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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Geometric dilution of precision for GPS single-point positioning based on four satellites显示文摘To improve the positioning accuracy in GPS point positioning, the geometric dilution of precision (GDOP) including HDOP, VDOP, TDOP, PDOP is commonly considered. The properties of the DOP for the GPS satellite navigation system are studied and the coordinate system is improved in order to decrease the amount of variables. In the end, by simulation and discussing the results, the corresponding conclusions are presented. | Wang Huihui Zhan Xingqun Zhang Yanhua | 2008 | Journal of Systems Engineering and Electronics2008，19，5： | 4 |
| 3 | Preparation and Characterization of Superparamagnetic Fe_3O_4/CNTs Nanocomposites Dual-drug Carrier显示文摘Fe_3O_4/carbon nanotubes(Fe_3O_4/CNTs) nanocomposites were prepared by polylol hightemperature decomposition of the precursor ferric chloride and CNTs in liquid triethylene glycol.After surface modification with hexanediamine,folate was covalently linked to the amine group of magnetic Fe_3O_4/CNTs nanocomposites.The products were characterized by Fourier-transform infrared spectroscopy,transmission electron microscopy,and vibrating sample magnetometry.Then Fe_3O_4/CNTs were used as a dual-drug carrier to co-delivery of the hydrophilic drug epirubicin hydrochloride and hydrophobic drug paclitaxel.The results indicated that the Fe_3O_4/CNTs had a favorable release property for epirubicin and paclitaxel,and thus had potential application in tumor-targeted combination chemotherapy. | 张小娟 郝凌云 WANG Hehe ZHU Xingqun ZHANG Zhiying HU Xiaohong JIANG Wei | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，1： | 2 |
| 4 | Improved Ambiguity Function Method Based on Analytical Resolution for GPS Attitude Determination显示文摘 | WANG Yongquan ZHAN Xingqun ZHANG Yanhua | 2007 | Measurement Science and Technology2007，18，9： | 1 |
| 5 | Improved ambi- guity function method based on analytical resolution for GPS atti- tude determination 显示文摘 | Wang Yongquan Zhan Xingqun Zhang Yanhua | 2007 | Measurement Science and Technology2007，18，9： | 1 |
| 6 | Effects of fan-starting methods on the reverse-cycle defrost perform- ance of an air-to-water heat pump 显示文摘 | Huang Dong Yuan Xiuling Zhang Xingqun | 2004 | International Jour- nal of Refrigeration2004，27，8： | 1 |
| 7 | Improved filtered-ε adaptive inverse control and its application on nonlinear ship maneuvering显示文摘The drawbacks of common nonlinear Filtered- ε adaptive inverse control (AIC) method, such as the unreliability due to the change of delay time and the faultiness existing in its disturbance control loop, are discussed. Based on it, the diagram of AIC is amended to accommodate with the characteristic of nonlinear object with time delay. The corresponding Filtered-ε adaptive algorithm based on RTRL is presented to identify the parameters and design the controller. The simulation results on a nonlinear ship model of “The R.O.V Zeefakkel” show that compared with the previous scheme and adaptive PID control, the improved method not only keeps the same dynamic response performance, but also owns higher robustness and disturbance rejection ability, and it is suitable for the control of nonlinear objects which have higher requirement to the maneuverability under complex disturbance environment. | Du Gang Zhan Xingqun Zhang Weiming Zhong Shan | 2006 | Journal of Systems Engineering and Electronics2006，17，4： | 1 |
| 8 | MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells显示文摘 | Junjie Xiao Dandan Liang Hong Zhang Ying Liu Dasheng Zhang Yi Liu Lei Pan Xiaoli Chen Pieter A. Doevendans Yunfu Sun Xingqun Liang Joost P.G. Sluijter Yi-Han Chen | 2012 | Journal of Molecular and Cellular Cardiology2012，，6： | 1 |
| 9 | Primary productivity in the western tropical Pacific and equatorial warm waters显示文摘Primary productivity in the western tropical Pacific and equatorial warm waters was studied in the WOCE cruise in November of 1991 and the TOGA-COARE cruise from November of 1992 to February of 1993.It is shown that the total amount of integrated chlorophyll a(chloro a)was 19 79 mg/m 2 in depthof0~150 m and the average daily primary productivity was 171 mg/(m 2·d)(C)appeared in the western tropical Pacific while a higher chloro a(21 68 mg/m 2)and primary productivity [228 mg/(m 2·d)(C)]were observed in the equatorial warm waters.The highest chloro a was found at the coastal stations of Philippines and Irian while the lowest chloro a was at the offshore areas bounded by 2°~4°N.The distribution pattern of chloro a biomass was related to different physical processes.Upwelling,which may have led to a high biomass, was a critical factor changing the distributions of temperature,salinity and nutrient in these areas. | Chen Xingqun 1,Zhang Ming 1,Chen Qihuan 1 ThirdInstituteofOceanography ,StateOceanicAdministration ,Xiamen 36 10 0 5 ,China | 2001 | Acta Oceanologica Sinica2001，20，1： | 1 |
| 10 | Effects of fan-starting methods on the reverse-cycle defrost per-formance of an air-to-water heat pump显示文摘 | Huang Dong Yuan Xiuling Zhang Xingqun | 2004 | Inter- national Journal of Refrigeration2004，27，8： | 1 |
| 11 | Effects of fan-starting methods on the reverse-cycle defrost performance of an air-to-water heat pump 显示文摘 | Huang Dong Yuan Xiuling Zhang Xingqun | 2004 | Int J Refrig2004，27，8： | 1 |
| 12 | Improved ambiguity function method based on analytical resolution for GPS attitude determination显示文摘 | WANG Yongquan ZHAN Xingqun ZHANG Yanhua | 2007 | Measurement Science and Technology2007，18，9： | 1 |
| 13 | Bioprocessing of bamboo materials显示文摘 | Fu Jiajia Zhang Xingqun Yu Chongwen | 2012 | Fibres and Textiles in Eastern Europe2012，20，1： | 1 |
| 14 | Distribution of Chlorophyll a and primary productivity in the neritic waters of Fujian Province显示文摘INTRODUCTIONThe coast zone is the area where most human activities take place and where the highest economic benefit is produced. The knowledge of the distribution and variation of primary production provides the bases as reference helping the marine exploitation and management. | Chen Qihuan, Chen Xingqun and Zhang Ming Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China | 1997 | Acta Oceanologica Sinica1997，16，1： | 0 |
| 15 | The distribution of chlorophyll a and its influencing factors in different regions of the Bering Sea显示文摘The distribution of chlorophyll a(Chl a) and its relationships with physical and chemical parameters in different regions of the Bering Sea were discussed in July 2010. The results showed the seawater column Chl a concentrations were 13.41–553.89 mg/m2 and the average value was 118.15 mg/m2 in the study areas. The horizontal distribution of Chl a varied remarkably from basin to shelf in the Bering Sea. The regional order of Chl a concentrations from low to high was basin, slope, outer shelf, inner shelf, and middle shelf. The vertical distribution of Chl a was grouped mainly from single-peak type in basin, slope, outer shelf, and middle shelf, where the deep Chl a maxima(DCM) layer was observed at 25–50 m, 30–35 m, 36–44 m, and 37–47 m, respectively. The vertical distribution of Chl a mainly had three basic patterns: standard single-peak type, surface maximum type, and bottom maximum type in the inner shelf. The analysis also showed that the transportation of ocean currents may control the distribution of Chl a, and the effects were not simple in the basin of the Bering Sea. There was a positive correlation between Chl a and temperature, but no significant correlation between Chl a and nutrients. The Bering Sea slope was an area deeply influenced by slope current. Silicate was the factor that controlled the distribution of Chl a within parts of the water in the slope. Light intensity was an important environmental factor in controlling seawater column Chl a in the shelf, where Chl a was limited by nitrate rather than phosphate within the upper water. Meanwhile, there was a positive relationship between Chl a and salinity. Algal blooms broke out at Sta. B6 of the southwestern St. Lawrence Island and Stas F6 and F11 in the middle of the Bering Strait. | KANG Jianhua CHEN Xingqun ZHANG Ming | 2014 | Acta Oceanologica Sinica2014，33，6： | 0 |
| 16 | A rapid and effective method for alloy materials design via sample data transfer machine learning显示文摘One of the challenges in material design is to rapidly develop new materials or improve the performance of materials by utilizing the data and knowledge of existing materials.Here,a rapid and effective method of alloy material design via data transfer learning is proposed to efficiently design new alloys using existing data.A new type of aluminum alloy(E2 alloy)with ultra strength and high toughness previously developed by the authors is used as an example.An optimal three-stage solution-aging treatment process(T66R)was efficiently designed transferring 1053 pieces of process-property relationship data of existing AA7xxx commercial aluminum alloys.It realizes the substantial improvement of strength and plasticity of E2 alloy simultaneously,which is of great significance for lightweight of high-end equipment.Meanwhile,the microstructure analysis clarifies the mechanism of alloy performance improvement.This study shows that transferring the existing alloy data is an effective method to design new alloys. | Lei Jiang Zhihao Zhang Hao Hu Xingqun He Huadong Fu Jianxin Xie | 2023 | npj Computational Materials2023，，1： | 0 |
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