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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | Arabidopsis onset of leaf death mutants identify a regulatory pathway controlling leaf senescence显示文摘 | Jing H C Sturre M J Hille J | 2002 | Plant J2002，32，1： | 1 |
| 3 | Isentropic cross-tropopause ozone transport in the Northern Hemisphere显示文摘 | Jing P Cunnold D M Wang H J | 2004 | Journal of the Atmospheric Sciences2004，61，： | 1 |
| 4 | Plant proteomics in the post-genomic era显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Acta Bot Sin2002，44，6： | 1 |
| 5 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 6 | Study on high-temperature naphthenic acid corrosion and erosion-corrosion of aluminized carbon steel显示文摘 | Wu X Q Jing H M Zheng Y G | 2004 | Journal of Materials Science2004，39，3： | 1 |
| 7 | A unified framework for image retrieval using keyword and visual features 显示文摘 | Jing F Li M J Zhang H J etal | 2005 | IEEE Transactions on Image Processing2005，14，7： | 1 |
| 8 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 9 | Correlation of chemical acute toxicity between the nematode and the rodent 显示文摘 | LI Y GAO S JING H M | 2013 | Toxicol Res2013，2，： | 1 |
| 10 | Random response of a single-degree-of-freedom vibro-impact system with clearance显示文摘 | Jing H S Young M | 1990 | Earthquake Engineering and Structural Dynamics1990，19，： | 1 |
| 11 | Resistance of Mo-bearing stainless steels and Mo-bearing stainless-steel coating to naphthenic acid corrosion and erosion-corrosion 显示文摘 | Wu X Q Jing H M Zheng Y G | 2004 | Corrosion Science2004，46，： | 1 |
| 12 | An image fusion method taking into account phenological analogies andh aze显示文摘 | Jing L H Cheng Q M | | 0，，06： | 1 |
| 13 | Cell-free DNA: Character- istics, Detection and its Applications in Myocardial Infarc- tion 显示文摘 | Jing R Cui M Wang H | 2013 | Curr Pharm Des2013，19，： | 1 |
| 14 | Antenna diversity in multiuser data networks显示文摘 | JING J BUEHRER R M TRANTER W H | 2004 | IEEE Transactions on Communications2004，52，3： | 1 |
| 15 | Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms显示文摘 | Kan B Wang M Jing H | 2005 | J Virol2005，79，11： | 1 |
| 16 | Comparison of Physicochemical and Antioxidant Properties of Egg-white Proteim and Fructose and Inulin Maillard Reaction Products显示文摘 | JING H YAP M WONG P Y | | 0，，： | 1 |
| 17 | Genome-Wide Identifi- cation of SNPs in MicroRNA Genes and the SNP Effects on MicroRNA Target Binding and Biogenesis显示文摘 | Jing G J Tong Y Zhang H M | 2012 | Human Muta- tion2012，33，： | 1 |
| 18 | Plant proteomies in the post-genomieera 显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Act a Bot Sin2002，44，6： | 1 |
| 19 | Asymptotic behavior of global solutions for a chemical reaction model显示文摘 | Jing C S Wang M X Xie C H | 1998 | Journal of Mathematical Analysis and Applications1998，20，2： | 1 |
| 20 | Hybrid molecular films of Gemini amphiphiles and Keggin - type polyoxometalates : effect of the spacer length on the electrochemical properties 显示文摘 | JING M ZHAI X D LIU M H | 2007 | Journal of Materials Chemistry2007，17，19： | 1 |
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