbon electrode modified with gold-platinum alloy nanoparticles/muhiwall carbon nanotubes显示文摘 | Kang Xinghuang Mai Zhibin Zou Xiaoyong | 2007 | Analytical Biochemistry2007，369，1： | 1 |
| 14 | A novel glucose biosensor based on immobilization of glucose oxidase in chitosan on a glassy carbon electrode modified with gold-platinum alloy nanoparticles/multiwall carbon nanotubes显示文摘 | Kang Xinhuang Mai Zhibin Zou Xiaoyong | 2007 | Analytical Biochemistry2007，369，1： | 1 |
| 15 | Determination of multi-residue for malachite green, gentian violet and their metabolites in aquatic products by high-performance liquid chromatography coupled with molecularly imprinted solid-phase extraction显示文摘 | Chaoyang Long Zhibin Mai Yingfen Yang Binghui Zhu Xiumin Xu Lin Lu Xiaoyong Zou | 2009 | Journal of Chromatography A2009，，12： | 1 |
| 16 | Fiber Supercapacitors Utilizing Pen Ink for Flexible/Wearable Energy Storage显示文摘 | Yongping Fu Xin Cai Hongwei Wu Zhibin Lv Shaocong Hou Ming Peng Xiao Yu Dechun Zou | 2012 | Adv Mater2012，，42： | 1 |
| 17 | Arabidopsis F-BOX STRESS INDUCED 4 is required to repress excessive divisions in stomatal development显示文摘During the terminal stage of stomatal development,the R2 R3-MYB transcription factors FOUR LIPS(FLP/MYB124) and MYB88 limit guard mother cell division by repressing the transcript levels of multiple cell-cycle genes. In Arabidopsis thaliana possessing the weak allele flp-1, an extra guard mother cell division results in two stomata having direct contact.Here, we identified an ethylmethane sulfonatemutagenized mutant, flp-1 xs01 c, which exhibited more severe defects than flp-1 alone, producing gianttumor-like cell clusters. XS01 C, encoding F-BOX STRESS-INDUCED 4(FBS4), is preferentially expressed in epidermal stomatal precursor cells.Overexpressing FBS4 rescued the defective stomatal phenotypes of flp-1 xs01 c and flp-1 mutants. The deletion or substitution of a conserved residue(Proline166) within the F-box domain of FBS4 abolished or reduced, respectively, its interaction with Arabidopsis Skp1-Like1(ASK1), the core subunit of the Skp1/Cullin/F-box E3 ubiquitin ligase complex. Furthermore, the FBS4 protein physically interacted with CYCA2;3 and induced its degradation through the ubiquitin-26 S proteasome pathway. Thus, in addition to the known transcriptional pathway, the terminal symmetric division in stomatal development is ensured at the post-translational level, such as through the ubiquitination of target proteins recognized by the stomatal lineage F-box protein FBS4. | Yi Li Shan Xue Qixiumei He Junxue Wang Lingling Zhu Junjie Zou Jie Zhang Chaoran Zuo Zhibin Fan Junling Yue Chunxia Zhang Kezhen Yang Jie Le | 2022 | Journal of Integrative Plant Biology2022，64，1： | 0 |
| 18 | GP30 of the mycobacteriophage CASbig impairs mycobacterial adaptation during acidic stress and in macrophages显示文摘The rapid emergence of multidrug-resistant and extensively drug-resistant Tuberculosis retrieved intense interest in phage-based therapy.This old approach,which was abandoned in the west in the 1940s but is generating renewed interest,has stimulated fresh research on mycobacteriophages and their lytic efficiency against their hosts.GP30 is a novel protein of the mycobacteriophage CASbig with undiscovered function.In this study,we analyzed the role of CASbig gp30 in the host Mycobacterium smegmatis.Overexpression of gp30 in the host led to reduced growth in acidic medium and attenuated the intracellular survival rate of M.smegmatis inside the THP-1 macrophages,which may be linked to the altered lipid profile of the recombinant bacterial cell wall.In a word,this study suggested that gp30,a novel gene from a mycobacteriophage,modulated lipid composition and content to hamper the survivability of bacteria under stress conditions. | WU LI JIANGZHE SI SHUAI QIU JING LUO HUIQIONG SUN XIAOQING LI ZHIBIN WAN WEI GAO HANLU ZOU LEI ZHANG XIAOHONG XIANG YANZHANG LI TIESHAN TENG | 2020 | BIOCELL2020，44，4： | 0 |
| 19 | High-sensitivity and fast-response fiber optic temperature sensor using an anti-resonant reflecting optical waveguide mechanism显示文摘Temperature sensing is essential for human health monitoring.High-sensitivity(>1 nm∕℃)fiber sensors always require long interference paths and temperature-sensitive materials,leading to a long sensor and thus slow response(6–14 s).To date,it is still challenging for a fiber optic temperature sensor to have an ultrafast(~ms)response simultaneously with high sensitivity.Here,a side-polished single-mode/hollow/single-mode fiber(SPSHSF)structure is proposed to meet the challenge by using the length-independent sensitivity of an anti-resonant reflecting optical waveguide mechanism.With a polydimethylsiloxane filled sub-nanoliter volume cavity in the SP-SHSF,the SP-SHSF exhibits a high temperature sensitivity of 4.223 nm/℃ with a compact length of 1.6 mm,allowing an ultrafast response(16 ms)and fast recovery time(176 ms).The figure of merit(FOM),defined as the absolute ratio of sensitivity to response time,is proposed to assess the comprehensive performance of the sensor.The FOM of the proposed sensor reaches up to 263.94(nm/℃)∕s,which is more than two to three orders of magnitude higher than those of other temperature fiber optic sensors reported previously.Additionally,a threemonth cycle test shows that the sensor is highly robust,with excellent reversibility and accuracy,allowing it to be incorporated with a wearable face mask for detecting temperature changes during human breathing.The high FOM and high stability of the proposed sensing fiber structure provide an excellent opportunity to develop both ultrafast and highly sensitive fiber optic sensors for wearable respiratory monitoring and contactless in vitro detection. | ZHIBIN LI ZIYE WU ZHUOQI LI LIANGXUN OU WENXIANG ZHANG ZHICONG LAI YU ZHANG MENGYUAN XIE JIEYUAN TANG WENGUO ZHU HUADAN ZHENG YONGCHUN ZHONG XIONG DENG XIHUA ZOU ZHE CHEN JIANHUI YU | 2023 | Photonics Research2023，11，8： | 0 |
| 20 | Dependence of Threshold Voltage of a-Si:H TFT on a-SiN_x:H Film显示文摘DependenceofThresholdVoltageofa-Si:HTFTona-SiNx:HFilm①XIONGZhibin,WANGChang’an,XUZhongyang,ZOUXuemei,ZHAOBofang,DAIYongbing,W... | XIONG Zhibin,WANG Chang’an,XU Zhongyang,ZOU Xuemei, ZHAO Bofang,DAI Yongbing,WAN Xinheng (Huazhong Univ.of Sci.and Tech.,Wuhan 430074,CHN) | 1997 | Semiconductor Photonics and Technology1997，3，4： | 0 |
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