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| 1 | PPAR activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with type 2 diabetes显示文摘 | Zsolt Bagi Akos Koller Gabor Kaley | 2004 | Am J Physiol Heart Circ Physiol2004，286，： | 1 |
| 2 | Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species显示文摘 | Feng Chen Scott Barman Yanfang Yu Steven Haigh Yusi Wang Huijuan Dou Zsolt Bagi Weihong Han Yunchao Su David J.R. Fulton | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 3 | Asymmetrical Dimethylarginine Inhibits Shear Stress–Induced Nitric Oxide Release and Dilation and Elicits Superoxide-Mediated Increase in Arteriolar Tone显示文摘 | Janos Toth Anita Racz Pawel M. Kaminski Michael S. Wolin Zsolt Bagi Akos Koller | 2007 | Hypertension2007，，3： | 1 |
| 4 | PPAR-γ Activation,by Reducing Oxidative Stress,Increases no Bioavailability in Coronary Arterioles of Mice With Type 2 Diabetes显示文摘 | ZSOLT BAGI AKOS KOLLER GABOR KALEY | 2004 | Am J Physiol Heart Circ Physiol2004，286，2： | 1 |
| 5 | Activation of the poly (ADP-Ribose) polymerase pathway in human heart failure显示文摘 | ANDREA MOLNaR ATTILA ToTH ZSOLT BAGI | 2006 | Mol Med2006，12，： | 1 |
| 6 | Hypoxic Pulmonary Vasoconstriction in Humans显示文摘 | Priyadharshanan Ariyaratnam Mahmoud Loubani Alyn H. Morice Zsolt Bagi | 2013 | BioMed Research International2013，，： | 1 |
| 7 | Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia显示文摘BACKGROUND The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy. Regionally distinct thickening of endothelial basement membrane(BM) of intestinal capillaries supplying the myenteric ganglia coincide with neuronal damage in different intestinal segments. Accelerated synthesis of matrix molecules and reduced degradation of matrix components may also contribute to the imbalance of extracellular matrix dynamics resulting in BM thickening. Among the matrix degrading proteinases, matrix metalloproteinase 9(MMP9) and its tissue inhibitor(TIMP1) are essential in regulating extracellular matrix remodelling.AIM To evaluate the intestinal segment-specific effects of diabetes and insulin replacement on ganglionic BM thickness, MMP9 and TIMP1 expression.METHODS Ten weeks after the onset of hyperglycaemia gut segments were taken from the duodenum and ileum of streptozotocin-induced diabetic, insulin-treated diabetic and sex-and age-matched control rats. The thickness of BM surrounding myenteric ganglia was measured by electron microscopic morphometry. Wholemount preparations of myenteric plexus were prepared from the different gut regions for MMP9/TIMP1 double-labelling fluorescent immunohistochemistry. Post-embedding immunogold electron microscopy was applied on ultrathin sections to evaluate the MMP9 and TIMP1 expression in myenteric ganglia and their microenvironment from different gut segments and conditions. The MMP9 and TIMP1 messenger ribonucleic acid(m RNA) level was measured by quantitative polymerase chain reaction.RESULTS Ten weeks after the onset of hyperglycaemia, the ganglionic BM was significantly thickened in the diabetic ileum, while it remained intact in the duodenum. The immediate insulin treatment prevented the diabetes-related thickening of the BM surrounding the ileal myenteric ganglia. Quantification of particle density showed an increasing tendency for MMP9 and a decreasing tendency for TIMP1 from the proximal to the distal small intestine under control conditions. In the diabetic ileum, the number of MMP9-indicating gold particles decreased in myenteric ganglia, endothelial cells of capillaries and intestinal smooth muscle cells, however, it remained unchanged in all duodenal compartments. The MMP9/TIMP1 ratio was also decreased in ileal ganglia only. However, a marked segment-specific induction was revealed in MMP9 and TIMP1 at the m RNA levels.CONCLUSION These findings support that the regional decrease in MMP9 expression in myenteric ganglia and their microenvironment may contribute to extracellular matrix accumulation, resulting in a region-specific thickening of ganglionic BM. | Nikolett Bódi Diána Mezei Payal Chakraborty Zita Szalai Bence Pál Barta János Balázs Zsolt Rázga Edit Hermesz Mária Bagyánszki | 2021 | World Journal of Diabetes2021，12，5： | 0 |
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