5篇
您的检索式：作者名="Zhang Zhenjuan"
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| 1 | Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in rats显示文摘The mammalian target of rapamycin (mTOR) pathway plays an important role in neuronal growth, proliferation and differentiation. To better understand the role of mTOR pathway involved in the induction of spinal cord injury, rat models of spinal cord injury were established by modified Allen's stall method and interfered for 7 days by intraperitoneal administration of mTOR activator adenosin triphosphate and mTOR kinase inhibitor rapamycin. At 1-4 weeks after spinal cord injury induction, the Basso, Beattie and Bresnahan locomotor rating scale was used to evaluate rat locomotor function, and immunohistochemical staining and western blot analysis were used to detect the expression of nestin (neural stem cell marker), neuronal nuclei (neuronal marker), neuron specific enolase, neurofilament protein 200 (axonal marker), glial fibrillary acidic protein (astrocyte marker), Akt, mTOR and signal transduction and activator of transcription 3 (STAT3). Results showed that adenosine triphosphate-mediated Akt/mTOR/STAT3 pathway increased endogenous neural stem cells, induced neurogenesis and axonal growth, inhibited excessive astrogliosis and improved the locomotor function of rats with spinal cord injury. | Zhengang Sun Lingyun Hu Yimin Wen Keming Chen Zhenjuan Sun Haiyuan Yue Chao Zhang | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 2 | Lymphangiogenesis and biological behavior in pancreatic carcinoma andother pancreatic tumors显示文摘 | Zhongqiu Wang Jiang Wu Guojun Li Xinhua Zhang Mingmin Tong Zhengcan Wu Zhenjuan Liu | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 3 | Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays显示文摘 | ZHANG Hongyan DUAN Zhenjuan WANG Lei | 2006 | Journal of Agricultural and Food Chemistry2006，54，13： | 1 |
| 4 | Synchronization of chaotic Lur′e systems with quantized sampled data controller显示文摘 | Xiao Xiaoqing Zhou Lei Zhang Zhenjuan | 2014 | Communications in Nonlinear Science and Numerical Simulation2014，19，6： | 1 |
| 5 | Excimer-based Activatable Fluorescent Sensor for Sensitive Detection of Alkaline Phosphatase显示文摘The accurate detection of related biomarkers at early stage is crucial in diagnosis and therapy of cancer.Small molecule fluorescence probes stand out acting as efficient tools to detect biomolecules,especially biomacromolecules.Herein,a new probe that features excimer formation has been designed to detect cancer-related biomarker alkaline phosphatase(ALP).The probe shows high sensitivity to ALP with a low limit detection of 0.13 U/L and high selectivity with resistance to the interference in the complex physiological system.Furthermore,this probe presents good biocompatibility with negligible cytotoxicity and displays remarkable cell imaging functions,which allows for its application in biosystems.Theoretical simulation validates the high affinity of the probe with ALP and depicts the details of the interaction modes,which provides the possible mechanisms underlying the efficient detection of the probe in atomic level.The study of synthesis,properties and applications of the activatable emissive excimers not only enriches the tools to detect ALP,but also provides a new strategy to comprehend the pathogenic mechanism of enzyme-related diseases. | YUAN Fang LI Yang CHEN Zhenjuan ZHANG Jianjian NING Lulu YANG Xiao-Feng PU Kanyi | 2021 | Chemical Research in Chinese Universities2021，37，4： | 0 |
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