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| 1 | Review on supermolecules as chemical drugs显示文摘Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceu-tical sciences,and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs,i.e. supramolecular chemical drugs or supramolecular drugs,which might have the excellences of lower cost,shorter period,higher potential as clinical drugs for their successful research and development,may possess higher bioavailability,better biocompatibility and drug-targeting,fewer multidrug-resistances,lower toxicity,less adverse effect,and better curative effects as well as safety,and therefore exhibit wide potential application. These overwhelming advan-tages have drawn enormous special attention. This paper gives the definition of supramolecular drugs,proposes the concept of supramolecular chemical drugs,and systematically reviews the recent ad-vances in the research and development of supermolecules,including organic and inorganic complex ones as chemical drugs in the area of antitumor,anti-inflammatory,analgesic,antimalarial,antibacterial,antifungal,antivirus,anti-epileptic,cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. | ZHOU ChengHe GAN LinLing ZHANG YiYi ZHANG FeiFei WANG GuangZhou JIN Lei GENG RongXia | 2009 | Science China Chemistry2009，52，4： | 17 |
| 2 | Fractional pyrolysis of Cyanobacteria from water blooms over HZSM-5 for high quality bio-oil production显示文摘Fractional pyrolysis and one-step pyrolysis of natural algae Cyanobacteria from Taihu Lake were comparatively studied from 200 to 500°C.One-step pyrolysis produced bio-oil with complex composition and low high heating value(HHV 30.9 MJ/kg). Fractional pyrolysis separated the degradation of different components in Cyanobacteria and improved the selectivity to products in bio-oil. That is, acids at 200°C, amides and acids at 300°C, phenols and nitriles at 400°C, and phenols at 500°C, were got as main products, respectively. HZSM-5 could promote the dehydration, cracking and aromatization of pyrolytic intermediates in fractional pyrolysis. At optimal HZSM-5 catalyst dosage of 1.0 g, the selectivity to products and the quality of bio-oil were improved obviously. The main products in bio-oil changed to nitriles(47.2%) at 300°C,indoles(51.3%) and phenols(36.3%) at 400°C. The oxygen content was reduced to 7.2 wt% and 9.4 wt%, and the HHV was raised to 38.1and 37.3 MJ/kg at 300 and 400°C, respectively. Fractional catalytic pyrolysis was proposed to be an efficient method not only to provide a potential solution for alleviating environmental pressure from water blooms, but also to improve the selectivity to products and obtain high quality bio-oil. | Huijuan Li Linling Li Rui Zhang Dongmei Tong Changwei Hu | 2014 | Journal of Energy Chemistry2014，23，6： | 3 |
| 3 | Statistical analysis and combination forecasting of environmental efficiency and its influential factors since China entered the WTO: 2002–2010–2012显示文摘 | Malin Song Linling Zhang Qingxian An Zeya Wang Zhen Li | 2012 | Journal of Cleaner Production2012，，： | 1 |
| 4 | Facile synthe- sis of water-soluble highly fluorescent grapheme quantum dots as a robust biological label for stern cells 显示文摘 | Mo Zhang Linling Bai Weihu Shang eta! | 2012 | J Master Chem2012，22，： | 1 |
| 5 | An R2R3-MYB transcription factor as a negative regulator of the flavonoid biosynthesis pathway in Ginkgo biloba显示文摘 | Feng Xu Yingjing Ning Weiwei Zhang Yongling Liao Linling Li Hua Cheng Shuiyuan Cheng | 2014 | Functional & Integrative Genomics2014，，1： | 1 |
| 6 | An R2R3-MYB transcription factor as a negative regulator of the flavonoid biosynthesis pathway in Ginkgo biloba显示文摘 | Feng Xu Yingjing Ning Weiwei Zhang Yongling Liao Linling Li Hua Cheng Shuiyuan Cheng | 2014 | Functional & Integrative Genomics2014，，1： | 1 |
| 7 | Isolation, charac terization, and function analysis of a flavonO显示文摘 | Feng Xu Linling Li Weiwei Zhang | 2012 | Mol Biol Rep2012，39，2： | 1 |
| 8 | LEO constellation design methodology for observing multi-targets显示文摘This paper is based on the second problem of the 8th China Space Trajectory Design Competition(CTOC8).The background is LEO constellation design strategy for monitoring discrete multi-targets with small stellite under J model.The difculty is that the small satellite is equipped with low-cost cameras with limited coverage ability and the targets are distributed separately in a key area,which result in long revisit time or large pumber of satelites based on traditional design method.In this paper,a speciflc LEO consellation design method is proposed to cope with the problems.First,grid search and numerical method are performed to construct a database consisting of repeating ground track orbits.Then several orbits are carefully selected by pruning method to visit each target.Finally,repeating ground track costellation is constructed to meet the maximun revisit time constraint.The present method provides a systematic constellation design methodology of remote sensing observation with limited coverage ability,and demonstrates the resulting constellation can obtain rapid revisit frequency over discrete multi-targets with the least number of satellites. | Chen Zhang Jin Jin Linling Kuang Jian Yan | 2018 | Astrodynamics2018，2，2： | 1 |
| 9 | Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid β-protein fibrillation and cytotoxicity显示文摘淀粉 --(A) 蛋白质聚集是 Alzheimers 疾病(广告) 的主要特点。纤维性颤动的抑制因此是广告的预防和处理的一条有希望的治疗学的途径。最近,我们设计了一个 heptapeptide 禁止者, LVFFARK (LK7 ) 。LK7 在纤维性颤动上显示出一个有希望的禁止的能力,但是对敏感自我装配并且显示高 cytotoxicity,它将妨碍它的实际申请。此处,我们由 head-to-tail 环合修改了 LK7 并且获得了周期的 LK7 (cLK7 ) 。cLK7 展览一不同自己组装从 LK7 的行为,并且比 LK7 和小 cytotoxicity 对解朊作用有更高的稳定性到 SHSY5Y 房间。热力学的分析表明 LK7 和 cLK7 能由静电的相互作用,氢结合和恐水病的相互作用绑在40,但是为40的 cLK7 的有约束力的亲密关系( K D = 4.96 mol/L )比 LK7 的高六倍( K D = 32.2 mol/L )。强壮的绑定使 cLK7 能稳定 40 的第二等的结构并且 potently 在广泛的集中范围禁止它的成核,纤维性颤动和 cytotoxicity,而 LK7 能仅仅中等在低集中禁止 A40 纤维性颤动和 cytotoxicity。调查结果显示肽环合是一条有希望的途径提高基于肽的淀粉的禁止者的表演。 | Shuai Ma Huan Zhang Xiaoyan Dong Linling Yu Jie Zheng Yan Sun | 2018 | Frontiers of Chemical Science and Engineering2018，12，2： | 1 |
| 10 | Game-Theoretic Analyses and Simulations of Adoptions of Security Policies for DRM in Contents Sharing Scenario 显示文摘 | Zhang Zhiyong Pei Qingqi Yang Linl | 2011 | Intelligent Automation and Soft Computing2011，17，2： | 1 |
| 11 | The hand Shaoyin meridian'shenmen effects on coronary heart disease patients with 显示文摘 | Leng Junyan Zhang Linling Zhao Ling | 2014 | Chinese clinical research2014，28，01： | 1 |
| 12 | Determination of oxytetracycline, tetracycline and chloramphenicol antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Analytica Chimca Acta2008，619，1： | 1 |
| 13 | Isolation, eharacteriza- tion, and function analysis if a flavonol synthase gene from Gink- go biloba显示文摘 | Xu Feng Li Linling Zhang Weiwei | 2012 | Mol Biol Rep2012，，39： | 1 |
| 14 | Determination of oxytetracycline, tetracycline and chlorampheni- col antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Anal Chim Acta2008，619，1： | 1 |
| 15 | Study on Saccharification of Saccharum spontaneum L. by Sulphuric Acid Hydrolysis显示文摘In order to improve the saccharification rate by acid hydrolysis in the technique for production of ethanol from biomass,in this study,Saccharum spontaneum L. was used as the experimental material to investigate the rules and technological conditions for two-step acid-hydrolysis saccharification by single factor experiment and orthogonal experiment. According to the results,concentrated sulfuric acid hydrolysis was the first step,with the liquid-solid ratio of 42∶ 1,sulfuric acid concentration of 70%,hydrolysis time of 20 min,and hydrolysis temperature of 55 ℃; dilute sulphuric acid hydrolysis was the second step,with the liquidsolid ratio of 115∶ 1,sulfuric acid concentration of 5. 5%,hydrolysis time of 155 min,and hydrolysis temperature of 100 ℃. In two-step acid hydrolysis process,the yield of reducing sugar was 48. 78%. The results indicated that two-step acid-hydrolysis saccharification required mild conditions,simple operation and low cost,and led to high reducing sugar yield,exhibiting a broad application prospect. | Jianle LIU Changjun BAI Linling YAN Qinglin JIA Yu ZHANG Hubiao YANG | 2014 | Agricultural Biotechnology2014，3，6： | 0 |
| 16 | Hallmark guided identification and characterization of a novel immune-relevant signature for prognostication of recurrence in stageⅠ-Ⅲlung adenocarcinoma显示文摘The high risk of postoperative mortality in lung adenocarcinoma(LUAD)patients is principally driven by cancer recurrence and low response rates to adjuvant treatment.Here,A combined cohort containing 1,026 stageⅠ-Ⅲpatients was divided into the learning(n Z 678)and validation datasets(n Z 348).The former was used to establish a 16-mRNA risk signature for recurrence prediction with multiple statistical algorithms,which was verified in the valida-tion set.Univariate and multivariate analyses confirmed it as an independent indicator for both recurrence-free survival(RFS)and overall survival(OS).Distinct molecular characteristics between the two groups including genomic alterations,and hallmark pathways were compre-hensively analyzed.Remarkably,the classifier was tightly linked to immune infiltrations,high-lighting the critical role of immune surveillance in prolonging survival for LUAD.Moreover,the classifier was a valuable predictor for therapeutic responses in patients,and the low-risk group was more likely to yield clinical benefits from immunotherapy.A transcription factor regulato-ry proteineprotein interaction network(TF-PPI-network)was constructed via weighted gene co-expression network analysis(WGCNA)concerning the hub genes of the signature.The con-structed multidimensional nomogram dramatically increased the predictive accuracy.There-fore,our signature provides a forceful basis for individualized LUAD management with promising potential implications. | Yongqiang Zhang Zhao Yang Yuqin Tang Chengbin Guo Danni Lin d Linling Cheng Xun Hu Kang Zhang Gen Li | 2023 | Genes & Diseases2023，10，4： | 0 |
| 17 | Effect of Several Common Processing Methods on Content Changes of Resistant Starch and Main Nutrients in ‘Luotian Chestnut’显示文摘Using‘Luotian chestnut'as the raw material,the content changes of resistant starch and main nutrients in the processed fruit were studied after taken common processing of high-temperature steaming of canned food,sand-mixed frying and cooking without shells,with the aim to find out the effects of different processing methods on the content changes of nutrients in chestnuts. The result showed that there were significant differences in the resistant starch contents by different processing methods. After processing,the retention degree of resistant starch was the lowest using the methods of sand-mixed frying,of 42. 42%,while the highest was found in canned chestnut products,of 93. 16%. Among the main nutrients,adding water and sugar would reduce content of resistant starch,while increasing the protein content would promote the retention of resistant starch retention. The changes in lipid content had no effect or not a single promoting or weakening effects on the content of resistant starch. | Linling LI Bingjie HUANG Hua CHENG Xuehua ZHANG Xiaoling CHEN Shuiyuan CHENG | 2018 | Agricultural Biotechnology2018，7，5： | 0 |
| 18 | Nutritional Value Evaluation of Saccharum spontaneum L. Germplasm Resources显示文摘The contents of dry matter, crude fat, crude protein, neutral detergent fiber, acid detergent fiber, crude ash, Ca and P in 43 Saccharum spontaneum L.germplasms during the vegetative period were determined. Among them, the crude protein, crude fat, neutral detergent fiber, acid detergent fiber, P and Ca contents were treated as the judging indicators. The nutritional value evaluation was carried out with the analytic hierarchy process(AHP). The results showed A49(Guangxi)had the highest nutritional value. Its dry matter, crude protein, crude fat, crude ash,neutral detergent fiber, acid detergent fiber, Ca and P contents were 32.35%,7.20%, 4.06%, 8.07%, 75.81%, 50.72%, 0.23% and 0.16% respectively. While A3(Guangdong) had the lowest nutritional value. Its dry matter, crude protein, crude fat, crude ash, neutral detergent fiber, acid detergent fiber, Ca and P contents were32.24%, 4.62%, 0.51%, 6.38%, 46.40%, 40.02%, 0.15% and 0.09% respectively.The crude protein content differed significantly among different germplasms. A48 had the highest crude protein content(9.11%), and A14 had the lowest crude protein content(3.72%). Based on the evaluation results, the 43 Saccharum spontaneum L.germplasms were divided into 3 groups: high-nutritional value type, moderate-nutritional value type and low-nutritional value type. We hoped to provide a theoretical reference for the application of Saccharum spontaneum L. as a forage grass. | Jianle LIU Changjun BAI Linling YAN Shimeng CHEN Yu ZHANG Hubiao YANG | 2014 | Agricultural Science & Technology2014，15，11： | 0 |
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