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| 1 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 2 | An analytical symplectic approach to the vibration analysis of orthotropic graphene sheets显示文摘A nonlocal continuum orthotropic plate model is proposed to study the vibration behavior of single-layer graphene sheets(SLGSs) using an analytical symplectic approach. A Hamiltonian system is established by introducing a total unknown vector consisting of the displacement amplitude, rotation angle, shear force, and bending moment.The high-order governing differential equation of the vibration of SLGSs is transformed into a set of ordinary differential equations in symplectic space. Exact solutions for free vibration are obtianed by the method of separation of variables without any trial shape functions and can be expanded in series of symplectic eigenfunctions. Analytical frequency equations are derived for all six possible boundary conditions. Vibration modes are expressed in terms of the symplectic eigenfunctions. In the numerical examples, comparison is presented to verify the accuracy of the proposed method. Comprehensive numerical examples for graphene sheets with Levy-type boundary conditions are given. A parametric study of the natural frequency is also included. | Xinsheng Xu Dalun Rong C.W.Lim Changyu Yang Zhenhuan Zhou | 2017 | Acta Mechanica Sinica2017，33，5： | 4 |
| 3 | A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance显示文摘When facing a sudden danger or aversive condition while engaged in on-going forward motion,animals transiently slow down and make a turn to escape.The neural mechanisms underlying stimulation-induced deceleration in avoidance behavior are largely unknown.Here, we report that in Drosophila larvae, light-induced deceleration was commanded by a continuous neural pathway that included prothoracicotropic hormone neurons, eclosion hormone neurons, and tyrosine decarboxylase 2 motor neurons(the PET pathway). Inhibiting neurons in the PET pathway led to defects in lightavoidance due to insufficient deceleration and head casting.On the other hand, activation of PET pathway neurons specifically caused immediate deceleration in larval locomotion. Our findings reveal a neural substrate for the emergent deceleration response and provide a new understanding of the relationship between behavioral modules in animal avoidance responses. | Caixia Gong Zhenhuan Ouyang Weiqiao Zhao Jie Wang Kun Li Peipei Zhou Ting Zhao Nenggan Zheng Zhefeng Gong | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 4 | Development of a widely targeted volatilomics method for profiling volatilomes in plants显示文摘Volatile organic compounds play essential roles in plant environment interactions as well as determining the fragrance of plants.Although gas chromatography-mass spectrometry-based untargeted metabolo-mics is commonly used to assess plant volatiles,it suffers from high spectral convolution,low detection sensitivity,a limited number of annotated metabolites,and relatively poor reproducibility.Here,we report a widely targeted volatilomics(WTV)method that involves using a“targeted spectra extraction”algorithm to address spectral convolution,constructing a high-coverage MS2 spectral tag library to expand volatile annotation,adapting a multiple reaction monitoring mode to improve sensitivity,and using regression models to adjust for signal drift.The newly developed method was used to profile the volatilome of rice grains.Compared with the untargeted method,the newly developed WTV method shows higher sensitivity(for example,the signal-to-noise ratio of guaicol increased from 4.1 to 18.8),high annotation coverage(the number of annotated volatiles increased from 43 to 132),and better reproducibility(the number of volatiles in quality control samples with relative standard deviation value below 30.0%increased from 14 to 92 after normalization).Using the WTV method,we studied the metabolic responses of tomato to environmental stimuli and profiled the volatilomes of different rice accessions.The results identified benzothiazole as a potential airborne signal priming tomato plants for enhanced defense and 2-nonanone and 2-heptanone as novel aromatic compounds contributing to rice fragrance.These case studies suggest that the widely targeted volatilomics method is more efficient than those currently used and may considerably promote plant volatilomics studies. | Honglun Yuan Guangping Cao Xiaodong Hou Menglan Huang Pengmeng Du Tingting Tan Youjin Zhang Haihong Zhou Xianqing Liu Ling Liu Yiding Jiangfang Yufei Li Zhenhuan Liu Chuanying Fang Liqing Zhao Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，1： | 2 |
| 5 | Novel Bronstedacidic ionic liquids for esterifications 显示文摘 | Xing Huabing Wang Tao Zhou Zhenhuan | 2005 | Industrial & Engineering Chemistry Research2005，44，： | 1 |
| 6 | scNanoATAC-seq:a long-read single-cell ATAC sequencing method to detect chromatin accessibility and genetic variants simultaneously within an individual cell显示文摘Dear Editor,The accessible chromatin regions were enriched in regulatory elements in human genome and many genetic variations associated with human diseases were identified within them.1 Single-cell assay for transposase-accessible chromatin using sequencing(scATAC-seq)on the next-generation sequencing(NGS)platform is a well-established method to detect open chromatin regions within an individual cell.2 However,there remain challenges in detection of large-scale structural variations(SVs,including insertions,deletions,duplications,inversions and translocations)and haplotype phasing from scATAC-seq data,which can be well resolved by third-generation sequencing(TGS)platform-based single-molecule long-read sequencing.To integrate advantages of long-read sequencing into scATAC-seq,we developed single-cell assay for transposase‐accessible chromatin on Nanopore sequencing platform(scNanoATAC-seq),a platebased scATAC-seq method suitable for TGS platform(Supplementary information,Fig.S1). | Yuqiong Hu Zhenhuan Jiang Kexuan Chen Zhangxian Zhou Xin Zhou Yan Wang Jingwei Yang Bo Zhang Lu Wen Fuchou Tang | 2023 | Cell Research2023，33，1： | 1 |
| 7 | The sufonic acid-functionalized ionic liquids with pyridinium cation:acidities and their acidity-catalytic activity rationships 显示文摘 | Xing Huabin Wang Tao Zhou Zhenhuan | 2007 | Journal of Molecular Catalysis A: chemical2007，264，12： | 1 |
| 8 | Novel bronsted-acidic ionic liquids for esterifications显示文摘 | XING Huabing WANG Tao ZHOU Zhenhuan | 2005 | Ind Eng Chem Res2005，44，11： | 1 |
| 9 | The sulfonic acid-functionalized ionic liquids with pyridinium cations:Acidities and their acid- ity-catalytic activity relationships显示文摘 | Xing Huabin Wang Tao Zhou Zhenhuan | 2007 | Journal of Molecular Catalysis A : Chemical2007，264，12： | 1 |
| 10 | Using benzene carboxylic acids to prepare zirconium-based catalysts for the conversion of biomass-derived furfural显示文摘Benzene carboxylic acid (BCAs) are common and useful chemical blocks, which can be derived from the abundant low rank coals (LRCs) via oxidative degradation. In this work, we proposed a novel strategy to utilize BCAs as raw materials to prepare catalysts with transition metal zirconium, and the prepared catalysts were applied into the conversion of the renewable biomass resources. Typical model BCAs in the oxidative products of LRCs, including pyromellitic acid, trimesic acid (TMSA), trimellitic acid, and benzoic acid, were used as the block to construct the Zr- BCAs catalysts. The chemoselective conversion of furfural into furfuryl alcohol (FAL). an important reaction in the biomass conversion chain, is chosen to evaluate the activity of the catalysts. The preparation conditions of the catalysts and experiment factors during the reaction were systematically investigated. The prepared catalysts were characterized by SEM, TEM, XRD and TG-DTG. The results showed that the prepared catalysts were efficient for the conversion of furfural into FAL, among which Zr-TMSA gave the highest activity. Zr-TMSA could be recycled for ten times without obvious deactivation, indicating an excellent stability. The strategy proposed in this work may be beneficial for the value-added utilization of both LRCs and biomass resources. | Huacong Zhou Yufei Sha Zhenhuan Xiao Lu Li Jianmin Hao Keli Yang Na Li Runxia He Quansheng Liu | 2018 | International Journal of Coal Science & Technology2018，5，4： | 1 |
| 11 | Analytic stress intensity factors for finite elastic disk using symplectic expansion显示文摘 | A.Y.T. Leung Xinsheng Xu Zhenhuan Zhou Y.F. Wu | 2009 | Engineering Fracture Mechanics2009，，12： | 1 |
| 12 | Modeling of C_(8) Aromatics Isomerization in a Radial Bed Reactor显示文摘Reactor models were developed to describe the isomerization reaction process of C_(8) aromatics by applying a six-component sequential reaction network.Lab-scale experimental data were used in an axial bed reactor model,and dynamic parameters were fitted by simulated annealing algorithm.In addition,industrial data and calculated dynamic parameters were used to determine the six-component concentration distributions using a radial reactor model.The influence of back-mixing on reaction performance was investigated.It was found that the model considering back-mixing was much closer to the real industrial reaction process. | Gao Ninghan Tang Xiaojin Zhou Zhenhuan Xu Jian | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 13 | Fracture analysis of magnetoelectroelastic bimaterials with imperfect interfaces by symplectic expansion显示文摘A Hamiltonian-based analytical method is used to study the mode Ⅲ interface cracks in magnetoelectroelastic bimaterials with an imperfect interface. By introducing an unknown vector, the governing equations are reformulated in sets of first-order ordinary differential equations. Using separation of variables, eigensolutions in the symplectic space are obtained. An exact solution of the unknown vector is obtained and expressed in terms of symplectic eigensolutions. Singularities of mechanical, electric, and magnetic fields are evaluated with the generalized intensity factors. Comparisons are made to verify accuracy and stability of the proposed method. Numerical examples including mixed boundary conditions are given. | Xinsheng XU Zhenzhen TONG Dalun RONG Xianhe CHENG Chenghui XU Zhenhuan ZHOU | 2017 | Applied Mathematics and Mechanics(English Edition)2017，38，8： | 0 |
| 14 | Single-cell RNA sequencing-based immunological feature analysis of a COVID-19 patient with recurrent positive SARS-CoV-2 RNA显示文摘To the Editor:Since the outbreak in December 2019,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected>2.4 billion people worldwide,resulting in>4.9 million deaths.To understand the pathogenesis of SARS-CoV-2 infection,single-cell RNA-sequencing(scRNA-seq)profiles of peripheral blood mononuclear cells(PBMCs)have been constructed in coronavirus disease-2019(COVID-19)patients at different disease stages. | Bin Su Ruya Sun Lili Zhang Jiaying Zhang Xia Feng Zhenhuan Cao Wei Hou Xianghua Guo Qing Ge Qinghua Cui Yuan Zhou Yingmin Ma Ronghua Jin Yingmei Feng | 2022 | Chinese Medical Journal2022，，8： | 0 |
| 15 | Hardware-in the-loop Simulator for ABS based on MATLAB/Simulink显示文摘A method for building a Hardware-in the-loop Simulator of ABS base on MATLAB/Simulink is presented in this paper. In this method, the vehicle transmission model, the AT model and ABS algorithm is built in Simulink. This system can simulate a vehicle system in the Simulink environment. Further more, the Hardware-in the-loop Simulator system can be connected with the real ABS by I/O boards to observe the algorithm is reasonable or not. At the same time, user can simulate some different conditions by changing the parameter. The system help the user heightening the efficiency when developing the electronic device. Also, the system can be used as teaching demo software. | Pan,Wei Gao,Jinghui Zhou,Yafu Song,Zhenhuan | 2003 | 微计算机信息2003，19，12： | 0 |
| 16 | Inverse Load Identification in Stiffened Plate Structure Based on in situ Strain Measurement显示文摘For practical engineering structures,it is usually difficult to measure external load distribution in a direct manner,which makes inverse load identification important.Specifically,load identification is a typical inverse problem,for which the models(e.g.,response matrix)are often ill-posed,resulting in degraded accuracy and impaired noise immunity of load identification.This study aims at identifying external loads in a stiffened plate structure,through comparing the effectiveness of different methods for parameter selection in regulation problems,including the Generalized Cross Validation(GCV)method,the Ordinary Cross Validation method and the truncated singular value decomposition method.With demonstrated high accuracy,the GCV method is used to identify concentrated loads in three different directions(e.g.,vertical,lateral and longitudinal)exerted on a stiffened plate.The results show that the GCV method is able to effectively identify multi-source static loads,with relative errors less than 5%.Moreover,under the situation of swept frequency excitation,when the excitation frequency is near the natural frequency of the structure,the GCV method can achieve much higher accuracy compared with direct inversion.At other excitation frequencies,the average recognition error of the GCV method load identification less than 10%. | Yihua Wang Zhenhuan Zhou Hao Xu Shuai Li Zhanjun Wu | 2021 | Structural Durability & Health Monitoring2021，15，2： | 0 |
| 17 | An Optimal Design of the Two-Staged Square Sectional Combined Energy Absorption Structure with Local Surface Nanocrystallization显示文摘In this paper,a local surface nanocrystallization technology is used for thin-walled structures with square cross sections,and an energy absorption device of two-staged combined energy absorption structure is proposed.In virtue of the surface nanocrystallization that enables to change the material on local positions,the structural deformation is induced and controlled to maximize the energy absorption capacity.A numerical model of the two-staged combined energy absorption structure is established,and the local surface nanocrystallization layout is optimized.The results show that the specific energy absorption of two-staged combined structure with local surface nanocrystallization can be increased by 34.36%compared with the untreated counterpart of the same material and structural shape.The ratio between the first and second peak crushing forces and the energy absorption allocation ratio between the two stages can be adjusted in the ranges of 0.26–0.55 and 0.31–0.45,respectively,which can be controlled by the local surface nanocrystallization designs.The numerical simulation and experimental results are in good agreement,which shows that the design for energy absorption device with local surface nanocrystallization is feasible and effective. | Xinsheng Xu Jianlong Qu Tong Li Zhenzhen Tong Zhen Zhao Zhenhuan Zhou | 2021 | Acta Mechanica Solida Sinica2021，34，6： | 0 |
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