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| 1 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | 平均动脉压、脉压与全因死亡率的纵向变化:来自71629名未经治疗的正常高值血压参与者的数据显示文摘血压通常包括平稳成分[平均动脉压(mean arterial pressure,MAP)]和波动成分,都可独立预测死亡率。目前还没有针对中心脉压(central pulse pressure,cPP)、肱动脉脉压(brachial pulse pressure,bPP)、MAP的纵向变化与死亡率之间关系的调查。方法:对年龄16~95岁未接受高血压治疗的71 629例参与者进行2次常规检查. | Protogerou AD Vlachopoulos C Thomas F Zhang Y Pannier B Blacher J Safar ME 陈云 | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 5 | Optimization of processing parameters for the uhrasonic extraction of goat kid rennet显示文摘 | ZHANG F WANG B | 2007 | International Journal of Dairy Technology2007，60，4： | 1 |
| 6 | Influences of Bentonite on conductivity of composite solid alkaline polymer electrolyte PVA- Bentonite-KOH-H2O显示文摘 | Sang S B Zhang J F Wu Q M | 2007 | Electrochim Acta2007，52，25： | 1 |
| 7 | Fatigue resistance of plasma - sprayed CrC - NiCr cermet coatings in rolling contact 显示文摘 | Zhang X C Xu B S Xuan F Z | 2008 | Applied Surface Science2008，254，13： | 1 |
| 8 | Asynchronous Interference Mitigation in Cooperative Base Station Systems显示文摘 | ZHANG Hong-yuan MEHTA N B MOLISCJ A F | 2008 | IEEE Transactions on Wireless Communications2008，7，1： | 1 |
| 9 | A Novel Strategy to Fabricate γ-Fe2O3-MWCNTs Hybrids with Selectively Ferromagnetic or Superparamagnetic Properties 显示文摘 | Fan X B Tan F Y Zhang G L | 2007 | Mater Sci & Eng A2007，45，： | 1 |
| 10 | Effect of genome composition and cytoplasm on petal colour in resynthesized amphidiploids and sesquidiploids derived from crosses between Brassica rapa and Brassica oleracea显示文摘 | Zhang B Lu C M Kakihara F | 2002 | Plant Breeding2002，121，： | 1 |
| 11 | Thermodynamic assessment of the Ag-Yb system显示文摘 | ZHANG L G MENG F G LIU H S LILT L B JIN Z P | 2008 | J Alloys and Compounds2008，452，： | 1 |
| 12 | Development of and Intelligen't CAE System for Auto-body Concept Design 显示文摘 | Hou W B Zhang H Z Chi R F | 2009 | Inter- national Journal of Automotive Technology2009，10，2： | 1 |
| 13 | Some inequalities on generalized Schur complements显示文摘 | Wang B Y Zhang X P Zhang F | 1999 | Linear Algebra Appl1999，，302303： | 1 |
| 14 | Effects of polarons and bipolarons on spin polarized transport in an organic device 显示文摘 | Zhang Y B Ren J F Hu G C Xie S J | 2008 | Organic Electronic2008，9，： | 1 |
| 15 | Mechanism and experimental verification of degradation of RC beams induced by concrete/rebar Engineering Materials, 2011 bonding failure显示文摘 | He X B Huang F Zhang C Y | 2011 | Key2011，，： | 1 |
| 16 | Induction of cell prolifera- tion and survival genes by estradiol-repressed microRNAs in breast cancer cells显示文摘 | Yu X F Zhang X M Dhakal I B | 2012 | BMC cancer2012，12，： | 1 |
| 17 | Usefulness of enhanced power Doppler imaging in monitoring acral microcirculation in type 2 diabetes mellitus and its complications 显示文摘 | Ma F Zhao B Zhang H | 2011 | Cell Biochem Biophys2011，61，2： | 1 |
| 18 | Preparation of titani- um silicalite-I catalytic films and apphcation as catalytic membrane reactors 显示文摘 | WANG X B ZHANG X F LIU H | 2010 | Chem Eng J2010，156，3： | 1 |
| 19 | A real explosion: The requirement of steam explosion pretreatment显示文摘 | Yu Z D Zhang B L Yu F Q | 2012 | Bioresource Technology2012，121，： | 1 |
| 20 | Particle stick- ing behavior near the throat of a low-NOx Lxial-swirl coal burner 显示文摘 | Li Z Q Zeng L Y Zhao G B Shen S P Zhang F C | 2011 | Applied Energy2011，88，： | 1 |
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