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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease显示文摘煽动性的肠疾病(IBD ) 是包括中国在亚洲增加的流行的世界范围的肠的免疫者不正常的疾病。它是有未知原因的胃肠的道的长期的疾病。Exosomes 是在各种各样的身体液体的小泡。他们有 40-120 的直径 ? nm,并且他们的功能之一是各种各样的物质的长途的转移。在这研究,我们与 IBD 并且在健康控制在病人调查了唾液的 exosomes 的内容与 IBD 在病人探索新 biomarker。在这研究,整个口水与 IBD 从病人被获得(ulcerative 大肠炎(UC ) , n ?=? 37;Crohns 疾病(CD ) , n ?=? 11 ) 并且显然健康的个人(HC, n ?=? 10 ) 。唾液的 exosomes 从样品被提取,并且在 exosomes 以内的蛋白质被液体用色层法分离团分光计(LC-MS/MS ) 识别。结果证明超过 2000 蛋白质与 IBD 从病人在唾液的 exosomes 被检测。通过基因本体论分析,我们发现(PSMA7 ) proteasome 子单元 alpha 类型 7 与 IBD 和健康控制显示出病人之间的特别显著的差别,因为它的表达式水平在 CD 和 UC 组是高得多的。这 exosomal 蛋白质与 proteasome 活动和煽动性的回答有关。我们因此断定在这研究,唾液的 exosomal PSMA7 在在从有 IBD 的题目的唾液的 exosomes 的高水平是在场的。免除病人 colonoscopy 的疼痛能是很有希望的 biomarker。 | Xiaowen Zheng Feng Chen Qian Zhang Yulan Liu Peng You Shan Sun Jiuxiang Lin Ning Chen | 2017 | Protein & Cell2017，8，9： | 19 |
| 3 | Glacier runoff variation and its influence on river runoff during 1961–2006 in the Tarim River Basin, China显示文摘Using monthly precipitation and temperature data from national meteorological stations, 90 m resolution DEM and a digital vector map of modern glaciers from the Chinese Glacier Inventory, the glacier mass balance and glacier runoff in the Tarim River Basin (TRB), China, were estimated based on a monthly degree-day model for 1961–2006. The results suggest that the modified monthly degree-day model can simulate the long-term changes in glacier mass balance and glacier runoff, which have been confirmed by short-term observation data and other results in literatures. The characteristics and trends of mass balance and glacier runoff variation were analyzed. It was found that the mean annual glacier mass balance during 1961–2006 was ?139.2 mm per year and the cumulative mass balance over the 46 year period was ?6.4 m in the TRB. The glacier mass balance displayed a clear decreasing trend over the entire TRB during 1961–2006. The average annual glacier runoff in the TRB was 144.16×108 m3 for 1961–2006. The results also show that glacier runoff has increased in the last 46 years, especially since the 1990s with 85.7% of the increased river flow being derived from the increased glacier runoff caused by loss of ice mass. Over the entire TRB, glacier runoff accounts for 41.5% of the total river flow during 1961–2006. The impact of glacier runoff on river flow has increased in the TRB as a result of glacier shrinkage. | Xin Gao BaiSheng Ye ShiQiang Zhang ChengJun Qiao XiaoWen Zhang | 2010 | Science China Earth Sciences2010，53，6： | 16 |
| 4 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 5 | Targeting cancer stem cell pathways for cancer therapy显示文摘Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. | Liqun Yang Pengfei Shi Gaichao Zhao Jie Xu Wen Peng Jiayi Zhang Guanghui Zhang Xiaowen Wang Zhen Dong Fei Chen Hongjuan Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 12 |
| 6 | Effects of Friction Heat on the Tribological Properties of the Woven Self-lubricating Liner显示文摘In the dry-sliding process of the woven self-lubricating liner which is used in the self-lubricating spherical plain bearing, the friction heat plays an important role in the tribological performances of the liner. It has important value to study on the relationship between tribological performances of the liner and the friction heat. Unfortunately, up to now, published work on this relationship is quite scarce. Therefore, the effect of friction heat on the tribological performances of the liner was investigated in the present work. The tribological behaviors of the liner were evaluated by using the high temperature end surface wear tester. Scanning electron microscopy (SEM) was utilized to examine the morphologies of worn surfaces of the liner and study the failure modes. Differential scanning calorimetry (DSC) measurement and X-ray diffraction (XRD) analysis were performed to study the behaviors of the wear debris. The temperature rise on the worn surface was calculated according to classical models. SEM observation shows that the dominating wear mechanism for the liner is mainly affected by friction shear force, contact pressure and friction heat. Higher fusion heat for the wear debris than that for the pure polytetrafluroethylene (PTFE) indicates that the PTFE is the main portion of the wear debris, and, the PTFE in the wear debris shows a higher crystallisation degree owing to the effects of friction shear force and the friction heat. Combining the calculated temperature rise results with the wear rate of the liner, it can be concluded that the effects of temperature rise on the tribological performances of the liner become more obvious when the temperature rise exceeds the glass transition temperature (Tg) of the PTFE. The wear resistance of the liner deteriorates dramatically when the temperature rise approaches to the melting point (Ton) of the PTFE. The tribological performances of the liner can be improved when the temperature rise exceeds Tg but is far lower than Ton. The present study on the relationship between the temperature rise and the tribological performances of the liner may provide the basis for further understanding of the wear mechanisms of the liner as well as the relationship between the formation of the PTFE transfer film and the friction heat during the dry-sliding of the liner. | YANG Yulin ZU Dalei ZHANG Ruijun QI Xiaowen | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 12 |
| 7 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 8 | Risk analysis for the highly pathogenic avian influenza in China's Mainland using meta-modeling显示文摘A logistic model was employed to correlate the outbreak of highly pathogenic avian influenza (HPAI) with related environmental factors and the migration of birds. Based on MODIS data of the normalized difference vegetation index, environmental factors were considered in generating a probability map with the aid of logistic regression. A Bayesian maximum entropy model was employed to explore the spatial and temporal correlations of HPAI incidence. The results show that proximity to water bodies and national highways was statistically relevant to the occurrence of HPAI. Migratory birds, mainly waterfowl, were important infection sources in HPAI transmission. In addition, the HPAI outbreaks had high spatiotemporal autocorrelation. This epidemic spatial range fluctuated 45 km owing to different distribution patterns of cities and water bodies. Furthermore, two outbreaks were likely to occur with a period of 22 d. The potential risk of occurrence of HPAI in China's Mainland for the period from January 23 to February 17, 2004 was simulated based on these findings, providing a useful meta-model framework for the application of environmental factors in the prediction of HPAI risk. | CAO ChunXiang XU Min CHANG ChaoYi XUE Yong ZHONG ShaoBo FANG LiQun CAO WuChun ZHANG Hao GAO MengXu HE QiSheng ZHAO Jian CHEN Wei ZHENG Sheng LI XiaoWen | 2010 | Chinese Science Bulletin2010，55，36： | 9 |
| 9 | Vertically standing PtSe_2 film: a saturable absorber for a passively mode-locked Nd:LuVO_4 laser显示文摘The novel vertically standing Pt Se2 film on transparent quartz was prepared by selenization of platinum film deposited by the magnetron sputtering method, and an Nd:Lu VO4 passively mode-locked solid-state laser was realized by using the fabricated Pt Se2 film as a saturable absorber. The X-ray diffraction pattern and Raman spectrum of the film indicate its good crystallinity with a layered structure. The thickness of Pt Se2 film is measured to be 24 nm according to the cross-section height profile of the atomic force microscope image. Highresolution transmission electron microscopy images clearly demonstrate its vertically standing structure with an interlayer distance of 0.54 nm along the c-axis direction. The modulation depth(ΔT) and saturation fluence(Φs)of Pt Se2 film are measured to be 12.6% and 17.1 μJ∕cm2, respectively. The obtained mode-locked laser spectrum has a central wavelength of 1066.573 nm, with a 3 d B bandwidth of 0.106 nm. The transform limited pulse width of the mode-locked laser was calculated to be 15.8 ps. A maximum average output power of 180 m W with a working repetition rate of 61.3 MHz is obtained. To the best of our knowledge, this is the first report of the generation of ultrafast mode-locked laser pulses by using layered Pt Se2 as a saturable absorber. | LILI TAO XIAOWEN HUANG JUNSHAN HE YAJUN LOU LONGHUI ZENG YONGHUI LI HUI LONG JINGBO LI LING ZHANG YUEN HONG TSANG | 2018 | Photonics Research2018，6，7： | 8 |
| 10 | Preparation and characterization of capric-palmitic-stearic acid ternary eutectic mixture/expanded vermiculite composites as form-stabilized thermal energy storage materials显示文摘In this study, a composite of form-stable phase change materials(FSPCMs) were prepared by the incorporation of a eutectic mixture of capric–palmitic–stearic acid(CA–PA–SA) into expanded vermiculite(EV)via vacuum impregnation. In the composites, CA–PA–SA was utilized as a thermal energy storage material,and EV served as the supporting material. X-ray diffraction and Fourier transform infrared spectroscopy results demonstrated that CA–PA–SA and EV in the composites only undergo physical combination, not a chemical reaction. Scanning electron microscopy images indicated that CA–PA–SA is sufficiently absorbed in the expanded vermiculite porous network. According to differential scanning calorimetry results, the70 wt% CA–PA–SA/EV sample melts at 19.3℃ with a latent heat of 117.6 J/g and solidifies at 17.1℃ with a latent heat of 118.3 J/g. Thermal cycling measurements indicated that FSPCMs exhibit adequate stability even after being subjected to 200 melting–freezing cycles. Furthermore, the thermal conductivity of the composites increased by approximately 49.58% with the addition of 5 wt% of Cu powder. Hence,CA–PA–SA/EV FSPCMs are effective latent heat thermal energy storage building materials. | Weiyi Zhang Xiaoguang Zhang Zhaohui Huang Zhaoyu Yin Ruilong Wen Yaoting Huang Xiaowen Wu Xin Min | 2018 | Journal of Materials Science & Technology2018，34，2： | 8 |
| 11 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 12 | Study of NMR porosity for terrestrial formation in China显示文摘NMR logging is an effective method for porosity measurement. NMR-derived porosity only comes from the pore fluid and is, in principle, not affected by rock matrix. However, it is found that the difference between NMR-derived and conventional log-derived porosities is often between 2 to 6 pu, which is unacceptable, in terrestrial formation in China. In the paper, the theory of NMR porosity was reviewed. The influence factors on NMR porosity error were analyzed based on NMR core measurements. More than 30 core samples with a wide range of porosities including sandstone, limestone and artificial ceramic were chosen for the conventional and NMR porosity measurements. The current NMR data acquisition method was studied based on laboratory NMR core meas- urements and found to be not good for terrestrial formation. A new NMR data acquisition method suiting for terrestrial formation in China was proposed and much improved the accuracy of NMR porosity measurement. It is suggested that the analysis of core samples from different regions should be carried out before logging in order to obtain accurate NMR porosity. | WANG Xiaowen XIAO Lizhi XIE Ranhong ZHANG Yuanzhong | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，3： | 8 |
| 13 | Highly stretchable polymer/silver nanowires composite sensor for human health monitoring显示文摘Flexible strain sensors exhibit outstanding advantages in terms of sensitivity and stability by detecting changes in physical signals.It can be easily attached to human skin and clothed to achieve monitoring of human motion and health.However,general sensing material shows low stretchability and cannot respond to signals under large deformation.In this work,a highly stretchable polymer composite was developed by adding small amount(0.17 wt.%)of silver nanowires(AgNWs)in stretchable conductive polymer materials.The conductivity of polymer/AgNWs composite is 1.3 S/m with the stretchability up to 500%.The stretchable strain sensor based on the polymer/AgNWs composite can respond to strain signals in real time,even for 1%strain response,and shows excellent stability over 1,000 loading/unloading cycles.Moreover,the strain sensor can be attached to human skin and clothed to monitor joints,throat and pulse of the human body.The human body electrocardiogram(ECG)signal was detected successfully with the polymer/AgNWs electrode,which is comparable to the signal obtained by the commercial electrode.Overall,the sensors enable monitoring of human movement and health.These advantages make it a potential application in wearable devices and electronic skin. | Yanjing Zhang Pei He Meng Luo Xiaowen Xu Guozhang Dai Junliang Yang | 2020 | Nano Research2020，13，4： | 7 |
| 14 | Genome evolution trend of common carp (Cyprinus carpio L.) as revealed by the analysis of microsatellite loci in a gynogentic family显示文摘Genome evolution arises from two main ways of duplication and reduction. Fish specific genome duplication (FSGD) may have occurred before the radiation of the teleosts. Common carp (Cyprinus carpio L.) has been considered to be a tetraploid species, because of its chromosome numbers (2n=100) and its high DNA content. Using 69 microsatellite primer pairs, the variations were studied to better understand the genome evolution (genome duplication and diploidization) of common carp from a gynogenetic family. About 48% of primer pairs were estimated to amplify duplicates based on the number of PCR amplification per individual. Segregation patterns in the family suggested a partially duplicated genome structure and disomic inheritance. This indicates that the common carp is tetraploid and polyploidy occurred by allotetraploidy. Two primer pairs (HLJ021 and HLJ332) were estimated to amplify reduction based on the number of PCR amplification per individual. One allele in HLJ002 locus and HLJ332 locus was clearly lost in the gynogenetic family and the same as in six wild populations. Segregation patterns in the family suggested a partially diplodization genome structure. A hypothesis transition (dynamic) and equilibrium (static) were proposed to explain the common carp genome evolution between genome duplication and diploidization. | Yah Zhang Liqun Liang Peng Jiang Dayu Li Cuiyun Lu Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，2： | 7 |
| 15 | Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial显示文摘We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard care.The control group was composed of 59 patients who received standard therapy alone.Treatment with SHL was not associated with a difference from standard care in the time to disease recovery.Patients with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL groups.This study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19. | Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li Runhua Zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang | 2021 | Frontiers of Medicine2021，15，5： | 7 |
| 16 | Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain:One of the predominant strains circulating in China from 2017 to 2021显示文摘Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets.Maternal vaccines can effectively enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge.From 2017 to 2021,we collected 882 diarrhea samples from 303 farms in China to investigate the epidemiology of PEDV.The result showed that about 52.15%(158/303)of the farms were positive for PEDV with an overall detection rate of 63.95%(564/882)of the samples.The S1 fragments of S gene from 104 strains were sequenced for the phylogenetic analysis.A total of 71 PEDV strains(68.27%)sequenced in this study were clustered into the predominant G2c subgroup,while the newly-defined G2d strains(9.62%)were identified in three provinces of China.The NH-TA2020 strain of G2c subgroup was isolated and cultured,and its infection to piglets caused watery diarrhea within 24 h,indicating its strong pathogenicity.Oral administration of NH-TA2020 strain to pregnant gilts stimulated high levels of IgA antibody in colostrum.The piglets fed by the gilts above were challenged with NH-TA2020 strain or CH-HeB-RY-2020 strain from G2d subgroup,and the clinical symptoms and virus shedding were significantly reduced compared to the mock group.Our findings suggest that G2c subgroup is the predominant branch circulating in China from 2017 to 2021.Oral administration of NH-TA2020 enhances maternal IgA and lactogenic immune responses,which confer protection against the homologous and emerging G2d PEDV strains challenges in neonates. | Xiaowen Li Yang Li Jiapei Huang Yali Yao Wenying Zhao Yunjing Zhang Jie Qing Jing Ren Zhong Yan Zewei Wang Xiaofang Hu Duli Kang Hongqiang Liu Zhichun Yan | 2022 | Virologica Sinica2022，37，5： | 6 |
| 17 | Recycled Nd-Fe-B sintered magnets prepared from sludges by calcium reduction-diffusion process显示文摘Environmental friendly recycling process for Nd-Fe-B sintered magnet sludges generated in the manufacturing process, which contain large amount of rare earth, including Nd, Pr and Dy, is badly needed so far. In present study, we have developed an effective route to obtain recycled sintered magnets from Nd-Fe-B sintered magnet sludges by calcium reduction-diffusion(RD) process. Compared to conventional recycling process, our research is focused on recovering most of the useful elements, including Nd, Pr, Dy, Co, and Fe together instead of just rare earth elements. To improve the recycling efficiency and reduce pollution, the co-precipitating parameters were simulated and calculated using MATLAB software. Most of useful elements were recovered by a co-precipitation method, and the obtained composite powders were then directly fabricated as recycled Nd-Fe-B powders by a calcium reduction-diffusion(RD) method. The recovery rates are 98%, 99%, 99%, 93%, and 99%, for Nd, Pr, Dy, Co, and Fe, respectively. The amount of useful elements contained in the recovered composite powders is greater than99.71 wt%. The process of RD for synthesizing Nd_2 Fe_(14)B and subsequently removing CaO was thoroughly investigated. Furthermore, the recycled Nd-Fe-B magnet exhibits a remanence of 1.1 T, a coercivity of1053 kA/m, and an energy product of 235.6 kJ/m^3, respectively, indicating that recycled Nd-Fe-B sintered magnet was successfully recovered from the severely contaminated sludges via an effective recycling route. | Xiaowen Yin Min Liu Baicen Wan Yu Zhang Weiqiang Liu Yufeng Wu Dongtao Zhang Ming Yue | 2018 | Journal of Rare Earths2018，36，12： | 6 |
| 18 | The novel H1N1 Influenza A global airline transmission and early warning without travel containments显示文摘A novel influenza A (H1N1) has been spreading worldwide. Early studies implied that international air travels might be key cause of a severe potential pandemic without appropriate containments. In this study, early outbreaks in Mexico and some cities of United States were used to estimate the preliminary epidemic parameters by applying adjusted SEIR epidemiological model, indicating transmissibility infectivity of the virus. According to the findings, a new spatial allocation model totally based on the real-time airline data was established to assess the potential spreading of H1N1 from Mexico to the world. Our estimates find the basic reproductive number R0 of H1N1 is around 3.4, and the effective reproductive number fall sharply by effective containment strategies. The finding also implies Spain, Canada, France, Panama, Peru are the most possible country to be involved in severe endemic H1N1 spreading. | CHANG ChaoYi CAO ChunXiang WANG Qiao CHEN Yu CAO ZhiDong ZHANG Hao DONG Lei ZHAO Jian XU Min GAO MengXu ZHONG ShaoBo HE QiSheng WANG JinFeng LI XiaoWen | 2010 | Chinese Science Bulletin2010，55，26： | 6 |
| 19 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 20 | Parallel implementation of fast multipole method based on JASMIN显示文摘Fast multipole method (FMM) may reduce the complexity of N-body problems from O(N 2 ) to O(N log N) or O(N).It was applied in problems ranging from electromagnetic scattering to dislocation dynamics.FMM can be divided into two parts: commonness and individuality.A parallel solver of FMM commonly used in various applications has been designed and implemented in JASMIN infrastructure.The solver encapsulates the commonness.Furthermore,it supplies users with abstract interfaces required to implement the individuality with serial mode.The commonness contains distributed storage of multi-levels,intra-level and inter-level data communication,and arrangement of computation,etc.The individuality contains various expansion and translation operators.We give here two applications that have used the solver.Scalability was demonstrated with a parallel efficiency above 80% on 1024 processors. | CAO XiaoLin MO ZeYao LIU Xu XU XiaoWen ZHANG AiQing | 2011 | Science China(Information Sciences)2011，54，4： | 5 |
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