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| 1 | Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia显示文摘Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles.Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover,the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning. | Dongsheng Zhou Feng Pang Shiyan Liu Ying Shen Lingjiang Liu Zezhong Fang Chuang Wang Zhenyu Hu Ti-Fei Yuan | 2017 | Neuroscience Bulletin2017，33，3： | 5 |
| 2 | The origin and geochemical cycle of soil selenium in a Se-rich area of China显示文摘 | Tao Yu Zhongfang Yang Yaoyao Lv Qingye Hou Xueqi Xia Haiyan Feng Meng Zhang Lixin Jin Zezhong Kan | 2013 | Journal of Geochemical Exploration2013，，： | 1 |
| 3 | Speetrofluorimetric study of the interaction of copper (Ⅲ) and bis-heterocyclictriazene reagent in the presence of β-cyclodextrin显示文摘 | Feng Fenga Liao Xueming Chen Zezhong | | Anatytica Chimica Aeta0，575，1： | 1 |
| 4 | Flow injection renewable drops spectro-fluorimetry tor sequential determinations of Vitamins B1, B2, B6显示文摘 | FENG Feng WANG Kemin CHEN Zezhong | 2004 | Anal Chim Acta2004，527，2： | 1 |
| 5 | Spectrofluorimetric study of the interaction of copper (Ⅱ) and bis-heteroegclieriacene reagent in the presence of β-cyclodexerin显示文摘 | Feng Feng Xueming Liao Zezhong Chen | 2006 | Analytical Chimica Acta2006，575，： | 1 |
| 6 | Classical swine fever virus NS5A protein antagonizes innate immune response by inhibiting the NF-κB signaling显示文摘The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellular signaling pathways.Previous report showed that NS5A inhibited nuclear factor kappa B(NF-κB)signaling induced by poly(I:C);however,the mechanism involved has not been elucidated.Here,we reported that NS5A directly interacted with NF-κB essential modulator(NEMO),a regulatory subunit of the IκB kinase(IKK)complex,to inhibit the NF-κB signaling pathway.Further investigations showed that the zinc finger domain of NEMO and the aa 126–250 segment of NS5A are essential for the interaction between NEMO and NS5A.Mechanistic analysis revealed that NS5A mediated the proteasomal degradation of NEMO.Ubiquitination assay showed that NS5A induced the K27-linked but not the K48-linked polyubiquitination of NEMO for proteasomal degradation.In addition,NS5A blocked the K63-linked polyubiquitination of NEMO,thus inhibiting IKK phosphorylation,IκBαdegradation,and NF-κB activation.These findings revealed a novel mechanism by which CSFV inhibits host innate immunity,which might guide the drug design against CSFV in the future. | Jinfu Sun Jiaying Li Liming Li Haixiao Yu Ping Ma Yingnan Wang Jinqi Zhu Zezhong Feng Changchun Tu | 2023 | Virologica Sinica2023，38，6： | 0 |
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