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| 1 | Microstructure control techniques in primary hot working of titanium alloy bars:A review显示文摘How to control the microstructure of titanium alloy bars is important to fabricating high-performance aerial forgings. This paper gives a thorough survey of the manufacturing methods and microstructure control techniques for titanium alloy bars. It summarizes the effects of processing parameters on the mechanisms and laws of microstructure evolution during b working and(a + b) working, including the kinetics and grains size of dynamic recrystallization(DRX) during b deformation and the kinetics and grains size of spheroidization during(a + b) deformation. The trends in microstructure control techniques are presented for fabricating titanium alloy bars with high efficiency, low cost, and high quality by means of b/(a + b) working, and the puzzles and challenges in the future are also pointed out. | Guo Lianggang Fan Xiaoguang Yu Gaofeng Yang He | 2016 | Chinese Journal of Aeronautics2016，29，1： | 19 |
| 2 | Formability,microstructure evolution and mechanical properties of wire arc additively manufactured AZ80M magnesium alloy using gas tungsten arc welding显示文摘Wire arc additive manufacturing(WAAM)technology has been used to fabricate the multi-layer single-pass deposited wall of AZ80M magnesium(Mg)alloy by gas tungsten arc welding.The formability,thermal cycles,microstructural evolution and mechanical properties of the WAAM AZ80M Mg alloy were investigated.The results show that there was significant difference in the temperature variation and the geometries between the original several layers and the subsequent deposited layers.Owing to the arc energy input,the interpass temperature rised rapidly and then stabilized at 150℃.As a result,the width of the deposited wall increased and then kept stable.There were obvious differences in the microstructure of the WAAM AZ80M Mg alloy among the top zone,intermediate zone and bottom zone of deposited wall.During the arc deposition process,theβphase of the WAAM AZ80M Mg alloy redissolved due to the cyclic heat accumulation,and then precipitated in the grain boundary.The cyclic heat accumulation also led to weakening of dendrite segregation.From the substrate to the top zone,the hardness of the deposited wall decreased gradually,and the intermediate zone which was the main body of deposited wall had relatively uniform hardness.The tensile properties of the WAAM AZ80M Mg alloy were different between the vertical direction and the horizontal direction.And the maximum ultimate tensile strength of the WAAM AZ80M Mg alloy was 308 MPa which was close to that of the as-extruded AZ80M Mg alloy. | Yangyang Guo Gaofeng Quan Yinglong Jiang Lingbao Ren Lingling Fan Houhong Pan | 2021 | Journal of Magnesium and Alloys2021，9，1： | 10 |
| 3 | Effect of heat treatment on the microstructure and mechanical properties of AZ80M magnesium alloy fabricated by wire arc additive manufacturing显示文摘To maximize the benefits of wire arc additive manufacturing(WAAM)processes,the effect of post-deposition heat treatment on the microstructure and mechanical properties of WAAM AZ80M magnesium(Mg)alloy was investigated.Three different heat treatment procedures(T4,T5 and T6)were performed.According to the results,after T4 heat treatment,the microsegregation of alloying elements was improved with the eutectic structure dissolved.Samples after T5 heat treatment inherited the net-like distribution of secondary phases similar to the as-deposited sample,where the eutectic structure covering the interdendritic regions and theβ-phase precipitated around the eutectic structure.After T6 heat treatment,the tinyβ-phases re-precipitated from the matrix and distributed in inner and outer of the grains.The hardness distribution of the samples went through T4 and T6 heat treatment was more uniform in comparison to that of T5 heat treated samples.The tensile test showed that the T6 heat treatment improved the strength and ductility,and the anisotropy between horizontal and vertical can be eliminated.Moreover,T4 treated samples exhibited highest ductility. | Yangyang Guo Gaofeng Quan Mert Celikin Lingbao Ren Yuhang Zhan Lingling Fan Houhong Pan | 2022 | Journal of Magnesium and Alloys2022，10，7： | 5 |
| 4 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 5 | Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness显示文摘Tonic signaling of chimeric antigen receptor(CAR),i.e.,the spontaneous CAR activation in the absence of tumor antigen stimulation,is considered to be a pivotal event controlling CAR-T efficacy.However,the molecular mechanism underlying the spontaneous CAR signals remains elusive.Here,we unveil that positively charged patches(PCPs)on the surface of the CAR antigenbinding domain mediate CAR clustering and result in CAR tonic signaling.For CARs with high tonic signaling(e.g.,GD2.CAR and CSPG4.CAR),reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion.In contrast,introducing PCPs into the CAR with weak tonic signaling,such as CD19.CAR,results in improved in vivo persistence and superior antitumor function.These results demonstrate that CAR tonic signaling is induced and maintained by PCP-mediated CAR clustering.Notably,the mutations we generated to alter the PCPs maintain the antigen-binding affinity and specificity of the CAR.Therefore,our findings suggest that the rational tuning of PCPs to optimize tonic signaling and in vivo fitness of CAR-T cells is a promising design strategy for the nextgeneration CAR. | Jian Chen Shizhen Qiu Wentao Li Kun Wang Yu Zhang Han Yang Baichuan Liu Guangfei Li Li Li Min Chen Junjie Lan Jiahua Niu Peijie He Lei Cheng Gaofeng Fan Xin Liu Xianmin Song Chenqi Xu Haitao Wu Haopeng Wang | 2023 | Cell Research2023，33，5： | 2 |
| 6 | Silicon-enhanced resistance to cadmium toxicity in Brassica chinensis L. is attributed to Si-suppressed cadmium uptake and transport and Si-enhanced antioxidant defense capacity显示文摘 | Alin Song Zhaojun Li Jie Zhang Gaofeng Xue Fenliang Fan Yongchao Liang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 7 | Key elements for designing and performing a CRISPR/Cas9-based genetic screen显示文摘Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field. | Wanjing Shang Fei Wang Gaofeng Fan Haopeng Wang | 2017 | Journal of Genetics and Genomics2017，44，9： | 1 |
| 8 | Silicon-enhanced resistance to rice blast is attributed to silicon-mediated defence resistance and its role as physical barrier显示文摘 | Wanchun Sun Jie Zhang Qionghua Fan Gaofeng Xue Zhaojun Li Yongchao Liang | 2010 | European Journal of Plant Pathology2010，，1： | 1 |
| 9 | Nano-porous anodic alu- mlnlum oxide membranes with 6-19rim pore diameters formed by a low potential anodizing process 显示文摘 | Zhang Fan Liu Xiaohua Pan Gaofeng | 2007 | Nanotechnology2007，18，： | 1 |
| 10 | The Research on Represention and Realization of Map Symbol Based on Text显示文摘 | DANG Lina DANG Gaofeng WU Fan | 2011 | Procedia Environmental Sciences2011，10，： | 1 |
| 11 | Assessment of five different cathode materials for Co(II) reduction with simultaneous hydrogen evolution in microbial electrolysis cells显示文摘 | Qiang Wang Liping Huang Hongtao Yu Xie Quan Yaxuan Li Gaofeng Fan Li Li | 2014 | International Journal of Hydrogen Energy2014，，： | 1 |
| 12 | A layered grouping random access scheme based on dynamic preamble selection for massive machine type communications显示文摘Dear editor,The massive random access(RA)schemes in the existing literature are mainly grant-free approaches,which are supported by non-orthogonal multiple access[1–3],compressive sensing(CS)[4,5],group paging[2,6],and multichannel ALOHA[7].However,they still face the challenges of high energy consumption and data overhead,especially in future ultra-dense Internet of Things(Io T)networks(>10^(6) devices/km^(2))[8]. | Gaofeng CHENG Huan CHEN Pingzhi FAN Li LI Li HAO | 2022 | Science China(Information Sciences)2022，65，7： | 0 |
| 13 | Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment显示文摘Hepatocellular carcinoma(HCC)is a life-threatening disease for which there is no effective treatment currently.Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy.Herein,we develop the sialic acid(SA)modified polymeric micelles at an upper critical solution temperature(UCST)of 43℃(sialic acid-poly(ethylene glycol)-poly(acrylamide-co-acrylonitrile),SA-PEG-p(AAm-co-AN)),which further encapsulated with doxorubicin(DOX)and Gd-CuS nanoparticles(Gd-CuS NPs)for chemo-photothermal treatment of HCC guided by magnetic resonance(MR)/photoacoustic(PA)dual-mode imaging.The resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS(SPDG)had an excellent photothermal conversion efficiency,enabling SPDG with an instantaneous release behavior of DOX under near-infrared(NIR)irradiation.This study also revealed that SPDG could actively target to HCC,which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site.Moreover,benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX,SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment.Overall,our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics. | Yan Du Di Liu Mingchen Sun Gaofeng Shu Jing Qi Yuchan You Yiting Xu Kai Fan Xiaoling Xu Feiyang Jin Jun Wang Qiying Shen Luwen Zhu Xiaoying Ying Jiansong Ji Liming Wu Daren Liu Yongzhong Du | 2022 | Nano Research2022，15，3： | 0 |
| 14 | Achievements and Prospects of Wind Power Prediction显示文摘Wind power prediction is crucial to the operation of the power system accommodating a large amount of wind power. From the perspective of power dispatch, this paper discusses the current situations of the technology, system building, prediction errors, the index for evaluating wind power prediction system and the main bodies responsible for the prediction. It delves into the existing problems such as incomplete basic data, poor prediction accuracy, short prediction time scale, as well as lacking of prediction in most wind farms. Suggestions on improvement are proposed including enhancing the construction of wind power prediction system on both the grid side and the wind farm side, speeding up the development of ultra-short term wind power prediction system, deepening the research on wind power prediction technology, strengthening the construction of technical standard system and carrying out cross-sector cooperation. | Fan Gaofeng, Pei Zheyi, Xin Yaozhong National Power Dispatching & Communication Center Han Ruiguo | 2011 | Electricity2011，22，5： | 0 |
| 15 | High-resolution sea surface wind speeds of Super Typhoon Lekima (2019) retrieved by Gaofen-3 SAR显示文摘Gaofen-3(GF-3)is the first Chinese spaceborne multi-polarization synthetic aperture radar(SAR)instrument at C-band(5.43 GHz).In this paper,we use data collected from GF-3 to observe Super Typhoon Lekima(2019)in the East China Sea.Using a VH-polarized wide ScanSAR(WSC)image,ocean surface wind speeds at 100m horizontal resolution are obtained at 21:56:59 UTC on 8 August 2019,with the maximum wind speed,38.9 m·s^(-1).Validating the SAR-retrieved winds with buoymeasured wind speeds,we find that the root mean square error(RMSE)is 1.86 m·s^(-1),and correlation coefficient,0.92.This suggests that wind speeds retrieved from GF-3 SAR are reliable.Both the European Centre for MediumRange Weather Forecasts(ECMWF)fine grid operational forecast products with spatial resolution,and China Global/Regional Assimilation and Prediction Enhance System(GRAPES)have good performances on surface wind prediction under weak wind speed condition(<24 m·s^(-1)),but underestimate the maximum wind speed when the storm is intensified as a severe tropical storm(>24m·s^(-1)).With respect to SAR-retrieved wind speeds,the RMSEs are 5.24 m·s^(–1) for ECMWF and 5.17 m·s^(–1) for GRAPES,with biases of 4.16 m·s^(–1) for ECMWF and 3.84 m·s^(-1)for GRAPES during Super Typhoon Lekima(2019). | He FANG William PERRIE Gaofeng FAN Zhengquan LI Juzhen CAI Yue HE Jingsong YANG Tao XIE Xuesong ZHU | 2022 | Frontiers of Earth Science2022，16，1： | 0 |
| 16 | Automatic Extraction of the Sparse Prior Correspondences for Non-Rigid Point Cloud Registration显示文摘Non-rigid registration of point clouds is still far from stable,especially for the largely deformed one.Sparse initial correspondences are often adopted to facilitate the process.However,there are few studies on how to build them automatically.Therefore,in this paper,we propose a robust method to compute such priors automatically,where a global and local combined strategy is adopted.These priors in different degrees of deformation are obtained by the locally geometrical-consistent point matches from the globally structural-consistent region correspondences.To further utilize the matches,this paper also proposes a novel registration method based on the Coherent Point Drift framework.This method takes both the spatial proximity and local structural consistency of the priors as supervision of the registration process and thus obtains a robust alignment for clouds with significantly different deformations.Qualitative and quantitative experiments demonstrate the advantages of the proposed method. | Yan Zhu Lili Tian Fan Ye Gaofeng Sun Xianyong Fang | 2023 | Computer Modeling in Engineering & Sciences2023，，8： | 0 |
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