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| 1 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 2 | Space-Air-Ground Integrated Network (SAGIN) for 6G: Requirements, Architecture and Challenges显示文摘As the fifth-generation(5G)mobile communication network may not meet the requirements of emerging technologies and applications,including ubiquitous coverage,industrial internet of things(IIoT),ubiquitous artificial intelligence(AI),digital twins(DT),etc.,this paper aims to explore a novel space-air-ground integrated network(SAGIN)architecture to support these new requirements for the sixth-generation(6G)mobile communication network in a flexible,low-latency and efficient manner.Specifically,we first review the evolution of the mobile communication network,followed by the application and technology requirements of 6G.Then the current 5G non-terrestrial network(NTN)architecture in supporting the new requirements is deeply analyzed.After that,we proposes a new flexible,low-latency and flat SAGIN architecture,and presents corresponding use cases.Finally,the future research directions are discussed. | Huanxi Cui Jun Zhang Yuhui Geng Zhenyu Xiao Tao Sun Ning Zhang Jiajia Liu Qihui Wu Xianbin Cao | 2022 | China Communications2022，19，2： | 11 |
| 3 | Characteristic of Torsional Vibration of Mill Main Drive Excited by Electromechanical Coupling显示文摘In the study of electromechanical coupling vibration of mill main drive system, the influence of electrical system on the mechanical transmission is considered generally, however the research for the mechanism of electromechanical interaction is lacked. In order to research the electromechanical coupling resonance of main drive system on the F3 mill in a plant, the cycloconverter and synchronous motor are modeled and simulated by the MTLAB/SIMULINK firstly, simulation result show that the current harmonic of the cycloconverter can lead to the pulsating torque of motor output. Then the natural characteristics of the mechanical drive system are calculated by ANSYS, the result show that the modal frequency contains the component which is close to the coupling vibration frequency of 42 Hz. According to the simulation result of the mechanical and electrical system, the closed loop feedback model including the two systems are built, and the mechanism analysis of electromechanical coupling presents that there is the interaction between the current harmonic of electrical system and the speed of the mechanical drive system. At last, by building and computing the equivalent nonlinear dynamics model of the mechanical drive system, the dynamic characteristics of system changing with the stiffness, damping coefficient and the electromagnetic torque are obtained. Such electromechanical interaction process is suggested to consider in research of mill vibration, which can induce strong coupling vibration behavior in the rolling mill drive system. | ZHANG Yifang YAN Xiaoqiang LIN Qihui | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 8 |
| 4 | A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy显示文摘Although notable progress has been made on novel cancer treatments,the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients.Chemoimmunotherapy,combining chemotherapeutics and immunotherapeutic drugs,has emerged as a promising approach for cancer treatment,with the advantages of cooperating two kinds of treatment mechanism,reducing the dosage of the drug and enhancing therapeutic effect.Moreover,nano-based drug delivery system(NDDS)was applied to encapsulate chemotherapeutic agents and exhibited outstanding properties such as targeted delivery,tumor microenvironment response and site-specific release.Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency compared with traditional formulations,such as liposomes(Doxil R,Lipusu R),nanoparticles(Abraxane R)and micelles(Genexol-PM R).The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment,which could greatly enhance the therapeutic efficacy,reduce the side effects and optimize the clinical outcomes of cancer patients.Herein,the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed,and recent advances of NDDS applied for chemoimmunotherapy were further reviewed. | Weiwei Mu Qihui Chu Yongjun Liu Na Zhang | 2020 | Nano-Micro Letters2020，12，10： | 8 |
| 5 | A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture显示文摘While human induced pluripotent stem cells(hiPSCs)have promising applications in regenerative medicine,most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials,such as sialic acid,and potential pathogens from animal-product-containing cell culture systems.Although several xeno-free cell culture systems have been established recently,their use of human fibroblasts as feeders reduces the clinical potential of hiPSCs due to batch-to-batch variation in the feeders and time-consuming preparation processes.In this study,we have developed a xeno-free and feeder-cell-free human embryonic stem cell(hESC)/hiPSC culture system using human plasma and human placenta extracts.The system maintains the self-renewing capacity and pluripotency of hESCs for more than 40 passages.Human iPSCs were also derived from human dermal fibroblasts using this culture system by overexpressing three transcription factors—Oct4,Sox2 and Nanog.The culture system developed here is inexpensive and suitable for large scale production. | Qihui Wang Xiaoning Mou Henghua Cao Qingzhang Meng Yanni Ma Pengcheng Han Junjie Jiang Hao Zhang Yue Ma | 2012 | Protein & Cell2012，3，1： | 6 |
| 6 | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis显示文摘Doxorubicin (纪录影片) ,广泛地使用的反肿瘤药,能由氧化应力和房间 apoptosis 产生严重 cardiotoxicity,它限制它的临床的申请。亚麻酸的酸(翼) 被显示了用作一个有势力 cardioprotective 代理人。这研究的目的是在老鼠为这 cardioprotection 在导致纪录影片的 cardiotoxicity 和内在的分子的机制上探索翼的保护的效果。老鼠随机被划分成四个组并且与正常管理了盐,翼(500 梭织,任何一个 CheRs 都不能维持上述的互补功能,考虑到类似于 E 的接受甲基的趋化性蛋白质,建议他们的关键角色。coli。由 microarray 试金示威了,在 L 的 cheR1 的表示。在 28 点有教养的 | Xiaohua Yu Libao Cui Zizhen Zhang Qihui Zhao Shuangjie Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 4 |
| 7 | Nutritional strategies to alleviate oxidative stress in sows显示文摘The performance of high-yielding sows is directly related to the productivity of pig farming. Fetaldevelopment mainly occurs during the last month of pregnancy, and the aggressive metabolic burden ofsows during this stage eventually leads to systemic oxidative stress. When affected by oxidative stress,sows exhibit adverse symptoms such as reduced feed intake, hindered fetal development, and evenabortion. In addition, milk synthesis during the lactation period causes a severe metabolic burden. Thebiological response to oxidative stress during this period is associated with a decrease in milk production,which further affects the growth of piglets. Understanding the nutritional strategies to alleviateoxidative stress in sows is crucial to maintain their reproduction and lactation performance. Recently,advances have been made in the field of nutrition to relieve oxidative stress in sows during late pregnancyand lactation. This review highlights the nutritional strategies to relieve oxidative stress in sowsreported within the last 20 years. | Qihui Li Siwang Yang Fang Chen Wutai Guan Shihai Zhang | 2022 | Animal Nutrition2022，，2： | 4 |
| 8 | Routing Protocol for Heterogeneous FANETs with Mobility Prediction显示文摘In recent years,with the growth in Unmanned Aerial Vehicles(UAVs),UAV-based systems have become popular in both military and civil applications.In these scenarios,the lack of reliable communication infrastructure has motivated UAVs to establish a network as flying nodes,also known as Flying Ad Hoc Networks(FANETs).However,in FANETs,the high mobility degree of flying and terrestrial users may be responsible for constant changes in the network topology,making end-to-end connections in FANETs challenging.Mobility estimation and prediction of UAVs can address the challenge mentioned above since it can provide better routing planning and improve overall FANET performance in terms of continuous service availability.We thus develop a Software Defined Network(SDN)-based heterogeneous architecture for reliable communication in FANETs.In this architecture,we apply an Extended Kalman Filter(EKF)for accurate mobility estimation and prediction of UAVs.In particular,we formulate the routing problem in SDN-based Heterogeneous FANETs as a graph decision problem.As the problem is NP-hard,we further propose a Directional Particle Swarming Optimization(DPSO)approach to solve it.The extensive simulation results demonstrate that the proposed DPSO routing can exhibit superior performance in improving the goodput,packet delivery ratio,and delay. | Qihui Wu Min Zhang Chao Dong Yong Feng Yanli Yuan Simeng Feng Tony Q.S.Quek | 2022 | China Communications2022，19，1： | 3 |
| 9 | Host cell apoptosis induced by infection with duck swollen head hemorrhagic disease virus显示文摘This study aimed to examine the host cell apoptosis in the tissues of Peking ducks infected with duck swollen head hemorrhagic disease virus(DSHDV).The dynamic changes associated with apoptosis occurring in the internal tissues were evaluated at different time points postinoculation(PI) by performing hematoxylin and eosin(HE) staining,followed by light microscopy,terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) assay,and transmission electron microscopy(TEM).The results showed that DSHDV infection could induce apoptosis in host cells,including those of the bursa of Fabricius(BF),thymus,spleen,liver,intestinal tract,kidney,and esophagus.The apoptotic index(AI) values increased with time from 2 to 72 h PI,and the highest values were recorded at 72 h PI.Further,cell death due to classic necrosis was observed in the dying or deceased ducks after 72 h PI.In conclusion,host cell apoptosis can be induced by DSHDV and may play an important role in the pathogenesis of duck viral swollen head hemorrhagic disease(DVSHD). | Chuanfeng Li Anchun Cheng Mingshu Wang Chanjuan Shen Na Zhang Yi Zhou Dekang Zhu Qihui Luo Renyong Jia Xiaoyue Chen | 2009 | Progress in Natural Science:Materials International2009，19，1： | 3 |
| 10 | Evolution and functional analysis of the Pif97 gene of the Pacific oyster Crassostrea gigas显示文摘 | Xiaotong WANG Xiaorui SONG Tong WANG Qihui ZHU Guoying MIAO Yuanxin CHEN Xiaodong FANG Huayong QUE Li LI Guofan ZHANG | 2013 | Current Zoology2013，59，1： | 3 |
| 11 | Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro显示文摘Dear Editor,Antibody-dependent enhancement(ADE)has long been recognized for dengue virus(DENV)in vitro and in vivo.It is now clear that antibodies to DENV can also enhance Zika virus(ZIKV)infection in vitro,and vice versa(Dejnirattisai et al.,2016;Stettler et al.,2016).The characteristics of enhancing antibodies,however,remain elusive.Some have suggested that non-neutralizing antibodies or antibodies recognizing specific antigenic sites are | Min Li Xin Wang Qihui Wang Lei Yu Lanfeng Wang Jinghua Yan Fuchun Zhang Linqi Zhang George F.Gao Xia Jin | 2017 | Science China(Life Sciences)2017，60，12： | 2 |
| 12 | Space-Air-Ground Integrated Network with Native Intelligence(NI-SAGIN):Concept,Architecture,Access and Networking显示文摘Ubiquitous coverage is one of the most important goals for mobile communication networks.To achieve this,integration of space,air,and ground networks is highly demanded,which expects to become the one of the enabling technologies for 6G networks. | Zhenyu Xiao Qihui Wu Jiajia Liu Ning Zhang Tao Sun | 2022 | China Communications2022，19，1： | 1 |
| 13 | Adaptive 3D Routing Protocol for Flying Ad Hoc Networks Based on Prediction-Driven Q-Learning显示文摘The routing protocols are paramount to guarantee the Quality of Service(QoS)for Flying Ad Hoc Networks(FANETs).However,they still face several challenges owing to high mobility and dynamic topology.This paper mainly focuses on the adaptive routing protocol and proposes a Three Dimensional Q-Learning(3DQ)based routing protocol to guarantee the packet delivery ratio and improve the QoS.In 3DQ routing,we propose a Q-Learning based routing decision scheme,which contains a link-state prediction module and routing decision module.The link-state prediction module allows each Unmanned Aerial Vehicle(UAV)to predict the link-state of Neighboring UAVs(NUs),considering their Three Dimensional mobility and packet arrival.Then,UAV can produce routing decisions with the help of the routing decision module considering the link-state.We evaluate the various performance of 3DQ routing,and simulation results demonstrate that 3DQ can improve packet delivery ratio,goodput and delay of baseline protocol at most 71.36%,89.32%and 83.54%in FANETs over a variety of communication scenarios. | Min Zhang Chao Dong Simeng Feng Xin Guan Huichao Chen Qihui Wu | 2022 | China Communications2022，19，5： | 1 |
| 14 | Thymosin beta-10 is Aberrantly Expressed in Pancreatic Cancer and Induces JNK Activation显示文摘 | Min Li Yuqing Zhang Qihui Zhai Louis W. Feurino William E. Fisher Changyi Chen Qizhi Yao | 2009 | Cancer Investigation2009，，3： | 1 |
| 15 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 16 | Clinical Study on Acute Pancreatitis in Pregnancy in 26 Cases显示文摘 | Cheng Qihui Zhang Xiping Ding Xianfeng Charles Melbern Wilcox | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 17 | Efficient Extractive Desulfurization of Fuel Oils Using N-Pyrrolidone/Alkylphosphate-Based Ionic Liquids显示文摘Four BrØsted acid ionic liquids(ILS)[MMP][DMP],[MEP][DEP],[HMP][DMP]and[HEP][DEP]were syn-thesized and used as extractants for desulfurization of aromatic sulfur compounds in model oil.The mutual solubil-ity of four ILs were investigated.The extraction equilibrium of four ILs could be reached in as soon as 5 min and the extraction capability followed the order[MMP][DMP]>[MEP][DEP]>[HEP][DEP]>[HMP][DMP].The S extraction showed the highest efficiency under the conditions of 30℃,30 min and 1∶1(V/V)IL∶oil.Under the optimal condition,70.9%of thiophene(TS),76.9%of benzothiophene(BT)and 87.5%of dibenzothiophene(DBT)in n-octane could be efficiently removed by[MMP][DMP].The multiple extraction and regeneration performance of[MMP][DMP]for TS was also investigated and the results were satisfying.These results suggest that[MMP][DMP]has the best extraction capability and can serve as a promising solvent for extractive desulfurization of fuel oils. | Chunhai Liu Qihui He Zheng Zhang Yangyang Su Renfu Xu Baixing Hu | 2014 | Chinese Journal of Chemistry2014，32，5： | 1 |
| 18 | Enhanced catalytic oxidation of 2,4-dichlorophenol via singlet oxygen dominated peroxymonosulfate activation on CoOOH@Bi_(2)O_(3)composite显示文摘Cobalt oxyhydroxide(CoOOH)has been turned out to be a high-efficiency catalyst for peroxymonosulfate(PMS)activation.In this study,CoOOH was loaded on bismuth oxide(Bi_(2)O_(3))using a facile chemical precipitation process to improve its catalytic activity and stability.The result showed that the catalytic performance on the 2,4-dichlorophenol(2,4-DCP)degradation was significantly enhanced with only 11 wt%Bi_(2)O_(3)loading.The degradation rate in the CoOOH@Bi_(2)O_(3)/PMS system(0.2011 min−1)was nearly 6.0 times higher than that in the CoOOH/PMS system(0.0337 min−1).Furthermore,CoOOH@Bi_(2)O_(3)displayed better stability with less Co ions leaching(16.4%lower than CoOOH)in the PMS system.These phenomena were attributed to the Bi_(2)O_(3)loading which significantly increased the conductivity and specific surface area of the CoOOH@Bi_(2)O_(3)composite.Faster electron transfer facilitated the redox reaction of Co(III)/Co(II)and thus was more favorable for reactive oxygen species(ROS)generation.Meanwhile,larger specific surface area furnished more active sites for PMS activation.More importantly,there were both non-radical(^(1)O_(2))and radicals(SO_(4)^(−)•,O_(2)^(−)•,and OH•)in the CoOOH@Bi_(2)O_(3)/PMS system and^(1)O_(2)was the dominant one.In general,this study provided a simple and practical strategy to enhance the catalytic activity and stability of cobalt oxyhydroxide in the PMS system. | Tianhao Xi Xiaodan Li Qihui Zhang Ning Liu Shu Niu Zhaojun Dong Cong Lyu | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 1 |
| 19 | An experimental study on the choked flow characteristics of CO_(2) pipelines in various phases显示文摘High pressure pipeline transportation has been an established technology for economically transporting large amounts of CO_(2).However,there are still issues and associated risks that have to be effectively addressed and adequately understood.It is well known that a strong JouleThomson Cooling effect can occur when pressurized CO_(2) flows through a choke valve.Thus,to investigate the choking characteristics especially the temperature drop of high pressure CO_(2),a new laboratory scale experimental setup(total length of 14.85 m and the inner diameter of 15 mm)was constructed.Steady choked flow and transient choked flow tests were carried out respectively for pressurized CO_(2) in various initial phases.The phase transitions and temperature drop characteristics were then studied following the choked flow and the results show that the phase transitions in steady choked flow differs significantly from that in transient choked flow.For transient choked flow of various initial phases,all the flows downstream would transfer from single phase to gas-liquid twophase flow.Furthermore,the effect of water on transient choked flow of supercritical CO_(2) pipeline was investigated,and the phenomena of solid particles deposition was captured which was paramount importance of ensuring the safety operation of CO_(2)pipelines when throttling by the choke valves. | Yuxing Li Shuaiwei Gu Datong Zhang Qihui Hu Lin Teng Cailin Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 1 |
| 20 | Studyon Design Criteria and Methods for the Valve Train of theCompressed-air Engine显示文摘 | ZHANG Zhao JIA Ruibin YU Qihui CAI Maolin | 2012 | Applied Mechanics and Materi-als2012，，278： | 1 |
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