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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Reductilization of an embrittled amorphous La55Al25Ni20 alloy by water quenching from supercooled liquid显示文摘	ZHANG T MATSUBARA E	1991	Materials Transactions JIM1991，32，3：	1
3	Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes显示文摘	LIU G T ZHANG T M WANG B E	1992	Biochem Pharmacol1992，43，2：	1
4	Surface studies of pristine and surface modified polypyrrole films显示文摘	ZHANG X KANG E T NEOH K G	1996	Journal of Applied Polymer Science1996，60，：	1
5	Gas-particle partitioning of PCBs and PAHs in the Chicago urban and adjacent coastal atmosphere: states of equilibrium 显示文摘	Simcik M E Franz T E Zhang H X	1998	Environmental Science and Technology1998，32，2：	1
6	An electrochemical method for accelerated testing of chloride diffusivity in concrete显示文摘	ZHANG T GJORV O E	1994	Cement and Concrete Research1994，24，8：	1
7	A review of paired catchment studies for determining changes in water yield resulting from alterations in vegetation显示文摘	Brown A E Zhang Lu McMahon T A et at	2005	Journal of hydrology2005，310，14：	1
8	Anti-Malassezia- specific IgE antibodies production in Japanese patients with head and neck atopic dermatitis: relationship be- tween the level of specific IgE antibody and the coloniza- tion frequency of cutaneous Malassezia species and clini- cal severity显示文摘	Zhang E Tanaka T Tajima M	2011	J Allergy ( Cairo)2011，2011，64：	1
9	Characterization of the skin fungal mierobiota in patients with atopic dermatitis and in healthy subjects 显示文摘	Zhang E Tanaka T Tajima M	2011	Mierobiol Immuno12011，55，9：	1
10	Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘	Zhang T Geoffrey S E Stephen C R etal	2012	Organic Geo- chemistry2012，47，：	1
11	Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘	Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C	2014	An- tiviral Research2014，110，：	1
12	Visual contour tracking based on particle filters 显示文摘	LIP H ZHANG T W ARRHUR E C P	2003	Image and Vision Computing2003，21，1：	1
13	Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy 显示文摘	Schacker T Little S Connick E Gebhard-Mitchell K Zhang ZQ Krieger J Pryor J Havlir D Wong JK Richman D Corey L Haase AT	2000	J Infect Dis2000，181，1：	1
14	Visual contour tracking based on particle filters显示文摘	Li P H Zhang T W Arthur E C P	2003	Image and Vision Computing2003，21，1：	1
15	Fabrication of Fe/Fe 3C@ porous carbon sheets from biomass and their applicationforsimultaneous reduction and adsorption of uranium(V I) from solution 显示文摘	Wang X Zhang S L i J e t a l	2014	Inorganic Chemistry Frontiers2014，1，8：	1
16	Reductilization of an embrittled amorphous La55A125Ni20 alloy by water quenching from supercooled liquid显示文摘	ZHANG T MATSUBARA E	1991	Materials Transactions JIM1991，32，3：	1
17	A biomarker panel for peripheral arterial disease显示文摘	Fung E T Wilson A M Zhang F Harris N Edwards K A Olin J W	2008	Vasc Med2008，13，：	1
18	Exposure to solar UV-B radiation accelerates mass and llgnin Inss of Larrea tridentata litter in the Sonoran Desert 显示文摘	Day T A Zhang E T Ruhland C T	2007	Plant Ecology2007，193，2：	1
19	Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors显示文摘	Dastagir T Forzani E S Zhang R		0，，08：	1
20	Evaluation of interface shear strength and residual stress of sol-gel derived fluoridated hydroxyapatite coatings on Ti6A14V substrates显示文摘	ZHANG S WANG Y S ZENG X T CHENG K QIAN M SUN D E WENG W J CHIA W Y		0，，：	1

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