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| 1 | Progress in monitoring high-temperature damage to rice through satellite and ground-based optical remote sensing显示文摘The occurrence of rice high-temperature damage (HTD) has increased with global warming. Cultivation of rice is seriously affected by the HTD in the middle and lower reaches of the Yangtze River, which directly affects food security in this region and in the whole of China. It is important to monitor and assess crop HTD using satellite remote sensing information. This paper reviews the recent development of monitoring rice HTD using optical remote sensing information. It includes the use of optical remote sensing information to obtain the regional spatial distribution of high temperatures, mixed-surface temperature retrieval for rice fields based on mixed decomposition information, the development of field and thermal infrared testing and modeling, and the satellite/ground-based remote sensing coupled method for monitoring rice HTD. Finally, the prospects for monitoring crop HTD based on remote sensing information are summarized. | ZHANG JiaHua YAO FengMei LI BingBai YAN Hao HOU YingYu CHENG GaoFeng Vijendra BOKEN | 2011 | Science China Earth Sciences2011，54，12： | 11 |
| 2 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 3 | Joint Computing and Communication Resource Allocation for Satellite Communication Networks with Edge Computing显示文摘Benefit from the enhanced onboard processing capacities and high-speed satellite-terrestrial links,satellite edge computing has been regarded as a promising technique to facilitate the execution of the computation-intensive applications for satellite communication networks(SCNs).By deploying edge computing servers in satellite and gateway stations,SCNs can achieve significant performance gains of the computing capacities at the expense of extending the dimensions and complexity of resource management.Therefore,in this paper,we investigate the joint computing and communication resource management problem for SCNs to minimize the execution latency of the computation-intensive applications,while two different satellite edge computing scenarios and local execution are considered.Furthermore,the joint computing and communication resource allocation problem for the computation-intensive services is formulated as a mixed-integer programming problem.A game-theoretic and many-to-one matching theorybased scheme(JCCRA-GM)is proposed to achieve an approximate optimal solution.Numerical results show that the proposed method with low complexity can achieve almost the same weight-sum latency as the Brute-force method. | Shanghong Zhang Gaofeng Cui Yating Long Weidong Wang | 2021 | China Communications2021，18，7： | 8 |
| 4 | Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China显示文摘Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. | Xiaolan Zhang Gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，6： | 8 |
| 5 | Chemical vapor deposition of monolayer WS2 nano- sheets on Au foils toward direct application in hydrogen evolution显示文摘Monolayer tungsten disulfide (WS2), a typical member of the semiconducting transition metal dichalcogenide family has drawn considerable interest because of its unique properties. Intriguingly the edge of WS2 exhibits an ideal hydrogen binding energy which makes WS2 a potential alternative to Pt-based electrocatalysts for the hydrogen evolution reaction (HER). Here, we demonstrate for the first time the successful synthesis of uniform monolayer WS2 nanosheets on centimeter- scale Au foils using a facile, low-pressure chemical vapor deposition method. The edge lengths of the universally observed triangular WS2 nanosheets are tunable from -100 to N1,000 nm. The WS2 nanosheets on Au foils featuring abundant edges were then discovered to be efficient catalysts for the HER, exhibiting a rather high exchange current density of -30.20 μA/cm2 and a small onset potential of Nl10 mV. The effects of coverage and domain size (which correlate closely with the active edge density of WS2) on the electrocatalytic activity were investigated. This work not only provides a novel route toward the batch-production of monolayer WS2 via the introduction of metal foil substrates but also opens up its direct application for facile HER. | Yanshuo Zhang Jianping Shi Gaofeng Han Minjie Li Qingqing Ji Donglin Ma Yu Zhang Cong Li Xingyou Lang Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，9： | 7 |
| 6 | Multivalent m^6A motifs promote phase separation of YTHDF proteins显示文摘Dear Editor,Posttranscriptional modifications of coding and non-coding RNAs are prevale nt in cells.N6-methylade no sine (m6A) is the most abundant type of modification on eukaryotic messenger RNAs (mRNAs).1 This modification plays important roles in multiple fundamental biological processes, for example, cell differentiation, tissue development and tumorigenesis. | Yifei Gao Gaofeng Pei Dongxue Li Ru Li Yanqiu Shao Qiangfeng Cliff Zhang Pilong Li | 2019 | Cell Research2019，29，9： | 7 |
| 7 | A case study of regional eco-hydrological characteristics in the Tao River Basin, northwestern China, based on evapotranspiration estimated by a coupled Budyko Equation-crop coefficient approach显示文摘In a case study in Tao River Basin, China, we derived a high spatial-resolution regional distribution of evapotranspiration(ET) using the single crop coefficient method and Budyko equation. We then further analyzed the spatio-temporal characteristics of this diverse eco-hydrological basin from 2001–2010. The results suggest that the single crop coefficient method based on leaf area index captures better spatial and temporal dynamics of the regional ET than did the Budyko Equation method. The rising temperature was the main reason for the increasing ET in the Tao River Basin during 2001–2010. Areas with high ET efficiency were distributed mainly in the areas where the vegetation coverage was high, and a lower runoff coefficient responded. The estimated spatial patterns of ET allowed an improved understanding of the eco-hydrological processes within the Tao River Basin and the method used might be generalized as a reference for future regional-scale eco-hydrological research. | LI ChangBin ZHANG XueLei QI JiaGuo WANG ShuaiBing YANG LinShan YANG WenJin ZHU GaoFeng HAO Qiang | 2015 | Science China Earth Sciences2015，58，11： | 5 |
| 8 | Ultralight Magnetic and Dielectric Aerogels Achieved by Metal-Organic Framework Initiated Gelation of Graphene Oxide for Enhanced Microwave Absorption显示文摘The development of a convenient methodology for synthesizing the hierarchically porous aerogels comprising metal–organic frameworks(MOFs)and graphene oxide(GO)building blocks that exhibit an ultralow density and uniformly distributed MOFs on GO sheets is important for various applications.Herein,we report a facile route for synthesizing MOF/reduced GO(rGO)aerogels based on the gelation of GO,which is directly initiated using MOF crystals.Free metal ions exposed on the surface of MIL-88A nanorods act as linkers that bind GO nanosheets to a three-dimensional porous network via metal–oxygen covalent or electrostatic interactions.The MOF/rGOderived magnetic and dielectric aerogels Fe_(3)O_(4)@C/rGO and Ni-doped Fe_(3)O_(4)@C/rGO show notable microwave absorption(MA)performance,simultaneously achieving strong absorption and broad bandwidth at low thickness of 2.5(-58.1 dB and 6.48 GHz)and 2.8 mm(-46.2 dB and 7.92 GHz)with ultralow filling contents of 0.7 and 0.6 wt%,respectively.The microwave attenuation ability of the prepared aerogels is further confirmed via a radar cross-sectional simulation,which is attributed to the synergistic effects of their hierarchically porous structures and heterointerface engineering.This work provides an effective pathway for fabricating hierarchically porous MOF/rGO hybrid aerogels and offers magnetic and dielectric aerogels for ultralight MA. | Xiaogu Huang Jiawen Wei Yunke Zhang BinBin Qian Qi Jia Jun Liu Xiaojia Zhao Gaofeng Shao | 2022 | Nano-Micro Letters2022，14，7： | 4 |
| 9 | A Predictive 6G Network with Environment Sensing Enhancement:From Radio Wave Propagation Perspective显示文摘In order to support the future digital society,sixth generation(6G)network faces the challenge to work efficiently and flexibly in a wider range of scenarios.The traditional way of system design is to sequentially get the electromagnetic wave propagation model of typical scenarios firstly and then do the network design by simulation offline,which obviously leads to a 6G network lacking of adaptation to dynamic environments.Recently,with the aid of sensing enhancement,more environment information can be obtained.Based on this,from radio wave propagation perspective,we propose a predictive 6G network with environment sensing enhancement,the electromagnetic wave propagation characteristics prediction enabled network(EWave Net),to further release the potential of 6G.To this end,a prediction plane is created to sense,predict and utilize the physical environment information in EWave Net to realize the electromagnetic wave propagation characteristics prediction timely.A two-level closed feedback workflow is also designed to enhance the sensing and prediction ability for EWave Net.Several promising application cases of EWave Net are analyzed and the open issues to achieve this goal are addressed finally. | Gaofeng Nie Jianhua Zhang Yuxiang Zhang Li Yu Zhen Zhang Yutong Sun Lei Tian Qixing Wang Liang Xia | 2022 | China Communications2022，19，6： | 4 |
| 10 | Interleukin-5 promotes ATP-binding cassette transporter A1 expression through miR-211/JAK2/STAT3 pathways in THP-1-dervied macrophages显示文摘Interleukin-5 (IL-5) is manifested as its involvement in the process of atherosclerosis, but the mechanism is still unknown. In this study, we explored the effect of IL-5 on lipid metabolism and its underlying mechanisms in THP-1-derived macrophages. The quantitative polymerase chain reaction (qPCR) and western blot analysis results showed that IL-5 significantly up-regulated ATP-binding cassette transporter A1 (ABCA1) expression in a dose-dependent and time-dependent manner. [3H]-labeled cholesterol was used to assess the levels of cholesterol efflux, and the results showed that IL-5 increased ABCA1-mediated cholesterol efflux. A high-performance liquid chromatography assay indicated that cellular cholesterol content was decreased by IL-5 treatment in THP-1-derived macrophages. The selective inhibitor and small interfering RNA were used to block the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway. The results of the qPCR and western blot analysis showed that IL-5 activated JAK2/STAT3 pathway to up-regulate ABCA1 expression. Meanwhile, IL-5 reduced the expression level of miR-211. Furthermore, we found that JAK2 is a target gene of miR-211 and miR-211 mimic inhibited the expression of JAK2 and reduced the levels of p-STAT3 and ABCA1 as revealed by luciferase reporter assay, qPCR and western blot analysis. In summary, these findings indicated that IL-5 promotes ABCA1 expression and cholesterol efflux through the miR-211/JAK2/STAT3 signaling pathway in THP-1-derived macrophages. | Kong Chen Zhenwang Zhao Gang Wang Jin Zou Xiaohua Yu Dawei Zhang Gaofeng Zeng Chaoke Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 3 |
| 11 | Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway显示文摘 | Li Yang Jing Chen Xiaoyan Han Enfan Zhang Xi Huang Xing Guo Qingxiao Chen Wenjun Wu Gaofeng Zheng Donghua He Yi Zhao Yang Yang Jingsong He Zhen Cai | 2018 | Protein & Cell2018，9，9： | 3 |
| 12 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 13 | Mapping QTL underlying tuber starch content and plant maturity in tetraploid potato显示文摘Tuber starch content and plant maturity are two important agronomic traits of potato. To investigate the complex genetic basis of these traits in the cultivated potato, as well as the relationship between them, we developed a linkage map in a tetraploid population of 192 clones derived from the cross Longshu 8 × Zaodabai and mapped quantitative trait loci(QTL) for tuber starch content and plant maturity using data collected in three diverse environments over two years. We detected eleven QTL for tuber starch content distributed on seven chromosomes, of which four, on chromosomes I, II, and VIII, were expressed in at least three environments. For plant maturity, we identified six QTL on chromosomes II, IV,V, VII, and XI, one of which, on chromosome V, showed LOD peaks ranging from 45.2 to 62.5 cM and explained 21.6%–26.6% of phenotypic variation was expressed in five of the six environments. Because the reproducible QTL for plant maturity and tuber starch content mapped to different chromosomes and neither overlapping QTL, nor any genetic interaction between QTL were detected, we infer that tuber starch content and plant maturity are controlled by independent genetic loci. This inference supports the prospect of breeding potato for both early maturity and high starch content. | Jianwu Li Yihang Wang Guohong Wen Gaofeng Li Zhang Li Rong Zhang Sheng Ma Jun Zhou Conghua Xie | 2019 | The Crop Journal2019，7，2： | 3 |
| 14 | Joint Estimation of Carrier Frequency and Phase Offset Based on Pilot Symbols in Quasi-Constant Envelope OFDM Satellite Systems显示文摘Spectral efficiency and energy efficiency are two important performance indicators of satellite systems. The Quasi-Constant Envelope Orthogonal Frequency Division Multiplexing(QCE-OFDM) technique can achieve both high spectral efficiency and low peak-to-average power ratio(PAPR). Therefore, the QCE-OFDM technique is considered as a promising candidate multi-carrier technique for satellite systems. However, the Doppler effect will cause the carrier frequency offset(CFO), and the non-ideal oscillator will cause the carrier phase offset(CPO) in satellite systems. The CFO and CPO will further result in the bit-error-rate(BER) performance degradation. Hence, it is important to estimate and compensate the CFO and CPO. This paper analyzes the effects of both CFO and CPO in QCE-OFDM satellite systems. Furthermore, we propose a joint CFO and CPO estimation method based on the pilot symbols in the frequency domain. In addition, the optimal pilot symbol structure with different pilot overheads is designed according to the minimum Cramer-Rao bound(CRB) criterion. Simulation results show that the estimation accuracy of the proposed method is close to the CRB. | Cheng Wang Gaofeng Cui Weidong Wang Yinghai Zhang | 2017 | China Communications2017，14，7： | 3 |
| 15 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 16 | Frequency Offset Compensation for Satellite Communication System with CE-OFDM显示文摘Constant envelope orthogonal frequency division multiplexing(CE-OFDM) is a waveform that can achieve 0d B peak-to-average power ratio and avoid the signal distortion caused by the nonlinear power amplifi er. However, the carrier frequency offset(CFO) in CE-OFDM systems can cause errors at phase unwrapper module. In this paper, a CFO estimation scheme is proposed for CEOFDM in satellite communication system. As the null subcarrier is inherent in the conjugate symmetric symbol structure at the transmitter, the proposed scheme uses the null subcarrier as prior information to estimate the CFO at the receiver. The ideal estimation range of normalized CFO is obtained by mathematical analysis. Simulation results show that the proposed scheme can estimate the CFO accurately under additive white Gaussian noise(AWGN) channel and multipath fading channel, especially for moderate and high signal-to-noise ratio(SNR). | Gaofeng Cui Cheng Wang Weidong Wang Yinghai Zhang | 2017 | China Communications2017，14，8： | 3 |
| 17 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 18 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 19 | Carbon emission analysis of a residential building in China through life cycle assessment显示文摘在这份报纸,为碳排放财务的一个量的生命周期模型基于生命周期评价(LCA ) 被开发理论。在中国新加坡的天津 Eco 城市的一座居住大楼(天津,中国) 作为一件样品被选择,它根据绿环境保护和持续开发的概念被构造了。在这的情形,研究,材料生产,建设,使用和维护,和拆毁阶段由造碳排放模型被估计。结果证明那个使用和维护阶段和材料生产阶段是到一座大楼的生命周期碳排出物的最重要的贡献者。我们也在 LCA 分析了一些因素影响,包括绝缘的层和造服务生活的长度的厚度。分析建议那更厚的绝缘层未必确实根据 LCA 生产更少的碳排出物,并且如果一座大楼的服务生活增加,它的碳排出物将也在整个生命周期期间升起,但是它的联合起来的碳排放将相反地减少。从大楼控制碳排出物上的一些忠告也被提供。 | Yin ZHANG Xuejing ZHENG Huan ZHANG Gaofeng CHEN Xia WANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，1： | 2 |
| 20 | Effect of ecdysterone on heteroptopic heart transplantation in rats显示文摘Objective:To investigate the protective effects of ecdysterone(EDS)on the allograft heart transplant model of rats.Methods:Fifty healthy Sprayue-Dawley(SD)rats were divided into donors and recipients randomly.Hearts were harvested and placed heterotopically into allogenic recipients.All animals were divided into three groups:sham-operation group(only opening and closing the abdomen, n=10),EDS group(injected intraperitoneally with 20 mg/(kg·day)of EDS,n=10),and control group(injected intraperitoneally with normal saline,n=10).The pathological changes of myocardial tissue were analyzed by light microscopy and transmission electron microscopy and the levels of myocardial enzymes(GOT,LDH,CPK),SOD,ET-1,NO,MDA in serum were measured.Tissue samples underwent the detection of apoptotic cell death by in situ terminal deoxyribonucleotide transferase-mediated dUTP nick end labeling for apoptotic index(AI)and also by immunohistochemistry method to study the expressions of Bcl-2 and Bax.Results:Pathological examination and transmission electron microscope observation showed greater myocardium damage in the control group.EDS group showed a decrease in the amount of myocardial enzymes,MDA,ET-1 and an increase in the levels of SOD,NO,compared to the control group.The AI of EDS group became lower than that of control group,meanwhile the EDS group increased the expression of Bcl-2 and decreased the expression of Bax.Conclusion:EDS has protective effects on heteroptopic heart transplantation,which provides a new idea for myocardial protection in heart transplantation.However,the mechanism of its protective effect needs further research. | Zhong Zhao Yangyang Zhang Wen Ge Gaofeng Zhang Biao Yuan Kejiang Cao | 2008 | Journal of Nanjing Medical University2008，22，5： | 2 |
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