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| 1 | In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma显示文摘iASPP is an inhibitory member of the apoptosis-stimulating proteins of P53(ASPP) family. iASPP is over expressed in several malignant tumors and potentially affects cancer progression. However, the expression and potential role of iASPP in oral tongue squamous cell carcinoma(OTSCC) have not been addressed. In our study, we detected iASPP expression in OTSCC by immunohistochemistry. iASPP expression is up-regulated in OTSCC tissues. Moreover, in clinical pathology specimens, we found that increased iASPP expression correlates with poor differentiation and lymph node metastasis. Using multicellular tumor spheroids(MTS) and flow cytometry, we demonstrated that iASPP down-regulation arrests OTSCC cells at the G0/G1 phase, induces OTSCC cell apoptosis and inhibits OTSCC cell proliferation. These results indicate that iASPP plays a significant role in the progression of OTSCC and may serve as a biomarker or therapeutic target for OTSCC patients. | Yu Chen Wangxiang Yan Shuqi He Jiechun Chen Dan Chen Zhaoqiang Zhang Zhiguo Liu Xueqiang Ding Anxun Wang | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 2 | Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E–Deficient Mice显示文摘 | Kimio Satoh Patrizia Nigro Asad Zeidan Nwe Nwe Soe Fabrice Jaffré Masayoshi Oikawa Michael R. O?Dell Zhaoqiang Cui Prashanthi Menon Yan Lu Amy Mohan Chen Yan Burns C. Blaxall Bradford C. Berk | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，5： | 1 |
| 3 | Splitting Regularities of Thin Ferrofluid Layer Manipulated by Vertical Magnetic Field显示文摘The regular distribution of micro-droplets splitting from thin ferrofluid layer is systematic experimentally investigated, as the layer is placed in a vertical magnetic field. In this work, the field is applied in an instant manner and a slow manner, respectively; the field strength is linear increased. With instantly raising the field, it is observed that the ferrofluid layer is split into several regularly distributed micro-droplets, and that the number of micro-droplets is linear to the magnetic field strength and the thickness of the liquid layers. When the field is slowly increased, a liquid ring together with several micro-droplets appears from the ferrofluid layer splitting. A spatial drift of the micro-droplets is also observed in the process of increasing the magnetic field. Our results are useful for manipulating the splitting regularities of ferrofluid layers by magnetic field, which may be used in non-contact segmentation, and magnetically manipulated drug carriers for targeting the therapy, etc. | 陈芳 SUN Cheng LI Xuehui ZHOU Qianru YAN Zhaoqiang 李军 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 1 |
| 4 | Blocking macrophage migration inhibitory factor activity alleviates mouse acute otitis media in vivo显示文摘 | Jin Zhang Min Xu Qingyin Zheng Yan Zhang Weijun Ma Zhaoqiang Zhang | 2014 | Immunology Letters2014，，1： | 1 |
| 5 | Effect of intracranial hypertension on cerebral hemorrhage induced autonomic nerve imbalance显示文摘BACKGROUND: Cerebral hemorrhage can cause the imbalance of nerve function, whereas its mechanism and main impact factors are still not quite clear. OBJECTIVE: To explore the rules about the changes of intracranial pressure in brainstem hemorrhage and internal capsule hemorrhage, and analyze the role of intracranial hypertension in the changes of nerve function caused by cerebral hemorrhage. DESIGN: A self-controlled trial. SETTING: Department of Physiology, Tianjin Medical University. MATERIALS: Sixty-five healthy male Japanese white rabbits with long ears (1.5–1.8 kg) were supplied and fed by the Department of Animal Experiment of Tianjin Medical University. The RM6240B biological signal collecting and processing system was used. METHODS: The experiments were conducted in the Department of Physiology, Tianjin Medical University from August 2001 to May 2006. ① The rabbits were anesthetized, then fixed onto the brain stereotaxic apparatus, and afterwards fenestration on skull and intubation to lateral ventricle were performed.The dynamic changes of intracranial pressure were monitored continuously. Rabbits were infused with autologous arterial blood (0.3 mL) into midbrain corpora quadrigemina inferior colliculus to induce model of acute brainstem hemorrhage; models of internal capsule hemorrhage were established by infusing autologous arterial blood into internal capsule. ② The dynamic intracranial pressures under the above conditions were recorded continuously with the RM6240B biological signal collecting and processing system. ③ An animal model of persistent intracranial hypertension was established by infusion of physiologic saline into lateral ventricle. ④ The changes of the intensity of autonomic nerve discharge were analyzed, using the biological signal collecting and processing system before and after hemorrhage and under persistent intracranial hypertension. ⑤ Ten animal models of internal capsule hemorrhage and 10 of brainstem hemorrhage were selected respectively, then gross pathological samples were cut open, and the accuracy of hemorrhage models was affirmed. Histological sections in hemorrhage point and around this point were prepared for with hematoxylin and eosin staining, and the pathological changes were observed under light microscope. MAIN OUTCOME MEASURES: ① Changes of intracranial pressures before and after internal capsule hemorrhage and brainstem hemorrhage; ② Changes of the discharge intensity of cervical vagus nerve trunk in animal models of internal capsule hemorrhage, brainstem hemorrhage and persistent intracranial hypertension without hemorrhage; ③ Accuracy of location of internal capsule hemorrhage and brainstem hemorrhage confirmed by gross pathological samples and sections. RESULTS: Totally 65 rabbits were involved in the analysis of results. ① Dynamic state of intracranial pressure: Intracranial pressure increased obviously at 45 minutes after internal capsule hemorrhage and brainstem hemorrhage, the intracranial pressures were (1.31±0.30), (1.82±0.45) kPa, which were obviously higher than those before hemorrhage [(1.04±0.18), ( 1.05±0.19) kPa, P < 0.01]. ② Discharge of vagus nerve: Under intracranial hypertension, the discharge of cervical vagus nerve trunk was enhanced, and the discharge intensity of vagus nerve trunk was significantly different before and after persistent intracranial hypertension [(364.28±78.55), (1252.19±151.75) μV·s, P < 0.01]. The discharges of cervical vagus nerve trunk were significantly enhanced after internal capsule hemorrhage and brainstem hemorrhage (P < 0.01). ③ Validation of hemorrhage sites: The hemorrhage sites were internal capsule and brainstem on histopathological sections. CONCLUSION: Intracranial pressure may play an important role in the pathophysiological process of vagus nerve imbalance caused by cerebral hemorrhage. | Xuelong Jin Wenli Jing Fengxia Yan Zhaoqiang Zhang Fengjun Lǚ Shuiqing Jing Na Sun Kazushige Mizoguchi | 2007 | Neural Regeneration Research2007，2，3： | 0 |
| 6 | Effects of medium fluid cavitation on fluctuation characteristics of magnetic fluid seal interface in agricultural centrifugal pump显示文摘The fluctuation law of magnetic fluid seal interface of an agricultural centrifugal pump is theoretically unknown;the pressure and velocity fluctuations are crucial factors that cause interface fluctuation.In this study,the pressure and velocity fluctuations of the sealing interface on an agricultural centrifugal pump during cavitation were investigated based on the methods of Ansys CFX numerical calculation and experimental verification.The results demonstrated that at the same flow rate,the pressure fluctuation amplitude of the sealing interface decreased gradually from the shaft surface to the bottom of the polar tooth.At different flow rates,the amplitude of the pressure fluctuation decreased with an increase in the flow rate.The cavitation of the medium aggravated the impact and water hammer of the liquid,leading to the occurrence of the jitter phenomenon in the sealing interface to accelerate the fluctuation frequency of the axial velocity of the sealing liquid,which accelerated the emulsification of the magnetic fluid.This law can provide a reference for the design of magnetic fluid sealing devices for agricultural centrifugal pumps. | Zhenggui Li Wangxu Li Qifan Wang Ru Xiang Jie Cheng Wei Han Zhaoqiang Yan | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 0 |
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