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| 1 | Hierarchical ferric-cobalt-nickel ternary oxide nanowire arrays supported on graphene fibers as high-performance electrodes for flexible asymmetric supercapacitors显示文摘基于纤维的 supercapacitors (FSC ) 是精力存储家庭的新成员。他们现在的优秀灵活性并且在小、灵活、便携的设备有有希望的应用。当保留灵活性时, FSC 的存在挑战之一正在提高他们的精力密度。我们开发了一个灵巧、划算的方法基于层次 ferric-cobalt-nickel 制作一个高度电容的积极电极第三的氧化物 nanowire arrays/graphene 纤维和一个否定电极基于导出 polyaniline 的碳 nanorods/graphene 纤维。漂亮微观结构和两个电极的优秀电气化学的表演使我们能构造 highperformance 灵活不对称的 graphene 有 1.4 V 的操作电压的基于纤维的 supercapacitor 设备,一个特定的电容直到 61.58 mF ??摔??圠敔????猯'T??????????????猯'T???????猯'T??? | Jingxin Zhao Chaowei Li Qichong Zhang Jun Zhang Xiaona Wang Juan Sun Juanjuan Wang Jixun Xie Ziyin Lin Zhuo Li Weibang Lu Conghua Lu Yagang Yao | 2018 | Nano Research2018，11，4： | 3 |
| 2 | Mapping QTL underlying tuber starch content and plant maturity in tetraploid potato显示文摘Tuber starch content and plant maturity are two important agronomic traits of potato. To investigate the complex genetic basis of these traits in the cultivated potato, as well as the relationship between them, we developed a linkage map in a tetraploid population of 192 clones derived from the cross Longshu 8 × Zaodabai and mapped quantitative trait loci(QTL) for tuber starch content and plant maturity using data collected in three diverse environments over two years. We detected eleven QTL for tuber starch content distributed on seven chromosomes, of which four, on chromosomes I, II, and VIII, were expressed in at least three environments. For plant maturity, we identified six QTL on chromosomes II, IV,V, VII, and XI, one of which, on chromosome V, showed LOD peaks ranging from 45.2 to 62.5 cM and explained 21.6%–26.6% of phenotypic variation was expressed in five of the six environments. Because the reproducible QTL for plant maturity and tuber starch content mapped to different chromosomes and neither overlapping QTL, nor any genetic interaction between QTL were detected, we infer that tuber starch content and plant maturity are controlled by independent genetic loci. This inference supports the prospect of breeding potato for both early maturity and high starch content. | Jianwu Li Yihang Wang Guohong Wen Gaofeng Li Zhang Li Rong Zhang Sheng Ma Jun Zhou Conghua Xie | 2019 | The Crop Journal2019，7，2： | 3 |
| 3 | Clinical outcomes of coronavirus disease 2019 (COVID-19) in cancer patients with prior exposure to immune checkpoint inhibitors显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has affected over 6,000,000 people globally[1].Patients with COVID-19 manifest with symptoms of fever,dry cough,dyspnea,and present with radiological changes that are consistent with atypical pneumonia[2].Pathogenetic mechanisms for these abnormalities involve the systemic immune response that is associated with the hyperactivation of peripheral CD8+and CD4+T cells,and a cytokine storm[3].Globally,the reported prevalence of patients with COVID-19 and cancer ranges from 0.5%to 6.0%in the different case series[4]. | Qiuji Wu Qian Chu Hongyan Zhang Bin Yang Xudong He Yahua Zhong Xianglin Yuan Melvin L.K.Chua Conghua Xie | 2020 | Cancer Communications2020，40，8： | 3 |
| 4 | The potato amylase inhibitor gene Sb AI regulates cold‐induced sweetening in potato tubers by modulating amylase activity显示文摘 | Huiling Zhang Jun Liu Juan Hou Ying Yao Yuan Lin Yongbin Ou Botao Song Conghua Xie | 2014 | Plant Biotechnol J2014，，7： | 2 |
| 5 | StInvInh2 as an inhibitor of Stvac INV 1 regulates the cold‐induced sweetening of potato tubers by specifically capping vacuolar invertase activity显示文摘 | Xun Liu Yuan Lin Jun Liu Botao Song Yongbin Ou Huiling Zhang Meng Li Conghua Xie | 2013 | Plant Biotechnol J2013，，5： | 2 |
| 6 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 7 | DNA methylation affects photoperiodic tuberization in potato (Solanum tuberosum L.) by mediating the expression of genes related to the photoperiod and GA pathways显示文摘Overcoming short-day-dependent tuberization to adapt to long-day conditions is critical for the widespread geographical success of potato.The genetic pathways of photoperiodic tuberization are similar to those of photoperiodic flowering.DNA methylation plays an important role in photoperiodic flowering.However,little is known about how DNA methylation affects photoperiodic tuberization in potato.Here,we verified the effect of a DNA methylation inhibitor on photoperiodic tuberization and compared the DNA methylation levels and differentially methylated genes(DMGs)in the photoperiodic tuberization process between photoperiod-sensitive and photoperiod-insensitive genotypes,aiming to dissect the role of DNA methylation in the photoperiodic tuberization of potato.We found that a DNA methylation inhibitor could promote tuber initiation in strict short-day genotypes.Whole-genome DNA methylation sequencing showed that the photoperiod-sensitive and photoperiod-insensitive genotypes had distinct DNA methylation modes in which few differentially methylated genes were shared.Transcriptome analysis confirmed that the DNA methylation inhibitor regulated the expression of the key genes involved in the photoperiod and GA pathways to promote tuber initiation in the photoperiod-sensitive genotype.Comparison of the DNA methylation levels and transcriptome levels identified 52 candidate genes regulated by DNA methylation that were predicted to be involved in photoperiodic tuberization.Our findings provide a new perspective for understanding the relationship between photoperiod-dependent and GA-regulated tuberization.Uncovering the epigenomic signatures of these pathways will greatly enhance potato breeding for adaptation to a wide range of environments. | Yanjun Ai Shenglin Jing Zhengnan Cheng Botao Song Conghua Xie Jun Liu Jun Zhou | 2021 | Horticulture Research2021，8，1： | 1 |
| 8 | Construction and functional characteristics of tuber-specific and cold-inducible chimeric promoters in potato显示文摘 | Qing Zhu Botao Song Chi Zhang Yongbin Ou Conghua Xie Jun Liu | 2008 | Plant Cell Reports2008，，1： | 1 |
| 9 | Rapid assembly of 1,3-indanedione-based spirocyclic tetrahydroquinolines for inducing human lung cancer cell apoptosis显示文摘The rapid collection of a library of biologically relevant molecules is essential in new drug discovery.Here we show a variety of bioactive 1,3-indanedione-based spirocyclic tetrahydroquinolines that have been concisely and efficiently constructed under the guidance of biology-oriented synthesis(BIOS).Using Pd(PPh_(3))_(4) as a catalyst,various 2-arylidene-1,3-indanediones can react with vinyl benzoxazinanones under the mild condition to afford a new class of spirocyclic tetrahydroquinolines in moderate to excellent yields(45%-99%)with high stereocontrol(>95:5 diastereoselectivity).Their structures were unambiguously confirmed by X-ray single crystal analysis.The biological evaluation revealed that two of the 1,3-indanedione-based spirocyclic tetrahydroquinolines show remarkable apoptosis-inducing activities over A549 human lung cancer cells,exceeding that of cisplatin.The antitur activities were triggered by reactive oxygen species,commonly overproduced in cancer cells.The clinical demand for antitumor chemotherapy for lung cancer has encouraged an all-out search for analogues with lower toxcity,improved therapeutic index and increased activity. | Fen Tan Luojia Chen Yuncong Yuan Xiaoyu He Yiwen Su Shuqiang Cao Conghua Xie Meijia Gu Youquan Zou | 2022 | Green Synthesis and Catalysis2022，3，4： | 0 |
| 10 | SETD2 mediates immunotherapy and radiotherapy efficacy via regulating DNA damage responses and genomic stability in lung adenocarcinoma显示文摘SETD2 is the main transferase for the trimethylation of histone H3 at lysine 36 (H3K36me3) in mammals. SETD2 plays important role in repairing DNA double strand breaks and maintaining chromatin integrity.1 In renal carcinoma, SETD2 deficiency caused DNA replication fork instability and DNA damage.2 The absence of SETD2 was also reported to have strong tumor-promoting effects in lung adenocarcinomas (LUAD).3 However, the other roles of SETD2 remain poorly understood in LUAD. In this study, we utilized comprehensive omics-data analysis to determine that SETD2 was associated with DNA damage and immune-related signals in LUAD. SETD2 knockdown induced DNA damage and cGAS activation in LUAD cells, and reduced the number of cells at the G1 phase. Moreover, SETD2 deficiency was conducive to mutation burden, immune cell infiltration, and immunotherapy responses. High SETD2 expression was associated with high radiocurability. These findings suggest that SETD2 may be a promising biomarker of therapeutic responses for LUAD patients, and offer novel insights into immunotherapy and radiotherapy. | Zihang Zeng Yanping Gao Jiali Li Jianguo Zhang Yangyi Li Fajian He Zhengrong Huang Linzhi Han Yan Gong Conghua Xie | 2023 | Genes & Diseases2023，10，2： | 0 |
| 11 | A New Method of Semantic Feature Extraction for Medical Images Data显示文摘In order to overcome the disadvantages of color, shape and texture-based features definition for medical images, this paper defines a new kind of semantic feature and its extraction algorithm. We firstly use kernel density estimation statistical model to describe the complicated medical image data, secondly, define some typical representative pixels of images as feature and finally, take hill-climbing strategy of Artificial Intelligence to extract those semantic features. Results of a content-based medial image retrieve system show that our semantic features have better distinguishing ability than those color, shape and texture-based features and can improve the ratios of recall and precision of this system smartly. | XIE Conghua SONG Yuqing CHANG Jinyi | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 0 |
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