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| 1 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 2 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 3 | Solvent-assisted microcontact molding: A convenient method for fabricating three-dimensional structures of polymeric materials 显示文摘 | Kim E Xia T Zhao X H Whitesides G M | 1997 | Adv Mater1997，9，： | 1 |
| 4 | Chromatic uniqueness and equivalence of k4 homeomorphs 显示文摘 | Whitehead E G Zhao L C | 1984 | J Graph Theory1984，，8： | 1 |
| 5 | The Innas hydraulic transformer: the key to the hydrostatic common pressure rail显示文摘 | VAEL G E ACHTEN P A J ZHAO Fu | 2000 | SAE2000，21，1： | 1 |
| 6 | Biochemical mechanisms and diagnostic microassays for pyrethroid, carbamate, and organophosphate insecticide resistance/ cross-resistance in the tobacco budworm, Heliothis virescens 显示文摘 | Zhao G Y Rose R L Hodgson E | 1996 | Pesticide Biochemistry and Physiology1996，56，3： | 1 |
| 7 | Chromatic uniqueness and equivalence of K4 -homeomorphs 显示文摘 | WHITEHEAD JR E G ZHAO L C | 1984 | J Graph Theory1984，8，： | 1 |
| 8 | Speciation of arsenic and chromium in coal and combustion ash by XAFS spectroscopy显示文摘 | HUFFMAN G P HUGGINS F E SHAH N ZHAO J | 1994 | Fuel Process Technol1994，39，13： | 1 |
| 9 | 查看详情显示文摘 | Xie G H Zhang Z S Xue Q Zhang S M Zhao L Luo Y Chen E Quan B F Zhao Y Liu S Y | | 0，，： | 1 |
| 10 | The relationship of personality to entrepreneurial intentions and performance : A meta - analytic review 显示文摘 | Zhao H Scott S E Lumpkin G T | 2010 | Journal of Management March2010，36，2： | 1 |
| 11 | Genetic diversity of Salmonella pathogenicity islands SPI-5 and SPI-6 in Salmonella Newport显示文摘 | Cao G Allard M Strain E Stones R Zhao S Brown E Meng J | 2014 | Foodborne Pathog Dis2014，11，10： | 1 |
| 12 | Tests on concrete-filled double-skin (CHS outer and SHS inner) composite short columns under axial compression显示文摘 | Mohamed E Zhao X L Raphael G | 2002 | Thin-Walled Structures2002，40，5： | 1 |
| 13 | Forging Preform Design Using the Inverse Die contact Tracking Method显示文摘 | Zhao G Wright E Grandhi R V | 1995 | NUMIFORM1995，，6： | 1 |
| 14 | Chemical engineering of the single-walled carbon nanotube-nylon 6 interface 显示文摘 | Junbo G Zhao B Itkis E M | 2006 | Journal of American Chemical Society2006，128，23： | 1 |
| 15 | Lipid lowering and plaque regression: new insights into prevention of plaque disruption and clinical events in coronary disease显示文摘 | Brown Z G Zhao X Q Sacco D E | 1993 | Ciroulation1993，87，： | 1 |
| 16 | Quadrupole deformation {fi,f) of light A hypemuclei in a constrained relativistic meanfield model显示文摘 | Lu B N Zhao E G Zhou S G | 2011 | Physical Review C2011，84，01： | 1 |
| 17 | Mir Tools:micro RNA profiling and discovery based on high-throughput sequencing显示文摘 | Zhu E Zhao F Xu G | 2010 | Nucleic Acids Research2010，38，： | 1 |
| 18 | Pre-Diabetes and the Risk for Cardiovascular DiseaseA Systematic Review of the Evidence显示文摘 | Ford E S Zhao G Li C | 2010 | Journal of the American College of Cardiology2010，55，13： | 1 |
| 19 | Scout robot with wheelinghopping combination locomotion显示文摘 | Zhao J Liu G E Yan J H | 2009 | Industrial Robot2009，36，3： | 1 |
| 20 | Preparation of ZrO2 supported MgO with high surface area and its use in mercaptan oxidation of jet fuel显示文摘 | D -e Jiang G Pan B Zhao | 2000 | Appl Catal A: General2000，201，2： | 1 |
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