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| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | Optimal operation of cold–heat–electricity multi-energy collaborative system based on price demand response显示文摘In a multi-energy collaboration system, cooling, heating, electricity, and other energy components are coupled to complement each other. Through multi-energy coordination and cooperation, they can significantly improve their individual operating efficiency and overall economic benefits. Demand response, as a multi-energy supply and demand balance method, can further improve system flexibility and economy. Therefore, a multi-energy cooperative system optimization model has been proposed, which is driven by price-based demand response to determine the impact of power-demand response on the optimal operating mode of a multi-energy cooperative system. The main components of the multi-energy collaborative system have been analyzed. The multi-energy coupling characteristics have been identified based on the energy hub model. Using market elasticity as a basis, a price-based demand response model has been built. The model has been optimized to minimize daily operating cost of the multi-energy collaborative system. Using data from an actual situation, the model has been verified, and we have shown that the adoption of price-based demand response measures can significantly improve the economy of multi-energy collaborative systems. | Yuwei Cao Liying Wang Shigong Jiang Weihong Yang Ming Zeng Xiaopeng Guo | 2020 | Global Energy Interconnection2020，3，5： | 4 |
| 3 | Electron beam welding, laser beam welding and gas tungsten arc welding of titanium sheet显示文摘 | Qi Yunlian Deng Ju Hong Quan Zeng Liying | 2000 | Materials Science & Engineering A2000，，1： | 2 |
| 4 | Rate Metal Materials and Engineering显示文摘 | Zeng liying Yang Guanjun Ge Peng | 2010 | 39(9):15052010，39，9： | 1 |
| 5 | Study on ignition proof magnesium alloy with beryllium and rare earth additions 显示文摘 | Zeng X Q Wang Q D Lii Y Z | 2000 | Scripta Materialia2000，43，5： | 1 |
| 6 | Effect of dietary supplementation of phospholipids and highly unsaturated fatty acids on reproductive performance and offspring quality of Chinese mitten crab, Eriocheir sinensis (H. Milne-Edwards), female broodstock显示文摘 | Xugan Wu Yongxu Cheng Liying Sui Chaoshu Zeng Paul C. Southgate Xiaozhen Yang | 2007 | Aquaculture2007，，4： | 1 |
| 7 | Effect of LB monolayers on the mixed crystals of lead and barium sulfate显示文摘 | Lu Lehui Wang Liying Zeng Guangfu | 2000 | Colloids and surfaces A Physicocheical and Engineering Aspects2000，175，： | 1 |
| 8 | Electron beam welding, laser beam welding and gas tungsten arc welding of titanium sheet显示文摘 | Qi Yunlian Deng Ju Hong Quan Zeng Liying | 2000 | Materials Science & Engineering A2000，，1： | 1 |
| 9 | Focused ultrasound-induced blood- brain barrier disruption enhances the delivery of cytarabine to the rat brain 显示文摘 | Zeng HQ Lii L Wang F | 2012 | J Chemother2012，24，6： | 1 |
| 10 | Electron beam welding, laser beam welding and gas tungsten arc welding of titanium sheet显示文摘 | Qi Yunlian Deng Ju Hong Quan Zeng Liying | 2000 | Materials Science and Engineering2000，280，17： | 1 |
| 11 | High cycle fatigue property of Ti-600 alloy at ambient temperature显示文摘 | Zeng Liying Zhao Yongqing | 2011 | J Alloys Compd2011，509，5： | 1 |
| 12 | Carrageenan oligosaccharides and associated carrageenan-degrading bacteria induce intestinal inflammation in germ-free mice显示文摘Carrageenans(CGNs)are widely used in foods and pharmaceuticals although their safety remains controversial.To investigate the effects of CGNs and CGN-degrading bacteria in the human colon,we screened for CGN degradation by human fecal microbiota,and for inflammatory response to CGNs and/or CGN-degrading bacteria in germ free mice.Thin-layer chromatography indicated that high molecular weight(MW)CGNs(!100 kDa)remained undegraded in the presence of human fecal microbiota,whereas low MW CGNs,i.e.,k-carrageenan oligosaccharides(KCO,~4.5 kDa)were degraded when exposed to seven of eight human fecal samples,although sulfate groups were not removed during degradation.Bacteroides xylanisolvens and Escherichia coli isolates from fecal samples apparently degraded KCO synergistically,with B.xylanisolvens serving as the primary degrader.Combined treatment of KCO with KCO-degrading bacteria led to greater pro-inflammatory effects in the colon and rectum of germ-free mice than either KCO or bacteria alone.Similarly,p-p38-,CD3-,and CD79a-positive immune cells were more abundant in combined treatment group mice than in either single treatment group.Our study shows that KCO-degrading bacteria and the low MW products of KCO can promote proinflammatory effects in mice,and represent two key markers for evaluating CGN safety in foods or medicines. | Yeshi Yin Miaomiao Li Weizhong Gu Benhua Zeng Wei Liu Liying Zhu Xionge Pi Donald A.Primerano Hongwei D.Yu Hong Wei Guangli Yu Xin Wang | 2021 | Journal of Genetics and Genomics2021，48，9： | 1 |
| 13 | Clinical efficacy of tacrolimus in systemic lupus erythematosus with various manifestations:a real-world study显示文摘To the Editor:Systemic lupus erythematosus(SLE)is an autoimmune disease involving multiple systems.In recent years,the therapeutic treat-to-target(T2T)strategy was recommended for SLE.^([1])The immunosuppressive drugs are the standard of care in SLE treatment.Tacrolimus was one of the calcineurin inhibitors which was recommended in the 2019 update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association recommendations for the management of lupus nephritis(LN)^([2]). | Wei Bai Mengtao Li Shuang Zhou Liying Peng Jiuliang Zhao Xinping Tian Qian Wang Xiaomei Leng Shangzhu Zhang Yanhong Wang Yan Zhao Xiaofeng Zeng | 2022 | Chinese Medical Journal2022，135，18： | 1 |
| 14 | Oral immunization withrecombinant Mycobacterium smegmatis expressing theouter membrane protein 26-kilodalton antigen confersprophylactic protection against Helicobacter pylori infec-tion显示文摘 | Lii L Zeng HQ Wang PL | 2011 | Clin Vaccine Immunol2011，18，11： | 1 |
| 15 | Impact of living donor liver with steatosis and idiopathic portal inflammation on clinical outcomes in pediatric liver transplantation:Beijing experience显示文摘Background:To evaluate the impact of steatosis and/or idiopathic portal inflammation(IPI)in living donor livers on recipients’clinical outcomes.Methods:We assessed 305 qualified donor liver samples from June 2013 to December 2018.Donors and recipients’clinical characteristics,including follow-up data were retrieved.The graft and overall survival with/without steatosis or portal inflammation were compared by Kaplan-Meier analysis.Results:For living donors,the medium age of was 31.2(28,35.8)years old;liver histopathology showed macrovesicular steatosis:0-5%264/305(86.6%)and 5-30%41/305(13.4%),IPI:no 220/305(72.1%)and mild 85/305(27.9%).For recipients,the medium age was 1.0(0.6,1.5)years old;the median pediatric-end-stage-liver-disease score was 16(5.0,26.0)and medium follow-up time was 32.8(24.8,52.0)months.Biliary atresia(69.5%)was the main indication for liver transplantation(LT).Conclusions:The presence of steatosis and portal inflammation of the donor liver did not impact the clinical outcomes including transaminase or bilirubin normalization,short-/long-term complications and recipients’survival.However,recipients with high pediatric-end-stage-liver-disease score(>16)receiving donor liver with portal inflammation,but not steatosis,had trend negative effect on recipients’survival.In conclusion,donor livers with mild steatosis and portal inflammation were qualified for pediatric living donor LT.However,donor liver with mild portal inflammation would better not be allocated to recipients with high pediatric-end-stage-liver-disease score.This study provided new evidence in pediatric living donor liver allocation. | Xinyan Zhao Yafei He Jimin Liu Qian Zhang Liwei Liu Wei Qu Ying Liu Zhigui Zeng Haiming Zhang Jidong Jia Liying Sun Lin Wei Zhijun Zhu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 1 |
| 16 | Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae显示文摘Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in N.gonorrhoeae from clinical samples(Zhang et al.,2021). | Chi Zhang Lulu Zhang Feng Wang Yaling Zeng Liying Sun Di Wang Yamei Li Liqin Wang Junping Peng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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