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| 1 | Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells显示文摘Mannan-binding lectin(MBL)plays a key role in the lectin pathway of complement activation and can influence cytokine expression.Toll-like receptor 4(TLR4)is expressed extensively and has been demonstrated to be involved in lipopolysaccharide(LPS)-induced signaling.We first sought to determine whether MBL exposure could modulate LPS-induced inflammatory cytokine secretion and nuclear factor-kB(NF-kB)activity by using the monocytoid cell line THP-1.We then investigated the possible mechanisms underlying any observed regulatory effect.Using ELISA and reverse transcriptase polymerase chain reaction(RT-PCR)analysis,we found that at both the protein andmRNAlevels,treatment withMBLsuppresses LPS-induced tumor-necrosis factor(TNF)-a and IL-12 production in THP-1 cells.An electrophoretic mobility shift assay and western blot analysis revealed that MBL treatment can inhibit LPS-induced NF-kB DNA binding and translocation in THP-1 cells.While the binding of MBL to THP-1 cells was evident at physiological calcium concentrations,this binding occurred optimally in response to supraphysiological calcium concentrations.This binding can be partly inhibited by treatment with either a soluble form of recombinant TLR4 extracellular domain or anti-TLR4 monoclonal antibody(HTA125).Activation of THP-1 cells by LPS treatment resulted in increased MBL binding.We also observed that MBL could directly bind to the extracellular domain of TLR4 in a dose-dependent manner,and this interaction could attenuate the binding of LPS to cell surfaces.Taken together,these data suggest that MBL may affect cytokine expression through modulation of LPS-/TLR-signaling pathways.These findings suggest that MBL may play an important role in both immune regulation and the signaling pathways involved in cytokine networks. | Mingyong Wang Yue Chen Yani Zhang Liyun Zhang Xiao Lu Zhengliang Chen | 2011 | Cellular & Molecular Immunology2011，8，3： | 21 |
| 2 | Spherical nano-Sb@C composite as a high-rate and ultra-stable anode material for sodium-ion batteries显示文摘一种喷雾器水花热分解技术被用来综合球形的 nano-Sb@C 合成。仪器的分析表明与 68.8 wt% 的一个优化 Sb 内容合成的 micro-nanostructured 一致地由极端小的 Sb nanoparticles (10 nm ) 组成在一个球形的多孔的 C 矩阵以内嵌入(作为 10-Sb @ C 表示了) 。Sb 的内容和尺寸能被改变先锋的集中控制。作为钠离子电池的阳极材料, 10-Sb @ C 提供 435 mAh 据 ? 椠据畬楤杮愠猠数楣楦 ? 慣慰楣慴据 ? 景ㄠ ? 的一个分泌物能力 ? 术挠浯慰敲 ? 楷桴琠敨瘠污敵漠 ??? 术映牯 ?? 瑡愠挠慨杲 ? 楤' 湛?慲整漠 ?? ‰ ? | Ning Zhang Yongchang Liu Yanying Lu Xiaopeng Han Fangyi Cheng Jun Chen | 2015 | Nano Research2015，8，10： | 14 |
| 3 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 4 | Self-template synthesis of double-layered porous nanotubes with spatially separated photoredox surfaces for efficient photocatalytic hydrogen production显示文摘Improving charge carriers separation to achieve high photoconversion efficiency in heterogeneous photocatalysts is highly desirable.Herein,heterostructured ZnS@CdS double-layered porous nanotubes(PNTs),in which the spatially separated reduction and oxidation reaction sites lie on the outer and inner shell,respectively,are fabricated through a robust self-template conversion strategy.After selective photo-deposition of Ni and CoO_x as dual cocatalysts,Ni nanoparticles as electron collectors and reduction reaction sites are loaded on the outer shell,while CoO_x nanoparticles as hole collectors and oxidation reaction sites are loaded on the inner shells.As a result,a novel CoO_x/ZnS@CdS/Ni photocatalyst is obtained and shows high visible-light-driven photocatalytic hydrogen production activity owing to the synergistic effect of self-template-derived thin mesoporous heterojunctions and photo-depositionderived spatially separated dual cocatalysts,which can significantly provide driving force for the ordered transfer of photogenerated electrons and holes toward opposite direction and promote the surface catalytic reaction.Additionally,the facile strategy can be broadened to the preparation of CoO_x/ZnSe@CdSe/NiPNTs with enhanced photocatalytic activity. | Yani Xin Yi Huang Kui Lin Yifu Yu Bin Zhang | 2018 | Science Bulletin2018，63，10： | 9 |
| 5 | Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells显示文摘Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose;(2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol;(3) HG medium (HG group) containing 30 mmol/L glucose;(4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG+ SKI group);or (5) 200 mg/L SKI treatment in control medium (control+ SKI group) for 72 h. HG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulation of P16INK4 and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expression of membrane decoy receptor 2. SKI treatment potently prevented these changes in a dose-independent manner. SKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycin and p66Shc and down-regulation of anti-senescence molecules klotho, sirt1, and peroxisome proliferator-activated receptor-g in renal tubular epithelial cells. SKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment of diabetic nephropathy. | Biqiong Fu Jie Yang Jia Chen Lirong Lin Kehong Chen Weiwei Zhang Jianguo Zhang Yani He | 2019 | Frontiers of Medicine2019，13，2： | 8 |
| 6 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 7 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 8 | Achievements in cancer research supported by National Natural Science Foundation of China显示文摘For the past two decades,great achievements have been made in cancer research of China and the majority of them were supported by the National Natural Science Foundation of China(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of NSFC.Also,the impacts of NSFC support on discipline development and talent fostering were analyzed.From 1987 to 2012,a total of 8738 proposals related to cancer research were funded by NSFC.The percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,respectively.Under the support of NSFC,cancer research in China has achieved a significantly rapid and balanced development in both disciplines and scientist resources. | HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan | 2013 | Chinese Science Bulletin2013，58，1： | 5 |
| 9 | The effects of asymmetric potential vorticity forcing on the instability of South Asia High and Indian summer monsoon onset显示文摘Based on the theory of potential vorticity(PV),the unstable development of the South Asia High(SAH)due to diabatic heating and its impacts on the Indian Summer Monsoon(ISM)onset are studied via a case diagnosis of 1998.The Indian Summer Monsoon onset in 1998 is related to the rapidly strengthening and northward moving of a tropical cyclone originally located in the south of Arabian Sea.It is demonstrated that the rapid enhancement of the cyclone is a consequence of a baroclinic development characterized by the phase-lock of high PV systems in the upper and lower troposphere.Both the intensification of the SAH and the development of the zonal asymmetric PV forcing are forced by the rapidly increasing latent heat released from the heavy rainfall in East Asia and South East Asia after the onsets of the Bay of Bengal(BOB)monsoon and the South China Sea(SCS)monsoon.High PV moves southwards along the intensified northerlies on the eastern side of the SAH and travels westwards on its south side,which can reach its northwest.Such a series of high PV eddies are transported to the west of the SAH continuously,which is the main source of PV anomalies in the upper troposphere over the Arabian Sea from late spring to early summer.A cyclonic curvature on the southwest of the SAH associated with increasing divergence,which forms a strong upper tropospheric pumping,is generated by the anomalous positive PV over the Arabian Sea on 355 K.The cyclone in the lower troposphere moves northwards from low latitudes of the Arabian Sea,and the upper-layer high PV extends downwards and southwards.Baroclinic development thus occurs and the tropical low-pressure system develops into an explosive vortex of the ISM,which leads to the onset of the ISM.In addition,evolution of subtropical anticyclone over the Arabian Peninsula is another important factor contributing to the onset of the ISM.Before the onset,the surface sensible heating on the Arabian Peninsula is very strong.Consequently the subtropical anticyclone which dominated the Arabian Sea in spring retreats westwards to the Arabian Peninsula and intensifies rapidly.The zonal asymmetric PV forcing develops gradually with high PV eddies moving southwards along northerlies on the eastern side of the anticyclone,and a high PV trough is formed in the middle troposphere over the Arabian Sea,which is favorable to the explosive barotropic development of the tropical cyclone into the vortex.Results from this study demonstrate that the ISM onset,which is different from the BOB and the SCS monsoon onset,is a special dynamical as well as thermodynamic process occurring under the condition of fully coupling of the upper,middle,and lower tropospheric circulations. | ZHANG YaNi WU GuoXiong LIU YiMin GUAN Yue | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 10 | Generation of 7-fs laser pulse directly from a compact Ti:sapphire laser with chirped mirrors显示文摘A compact femtosecond Ti:sapphire laser resonator consisting of three chirped mirrors and one output coupler was designed. By accurately balancing the intra- cavity dispersions between Ti:sapphire crystal, air and chirped mirrors, we directly generated the laser pulse shorter than 7 fs at the average power of 340 mW with 3.1 W pump. The repetition rate of the laser oscillator is 173 MHz at the centre wavelength of 791 nm, and the ultrabroaden spectrum covers from 600 nm to 1000 nm. To the best of our knowledge, this is the simplest laser resonator capable of generating sub-10 fs laser pulse. | ZHAO YanYing WANG Peng ZHANG Wei TIAN JinRong WEI ZhiYi | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，3： | 4 |
| 11 | Scalable and ultrafast epitaxial growth of single-crystal graphene wafers for electrically tunable liquid-crystal microlens arrays显示文摘The scalable growth of wafer-sized single-crystal graphene in an energy-efficient manner and compatible with wafer process is critical for the killer applications of graphene in high-performance electronics and optoelectronics. Here, ultrafast epitaxial growth of single-crystal graphene wafers is realized on singlecrystal Cu90Ni10(1 1 1) thin films fabricated by a tailored two-step magnetron sputtering and recrystallization process. The minor nickel(Ni) content greatly enhances the catalytic activity of Cu, rendering the growth of a 4 in. single-crystal monolayer graphene wafer in 10 min on Cu90Ni10(1 1 1), 50 folds faster than graphene growth on Cu(1 1 1). Through the carbon isotope labeling experiments, graphene growth on Cu90Ni10(1 1 1) is proved to be exclusively surface-reaction dominated, which is ascribed to the Cu surface enrichment in the Cu Ni alloy, as indicated by element in-depth profile. One of the best benefits of our protocol is the compatibility with wafer process and excellent scalability. A pilot-scale chemical vapor deposition(CVD) system is designed and built for the mass production of single-crystal graphene wafers, with productivity of 25 pieces in one process cycle. Furthermore, we demonstrate the application of single-crystal graphene in electrically controlled liquid-crystal microlens arrays(LCMLA), which exhibit highly tunable focal lengths near 2 mm under small driving voltages. By integration of the graphene based LCMLA and a CMOS sensor, a prototype camera is proposed that is available for simultaneous light-field and light intensity imaging. The single-crystal graphene wafers could hold great promising for highperformance electronics and optoelectronics that are compatible with wafer process. | Bing Deng Zhaowei Xin Ruiwen Xue Shishu Zhang Xiaozhi Xu Jing Gao Jilin Tang Yue Qi Yani Wang Yan Zhao Luzhao Sun Huihui Wang Kaihui Liu Mark H. Rummeli Lu-Tao Weng Zhengtang Luo Lianming Tong Xinyu Zhang Changsheng Xie Zhongfan Liu Hailin Peng | 2019 | Science Bulletin2019，64，10： | 4 |
| 12 | Synthesis and Microstructure Analysis of Autoclaved Aerated Concrete with Carbide Slag Addition显示文摘Synthesis of autoclaved aerated concrete(AAC) has been carried out with carbide slag addition, and the carbide slag could be used as a main material to produce the AAC with the compressive strength about 2 MPa and the density below 0.6 g?cm-3. In this study, quartz sand acted as frame structure phase in the matrix, and quartz addition also infl uenced the Si/Ca of starting material. Tobermorite and CSH gel were formed readily at 62%, which seemed to enhance the compressive strength of samples. Curing time seemed to affect the morphology of phase produced, and specimen with the plate-like tobermorite formed at 10 h appeared to have a better compressive strength development than the fiber-like one at 18 h. The higher curing temperature seemed to favor the tobermorite and CSH gel formation, which also exerted a significant effect on the strength development of the samples. On the micro-scale, the formed CSH gel was filled in the interface of the matrix, and the tobermorite appeared to grow in internal-surface of the pores and interstices. The tobermorite or/and CSH formation seemed to densify the matrix, and therefore enhanced the strength of the samples. | 范俊杰 CAO Deguang 景镇子 ZHANG Yi PU Li JING Yani | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 4 |
| 13 | Early candidate biomarkers found from urine of glioblastoma multiforme rat before changes in MRI显示文摘Dear Editor,Gliomas are the most frequent primary tumors of the central nervous system,accounting for more than 60%of all brain tumors(Wang and Bettegowda,2015).Among them,glioblastoma multiforme(GBM)is the most common aggressive glioma,and the average survival rate remains low(Chen et al.,2015).The standard combination of surgery and radiotherapy or chemotherapy can only extend the progressionfree survival time for 12–18 months,with a high risk of recurrence(Li et al.,2008).In addition,the incidence of | Yanying Ni Fanshuang Zhang Manxia An Wei Yin Youhe Gao | 2018 | Science China(Life Sciences)2018，61，8： | 4 |
| 14 | Measurement of electric properties of the single supersaturated aerosol droplet显示文摘A system for measuring the electric properties of single aerosol droplet is designed and applied to the NaClO4 aerosol droplet in different relative humidity (RH). The conductance and capacitance are ob-tained within the whole RH range, especially in the supersaturated state which cannot be acquired from the bulk solution. These results reflect the situation of ions in the droplet macroscopically and supply useful information for other relative study fields, such as crystallogeny and aerography. | HE KeJuan CHENG Hua ZHU YanYing WANG LiangYu ZHANG YunHong | 2008 | Chinese Science Bulletin2008，53，11： | 3 |
| 15 | Early urinary candidate biomarker discovery in a rat thioacetamide-induced liver fibrosis model显示文摘Biomarker is the change associated with the disease. Blood is relatively stable because of the homeostatic mechanisms of the body. However, urine accumulates changes of the body, which makes it a better early biomarker source. Liver fibrosis is a reversible pathological condition, whereas cirrhosis, the end-stage of liver fibrosis, is irreversible. Consequently, noninvasive early biomarkers for fibrosis are desperately needed. In this study, differential urinary proteins were identified in the thioacetamide liver fibrosis rat model using tandem mass tagging and two-dimensional liquid chromatography tandem mass spectrometry. A total of 766 urinary proteins were identified, 143 and 118 of which were significantly changed in the TAA 1-week and3-week groups, respectively. Multiple reaction monitoring(MRM)-targeted proteomics was used to further validate the abundant differentially expressed proteins. A total of 40 urinary proteins were statistically significant, 15 of which had been previously reported as biomarkers of liver fibrosis, cirrhosis or other related diseases and 10 of which had been reported to be associated with the pathology and mechanism of liver fibrosis. These differential proteins were detected in urine before the alanine aminotransferase and aspartate transaminase changes in the serum and before fibrosis was observed upon hematoxylin and eosin(HE) and Masson's staining. | Fanshuang Zhang Yanying Ni Yuan Yuan Wei Yin Youhe Gao | 2018 | Science China(Life Sciences)2018，61，11： | 3 |
| 16 | Sub-10 fs laser pulses with repetition rate of 1.1 GHz by a Ti:sapphire oscillator显示文摘We demonstrate a compact Ti:sapphire oscillator with ring cavity configuration.By optimizing the intra-cavity dispersion with chirped mirrors,pulses with repetition rate of 1.1 GHz are coupled out by the uncoated wedges in the cavity.Under 7W CW pump laser centered at 532 nm,the average power of the output pulses is about 30 mW,the duration is less than 10fs and the spectrum spans from 670 nm to 920 nm. | ZHANG Qing ZHAO YanYing WEI ZhiYi | 2009 | Chinese Science Bulletin2009，54，20： | 3 |
| 17 | The protective effect of 17 beta-estradiol on oxygen-induced retinopathy and its relation with the changes of malondialdehyde显示文摘Objective:Retinopathy of prematurity is becoming obvious with the improvement of neonatal ambulance. However there is still not a good treatment. The present study is to observe the effect of 17 beta-estradiol (E2) on oxygen-induced retinopathy (OIR), and explore the relationship between the changes of avascular area and malondialdehyde (MDA) in retina. Methods: Newborn oxygen-exposed mice underwent subcutaneous injections of different dose of E2 (0.1 μg, 1.0 μg, 10.0 μg ), tamoxifen or phosphate buffered saline (PBS; controls)everyday from post-natal day (p)7 to p17. At p17, retinal flat mounts were scored for the percentage of avascular/total retinal area, and pathological changes during revascularization. The MDA concentration in the retina was determined also. In the most efficacious E2 group (10.0 μg), 100.0 μg tamoxifen was also administered, and the percentage of capillary-free/total retinal area determined, and the retinal malondialdehyde concentration assayed. Results: The mean percentage of capillary-free area over total retinal area was 0(PBS, in room air), 34.197±1.301(PBS, in hyperoxia), 23.685±0.407 (0.1 μg E2), 14.648±0.355 (1.0 μg E2), 4.693±0.450 (10.0 μg E2) and 32.240±0.654 (10.0 μg E2 +100.0 μg tamoxifen). The difference was significant (F=2778.759, P<0.01), and the difference between any two groups were also significant (all P value were less than 0.01). The predilection of tufts and clusters during revascularization was mainly aggregated in zones 2 and 3, but the difference of retinal neovascular clusters and tufts in fourth zone among different groups were significant [clusters (F=44.719, P<0.01) vs tufts (F =39.997,P<0.01)]. The mean MDA concentration were 0.711±0.037(PBS, in room air), 2.084±0.066 (PBS, in hyperoxia), 1.829±0.091(0.1 μg E2), 1.152±0.067(1.0 μg E2), 0.796±0.027(10.0 μg E2), 1.988±0.049(10.0 μg E2 +100.0 μg tamoxifen) (F=628.103, P<0.01). The difference between any two groups were also significant (all P value were less than 0.05). The close relation between the percentage of avascular/total retinal area and MDA concentration was also verified (r=0.981, P<0.01). Conclusion: Oxidative stress responses play a pivotal role in OIR, by means of receptor pathway. E2 can alleviate oxidative stress reaction, and thus ameliorate the severity of oxygen induced retinopathy. | Hongbing Zhang Naixue Sun Houcheng Liang Xianghua Xiao Xianning Liu Yani Wang | 2010 | The Journal of Biomedical Research2010，24，2： | 3 |
| 18 | The Application of LM-BP Neural Network in the Prediction of Total Output Value of Agriculture显示文摘Gross agricultural product is an important indication to measure the agricultural development level of a region. It would be affected by many factors,having the characteristics of non- linearity. For this reason,LM- BP neural network was put forward as the model and method for predicting gross agricultural product. Taking the indications of the sown area of crop,the output of grain,sugarcane,cassava,tea,meat,aquatic products,turpentine and camellia seed,etc. as inputs,during 2000 to 2012 in Guangxi,the gross agricultural product data from the analysis of simulation experiment show that the prediction of LM- BP neural network fits well with actual results. | Zimin ZHANG Yanying FAN Guanping CHEN | 2015 | Asian Agricultural Research2015，7，2： | 2 |
| 19 | Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis显示文摘Marsdenia tenacissima injection,a standard Marsdenia tenacissima extract(MTE),has been approved as an adjuvant therapeutic agent for various cancers.Our previous study showed that MTE inhibited the proliferation and metastasis of prostate cancer(PCa)cells.However,the underlying mechanisms and active ingredients of MTE against PCa were not completely understood.This study revealed that MTE induced significant decreases in cell viability and clonal growth in PCa cells.In addition,MTE induced the apoptosis of DU145 cells by reducing the mitochondrial membrane potential and increasing the expression of Cleaved Caspase 3/7,Cyt c,and Bax.In vivo,DU145 xenografted NOD-SCID mice treated with MTE showed significantly decreased tumor size.TUNEL staining and Western blot confirmed the pro-apoptotic effects of MTE.Network pharmacology analysis collected 196 ingredients of MTE linked to 655 potential targets,and 709 PCa-associated targets were retrieved,from which 149 overlapped targets were screened out.Pathway enrichment analysis showed that the HIF-1,PI3K-AKT,and ErbB signaling pathways were closely related to tumor apoptosis.Western blot results confirmed that MTE increased the expression of p-AKT^(Ser473) and p-GSK3β^(Ser9),and decreased the expression of p-STAT3^(Tyr705) in vitro and in vivo.A total of 13 compounds in MTE were identified by HPLC-CAD-QTOF-MS/MS and UPLCQTOF-MS/MS.Molecular docking analysis indicated that six compounds may interact with AKT,GSK3β,and STAT3.In conclusion,MTE induces the endogenous mitochondrial apoptosis of PCa by regulating the AKT/GSK3β/STAT3 signaling axis,resulting in inhibition of PCa growth in vitro and in vivo. | LI Xiaolan HE Songhua LIANG Wei ZHANG Weiquan CHEN Xin LI Qiaofeng YANG Xin LIU Yanying ZHU Dan LI Li LIU Buming SU Zhiheng CHEN Jie GUO Hongwei | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 2 |
| 20 | Modeling and Thermodynamics of Methylene Blue and Acid Blue 80 Adsorption onto Potato Residue Based Activated Carbon显示文摘 | LIU Yani LUO Xinsheng ZHANG Zhe ZHOU Pengxin YANG Zhiwang | 2015 | Chemical Research in Chinese Universities2015，31，4： | 2 |
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