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| 1 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | On solutions of matrix equation AXB+CVD=F显示文摘 | Xu G Wei M Zheng D | 1998 | Linear Algebra Appl1998，279，： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Perturbing Bezier coefficients for best constrained degree reduction in the L2-norm 显示文摘 | Zheng J M Wang G Z | 2003 | Graphical Models2003，65，6： | 1 |
| 6 | Relationshipsbetween tissue concentrations of polycyclic aromatic hydro-carbons and antioxidative responses of marine musselsPerna viridis显示文摘 | Cheung C C C Zheng G J Li A M Y | 2001 | Aquatic Toxicology2001，52，34： | 1 |
| 7 | The synergistic effect between erosion and corrosion in acidic slurry medium显示文摘 | ZHENG Y G YAO Z M WEI X Y | 1995 | Wear1995，，6： | 1 |
| 8 | Gas-assisted In- jection Molded Polypropylene: The Skin-core Structure 显示文摘 | Zheng G Q Yang W Yang M B | 2008 | Polymer Engineering and Science2008，48，5： | 1 |
| 9 | Localization of nitration and chlorination sites on apolipoprotein A-I catalyzed by myeloperoxidase in human atheroma and associated oxidative impairment in ABCA1-dependent cholesterol efflux from macrophages 显示文摘 | Zheng L Settle M Brubaker G | 2005 | J Biol Chem2005，280，1： | 1 |
| 10 | Study on high-temperature naphthenic acid corrosion and erosion-corrosion of aluminized carbon steel显示文摘 | Wu X Q Jing H M Zheng Y G | 2004 | Journal of Materials Science2004，39，3： | 1 |
| 11 | Novel Activity of a Phycobiliprotein Lyase: Both the Attachment of Phycocyanobilin and the Isomerization to PhycovioLobilin are Catalyzed by the Proteins PecE and PecF Encoded by the Phycoerythrocyanin Operon显示文摘 | Deng M G Zheng M | 2000 | FEBS Letters2000，469，1： | 1 |
| 12 | Localization of nitration and chlorination sites on apolipoptrotein AI catalyzed by myelopemxidase in human atheroma and assecaiated oxidative impairment in ABCAI-dependent cholesterol effux from macrophages显示文摘 | Bmbaker G | 2005 | J Biol Chem2005，280，： | 1 |
| 13 | CD4 + and CD8 + regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome显示文摘 | Zheng S G Wang J H Koss M N | 2004 | J Immunol2004，172，3： | 1 |
| 14 | Perturbing Bezier coefficients for best constrained degree reduction in the Lz-norm 显示文摘 | Zheng J M Wang G Z | 2003 | Graphical Models2003，65，6： | 1 |
| 15 | An acid-tolerant heterotrophic microorganism role in improving tannery sludge bioleaching conducted in successive multi-batch reaction systems显示文摘 | Zheng G Y Zhou L X Wang S M | 2009 | Environmental Science and Technology2009，43，11： | 1 |
| 16 | Direct catalytic conversion of cellulose into ethylene glycol using nickel-promoted tungsten carbide catalysts显示文摘 | JI N ZHANG T ZHENG M Y WANG A Q WANG H WANG X D CHENG J G | 2008 | Angew Chem2008，120，44： | 1 |
| 17 | Seasonal trends in PM25 source contributions in Beijing, China显示文摘 | Zheng M Salmon L G Schauer J J | 2005 | Atmospheric Environment2005，39，： | 1 |
| 18 | Experimental Investi- gation on Damping Behavior of Normal Joint Surfaces at U- nit Area显示文摘 | FU W P HUANG Y M ZHENG G P | 1993 | Modeling Measurement & Control B1993，51，5： | 1 |
| 19 | Preparation, characterization and electrochemical catalytic properties of hollandite Ag2MnsOl6 for Li-air batteries显示文摘 | ZHANG G Q HENDR1CKSON M PLICHTA E J AU M ZHENG J P | 2012 | Journal of Electrochemical Society2012，159，： | 1 |
| 20 | Ehd4 encodes a novel and Oryza-Genus-Specific regulator of photoperiodic flowering in rice显示文摘 | Gao H Zheng X M Fei G etal | 2013 | PLoS Genetics2013，9，10： | 1 |
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