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| 1 | Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of rapamycin pathway in rats显示文摘The mammalian target of rapamycin (mTOR) pathway plays an important role in neuronal growth, proliferation and differentiation. To better understand the role of mTOR pathway involved in the induction of spinal cord injury, rat models of spinal cord injury were established by modified Allen's stall method and interfered for 7 days by intraperitoneal administration of mTOR activator adenosin triphosphate and mTOR kinase inhibitor rapamycin. At 1-4 weeks after spinal cord injury induction, the Basso, Beattie and Bresnahan locomotor rating scale was used to evaluate rat locomotor function, and immunohistochemical staining and western blot analysis were used to detect the expression of nestin (neural stem cell marker), neuronal nuclei (neuronal marker), neuron specific enolase, neurofilament protein 200 (axonal marker), glial fibrillary acidic protein (astrocyte marker), Akt, mTOR and signal transduction and activator of transcription 3 (STAT3). Results showed that adenosine triphosphate-mediated Akt/mTOR/STAT3 pathway increased endogenous neural stem cells, induced neurogenesis and axonal growth, inhibited excessive astrogliosis and improved the locomotor function of rats with spinal cord injury. | Zhengang Sun Lingyun Hu Yimin Wen Keming Chen Zhenjuan Sun Haiyuan Yue Chao Zhang | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 2 | Lymphangiogenesis and biological behavior in pancreatic carcinoma andother pancreatic tumors显示文摘 | Zhongqiu Wang Jiang Wu Guojun Li Xinhua Zhang Mingmin Tong Zhengcan Wu Zhenjuan Liu | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 3 | Prenatal ultrasonographic characteristics and prognosis of isolated redundant foramen ovale flap显示文摘Objective:To analyze the prenatal ultrasonographic characteristics and prognosis of the isolated redundant foramen ovale flap(RFOF).Methods:From January 2014 to December 2021,we collected data on fetal echocardiography analyses and perinatal outcomes for fetuses with isolated RFOF in Peking University People's Hospital.Results:We found that 0.31%(87/28308)of participants have RFOF.The four-chamber results of the foramen ovale flap(FOF)showed that it was stiff and extended>50%or reached the lateral wall of the left atrium(LA)in diastole.As seen from the foramen ovale(FO)channel and four-chamber views,the hypermobile and redundant flap were observed shrinking and stretching with the fetal cardiac cycle,which is similar to jellyfish.The lateral displacement of flow from LA to the left ventricle(LV)around the FOF on color doppler demonstrated thin linear blood flow from the right to left and a reversal of flow across FO.A uniphasic,but not biphasic,pattern of FOF displacement was observed on M-mode.Stages I(23/87)and II(51/87)had a higher ratio of ventricular disproportion than Stage 0(11/87)and III(2/87).We observed the RA/LA(right/left atrium)>1.2 in 53 cases(60.9%),RV/LV(right/left ventricle)>1.2 in 53 cases(60.9%),PA/AO(pulmonary/aortic artery)>1.2 in 53 cases(60.9%),and moderate or severe tricuspid regurgitation in 10 cases and moderate pericardial effusion in 2 cases(2.2%).Seventy-four RFOF cases had follow-up data.Neonatal death occurred in 2 cases;72 fetuses survived with normal or minor heart defects.Conclusion:RFOF should be considered if the left side of the heart of a fetus is smaller and related to hypermobile FOF.For isolated RFOF cases,a monthly follow-up is recommended to monitor arrhythmia or fetal hydrop status.Prompt treatment is recommended for those with adequate gestational age and lung maturity. | Yuntao Li Qiuyan Pei Zhenjuan Yang Yani Yan Xiaowei Xue | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，3： | 1 |
| 4 | Recent TwoStage Sample Selection Procedures with an Application to the Gender Wage Gap显示文摘 | Qi Li and Zhenjuan Liu | 2003 | Journal of Business & Economic Statistics2003，21，3： | 1 |
| 5 | Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays显示文摘 | ZHANG Hongyan DUAN Zhenjuan WANG Lei | 2006 | Journal of Agricultural and Food Chemistry2006，54，13： | 1 |
| 6 | Electrochemical sensor using methimazole imprinted polymer sensitized with MWCNTs and Salen-Co(III) as recognition element 显示文摘 | Pan Mingfei Fang Guozhen Duan Zhenjuan | 2012 | Biosens Bioelectron2012，31，： | 1 |
| 7 | Fabrication and phase transition of La2-xLuxZr2O7transparent ceramics显示文摘 | WANG Zhenjuan ZHOU Guohong QIN Xianpeng | 2014 | Journal of the European Ceramic Society2014，34，15： | 1 |
| 8 | Fabrication of LaGdZr2O7transparent ceramic显示文摘 | WANG Zhenjuan ZHOU Guohong QIN Xianpeng | 2013 | Journal of the European Ceramic Society2013，33，： | 1 |
| 9 | Synchronization of chaotic Lur′e systems with quantized sampled data controller显示文摘 | Xiao Xiaoqing Zhou Lei Zhang Zhenjuan | 2014 | Communications in Nonlinear Science and Numerical Simulation2014，19，6： | 1 |
| 10 | Towards timed fuzzy Petri net algorithms for chemical abnormality monitoring显示文摘 | Zhenjuan Liu Hongguang Li Peijian Zhou | 2011 | Expert Systems with Applications2011，38，： | 1 |
| 11 | Research on Monitoring Methods for Electricity Hall Staff Based on Autonomous Updating and Semi-supervising Model显示文摘 | Yao Tang Zhenjuan Qiao Rui Zou Xueming Qiao Chenglin Liu Yiliang Wang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 12 | Excimer-based Activatable Fluorescent Sensor for Sensitive Detection of Alkaline Phosphatase显示文摘The accurate detection of related biomarkers at early stage is crucial in diagnosis and therapy of cancer.Small molecule fluorescence probes stand out acting as efficient tools to detect biomolecules,especially biomacromolecules.Herein,a new probe that features excimer formation has been designed to detect cancer-related biomarker alkaline phosphatase(ALP).The probe shows high sensitivity to ALP with a low limit detection of 0.13 U/L and high selectivity with resistance to the interference in the complex physiological system.Furthermore,this probe presents good biocompatibility with negligible cytotoxicity and displays remarkable cell imaging functions,which allows for its application in biosystems.Theoretical simulation validates the high affinity of the probe with ALP and depicts the details of the interaction modes,which provides the possible mechanisms underlying the efficient detection of the probe in atomic level.The study of synthesis,properties and applications of the activatable emissive excimers not only enriches the tools to detect ALP,but also provides a new strategy to comprehend the pathogenic mechanism of enzyme-related diseases. | YUAN Fang LI Yang CHEN Zhenjuan ZHANG Jianjian NING Lulu YANG Xiao-Feng PU Kanyi | 2021 | Chemical Research in Chinese Universities2021，37，4： | 0 |
| 13 | Effect of high-pressure detonation products on fuel injection and propagation characteristics of detonation wave显示文摘The effect of high-pressure detonation products on fuel injection and propagation characteristics of detonation wave has been investigated in the form of ion voltage by varying the equivalence ratio(ER),air mass flux,and operation duration with hydrogen-air mixtures.It has been shown experimentally that the ion voltage decays gradually during the initial stage of rotating detonation wave(RDW).The attenuation of ion voltage is a general phenomenon,and the decay rate of ion voltage and its peak value of the trough state are related to the equivalence ratio and air mass flux.The analysis of interaction between the combustor and hydrogen plenum indicates that the feedback of high-pressure detonation products leads to the attenuation of ion voltage.In addition,the long-duration tests show that the ion voltage will recover to a steady state with the extension of reaction time,when the purgation(products leaving plenums)of detonation products is greater than feedback(products entering plenums)of detonation products in the hydrogen plenum.The recovery of ion voltage starts earlier at the higher equivalence ratio and air mass flux,and the peak value of ion voltage in the steady state also increases with the increase of equivalence ratio and air mass flux.A low frequency oscillation about 10 e12 Hz occurs in the RDW at some operation conditions.This low frequency oscillation is related to the interaction between the combustor and hydrogen plenum,and can be eliminated by either increasing the equivalence ratio or decreasing the air mass flux. | Gaoyang Ge Li Deng Hu Ma Zhenjuan Xia Xiao Liu Changsheng Zhou | 2022 | Propulsion and Power Research2022，11，1： | 0 |
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