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| 1 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D'Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 2 |
| 3 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D’Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 1 |
| 4 | Sensitization of photocatalytic activity of S- or N-doped TiO 2 particles by adsorbing Fe 3+ cations显示文摘 | Teruhisa Ohno Zenta Miyamoto Kazumoto Nishijima Hidekazu Kanemitsu Feng Xueyuan | 2005 | Applied Catalysis A, General2005，，： | 1 |
| 5 | Effect of high moleculer weight glutenin subunits on bread-making quality using near-isogenie lines 显示文摘 | Kanenori Takata Hiroaki Yamauchi Zenta Nishio | 2000 | Breeding Science2000，50，： | 1 |
| 6 | Effect of high molecular weight glutenin subunits on bread-making quality using near-isogenic lines显示文摘 | Hiroaki Yamauchi Zenta Nishio | 2000 | Breeding Science2000，50，4： | 1 |
| 7 | Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori)显示文摘 | Hongxiu Wen Xiqian Lan Tingcai Cheng Ningjia He Kunihiro Shiomi Zenta Kajiura Zeyang Zhou Qingyou Xia Zhonghuai Xiang Masao Nakagaki | 2009 | Molecular Biology Reports2009，，4： | 1 |
| 8 | Difference iri combination between Glu- B1 and Glu- D1 alleles in bread-making quality using near-isogenic lines显示文摘 | Kaneori Takata Zenta Nishio Wakako Funatsuk | 2003 | Food Sci Technol Res2003，9，1： | 1 |
| 9 | Plasma interleukin (IL)-18 (interferon-γ-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18显示文摘 | Taku Inokuchi Yuji Moriwaki Hiroko Tsutsui Asako Yamamoto Sumio Takahashi Zenta Tsutsumi Tuneyoshi Ka Kenji Nakanishi Tetsuya Yamamoto | 2005 | Cytokine2005，，1： | 1 |
| 10 | Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats显示文摘 | Yuji Moriwaki Taku Inokuchi Asako Yamamoto Tsuneyoshi Ka Zenta Tsutsumi Sumio Takahashi Tetsuya Yamamoto | 2007 | Acta Diabetologica2007，，4： | 1 |
| 11 | Growth of lransparent SrB4O7 single crvslal and its new applications 显示文摘 | RYUICH1 K HIROAKI K ZENTA O at al | 2005 | Journal of Crvstal Growth2005，275，： | 1 |
| 12 | Reciprocal Transplant of an Ovarian Imaginal Disc and Uptake of Vitellogenin by the Ovaries of Two Wild Silkworms Antheraea pernyi and Antheraea yamamai显示文摘 | LIU Chao-liang ZENTA K RYUZO T M | 2000 | Seric Sci Jpn2000，69，： | 1 |
| 13 | Sensitization of photo catalytic activity of S-or N-doped TiO2 particles by adsorbing Fe^3+ cations显示文摘 | Teruhisa Ohno Zenta Miyamoto Kazumoto Nishijima | 2006 | Applied Catalysis A:General2006，302，： | 1 |
| 14 | Sensitization of photo- catalytic activity of S or N-doped TiO2 particles by absorbing Fe3+ cations显示文摘 | Teruhisa O Zenta M Kazumoto N | 2006 | Appl Catal A2006，302，1： | 1 |
| 15 | Effect of high-molecular-weight glutenin subunits with different protein contents on bread-making quality 显示文摘 | Kanenori Takata Hiroaki Yamauchi Zenta Nishio | 2002 | Food Sci Technol Res2002，8，2： | 1 |
| 16 | A versatile vector for gene and ohgonueleotide transfer into cells in culture and in vivo: polyethylenimine 显示文摘 | Boussif O Lezoualeh F Zenta M A | 1995 | Proc Natl Acad Sci1995，92，： | 1 |
| 17 | The quality of extra strong flour used in bread production with frozen dough 显示文摘 | HIROAKI YAMAUCHI ZENTA HISHIO KANENORI TAKATA | 2001 | Food Science and Technology Research2001，7，2： | 1 |
| 18 | Female accessory glands (colleterial glands) of the wild silkmoth and their secretory proteins显示文摘 | Zenta Kajiura Takesi Ohshima Masao Nakagaki | 1997 | J Ser Sci Jpn1997，66，6： | 1 |
| 19 | Sensitization of photocatalytic activity of S - or N - doped TiO2 particles by absorbing Fe3+ cations显示文摘 | TERUHISA O ZENTA M KAZUMOTO N | 2006 | Appl Catal A2006，302，1： | 1 |
| 20 | Female accessary glangs of the wildsilkwormothes and their secretory proteins 显示文摘 | ZENTA K TAKEAI N | 1997 | Jpn J Seric Sci1997，66，6： | 1 |
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