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| 1 | Comparison of dimension reduction-based logistic regression models for case-control genome-wide association study:principal components analysis vs.partial least squares显示文摘With recent advances in biotechnology, genome-wide association study(GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression(LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk of inflating type I error and reducing power. Dimension reduction-based techniques, such as principal component-based logistic regression(PC-LR), partial least squares-based logistic regression(PLS-LR), have recently gained much attention in the analysis of high dimensional genomic data. However, the perfor?mance of these methods is still not clear, especially in GWAS. We conducted simulations and real data application to compare the type I error and power of PC-LR, PLS-LR and LR applicable to GWAS within a defined single nucleotide polymorphism(SNP) set region. We found that PC-LR and PLS can reasonably control type I error under null hypothesis.On contrast, LR, which is corrected by Bonferroni method, was more conserved in all simulation settings. In particular, we found that PC-LR and PLS-LR had comparable power and they both outperformed LR, especially when the causal SNP was in high linkage disequilibrium with genotyped ones and with a small effective size in simulation. Based on SNP set analysis, we applied all three methods to analyze non-small cell lung cancer GWAS data. | Honggang Yi Hongmei Wo Yang Zhao Ruyang Zhang Junchen Dai Guangfu Jin Hongxia Ma Tangchun Wu Zhibin Hu Dongxin Lin Hongbing Shen Feng Chen | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
| 2 | TREM-1 is a positive regulator of TNF- alphaand IL-8 production in U937 foam ceils 显示文摘 | Wang YS Li XJ Zhao WO | 2012 | Bosn J Basic Mcd Sci2012，12，2： | 1 |
| 3 | Technology Dine and case analysis of heat metering and energy efficiency retrofit of existing residential buildings in northern heating areas of China 显示文摘 | Zhao Jing Zhu Neng Wo Yong | 2009 | Energy Policy2009，37，6： | 1 |
| 4 | Interannual variation of phytoplankton Pseudonitzschia pungens in Jiaozhou Bay显示文摘 | Zhao S Wo Y 2002 | 2002 | Chinese Journal of Oceanology and Limnology2002，20，： | 1 |
| 5 | Detection of enterovirus 68as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China显示文摘 | Lu Q B Wo Y Wang H Y Wei M T Zhang L Yang H Liu E M Li T Y Zhao Z T Liu W Cao W C | 2014 | J Med Microbiol2014，63，3： | 1 |
| 6 | Detection of enterovirus 68as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China显示文摘 | Lu Q B Wo Y Wang H Y Wei M T Zhang L Yang H Liu E M Li T Y Zhao Z T Liu W Cao W C | 2014 | J Med Mi-crobiol2014，63，3： | 1 |
| 7 | Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker显示文摘Stem cell therapy holds high promises in regenerative medicine.The major challenge of clinical translation is to precisely and quantitatively evaluate the in vivo cell distribution,migration,and engraftment,which cannot be easily achieved by current techniques.To address this issue,for the first time,we have developed a molecular cell tracker with a strong fluorescence signal in the second near-infrared(NIR-II)window(1,000-1,700 nm)for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models.The NIR-II tracker(CelTrac1000)has shown complete cell labeling with low cytotoxicity and profound long-term tracking ability for 30 days in high spatiotemporal resolution for semiquantification of the biodistribution of transplanted stem cells.Taking advantage of the unique merits of CelTrac1000,the responses of transplanted stem cells to different diseased environments have been discriminated and unveiled.Furthermore,we also demonstrate CelTrac1000 as a universal and effective technique for ultrafast real-time tracking of the cellular migration and distribution in a 100μm single-cell cluster spatial resolution,along with the lung contraction and heart beating.As such,this NIR-II tracker will shift the optical cell tracking into a single-cell cluster and millisecond temporal resolution for better evaluating and understanding stem cell therapy,affording optimal doses and efficacy. | Hao Chen Huaxiao Yang Chen Zhang Si Chen Xin Zhao Mark Zhu Zhiming Wang Yuebing Wang Hung-Ta Wo Kai Li Zhen Cheng | 2021 | Research2021，，1： | 1 |
| 8 | A new heuristic metatask scheduling algorithm based on choosing QoS policy mechanism显示文摘 | Hou Yong Wo Xur Zhao Hong | 2009 | Internation Journal of Distributed Sensor Networks2009，5，1： | 1 |
| 9 | Effects of curcumin purification to blood vascular smooth cell proliferation显示文摘 | ZHAO G P WO X D HONG X D | 1999 | Journal of Zhejiang College of TCM ( Chinese)1999，23，3： | 1 |
| 10 | TREM-1 is a positive regulator of TNF-α and IL-8 production in U937 foam cells显示文摘 | Wang YS Li XJ Zhao WO | 2012 | Bosn J Basic Med Sci2012，12，2： | 1 |
| 11 | Extremely hard, damage-tolerant ceramic coatings with functionally graded, periodically varying architecture显示文摘 | WO P C ZHAO X L MUNROE P R | 2013 | Acta Materialia2013，61，1： | 1 |
| 12 | Evaluation of cardiac function by pacing at different right ventricular sites in patients with thirddegree atrioventricular block using Doppler ultrasound显示文摘 | Zhao Q Wo JS Guo J | 2015 | Int J Clin Exp Med2015，8，5： | 1 |
| 13 | Software sharing technology based on grid 显示文摘 | Zhao Hong Wo Xur Liu Mixia | 2007 | Engineering and Science2007，，8： | 1 |
| 14 | CRYSTALLIZATION OF AMORPHOUS Fe_(62)Co_(15.5)Nd_(4)B_(18.5) ALLOY AND ITS INFLUENCE ON HARD MAGNETIC PROPERTIES显示文摘Magnetic properties and crystallization of amorphous Fe_(62)Co_(15.5)Nd_(4)B_(18.5) alloy are studied.The Curie temperature of the present sample is 127K higher than that of amorphous Fe_(77.5)Nd_(4)B_(18.5) alloy,but their crystallization temperature is compatible with each other.A coercive field of 2.34kOe,a remanence of 12.3kG and an energy product of 11.6MGOe are obtained at room temperature in the Fe_(62)Co_(15.5)Nd_(4)B_(18.5) alloy annealed at 650°C.The 15.5at.%-Co substitution for Fe results in an increase of about 1l0K in Tc of 2:14:1 phase. | SHEN Baogen YANG Linyuan ZHANG Junxian WO Feng NING Taishan ZHAO Jiangao GUO Huiqun ZHAN Wenshan | 1990 | Chinese Physics Letters1990，7，9： | 0 |
| 15 | Field-tuned magnetic structure and phase diagram of the honeycomb magnet YbCl_(3)显示文摘We report thermodynamic and neutron diffraction measurements on the magnetic ordering properties of the honeycomb lattice magnet YbCl_(3). We find YbCl_(3) exhibits a Ne′el type long-range magnetic order at the wavevector(0, 0, 0) below TN= 600 mK.This magnetic order is associated with a small sharp peak in heat capacity and most magnetic entropy release occurs above the magnetic ordering temperature. The magnetic moment lies in-plane, parallel to the monoclinic a-axis, whose magnitude mYb= 0.86(3) μBis considerably smaller than the expected fully ordered moment of 2.24 μBfor the doublet crystal-field ground state. The magnetic ordering moment gradually increases with increasing magnetic field perpendicular to the ab-plane, reaching a maximum value of 1.6(2) μBat 4 T, before it is completely suppressed above ~ 9 T. These results indicate the presence of strong quantum fluctuations in YbCl_(3). | YiQing Hao HongLiang Wo YiMeng Gu XiaoWen Zhang YiQing Gu ShiYi Zheng Yang Zhao GuangYong Xu Jeffrey WLynn Kenji Nakajima Naoki Murai WenBin Wang Jun Zhao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，3： | 0 |
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