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| 1 | Advances and Trends on Tube Bending Forming Technologies显示文摘作为有庞大的数量和差异的一个种关键部件,弄弯的试管部分从材料和结构方面为无足轻重的人和高张力产品满足增加的需要。弄弯的试管广泛地在象航空,太空,造船,汽车,精力和护理那样的许多高端工业被使用了。弯曲的试管成为了为小产品形成生产技术的钥匙之一。经由把特征和多重缺点弄弯的分析,在试管弯曲探索普通问题上的进展在穹隆之内面关于起皱的不稳定性被总结,墙变瘦(裂开) 在拱背, springback 现象,剖面图变丑,形成的限制和过程 / 工具设计 / 优化。一些当前发达的弯曲技术以他们的优点和限制被考察。最后,鉴于高效的建筑群的迫切要求,在航空与 difficult-to-deform 和小材料把试管部件弄弯,太空域,发展趋势和相应挑战为认识到把变丑弄弯的精确、高效率的试管被介绍。 | YANG He LI Heng ZHANG Zhiyong ZHAN Mei LIU Jing LI Guanjun | 2012 | Chinese Journal of Aeronautics2012，25，1： | 86 |
| 2 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 3 | Recent developments in plastic forming technology of titanium alloys显示文摘Titanium alloys have been used extensively in industry fields including aviation,aerospace and automobile due to their excellent comprehensive properties.Research and development of advanced plastic forming technology are of great importance to manufacturing titanium products of high performance and lightweight with low cost and short cycle.This paper analyzes the development tendencies of titanium alloy forming technology.Recent achievements in precision forming,microstructure control and multi-scale simulation of titanium alloys are reviewed.The forming techniques of large-sale integral complex components are presented. | YANG He FAN XiaoGuang SUN ZhiChao GUO LiangGang ZHAN Mei | 2011 | Science China(Technological Sciences)2011，54，2： | 33 |
| 4 | NEW METHOD OF SIMULATING CONCENTRATED DRAIN HOLES IN SEEPAGE CONTROL ANALYSIS显示文摘In this paper, based upon the basic solution of sink, the approximate solution of single drain hole in finite elements is derived by use of the superposition principle. Then, the theoretical solution is extended to the case of some drain holes in one finite element, and the method is used in seepage control analysis with quick convergence and high accuracy. On the other hand, if the positions of the drain holes are changed, only some control factors of drain holes are changed, but the finite element grid need not to be reformed. Therefore, the method is more suitable in optimal research of seepage control. | Zhan Mei li, Su Bao yu , Liu Jun yong, Shen Zhen zhong College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, P.R.China (Received Aug.1, 1998) | 1999 | Journal of Hydrodynamics1999，11，3： | 22 |
| 5 | Forming limits under multi-index constraints in NC bending of aluminum alloy thin-walled tubes with large diameters显示文摘With increasing diameters of aluminum alloy thin-walled tubes (AATTs), the tube forming limits, i.e. the minimum bending factors, and their predictions under multi-index constraints including wrinkling, thinning and flattening have been being a key problem to be urgently solved for improving tube forming potential in numerical control (NC) bending processes of AATTs with large diameters. Thus in this paper, a search algorithm of the forming limits is put forward based on a 3D elastic-plastic finite element (FE) model and a wrinkling energy prediction model for the bending processes under axial compression loading (ACL) or not. This algorithm enables to be considered the effects of process parameter combinations including die, friction parameters on the multi-indices. Based on this algorithm, the forming limits of the different size tubes are obtained, and the roles of the process parameter combinations in enabling the limit bending processes are also revealed. The followings are found: the first, within the appropriate ranges of friction and clearances between the different dies and the tubes enabling the bending processes with smaller bending factors, the ACL enables the tube limit bending processes after a decrease of the mandrel ball thickness and diameters; then, without considering the effects of the tube geometry sizes on the tube constitutive equations, the forming limits will be decided by the limit thinning values for the tubes with diameters smaller than 80 mm, while the wrinkling for the tubes with diameters no less than 80 mm. The forming limits obtained from this algorithm are smaller than the analytical results, and reduced by 57.39%; the last, the roles of the process parameter combinations in enabling the limit bending processes are verified by experimental results. | YAN Jing, YANG He, ZHAN Mei & LI Heng College of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Technological Sciences)2010，53，2： | 21 |
| 6 | Deformation Behavior of Medium-strength TA18 High-pressure Tubes During NC Bending with Different Bending Radii显示文摘To improve the forming quality and forming limit of the numerical control (NC) bending of high-pressure titanium alloy tubes, in this study, using three-dimensional (3D) finite element method, deformation behavior of medium-strength TA18 high-pressure tubes during NC bending with different bending radii is investigated. The results show that the cross-sectional deformation and the wall thickness variation during NC bending of TA18 tubes using a small bending radius (less than 2 times of tube outside diameter) are clearly different from that using a normal bending radius (between 2 and 4 times of tube outside diameter). For bending with a normal bending radius, with or without a mandrel, the distribution of the flattening in the bending area resembles a platform and an asymmetric parabola, respectively. For bending with a small bending radius, with or without a mandrel, the flattening both distributes like a parabola, but the former has a stable peak which deflects toward the initial bending section, and the latter has a more pronounced peak with a bending angle and deflects slightly toward the bending section. The wall thickness variations with a normal bending radius, with and without a mandrel, both resemble a platform when the bending angle exceeds a certain angle. For the bending with a small radius, the distribution of the wall thickness variation without a mandrel follows an approximate parabola which increases in value as the bending angle increases. If a mandrel is used, the thickening ratio increases from the initial bending section to the bending section. | JIANG Zhiqiang ZHAN Mei YANG He XU Xudong LI Guangjun | 2011 | Chinese Journal of Aeronautics2011，24，5： | 16 |
| 7 | Springback prediction of thick-walled high-strength titanium tube bending显示文摘Signifcant springback occurs after tube rotary-draw-bending(RDB),especially for a high-strength Ti–3Al–2.5V tube(HSTT) due to its high ratio of yield strength to Young's modulus.The combination scheme of explicit and implicit is preferred to predict the springback.This simulation strategy includes several numerical parameters,such as element type,number of elements through thickness(NEL),element size,etc.However,the influences of these parameters on springback prediction accuracy are not fully understood.Thus,taking the geometrical specifcation9.525 mm · 0.508 mm of a HSTT as the objective,the effects of numerical parameters on prediction accuracy and computation effciency of springback simulation of HSTT RDB are investigated.The simulated springback results are compared with experimental ones.The main results are:(1) solid and continuum-shell elements predict the experimental results well;(2) for C3D8R elements,NEL of at least 3 is required to obtain reliable results and a relative error of 29% can occur as NEL is varied in the range of 1–3;(3) specifying damping factor typically works well in Abaqus/Emplicit simulation of springback and the springback results are sensitive to the magnitude of damping factor.In addition,the explanations of the effect rules are given and a guideline is added. | Song Feifei Yang He Li Heng Zhan Mei Li Guangjun | 2013 | Chinese Journal of Aeronautics2013，26，5： | 15 |
| 8 | Unequal-thickness billet optimization in transitional region during isothermal local loading forming of Ti-alloy rib-web component using response surface method显示文摘Avoiding the folding defect and improving the die filling capability in the transitional region are desired in isothermal local loading forming of a large-scale Ti-alloy rib-web component(LTRC). To achieve a high-precision LTRC, the folding evolution and die filling process in the transitional region were investigated by 3 D finite element simulation and experiment using an equal-thickness billet(ETB). It is found that the initial volume distribution in the second-loading region can greatly affect the amount of material transferred into the first-loading region during the second-loading step, and thus lead to the folding defect. Besides, an improper initial volume distribution results in non-concurrent die filling in the cavities of ribs after the second-loading step, and then causes die underfilling. To this end, an unequal-thickness billet(UTB) was employed with the initial volume distribution optimized by the response surface method(RSM). For a certain eigenstructure, the critical value of the percentage of transferred material determined by the ETB was taken as a constraint condition for avoiding the folding defect in the UTB optimization process,and the die underfilling rate was considered as the optimization objective. Then, based on the RSM models of the percentage of transferred material and the die underfilling rate, non-folding parameter combinations and optimum die filling were achieved. Lastly, an optimized UTB was obtained and verified by the simulation and experiment. | Ke WEI Mei ZHAN Xiaoguang FAN He YANG Pengfei GAO Miao MENG | 2018 | Chinese Journal of Aeronautics2018，31，4： | 13 |
| 9 | Numerically controlled bending performance of medium strength TA18 titanium alloy tubes under different die sets显示文摘The rapid development of aviation and aerospace technologies has led to increased interest in the application of numerically controlled(NC) technology for bending light-weight titanium alloy tubes.In order to study and develop advanced NC bending technology,it is necessary to understand the bending performance of medium strength TA18(Ti-3Al-2.5V,ASTM Gr.9) titanium alloy tubes during NC bending under different die sets.This paper focuses on the bending performance of medium strength TA18 tubes under different NC bending die sets,including the variations in the stress,strain,wall thickness,cross sectional deformation,and defects.The results show that adding a wiper die to the base die set decreases the radial,hoop,and tangential compressive stress and the tangential compressive strain,and adding a mandrel to the base die set also decreases these stresses,but increases the radial and hoop tensile stress and decreases the hoop compressive strain obviously,and brings about a three-dimensional tensile stress concentration where the mandrel provides support.For the NC bending of medium strength TA18 tubes,the flattening of cross section is more sensitive index than the thinning of wall thickness.Introducing a mandrel can improve the flattening of cross section obviously but it has a little worse effect on the thinning of wall thickness,and adding a wiper die to the base die set can inhibit the occurrence of the inside bulge but worsen the flattening of the cross section remarkably.Considering the above effects of the mandrel and wiper die on bending performance,it is reasonable to apply the die set comprising a bending die,clamp die,and pressure die for tubes with a small diameter and the die set including an appropriate mandrel additionally for tubes with a larger diameter,in order to bend the medium strength TA18 tubes with high quality and at low cost. | ZHAN Mei JIANG ZhiQiang YANG He XU XuDong LI GuangJun | 2011 | Science China(Technological Sciences)2011，54，4： | 13 |
| 10 | Electron force-induced dislocations annihilation and regeneration of a superalloy through electrical in-situ transmission electron microscopy observations显示文摘What effect does electric current do on dislocation evolution of metals keeps being a confusing question to be answered and proved. To this end, the dislocation evolution of a superalloy with electric current was directly observed by electrical in-situ transmission electron microscopy in this work. Dislocations annihilation at first and then regeneration was found for the first time, which directly proves the existence of electron force during the electrically-assisted manufacturing. Dislocations regeneration would be driven by the electron force and the resistance softening by the local Joule heating effect. Resultantly,a base could be provided for future electrically-assisted research. | Xina Zhang Hongwei Li Mei Zhan Zebang Zheng Jia Gao Guangda Shao | 2020 | Journal of Materials Science & Technology2020，36，1： | 12 |
| 11 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 12 | Nitrogen Deposition and Its Spatial Pattern in Main Forest Ecosystems along North-South Transect of Eastern China显示文摘A continuous three-year observation(from May 2008 to April 2011)was conducted to characterize the spatial variation of dissolved inorganic nitrogen(DIN)deposition at eight main forest ecosystems along the north-south transect of eastern China(NSTEC).The results show that both throughfall DIN deposition and bulk DIN deposition increase from north to south along the NSTEC.Throughfall DIN deposition varies greatly from 2.7 kg N/(ha·yr)to 33.0 kg N/(ha·yr),with an average of 10.6 kg N/(ha·yr),and bulk DIN deposition ranges from 4.1 kg N/(ha·yr)to 25.4 kg N/(ha·yr),with an average of 9.8 kg N/(ha·yr).NH4+-N is the dominant form of DIN deposition at most sampling sites.Additionally,the spatial variation of DIN deposition is controlled mainly by precipitation.Moreover,in the northern part of the NSTEC,bulk DIN deposition is 17%higher than throughfall DIN deposition,whereas the trend is opposite in the southern part of the NSTEC.The results demonstrate that DIN deposition would likely threaten the forest ecosystems along the NSTEC,compared with the critical loads(CL)of N deposition,and DIN deposition in this region is mostly controlled by agricultural activities rather than industrial activities or transportation. | ZHAN Xiaoyun YU Guirui HE Nianpeng FANG Huajun JIA Bingrui ZHOU Mei WANG Chuankuan ZHANG Junhui ZHAO Guangdong WANG Silong LIU Yunfen YAN Junhua | 2014 | Chinese Geographical Science2014，24，2： | 10 |
| 13 | A novel unified model predicting flow stress and grain size evolutions during hot working of non-uniform as-cast 42CrMo billets显示文摘The cast preformed forming process(CPFP) is increasingly considered and applied in the metal forming industries due to its short process, low cost, and environmental friendliness, especially in the aerospace field. However, how to establish a unified model of a non-uniform as-cast billet depicting the flow stress and microstructure evolution behaviors during hot working is the key to microstructure prediction and parameter optimization of the CPFP. In this work, hot compression tests are performed using a non-uniform as-cast 42 CrMo billet at 1123–1423 K and 0.01–1sà1. The effect laws of the non-uniform state of the as-cast billet with different initial grain sizes on the flow stress and microstructure are revealed deeply. Based on experimental results, a unified model of flow stress and grain size evolutions is developed by the internal variable modeling method. Verified results show that the model can well describe the responses of the flow stress and microstructure to deformation conditions and initial grain sizes. To further evaluate its reliability, the unified model is applied to FE simulation of the cast preformed ring rolling process.The predictions of the rolling force and grain size indicate that it could well describe the flow stress and microstructure evolutions during the process. | Lianggang GUO Fengqi WANG Pengliang ZHEN Xuechao LI Mei ZHAN | 2019 | Chinese Journal of Aeronautics2019，32，2： | 8 |
| 14 | Kindlin-2 expression in adult tissues correlates with their embryonic origins显示文摘Kindlin-2 functions in the maintenance of homeostasis and in human diseases.This study investigated the interrelationship between Kindlin-2 expression in tissues and the corresponding germ layers from which these tissues originated.Kindlin-2 expression was examined in normal adult human organs and human cancer tissues by immunohistochemical analyses.Analysis of Kindlin-2 mRNA levels in adult human organs in the Oncomine dataset revealed Kindlin-2 is highly expressed in mesoderm-derived organs.However,Kindlin-2 was negative or weakly expressed in endoderm/ectoderm-derived organs.Interestingly,the abnormal expression of Kindlin-2 was observed in a variety of human cancers.In agreement with its expression profile in humans,Kindlin-2 was also highly expressed in mesoderm-derived organs in mouse embryos with the exception of strong Kindlin-2 expression in ectoderm-derived spinal cord and ganglia,tissues that are highly mobile during embryonic development.Importantly,we demonstrated the expression level of Kindlin-2 in adult organs correlated with their embryonic dermal origins and deregulation of Kindlin-2 in tissues is associated with tumor progression.This finding will help us understand the dual role of Kindlin-2 in the regulation of tumor progression and embryonic development. | ZHAN Jun YANG Mei CHI XiaoChun ZHANG Jing PEI XueLian REN CaiXia GUO YongQing LIU Wei ZHANG HongQuan | 2014 | Science China(Life Sciences)2014，57，7： | 8 |
| 15 | ESTABLISHMENT OF 3D FEM MODEL OF MULTI-PASS SPINNING显示文摘以便改进计算精确性和效率,建立合理 3D 是必要的为包括旋转旋转的多传递的女性的模型不仅处理而且弹回并且退火过程。为多传递旋转的一个数字模型用联合被建立明确、含蓄女性,与他们的优点不确和效率。为模型建立的过程详细被介绍,并且模型被验证。到二通行证的旋转的女性的模型显示出的 3D 的应用程序下列:象在完整的旋转进程期间的压力,紧张和墙厚度那样的域变量能被获得,不是仅仅在旋转进程期间而且在期间弹回并且退火进程,并且他们的分布和变化的趋势在对实际多旋转的进程的好同意。因此 3D 为多传递旋转的女性的模型可以是为多传递旋转的过程参数的决心和优化的一个有用工具过程。 | ZHAN Mei ZHOU Qiang YANG He ZHANG Jinhui | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 7 |
| 16 | A constitutive model coupling damage and material anisotropy for wide stress triaxiality显示文摘A constitutive model that can describe the damage evolution of anisotropic metal sheets during the complex forming processes which experience wide stress triaxiality history is essential to accurately predict the deformation and rupture behaviors of the processes.In this study,a modified Lemaitre damage criterion which couples with the anisotropic Barlat 89 yield function is established.The effects of stress triaxiality,Lode parameter and shear stress on damage accumulation are considered in the constitutive model.The model is numerically implemented and applied to fracture prediction in tensile tests with different stress triaxialities and a complex deformation process with wide stress triaxiality history.The good consistency of predictions and experiments indicates that the modified Lemaitre damage model has excellent fracture prediction ability.Finally,the accuracy of the model is analyzed and discussed. | Rui LI Mei ZHAN Zebang ZHENG Hongrui ZHANG Xiaolei CUI Wei LV Yudong LEI | 2020 | Chinese Journal of Aeronautics2020，33，12： | 7 |
| 17 | Forming the transverse inner rib of a curved generatrix part through power spinning显示文摘How to form high-quality transverse inner ribs through power spinning is a key issue for complicated integrated curved generatrix parts with transverse inner ribs. In this study, the forming characteristics and laws during the power spinning process were investigated using a finite element simulation based on the orthogonal design method. The results show that the transverse inner rib distributes homogeneously along the circumferential direction but inhomogeneously along the generatrix direction. Depressions occur easily in the middle zone of the rib (MZR). The roller nose radius is the most significant parameter of the MZR underfill degree. A larger roller nose radius is helpful to decrease the MZR underfill degree. Furthermore, the preformed billet thickness also plays a vital role in the underfill degree of the front zone of the rib and the back zone of the rib, as well as the depression degree of the outer surface of the rib. By combining the ribfilling characteristics and laws, the optimized forming process window for obtaining high-quality inner ribs was obtained by regression analysis, thus laying a basis for improving the forming quality of curved generatrix parts with transverse inner ribs in power spinning. | Hong-Rui Zhang Mei Zhan Jing Guo Xian-Xian Wang Peng-Fei Gao Fei Ma | 2019 | Advances in Manufacturing2019，7，1： | 7 |
| 18 | Advances and trends in plastic forming technologies for welded tubes显示文摘With the implementation of environmental protection, sustainable development and conservation-oriented policies, components and parts of thin-walled welded tubes have gained increasing application in the aircraft and automotive industries because of their advantages: easily achieving forming and manufacturing process at low cost and in a short time. The current research on welded tube plastic forming is mainly concentrated on tube internal high-pressure forming, tube bending forming, and tube spinning forming. The focuses are on the material properties and characterization of welded tubes, finite element modeling for welded tube forming, and inhomogeneous deformation behavior and the mechanism and rules of deformation coordination in welded tube plastic forming. This paper summarizes the research progress in welded tube plastic forming from these aspects. Finally, with a focus on the urgent demand of the aviation, aerospace and automotive industries for high-strength and light-weight tubes, this paper discusses the development trends and challenges in the theory and technology of welded tube plastic forming in the future. Among them,laser tailor-welded technology will find application in the manufacture of high-strength steel tubes.Tube-end forming technology, such as tube flaring and flanging technology, will expand its application in welded tubes. Therefore, future studies will focus on the FE modeling regarding how to consider effects of welding on residual stresses, welding distortions and microstructure, the inhomogeneous deformation and coordination mechanism of the plastic forming process of tailor-welded tubes, and some end-forming processes of welded tubes, and more comprehensive research on the forming mechanism and limit of welded tubes. | Zhan Mei Guo Kun Yang He | 2016 | Chinese Journal of Aeronautics2016，29，2： | 7 |
| 19 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 20 | Ketoconazole Associated Hepatotoxicity: A Systematic Review and Metaanalysis显示文摘Objective To evaluate the incidence of Ketoconazole associated hepatotoxicity and related factors. Methods Literature retrieval was conducted by using multi-databases for meta-analysis on Ketoconazole associated hepatotoxicity. The data were collected with a standardized form. Overall estimation of incidence of hepatotoxicity for specific study type was calculated by using a DerSimonian-Laird random-effects model owing to the substantial differences among the studies. Results Totally 204 eligible studies were included in the analysis. The incidence of Ketoconazole associated hepatotoxicity was 3.6%-4.2%. The dosage and duration specific subgroup analyses did not show any significant difference among groups, while the age specific subgroup analysis showed the incidence in children and people aged >60 years was 1.4% (95% CI: 0.5%-4.2%) and 3.2% (95% CI: 1.1%-8.7%) respectively. Additionally, the incidence of the hepatotoxicity was higher in people who had oral administration of ketoconazole beyond the provisions of the usage instructions, and the incidence was 5.7% (95% CI: 4.5%-7.2%). Conclusion Ketoconazole associated hepatotoxicity was common. Off-label use might increase the risk of liver damage. Well-designed large sample studies are needed to identify the risk factors in future. | YAN Jiang Ying NIE Xiao Lu TAO Qing Mei ZHAN Si Yan ZHANG Yan De | 2013 | Biomedical and Environmental Sciences2013，26，7： | 6 |
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