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| 1 | Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons显示文摘 | Xuemei Shi Fuguo Zhou Xiaojie Li Benny Chang Depei Li Yi Wang Qingchun Tong Yong Xu Makoto Fukuda Jean J. Zhao Defa Li Douglas G. Burrin Lawrence Chan Xinfu Guan | 2013 | Cell Metabolism2013，，1： | 1 |
| 2 | Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is one type of the most aggressive breast can cers with poor prog no sis.It is of great urgency to develop new therapeutics for treati ng TNBC.Based on curre nt treatment guideline and genetic informatio n of TNBC,a combi nation al therapy platform in tegrati ng chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy.In this study,we developed paclitaxel amino lipid(PAL)derived nanoparticles(NPs)to incorporate both chemotherapy drugs and P53 mRNA.The PAL P53 mRNA NPs showed superior properties compared to Abraxane? and Lipusu? used in the clinic including high paclitaxel loading capacity(24 wt.%,calculated by paclitaxel in PAL),PAL encapsulation efficiency(94.7%±6.8%)and mRNA encapsulation efficiency(88.7%±0.7%).Meanwhile,these NPs displayed synergetic cytotoxicity of paclitaxel and P53 mRNA in cultured TNBC cells.More importantly,we demonstrated in vivo anti-tumor efficacy of PAL P53 mRNA NPs in an orthotopic TNBC mouse model.Overall,these chemotherapy drugs derived mRNA NPs provide a new platform to integrate chemotherapy and personalized medicine using tumor genetic information,and therefore represent a promising approach for TNBC treatment. | Chengxiang Zhang Xinfu Zhang Weiyu Zhao Chunxi Zeng Wenqing Li Bin Li Xiao Luo Junan Li Justin Jiang Binbin Deng David W. McComb Yizhou Dong | 2019 | Nano Research2019，12，4： | 1 |
| 3 | Reversal of cardiomyopathy in patients with congestive heart failure secondary to tachycardia显示文摘 | Zhao Donghua Peng Jian Xiao Zhongbo Zhang Feifei Peng Xinhui Yang Hao Liu Fuqiang Li Yan Xie Yong Huang Xinfu Meng Surong Wu Muli Xu Dingli | 2013 | Journal of Interventional Cardiac Electrophysiology2013，，： | 1 |
| 4 | Origin of the Tongshankou porphyry-skarn Cu-Mo deposit, eastern Yangtze eraton, Eastern China: geochronological, geochemical, and Sr-Nd-I-If isotopic constraints 显示文摘 | Li Jianwei Zhao Xinfu Zhou Meifu | 2008 | Miner Deposit2008，43，3： | 1 |
| 5 | Re-Os Dating of pyrrhotite from the Chaoshan gold skarn,Eastern Yangtze Craton,Eastern China显示文摘 | Wang Jianzhong Li Jianwei Zhao Xinfu Ma Changqian Qu Wenjun Du Andao | 2008 | International Geology Review2008，50，： | 1 |
| 6 | Association of Neopro- terozoic A- and I-type granites in South China: Implications for generation of A-type granites in a subduction-related environment 显示文摘 | Zhao Xinfu Zhou Meifu Li Jianwei | 2008 | Chemical Geology2008，257，： | 1 |
| 7 | A novel approach to fabricate Zn coating on Mg foam through a modified thermal evaporation technique显示文摘Zn enriched coatings with distinct microstructures and properties were fabricated on Mg foams by a modified thermal evaporation technique using a tubular resistance furnace. As the temperature and kinetic energy of Zn vapor varied along the tubular system, a spatial variation of preparation conditions was created and the obtained coatings were found to follow two growth mechanisms: a thermal diffusion pattern in high-temperature zone and the a relatively low-temperature deposition model. AZn-based deposition coating with dense texture and nearly uniform structure was acquired while Mg foam was placed 20 cm far from the evaporation source, where the Zn vapor deposition model dominated the coating growth.Mechanical properties and bio-corrosion behaviors of the samples were investigated. Results showed that the Zn coatings brought dramatic improvements in compression strength, but exhibited differently in biodegradation performance. It was confirmed that the diffusion layer accelerated corrosion of Mg foam due to the galvanic effect, while the Zn-based deposition coating displayed excellent anti-corrosion performance, showing great potential as bone implant materials. This technique provides a novel and convenient approach to tailor the biodegradability of Mg foams for biomedical applications. | Xingfu Wang Xinfu Wang Dan Wang Modi Zhao Fusheng Han | 2018 | Journal of Materials Science & Technology2018，34，9： | 1 |
| 8 | Pyrolysis behavior of vitrinite and inertinite from Chinese Pingshuo coal by TG–MS and in a fixed bed reactor显示文摘 | Yunpeng Zhao Haoquan Hu Lijun Jin Xinfu He Bo Wu | 2010 | Fuel Processing Technology2010，，4： | 1 |
| 9 | Co-delivery of mRNA and SPIONs through amino-ester nanomaterials显示文摘 | Xiao Luo Weiyu Zhao Bin Li Xinfu Zhang Chengxiang Zhang Anna Bratas Binbin Deng David W. McComb Yizhou Dong | 2018 | Nano Research2018，11，10： | 1 |
| 10 | Late Paleoproterozoic to early Mesoproterozoic Dongchuan Group in Yunnan, SW China: Implications for tectonic evolution of the Yangtze Block显示文摘 | Zhao Xinfu Zhou Meifu Li Jianwei | 2010 | Precambrian Research2010，182，12： | 1 |
| 11 | Fe-Cu deposit in the Kangdian region, SW China: A Proterozoic IOCG(iron- oxide- copper- gold) metallogenic province显示文摘 | Zhao Xinfu Zhou Meifu | 2011 | Mineralium Deposita2011，46，7： | 1 |
| 12 | Yield Stress Prediction Model of RAFM Steel Based on the Improved GDM-SA-SVR Algorithm显示文摘With the development of society and the exhaustion of fossil energy,researcher need to identify new alternative energy sources.Nuclear energy is a very good choice,but the key to the successful application of nuclear technology is determined primarily by the behavior of nuclear materials in reactors.Therefore,we studied the radiation performance of the fusion material reduced activation ferritic/martensitic(RAFM)steel.The main novelty of this paper are the statistical analysis of RAFM steel data sets through related statistical analysis and the formula derivation of the gradient descent method(GDM)which combines the gradient descent search strategy of the Convex Optimization Theory to get the best value.Use GDM algorithm to upgrade the annealing stabilization process of simulated annealing algorithm.The yield stress performance of RAFM steel is successfully predicted by the hybrid model which is combined by simulated annealing(SA)with support vector machine(SVM)as the first time.The effect on yield stress by the main physical quantities such as irradiation temperature,irradiation dose and test temperature is also analyzed.The related prediction process is:first,we used the improved annealing algorithm to optimize the SVR model after training the SVR model on a training data set.Next,we established the yield stress prediction model of RAFM steel.The model can predict up to 96%of the data points with the prediction in the test set and the original data point in the 2range.The statistical test analysis shows that under the condition of confidence level=0.01,the calculation results of the regression effect significance analysis pass the T-test. | Sifan Long Ming Zhao Xinfu He | 2019 | Computers, Materials & Continua2019，，3： | 0 |
| 13 | Shear-wave Splitting of Aftershocks of the M_S 5.7 Jiujiang-Ruichang Earthquake显示文摘Shear wave splitting is studied based on the digital waveforms of three seismic stations DJS, SZD and WUJ, which were set up after the Jiujiang-Ruichang MS5.7 earthquake of November 26, 2005 around the epicenter area. The result shows that the time delays of slow shear waves of the DJS station, which is not far from the epicenter and where the distribution of faults is complex near the station, are relatively larger and the polarization directions of fast shear waves are not concentrated; the predominant polarization direction of fast shear waves of WUJ station, with single fault distributed nearby, has a difference of 35° to the strike of the fault and is inconsistent with the direction of regional principal compressive stress. The predominant polarization direction of fast shear waves of SZD station with no faults nearby is in accordance with regional principal compressive stress. There is no obvious regular relationshipship between the delay time and the focal depth. | Tang Lanrong Shi Yutao Zeng Xinfu Zheng Bin Zhao Bo Lv Jian | 2013 | Earthquake Research in China2013，27，1： | 0 |
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