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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 3 | A Novel Protein RLS1 with NB-ARM Domains Is Involved in Chloroplast Degradation during Leaf Senescence in Rice显示文摘叶老朽,规划细胞死亡(PCD ) 的一种类型由叶绿素降级描绘了,是重要的种生长和庄稼生产率。autophagy 在叶老朽期间涉及叶绿体降级,这出现。然而,涉及这个过程的分子的机制很好没被理解。在这研究,米饭 rls1 (快速的叶老朽 1 ) 的基因、生理的特征异种被识别。rls1 异种开发了类似于在野类型的植物比那些显示了更早的老朽的叶子的整个表面上散布的疾病的小、黄褐的损害。在老朽期间满意的叶绿素的快速的损失是在 rls1 的加速的叶老朽的主要原因。显微镜的观察显示 PCD 被调整,可能在 rls1 导致叶绿体的加速的降级离开。RLS1 基因的基于地图的克隆表明它编码一以前在 carboxyl 终点与一个手臂(犰狳) 领域包含蛋白质的 uncharacterized NB (核苷酸绑定地点) 。与它在叶老朽的参与一致, RLS1 在导致黑暗的叶老朽期间是起来调整的并且由细胞激动素下面调整。有趣地, RLS1 的组成的表示稍微也在转基因的米饭植物与减少的叶绿素内容加速了叶老朽。我们识别的学习一以前, uncharacterized NBARM 蛋白质在植物生长和开发期间在 PCD 包含了,为把提供一个唯一的工具可能的调停 autophagy 的 PCD 在在植物的老朽期间。 | Bin-Bin Jiao Jian-Jun Wang Xu-Dong Zhu Long-Jun Zeng Qun Li Zu-Hua He | 2012 | Molecular Plant2012，5，1： | 45 |
| 4 | An Outbreak of NCIP (2019-nCoV) Infection in China --Wuhan, Hubei Province, 2019−2020显示文摘Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of cases of viral pneumonia of unknown etiology(VPUE),now known as novel coronavirus-infected pneumonia(NCIP),occurred in Wuhan,Hubei Province and was reported to health authorities on December 29,2019(2).A national,provincial,and municipal joint investigation team has been assembled to conduct field investigations and implement disease control and prevention measures.This report shows interim results of the investigation and makes recommendations for response measures. | The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team Qun Li | 2020 | China CDC weekly2020，2，5： | 31 |
| 5 | Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance显示文摘赤霉素(气体) 形成涉及植物生长和开发的许多方面的一组重要植物 tetracyclic diterpenoid 荷尔蒙。新兴的证据含有那气体也在压力回答起作用。然而,在关於生命的应力的气体的角色大部分是未知的。这里,我们报导那个大美人或 overexpression 伸长最高编码撤销的 GA 的 internode (Eui ) 基因分别地,酶损害或增加疾病抵抗到细菌的老家(Xanthomonas oryzae pv。oyrzae ) 并且米饭强风(Magnaporthe oryzae ) 。分别地, GA3 和 GA 合成(uniconazol ) 的禁止者的外长的申请能增加疾病危险性和抵抗到细菌的老家。同样, uniconazol 恢复了 eui 异种的疾病抵抗, GA3 减少了到细菌的老家的 Eui overexpressors 的疾病抵抗。因此,抵抗的变化把层次归因于 GA。在有这的一致性, GA 新陈代谢基因 OsGA20ox2 和 OsGA2ox1 在病原体挑战期间是下面调整的。我们也发现那 PR1a 正式就职被提高,但是 SA 水平在 Eui overexpressor 被减少,当 JA 水平在 eui 异种被减少时。一起,我们的当前的学习显示气体在米饭起一个否定作用基础疾病电阻,与是的 EUI 通过调整 bioactive 气体的水平的一个积极调节的人。 | Dong-Lei Yang Qun Li Yi-Wen Deng Yong-Gen Lou Mu-Yang Wang Guo-Xing Zhou Ying-Ying Zhang Zu-Hua He | 2008 | Molecular Plant2008，1，3： | 29 |
| 6 | Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence显示文摘新兴的证据建议 E3 ligases 在多样的生物过程起关键作用,包括在植物的天生的有免疫力的回答。然而,在植物的 E3 ligase 参与的机制天生的免疫是不清楚的。我们报导那米饭基因, OsBBI1,与 E3 ligase 活动编码戒指手指蛋白质,调停用途广泛的疾病抵抗。OsBBI1 的表示被米饭强风真菌 Magnaporthe oryzae,以及化学 inducers 导致, benzothiadiazole 和水杨酸酸。生物化学的分析表明那 OsBBI1 蛋白质在 vitro 拥有 E3 ubiquitin ligase 活动。基因分析表明在一根 Tos17 插入线的 OsBBI1 功能的损失增加了危险性,当在转基因的植物的 OsBBI1 的 overexpression 授与提高的抵抗到 M 的多重赛跑时。oryzae。这显示 OsBBI1 对强风真菌调制用途广泛的抵抗。OsBBI1-overexpressing 植物由 M 在感染地点在房间墙中在酉分的混合物的房间和蛋白质的 cross-linking 显示出 H2O2 累积的高水平。oryzae 与相比野类型(WT ) 植物。房间墙在 OsBBI1-overexpressing 植物是更厚的并且在变异的植物更薄比在 WT 植物。我们的结果建议 OsBBI1 由修改房间墙防卫回答调制用途广泛的抵抗到强风真菌。OsBBI1 的功能的描述为在米饭对最破坏的疾病构造用途广泛的抵抗提供卓见进 E3 调停 ligase 的天生的免疫,和一个实际工具。 | Wei Li Sihui Zhong Guojun Li Qun Li Bizeng Mao Yiwen Deng Huijuan Zhang Longjun Zeng Fengming Song Zuhua He | 2011 | Cell Research2011，21，5： | 30 |
| 7 | Spatiotemporal dynamics of electric power consumption in Chinese Mainland from 1995 to 2008 modeled using DMSP/OLS stable nighttime lights data显示文摘电力消费(EPC ) 是为评估电力使用的基本索引之一。在 EPC 的空间与时间的动力学上获得及时、精确的数据为理解和电力资源的实际推广是关键的。在这研究,一个 EPC 模型从防卫气象学的卫星程序用稳定的夜间灯时间系列数据被开发运作的 Linescan 系统(DMSP/OLS ) 。模型被用来重建在在县的中国大陆的 EPC 的空间模式从 1995 ~ 2008 铺平。另外, EPC 的空间与时间的动力学被分析,并且下列结论被得出。(1 ) EPC 模型可靠地与约 70% 精确性在中国大陆代表了 EPC 的空间与时间的动力学。(2 ) 在中国大陆的大多数区域的 EPC 在对中等层次低,与显著时间、空间的变化;高级 EPC, 58.26% 在东方中国被集中。六城市的凝块(Beijing-Tianjin-Tangshan 区域, Shanghai-Nanjing-Hangzhou 区域,珀尔河三角洲,山东半岛,辽宁省,和四川盆中间南方) 说明了中国大陆的 10.69% 全部的区域,但是消费了 39.23% 电。(3 ) 在从 1995 ~ 2008,和 64% 大陆区域增加的中国大陆的大多数区域的 EPC 在 EPC 显示出重要增加。EPC 的中等增加从 1995 ~ 2008 在 61.62% 东方中国和 80.65% 华中被发现,而 75.69% 西方的中国没在 EPC 显示出重要增加。同时,分别地, 77.27% , 89.35% ,和 66.72% Shanghai-Nanjing-Hangzhou 区域,珀尔河三角洲,和山东半岛在 EPC 显示出高速度的增加。EPC 的中等增加发生在 71.12% Beijing-Tianjin-Tangshan 区域和 72.13% 并且辽宁省中间南方,分别地当没有重要增加发生在 56.34% 四川盆时。 | HE Chunyang MA Qun LI Tong YANG Yang LIU Zhifeng | 2012 | Journal of Geographical Sciences2012，22，1： | 25 |
| 8 | Thermodynamics and kinetics of phase transformation in rare earth–magnesium alloys:A critical review显示文摘Magnesium and its alloys are significant superior metallic materials for structural components in automobile and aerospace industries due to their excellent physicomechanical properties.The Mg–rare earth(RE)systems have attracted great interests because RE additions can improve both the deformability and the strength of Mg alloys through solid solution strengthening and precipitation hardening mechanisms.This paper focuses on the interface stability,together with thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases in Mg–RE alloys.In this paper,the theory and recent advances on Mg–RE alloys,especially for the interface stability,thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases,together with their relationships with micro-structures,and macroscopic properties,are reviewed.By combining the thermodynamics/kinetics integrated simulations with various advanced experimental techniques,“reverse”design of Mg–RE alloys starting from the target service performance is put forward as a kind of scientific paradigm with rational design. | Qun Luo Yanlin Guo Bin Liu Yujun Feng Jieyu Zhang Qian Li Kuochih Chou | 2020 | Journal of Materials Science & Technology2020，44，9： | 26 |
| 9 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 10 | Chemical characteristics and source apportionment of PM_(2.5) between heavily polluted days and other days in Zhengzhou, China显示文摘PM_(2.5) samples were collected in Zhengzhou during 3 years of observation, and chemical characteristics and source contribution were analyzed. Approximately 96% of the daily PM_(2.5) concentrations and annual average values exceeded the Chinese National Ambient Air Quality Daily and Annual Standards, indicating serious PM_(2.5) pollution. The average concentration of water-soluble inorganic ions was 2.4 times higher in heavily polluted days(daily PM32.5 concentrations > 250 μg/mand visibility < 3 km) than that in other days, with sulfate, nitrate, and ammonium as major ions. According to the ratio of NO-3/SO2-4,stationary sources are still the dominant source of PM_(2.5) and vehicle emission could not be ignored. The ratio of secondary organic carbon to organic carbon indicated that photochemical reactivity in heavily polluted days was more intense than in other days.Crustal elements were the most abundant elements, accounting for more than 60% of 23 elements. Chemical Mass Balance results indicated that the contributions of major sources(i.e., nitrate, sulfate, biomass, carbon and refractory material, coal combustion, soil dust,vehicle, and industry) of PM_(2.5) were 13%, 16%, 12%, 2%, 14%, 8%, 7%, and 8% in heavily polluted days and 20%, 18%, 9%, 2%, 27%, 14%, 15%, and 9% in other days, respectively.Extensive combustion activities were the main sources of polycyclic aromatic hydrocarbons during the episode(Jan 1-9, 2015) and the total benzo[a]pyrene equivalency concentrations in heavily polluted days present significant health threat. Because of the effect of regional transport, the pollution level of PM_(2.5) in the study area was aggravated. | Nan Jiang Qiang Li Fangcheng Su Qun Wang Xue Yu Panru Kang Ruiqin Zhang Xiaoyan Tang | 2018 | Journal of Environmental Sciences2018，30，4： | 22 |
| 11 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 12 | Calcineurin B-like interacting protein kinase OsCIPK23 functions in pollination and drought stress responses in rice (Oryza sativa L.)显示文摘Drought is very harmful to grain yield due to its adverse effect on reproduction, especially on pollination process in rice. However, the molecular basis of such an effect still remains largely unknown. Here, we report the role of a member of CBL (Calcineurin B-Like) Interacting Protein Kinase (CIPK) family, OsCIPK23, in pollination and stress responses in rice. Molecular analyses revealed that it is mainly expressed in pistil and anther but up-regulated by pollination, as well as by treatments of various abiotic stresses and phytohormones. RNA interference-mediated suppression of OsCIPK23 expression significantly reduced seed set and conferred a hypersensitive response to drought stress, indicating its possible roles in pollination and drought stress. In consistent, overexpression of OsCIPK23 induced the expression of several drought tolerance related genes. Taken together, these results indicate that OsCIPK23 is a multistress induced gene and likely mediates a signaling pathway commonly shared by both pollination and drought stress responses in rice. | Wenqiang Yang Zhaosheng Kong Edith Omo-Ikerodah Wenying Xu Qun Li Yongbiao Xue | 2008 | Journal of Genetics and Genomics2008，35，9： | 21 |
| 13 | Moisture transfer resistance method for liquid desiccant dehumidification analysis and optimization显示文摘The concepts of entransy, entransy dissipation and transfer resistance are introduced into liquid desiccant dehumidification analysis to reveal the irreversibility and moisture transfer resistance between moist air and liquid desiccant.By analyzing a typical water (vapor) transfer process coupled with heat transfer, we define the concepts of mass entransy of water and its dissipation, derive the expression of moisture transfer resistance (MTR) that reflects the irreversibility of water transfer during dehumidification processes, and also point out the relationship between MTR and dehumidification performance. With these concepts, both adiabatic and internal cooling liquid desiccant dehumidification systems with various operation conditions are analyzed and optimized. It is found that for the adiabatic dehumidification system, increasing the mass transfer coefficient leads to the reduction of MTR, and consequently, the improvement of dehumidification performance. Meanwhile, for the dehumidification system with internal cooling, in order to reduce the MTR and improve the dehumidification performance, pre-cooling should be centralized ahead of the liquid desiccant inlet when the flow rates ratio of air to desiccant is small, whereas, uniform cooling should be applied when the flow rates ratio of air to desiccant is large. | CHEN Lin CHEN Qun LI Zhen GUO ZengYuan | 2010 | Chinese Science Bulletin2010，55，14： | 20 |
| 14 | Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae显示文摘Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term survival.Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT.Results: With a median follow?up of 18 months(range, 3–39 months), patients' 1?year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P < 0.001) were sig= 0.003), increase i= 0.024), fistula closure(P = 0.011), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 11 patients(27.5%), and grade 3 cough was observed in 13 patients(32.5%); 2 patients(5.0%) died of massive bleeding during treatment.Conclusions: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be cured, especially those who experience complete response and have an increase in NRS score. Careful observation and nutrition support are required for patients with advanced T?category ESCC who undergo CCRT. | Li Ma Guang-Yu Luo Yu-Feng Ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu Shi-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-Feng Ye Hui Liu | 2017 | Chinese Journal of Cancer2017，36，1： | 19 |
| 15 | Expression of CD133, PAX2, ESA, and GPR30 in invasive ductal breast carcinomas显示文摘在瘤提供无价的信息考虑的胸的背景 Biomarkers 决定最佳的治疗的预后和帮助。我们检验了在癌症之间的可能的关联干细胞( CSC ) -Iike 标记( CD133 ,配对的盒子基因 2 蛋白质( PAX2 ),上皮的特定的抗原( ESA )),并且新膜雌激素受体(G蛋白质联合了受体 30 ( GPR30 ))在 74 侵略 ductal 胸癌在有一些的已知的 clinicopathological 参数,肿瘤复发,和表情的侵略 ductal 胸癌知道 biomarkers.Methods ,我们由 immunohistoche 调查了这些分子的标记的蛋白质表示我们学习了在这些 proteins.Results CD133 的表情之间的相互关系,一个通常认为的 CSC 标记,否定地断然与肿瘤与节点 metastasis.PAX2 是的肿瘤尺寸,肿瘤阶段,和淋巴有关被相关复发。ESA,胸 CSC 标记之一,是肿瘤的指示物复发。GPR30 与荷尔蒙受体被联系。尽管有在 GPR30 和原子雌激素受体之间的关联,表示是依赖的。在肿瘤的 GPR30 的积极染色为肿瘤复发与高 C-erbB2 表示和一个趋势显示了一个重要协会。在在侵略 ductal 胸癌检测 CD133, PAX2, ESA,和 GPR30 的表示的 GPR30 和 CD133 existed.Conclusion 之间的一种积极关系可能精确地具有在更多的帮助预言乳癌的好攻击的性质并且决定最佳的治疗。 | LIU Qun LI Ji-guang ZHENG Xin-yu JIN Feng DONG Hui-ting | 2009 | Chinese Medical Journal2009，，22： | 17 |
| 16 | Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma显示文摘AIM:To investigate the value of combined detection of circulating cell-free DNA(cfDNA),a-fetal protein(AFP) and a L-fucosidase(AFU) for diagnosis of hepatocellular carcinoma(HCC).METHODS:Serum samples from 39 HCC patients and 45 normal controls were collected.Branched DNA(bDNA) was used to detect the level of cfDNA,and a receiver operating characteristic curve was employed to evaluate the diagnostic sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio,negative likelihood ratio and Youden index,and to assess the diagnostic efficiency and their correlations with the clinicopathological features.AFP and AFU were detected by chemiluminescence and colorimetry,respectively.The significance of combined detection of the three biomarkers was discussed.RESULTS:cfDNA level was increased in 22 of the 39 HCC samples and in 2 of the 45 normal controls.cfDNA level in HCC samples was significantly higher than that in normal controls(P < 0.05).There were significant differences in sex and extra-and intrahepatic metastasis(P < 0.05).There was no significant correlation between cfDNA,AFP and AFU in the detection of HCC.The sensitivity of combined detection of cfDNA with one marker(AFP or AFU) and cfDNA with two markers(AFP and AFU) was 71.8%,87.2% and 89.7% vs 56.4%,53.8% and 66.7% for cfDNA,AFP and AFU used alone,respectively,the difference being statistically significant(P < 0.05).CONCLUSION:Quantitative analysis of cfDNA is sensitive and feasible,and the combined detection of cfDNA with AFP or AFU or both could improve the diagnostic sensitivity for HCC. | Ken Chen Hong Zhang Li-Na Zhang Shao-Qing Ju Jing Qi Dong-Feng Huang Feng Li Qun Wei Jing Zhang | 2013 | World Journal of Gastroenterology2013，19，20： | 16 |
| 17 | Control of Rice Embryo Development, Shoot Apical Meristem Maintenance, and Grain Yield by a Novel Cytochrome P450显示文摘被子植物种子通常由二主要部分组成:胚胎和内乳。然而,分子的机制 underlyingembryo 和内乳发展仍然保持大部分未知,特别地在米饭,模型谷物。这里,我们报导 identificationand 米饭巨人胚胎(GE ) 基因的功能的描述。GE 的变化在种子导致了一个大胚胎,它被胚鳞房间的过多的扩大引起。embryonic 以后 growthof ge 幼苗严重地由于有缺点的射击被禁止顶端的分裂组织(SAM ) 维护。基于地图的克隆表明 thatGE 编码对 endoplasmic 蜂窝胃局部性的 CYP78A 亚科 P450 monooxygenase。GE 在 scutellar 上皮主要被表示,在胚胎和内乳之间的接口区域。Overexpressionof GE 支持了细胞增长并且提高了米饭植物生长和谷物产量,但是减少了胚胎尺寸,建议 GE 为协调米饭胚胎和内乳开发是批评的。而且,转基因的 Arabidopsis 植物 overexpressing AtCYP78A10,一个 GE 相当或相同的事物,也生产的更大的种子,在一起调整种子 development.Taken 为 P450s 的 CYP78A 亚科暗示一个保存角色,我们的结果显示 GE 在调整胚胎发展和 SAM maintenance.Key 词起关键作用: | Weibing Yang Mingjun Gao Xin Yin Jiyun Liu Yonghan Xu Longjun Zeng Qun Li Shubiao Zhang Junmin Wang Xiaoming Zhang Zuhua He | 2013 | Molecular Plant2013，6，6： | 16 |
| 18 | Epidemic Update and Risk Assessment of 2019 Novel Coronavirus--China, January 28, 2020显示文摘On December 29,2019,the health authorities in Hubei Province and Wuhan City received a report of a cluster of pneumonia cases of unknown etiology from a local hospital,and all four patients were employees of the Wuhan Huanan Seafood Wholesale Market(HN market for short)(1).By January 8,2020,Chinese authorities had identified a new virus 2019 novel coronavirus(2019-nCoV)linked with the outbreak of disease,which has been named novel coronavirusinfected pneumonia(NCIP)(2).On 15 January,the National Health Commission(NHC)issued guidelines for the diagnosis,treatment,prevention,and control of NCIP.These guidelines directed case monitoring,reporting,diagnosis,treatment,management,close contact management,and laboratory testing. | Wenxiao Tu Houlin Tang Fangfang Chen Yinong Wei Tingling Xu Kaiju Liao Nijian Xiang Guoqing Shi Qun Li Zijian Feng | 2020 | China CDC weekly2020，2，6： | 15 |
| 19 | Evaluation of an extracellular matrix-derived acellular biphasic scaffold/cell construct in the repair of a large articular high-load-bearing osteochondral defect in a canine model显示文摘 | YANG Qiang PENG Jiang LU Shi-bi GUO Quan-yi ZHAO Bin ZHANG Li WANG Ai-yuan XU Weng-jing XIA Qun MA Xin-long HU Yong-cheng XU Bao-shan | 2011 | Chinese Medical Journal2011，，23： | 15 |
| 20 | Kinetics in Mg-based hydrogen storage materials:Enhancement and mechanism显示文摘Mg-based materials have been intensively studied for hydrogen storage applications due to their high energy density up to 2600 Wh/kg or 3700 Wh/L.However,the Mg-based materials with poor kinetics and the necessity for a high temperature to achieve 0.1 MPa hydrogen equilibrium pressure limit the applications in the onboard storage in Fuel cell vehicles(FCVs).Over the past decades,many methods have been applied to improve the hydriding/dehydriding(H/D)kinetics of Mg/MgH 2 by forming amorphous or nanosized particles,adding catalysts and employing external energy field,etc.However,which method is more effective and the intrinsic mechanism they work are widely differing versions.The hydrogenation and dehydrogenation behaviors of Mg-based alloys analyzing by kinetic models is an efficient way to reveal the H/D kinetic mechanism.However,some recently proposed models with physical meaning and simple analysis method are not known intimately by researchers.Therefore,this review focuses on the enhancement method of kinetics in Mg-based hydrogen storage materials and introduces the new kinetic models. | Qun Luo Jianding Li Bo Li Bin Liu Huaiyu Shao Qian Li | 2019 | Journal of Magnesium and Alloys2019，7，1： | 15 |
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