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| 1 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 2 | Epicardial adipose tissue: the accomplice implicated in the genesis and maintenance of atrial fibrillation显示文摘 | Fang Mingcheng Chen Yangxin Wang Jingfeng | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 3 | ADSORPTION DYNAMICS OF MACROPOROUS POLYMERIC ADSORBENT Ⅱ. The Studies on the Film Diffusion Mass-Transfer Process显示文摘The film diffusion mass-transfer process of adsorption of phenol on macroporous polystyrene resin was investigated in detail In order to revise the Boyd film diffusion kinetics equation, the out-surface structure of the macroporous resin and that of gel-type ion-exchange resin was compared and the new film diffusion equation was also suggested. These results showed that the film diffusion was influenced by porosity of the macroporous resin greatly, which differed from the film diffusion behavior of ion-exchange resin obviously. | WANG Chunhong, XU Mingcheng, SHI Zuoqing, FAN Yunge, FI Chengiie (Institute of Polymer Chemistry, Nankai University, Tianjin, 300071) | 2000 | Chinese Journal of Reactive Polymers2000，9，1： | 3 |
| 4 | ADSORPTION DYNAMICS OF MACROPOROUS POLYMERIC ADSORBENT I.The Studies on the Particle Diffusion Mass-Transfer Process显示文摘The adsorption dynamics for phenol in aqueous solution of the adsorbent based on polystyrene was studied. In order to distinguish with the Boyd quasi-homogeneous model of the inner structure of ion-exchanger, the particle diffusion model including surface diffusion model and pore diffusion model was suggested which is suitable to the macroporous adsorbent. The diffusiondetermination step of the adsorption process was established and the effective diffusion coefficient was also determined. The influence of surface diffusion and pore diffusion on the particle diffusion rate was investigated qualitatively. All of these were very important to improve the structure of the macroporous adsorbent in order to improve the mass-transfer rate. | WANG Chunhong ,XU Mingcheng, SHI Zuoqing, FAN Yunge ,JI Chengjie (Institute of Polymer Chemistry, Nankai University ,Tianjin, 300071) | 2000 | Chinese Journal of Reactive Polymers2000，9，1： | 2 |
| 5 | Preparation of ZrB_(2)-MoSi_(2) high oxygen resistant coating using nonequilibrium state powders by self-propagating high-temperature synthesis显示文摘To achieve high oxygen blocking structure of the ZrB_(2)-MoSi_(2) coating applied on carbon structural material,ZrB_(2)-MoSi_(2) coating was prepared by spark plasma sintering(SPS)method utilizing ZrB_(2)-MoSi_(2) composite powders synthesized by self-propagating high-temperature synthesis(SHS)technique as raw materials.The oxygen blocking mechanism of the ZrB_(2)-MoSi_(2) coatings at 1973 K was investigated.Compared with commercial powders,the coatings prepared by SHS powders exhibited superior density and inferior oxidation activity,which significantly heightened the structural oxygen blocking ability of the coatings in the active oxidation stage,thus characterizing higher oxidation protection efficiency.The rise of MoSi_(2) content facilitated the dispersion of transition metal oxide nanocrystals(5-20 nm)in the SiO_(2) glass layer and conduced to the increasing viscosity,thus strengthening the inerting impact of the compound glass layer in the inert oxidation stage.Nevertheless,the ZrB_(2)-40 vol% MoSi_(2) coating sample prepared by SHS powders presented the lowest oxygen permeability of 0.3% and carbon loss rate of 0.29×10^(6)g·cm^(-2)·s^(-1).Owing to the gradient oxygen partial pressure inside the coatings,the Si-depleted layer was developed under the compound glass layer,which brought about acute oxygen erosion. | Menglin ZHANG Xuanru REN Mingcheng ZHANG Songsong WANG Li WANG Qingqing YANG Hongao CHU Peizhong FENG | 2021 | Journal of Advanced Ceramics2021，10，5： | 2 |
| 6 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 7 | Asymmetry of Atmospheric Responses to Two-Type El Nino and La Nina over Northwest Pacific显示文摘The mechanism for asymmetric atmospheric responses to the central Pacific(CP) El Ni?o and La Ni?a over the western North Pacific(WNP) is studied in this paper. The negative anomalies of rainfall over the key region of WNP are explained by diagnosing the column-integrated equations of moisture and moist static energy(MSE). It is revealed that the nonlinear advection of moist enthalpy is critical to introduce negative rainfall anomalies over the region. The anomalous easterly(westerly) in La Ni?a(CP El Ni?o) causes negative advection of anomalous moist enthalpy, inducing negative heating anomaly and an anticyclone anomaly in the WNP, which weakens(strengthens) the cyclone(anticyclone) in La Ni?a(CP El Ni?o). The MSE budget analysis shows a larger nonlinear term in CP El Ni?o than in eastern Pacific(EP) El Ni?o, inconsistent with the amplitudes of sea surface temperature anomalies. The reason is that the nonlinear term transforms to positive above 700 h Pa in EP El Ni?o, offsetting the negative advection below 700 h Pa and thus making the nonlinear term smaller. The nonlinear term is negative at low levels in CP El Ni?o, resulting in a larger nonlinear term. The stronger precipitation anomalies in the WNP during EP El Ni?o can be attributed to the linear moist enthalpy advection. The mean easterly wind at mid levels causes a larger(smaller) positive moist enthalpy advection in CP(EP) El Ni?o, due to a larger(smaller) moist enthalpy gradient, resulting in a positive(negative) linear moist enthalpy advection, which weakens(strengthens) the negative precipitation anomalies in the key region. | Mingcheng CHEN Tim LI Xiaohui WANG | 2019 | Journal of Meteorological Research2019，33，5： | 1 |
| 8 | Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice显示文摘 | Qingyun Liu Chang Bai Fang Chen Ruiping Wang Terry MacDonald Mingcheng Gu Qing Zhang Manal A Morsy C.Thomas Caskey | 1998 | Gene1998，，1： | 1 |
| 9 | The modeling of workflow based on object oriented timed petri net显示文摘 | Sheng Mingcheng Wang Huifen etc | 2003 | MIE of China2003，32，6： | 1 |
| 10 | Business type, industry value chain,and Rg-D performance:Evidence from high-tech firms in an emerging market显示文摘 | WANG Hsiaowen WU Mingcheng | 2012 | Technological Forecasting and Social Change2012，79，32： | 1 |
| 11 | Enhancement of a{ternoon thunderstorm activity by urbanization in a rally: Taipei 显示文摘 | Chen Tsingchang Wang Shiyu Yen Mingcheng | 2007 | Journal of Applied Meteorology and Climatology2007，46，： | 1 |
| 12 | Confinement Leads to Spatially Oscillatory Collective Motion of Chiral Active Matter显示文摘Active matter consisting of self-propelling units,e.g.bacterial solutions and self-driven colloids,is an important class of soft matter systems.Due to its inherent out-of-equilibrium nature,active matter often exliibits exotic behaviors and has potential applications in microdevices and smart materials. | WANG Mingcheng | 2020 | Bulletin of the Chinese Academy of Sciences2020，34，2： | 0 |
| 13 | Highly transparent and super-wettable nanocoatings hybridized with isocyanate-silane modified surfactant for multifunctional applications显示文摘Highly transparent and super-wettable nanocoatings for multifunctional applications with outstanding physical properties are in high demanded.However,such nanocoatings resistant to water invasion and Ultraviolet(UV)weathering remain a significant challenge.In this work,physically durable coatings based on inorganic nanoparticles(NPs)and an organic segment(isocyanate-silane modified surfactant)have been synthesized via a sol-gel approach.It is noteworthy the isocyanate-silane with-NH-C=O-functional group creates a strong bonding between the highly hydrophilic surfactant and the inorganic NPs.This in-house synthesized organic segment can render the coating long-lasting wetting properties and resist to be washed away by water,while the inorganic NPs can form sturdy covalent bonds with the nano-scale hierarchical structure on the glazing substrate to improve the durability.This nanocoating demonstrates high transparency with superwetting property(water contact angle,WCA=4.4±0.3°),effective de-frosting performance.Water invasion or UV accelerated weathering tests do not significantly affect the self-cleaning performance of nanocoating.Physical properties,including coating adhesion,hardness,Young's modulus,and abrasion resistance are systematically investigated.Interestingly,this clear coating shows prominent infrared shielding property attributed to Antimony-doped tin oxide(Sb-doped SnO_(2))NPs.The developed nanocoating process is easy to scale up for larger areas that require multipurpose self-cleaning functions. | Man Kwan Law Ying Zhao Weibin Zhang Rui Wang Mingcheng Shi Yunxiao Zhang Shusheng Chen Jinglei Yang | 2022 | Nano Materials Science2022，4，2： | 0 |
| 14 | Using CloudSat observations to evaluate cloud top heights from convection parameterization显示文摘How high convective clouds can go is of great importance to climate. Cloud ice and liquid water that detrain near the top of convective cores are important for the formation of anvil clouds and thus impact cloud radiative forcing and the Earth’s radiation budget. This study uses CloudSat observations to evaluate convective cloud top heights in the National Center for Atmospheric Research (NCAR) Community Atmosphere Model (CAM5). Results show that convective cloud top heights in the tropics are much lower than observed by CloudSat, by more than 2 km on average. Temperature and moisture anomalies from climatological means are composited for convective clouds of different heights for both observations and model simulation. It is found that convective environment is warmer and moister, and the anomalies are larger for clouds of higher tops. For a given convective cloud top height, the corresponding atmosphere in CAM5 is more convectively unstable than what the CloudSat observations indicate, suggesting that there is too much entrainment into convective clouds in the model. | Guang Jun Zhang Mingcheng Wang | 2017 | Satellite Oceanography and Meteorology2017，2，2： | 0 |
| 15 | Compression induced crystal-to-glass transition in soft colloidal solids显示文摘Using colloidal particles with different thermosensitivities,we observe the transition from a crystalline solid to a dis-ordered glass by tuning the size mismatch of the constituent particles in quasi-two-dimensional configurations.The transition is clearly identifiable by the correlation functions of the orientational order parameters and its susceptibilities.Different from typical order-to-disorder transitions such as melting,where the underlying mechanism involves the diffusion of defects,the disordered phase in the crystal-to-glass transition grows via a nucleation process.The disordered clusters grow in size as the particle mismatch increases,and eventually percolate the whole system,which signifies the qualitative change from an ordered crystal to a disordered glass. | Li Chen Xiunan Yang Mingcheng Yang Chenhong Wang Ke Chen | 2023 | National Science Open2023，2，3： | 0 |
| 16 | Valence electronic engineering of superhydrophilic Dy-evoked Ni-MOF outperforming RuO_(2) for highly efficient electrocatalytic oxygen evolution显示文摘Tackling the problem of poor conductivity and catalytic stability of pristine metal-organic frameworks(MOFs) is crucial to improve their oxygen evolution reaction(OER) performance.Herein,we introduce a novel strategy of dysprosium(Dy) doping,using the unique 4f orbitals of this rare earth element to enhance electrocatalytic activity of MOFs.Our method involves constructing Dy-doped Ni-MOF(Dy@Ni-MOF) nanoneedles on carbon cloth via a Dy-induced valence electronic perturbation approach.Experiments and density functional theory(DFT) calculations reveal that Dy doping can effectively modify the electronic structure of the Ni active centers and foster a strong electronic interaction between Ni and Dy.The resulting benefits include a reduced work function and a closer proximity of the d-band center to the Fermi level,which is conducive to improving electrical conductivity and promoting the adsorption of oxygen-containing intermediates.Furthermore,the Dy@Ni-MOF achieves superhydrophilicity,ensuring effective electrolyte contact and thus accelerating reaction kinetics,Ex-situ and in-situ analysis results manifest Dy_(2)O_(3)/NiOOH as the actual active species.Therefore,Dy@Ni-MOF shows impressive OER performance,significantly surpassing Ni-MOF.Besides,the overall water splitting device with Dy@NiMOF as an anode delivers a low cell voltage of 1.51 V at 10 mA cm^(-2) and demonstrates long-term stability for 100 h,positioning it as a promising substitute for precious metal catalysts. | Zhiyang Huang Miao Liao Shifan Zhang Lixia Wang Mingcheng Gao Zuyang Luo Tayirjan Taylor Isimjan Bao Wang Xiulin Yang | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 17 | Screening and Assessing 11 Mycobacterium tuberculosis Proteins as Potential Serodiagnostical Markers for Discriminating TB Patients from BCG Vaccinees显示文摘Purified protein derivative (PPD) skin tests often yield poor specificity, so that to develop new serological antigens for distinguishing between Mycobacterium tuberculosis infection and Bacille Calmette-Guerin (BCG) vaccination is a priority, especially for developing countries like China. We predicted the antigenicity for selected open reading frames (ORFs) based on the genome sequences of M. tuberculosis H37Rv and M. bovis BCG, as well as their functions and differences of expression under different stimulus. The candidate ORFs were cloned from H37Rv sequences and expressed as recombinant proteins in Escherichia coli. We studied the serodiagnostic potential of 11 purified recombinants by using enzyme-linked immunosorbent assay (ELISA) and involving a cohort composed of 58 TB patients (34 males and 24 females), 8 healthy volunteers and 50 PPD-negative individuals before and after BCG vaccination. For all the 11 antigens, the median OD values for the sera from TB patients were statistically significantly higher than those for PPD-negative individuals before or after BCG vaccination (P<0.01). They had at least 92% specificity in healthy controls and six seroantigens (Rv0251c, Rv1973, Rv2376c, Rv2537c, Rv2785c and Rv3873A) were never reported with seroantigenicities previously. Thus the approach combining comparative genomics, bioinformatics and ELISA techniques can be employed to identify new seroantigens distinguishing M. tuberculosis infection from BCG vaccination. | Guoqiang Zhang Lingxia Zhang Mingcheng Zhang Linlin Pan Fengyu Wang Jun Huang Guoli Li Jun Yu Songnian Hu | 2009 | Genomics, Proteomics & Bioinformatics2009，7，3： | 0 |
| 18 | Crystal phase engineering of electrocatalysts for energy conversions显示文摘Crystal phase is an intrinsic structural parameter to determine the physicochemical properties and functionalities of materials.The unconventional phases of materials with distinct atomic arrangements from their thermodynamically stable phases have attracted enormous attention.Phase engineering has recently made fruitful achievements in electrocatalysis field to optimize the performance of various electrochemical reactions.In this review,theoretical and experimental advances made in phase engineering of electrocatalysts are summarized.First,we introduce basic understanding on crystal phases of catalysts to show the dialectical relationship between bulk phase and surface catalytic layer,and highlight the multiple functions of phase engineering in catalysis studies.We then describe phase-controlled synthesis of materials through various experimental methods such as wet-chemical method,phase transition,and template growth.As a focus,we discuss the wide usage of phase engineering strategy in different kinds of electrocatalytic materials,and particular emphasis is given to establishment of reasonable crystal phase-activity relationship.Finally,we propose several future directions for developing more desirable electrocatalysts by rational crystal phase design. | Hui Chen Mingcheng Zhang Yanfei Wang Ke Sun Lina Wang Zhoubing Xie Yucheng Shen Xindi Han Lan Yang Xiaoxin Zou | 2022 | Nano Research2022，15，12： | 0 |
| 19 | Novel pipe-roof method for a super shallow buried and large-span metro underground station显示文摘To address the inadequacies of traditional pipe-roof methods,the steel support cutting pipe method(SSCP)—a novel pipe-roof method that improves construction security and underground space usage—is proposed.To further explore the applications of SSCP,its design scheme ought to be optimized.The failure mode and mechanical behaviors of the SSCP were investigated through laboratory experiments.Subsequently,a series of finite element models(FEMs)was established to study the deformation characteristics.Further,the parameters of the steel support of the proposed structure were optimized using fuzzy mathematics.The results indicated the ultimate bearing capacity to be 366.8 kN,and the specimen began to yield when the external load reached 70%of the ultimate value.The lon-gitudinal spacing of the steel supports,transverse steel support size,and vertical steel support size had significant effect on the vertical deformation of the steel support and the ground settlement.Finally,the optimal combination of steel supports for the SSCP structure was obtained. | Bo Lu Jiachao Dong Wen Zhao Xi Du Cheng Cheng Qian Bai Zhiguo Wang Mingcheng Zhao Jianyong Han | 2022 | Underground Space2022，7，1： | 0 |
| 20 | Histopathological Analysis of Liver During Pregnancy Toxemia in Small-tailed Han Sheep显示文摘The present work aimed to investigate the microscopic and ultramicroscopic structure of the liver to assess the level of hepatic impairment during pregnancy toxemia. Seven pregnant small-tailed Han sheep of negative urine ketone bodies were assessed in this study. Toxemia was induced by limiting food and movement late in pregnancy. Three sheep developed obvious clinical symptoms with motor weakness, depression, anorexia, locomotion disturbances, blindness and languishment. We harvested their liver tissues as pathological material, and used routine histological and electronic microscopy methods to observe the histopathological changes in small-tailed Han sheep induced by pregnancy toxemia. Autopsy of the livers of the sheep revealed deep yellow coloration, intumescence and hemorrhage on the surface. Microstructural features indicated fatty degeneration, which is a main characteristic of fatty liver. Hepatocellular ultrastructural changes were observed under an electronic microscope. The characteristic findings were nucleolus concentration, vacuolation of mitochondria and excessive glycogen granules in the cytoplasm. Via this experimental protocol, pregnancy toxemia of sheep was successfully induced, providing a pathological model for the study of this disease. After the experimental induction of pregnancy toxemia, the clinical symptoms of pathogenic sheep and pathological changes to their livers exhibited obvious characteristics of pregnancy toxemia. | Mingcheng WANG Enzhong LI Gailing WANG | 2014 | Agricultural Science & Technology2014，15，3： | 0 |
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