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| 1 | Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer显示文摘Clusterin/apolipoprotein J (Clu ) 是在几个生理的过程被含有的无所不在地表示的分泌 heterodimeric glycoprotein。这被报导了分泌 clusterin (sClu ) 的提高的水平蛋白质在乳癌病人与差的幸存被联系并且能在啮齿类动物模型导致转移。在这研究,我们在 vitro 并且在 vivo 在细胞活动性,侵略,和生长上与小介入 RNA (siRNAs ) 调查了 sClu 抑制的效果。MDA-MB-231 房间是有 pSuper-siRNA/sClu 的 transfected。房间幸存和增长被 3-(4,5-dimethyl-thiazol-2yl ) 检验 -5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 和 clonogenic 幸存试金。结果证明 sClu silencing 显著地禁止了 MDA-MB-231 房间的增长。侵略和迁居能力戏剧性地也被减少,它被 matrigel 试金检测。染色的 TUNEL 和 caspase-3 活动试金证明 sClu silencing 能也增加房间的 apoptosis 率,导致房间生长的抑制。我们也在一个 orthotopic 乳癌模型在肿瘤生长和变形前进上决定了 sClu silencing 的效果。结果比肿瘤源于父母 MDA-MB-231 或 MDA-MB-231/pSuper 的证明主要肿瘤从 MDA-MB-231/pSuper sClu siRNA 房间导出的 orthotopic 变得显著地慢爬 siRNA 房间,并且少些转移到肺。这些数据建议能分泌的 clusterin 在肿瘤生长和变形前进起一个重要作用。敲门下面 sClu 基因表示可以为乳癌治疗提供一个珍贵方法。 | Zhaohe Niu Xinhui Li Bin Hu Rong Li Ligang Wang Lilin Wu Xingang Wang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 6 |
| 2 | A temperature-activated nanocomposite metamaterial absorber with a wide tunability显示文摘新奇薄、灵活的宽带电磁的微波吸收器与 nanocomposites 被认识到并且完成宽频率 tunability (从 10 ~ 17.2 GHz ) 由活跃地调整抵抗。建议吸收器被可伸缩的屏幕打印优化 nanoparticle 墨水到灵活绝缘的合成底层上制作。基于底层的形状记忆效果和 nanocomposite 频率的 piezoresistive 效果选择表面,一个可控制的表电阻,和从而悦耳的波浪吸收性能,能以一种激活温度、动态地稳定的方式被认识到。结果由利用人工的材料和基于聚合物的 nanocomposites 的聪明的行为的以前低估的内在的性质为活跃电磁的设备的设计提供新尺寸。 | Weiwei Li Lingyu Zhao Zhaohe Dai Hao Jin Feng Duan Junchao Liu Zhihui Zeng Jun Zhao Zhong Zhang | 2018 | Nano Research2018，11，7： | 6 |
| 3 | Effects of Ytterbium and Zirconium on precipitation evolution and coarsening resistance in aluminum during isothermal aging 显示文摘 | Gao Zhaohe Li I-Iongying Liu Jiaojiao | 2014 | Journal of Alloys and Compounds2014，592，1： | 1 |
| 4 | Characterization of Amphidinium(Amphidiniales,Dinophyceae)species from the China Sea based on morphological,molecular,and pigment data显示文摘Amphidinium species are amongst the most abundant benthic dinoflagellates in marine intertidal sandy ecosystems.Some of them are able to produce a variety of bioactive compounds that can have both harmful effects and pharmaceutical potentials.The diversity of Amphidinium in shallow waters along the Chinese coast was investigated by isolating single cells from sand,coral,and macroalgal samples collected from 2012 to 2020.Their morphologies were subjected to examination using light microscopy(LM)and scanning electron microscopy(SEM).A total of 74 Amphidinium strains were morphologically identified,belonging to 11 species:A.carterae,A.gibbosum,A.operculatum,A.massartii,A.cf.massartii,A.fijiensis,A.pseudomassartii,A.steinii,A.thermaeum,A.theodori,A.tomasii,as well as an undefined species.The last seven species have not been previously reported in Chinese waters.Amphidinium carterae subcladesⅠ,Ⅱ,andⅣwere found in the South China Sea,while subcladeⅢwas only found in the Yellow Sea.Threadlike body scales were observed on the surface of subcladesⅢ and Ⅳ,supporting the idea that A.carterae might contain several different species.Large subunit ribosomal RNA(LSU rRNA)sequencesbased phylogeny revealed two groups(GroupsⅠandⅡ)within Amphidinium,which is consistent with the relative position of sulcus(in touch with cingulum or not).In addition,large differences in morphology and molecular phylogeny between A.operculatum(the type species of Amphidinium)and other species,suggest that a subdivision of Amphidinium might be needed.The pigment profiles of all available strains were analyzed by high performance liquid chromatography(HPLC).Eleven pigments,including peridinin,diadinoxanthin,diatoxanthin,pheophorbide(and pheophorbide a),antheraxanthin,β-carotene,and four different chlorophylls were detected.The high pheophorbide/pheophorbide a ratio in Amphidinium implies that it may be a good candidate as a natural source of photosensitizers,a well-known anticancer drug. | Zhaohe LUO Hua ZHANG Qun LI Lei WANG Hala F MOHAMED Songhui LÜ Haifeng GU | 2022 | Journal of Oceanology and Limnology2022，40，3： | 1 |
| 5 | Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly显示文摘 | Guoyi Wu Bo Liu Yingjun Zhang Jing Li Alla Arzumanyan Marcia M. Clayton Raymond F. Schinazi Zhaohe Wang Siegfried Goldmann Qingyun Ren Faxhou Zhang Mark A. Feitelson | 2013 | Antimicrobial Agents and Chemotherapy2013，，11： | 1 |
| 6 | Knowledge,Attitude,and Practice Towards Mpox and Associated Factors Among HIV-Infected Individuals—Beijing Municipality,China,2023显示文摘Summary What is already known about this topic?Approximately 50%of patients with mpox are human immunodeficiency virus(HIV)-infected globally.Studies have shown that individuals with advanced HIV infection tend to have more severe clinical manifestations and higher mortality rates after mpox infection.What is added by this report? | Yue Gu Ruiqi Ren Jing Han Wenqing Bai Yuanyuan Zhang Haoliang Liu Zhaohe Li Chao Li Rui Song Lei Zhou | 2024 | China CDC weekly2024，6，7： | 0 |
| 7 | Chinese New Year Celebrated in Los Angeles显示文摘In the beginning of 2013, a great variety of cultural events were held in Los Angeles, USA in celebration of the Chinese New Year. These events, as part of 'Happy Chinese New Year' celebrations, highlight Chinese cultural elements with great scale and diverse forms, attracting both Chinese immigrants and local Americans. | Che Zhaohe Li Bing | 2013 | China & The World Cultural Exchange2013，79，4： | 0 |
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