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| 1 | Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress显示文摘Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H 2 O 2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H 2 O 2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. | Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao | 2014 | Neural Regeneration Research2014，9，3： | 17 |
| 2 | Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats显示文摘Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. | Zheng Gong Lijuan Yang Hongmei Tang Rui Pan Sai Xie Luyan Guo Junbin Wang Qinyin Deng Guoyin Xiong Yanyan Xing Jun Dong | 2012 | Neural Regeneration Research2012，7，3： | 5 |
| 3 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 4 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | An Improved Polar Codes-Based Key Reconciliation for Practical Quantum Key Distribution显示文摘Key reconciliation is important for practical Quantum key distribution(QKD) systems since it corrects the error bits in a key string by sacrificing some key bits. Therefore, its performance directly affects the secret key rate of a practical QKD system. Although key reconciliation scheme based on polar codes can achieve a high coding efficiency, the high frame error rate causes discarding key strings and decreases the secret key rate. In this paper, we fist analyze the limitation of successive cancellation decoding of polar codes, and then we propose an improved key reconciliation scheme using polar codes with successive cancellation list decoding and optimized coding structures, which can decrease the frame error probability, resulting in a higher secret key rate. Numerical results show that the proposed scheme can achieve a 12.8% higher secret key rate than the previous polar codes-based scheme with a code length of 216 bits and a quantum bit error rate of 2%. Besides, the proposed scheme is robust and it can extract secret key bits even when the quantum bit error rate reaches 10.2% with a code length of 2^(20) bits and a coding efficiency of 90.6%. | YAN Shiling WANG Jindong FANG Junbin JIANG Lin WANG Xuan | 2018 | Chinese Journal of Electronics2018，27，2： | 2 |
| 6 | Influence of synthesis temperatures on the crystalline grain growth and morphology of lanthanum magnesium hexaaluminate显示文摘Lanthanum magnesium hexaaluminate(LaMgAl_(11)O_(19), LMA) was prepared at different temperatures by solid-state reaction. Phase compositions and crystal morphologies of specimens synthesized at different temperatures were investigated using X-ray diffraction(XRD), scanning electron microscopy(SEM). It was observed that the crystalline grain size of LMA was not only dependent on the preparation temperature but also on its powder morphology. In the temperature range of 1300 e1550℃, LMA showed platelet grain and the average crystalline grain size increases with the increase in temperature. At1600℃, if the powder was sintered for two times, the equiaxed grain could be found with the decrease in grain space, resulting in the reduction of the crystalline grain size. Styles of specimens(powder or disk) might have no obvious influence on morphologies and sizes of LMA crystalline grains which were synthesized with the well-dispersed raw material mixtures. The synthesis temperature played a key role in influencing the free space for the formation and growth of crystalline grains. | Junbin Sun Jinshuang Wang Wenzhi Huang Yu Hui Xin Zhou Lifen Li Jianing Jiang Longhui Deng Yunya Niu Shujuan Dong Xueqiang Cao | 2017 | Journal of Rare Earths2017，35，12： | 2 |
| 7 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 8 | Research of the planar optical fiber Bragg grating hydrophone probe显示文摘这篇论文论述平面纤维布拉格栅栏(FBG ) 水中听音器探查察觉到原则,并且理论上并且试验性地研究探查结构敏感,收到的敏感频率反应特征和加速反应性质。平面表用不锈钢做的,它的厚度是 0.15 公羊,它的直径是空圆形的壳的 15mm,和长度是 20 公羊。为结构的这种尺寸,探查结构敏感直到 23 fm/Pa,它是大约 7300 次赤裸的纤维的价值。回声频率是 6.5 kHz,和反应是的收到的敏感的振幅频率曲线相对在到 5.5 kHz 的 100 Hz 的频率范围以内的命令。一单位加速(1 m/s2 ) 产出的产量等价于(2.52 ~ 3.26 Pa ) 声学的压力代理输出。这探查结构是容易的由 multiplexing technique.The 研究表演形成 FBG 水中听音器数组这平面结构能不仅形成 FBG 水中听音器探查,而且能组成光 FBG 激光水中听音器探查。结构能认识到不同带宽,不同范围由调整表的几何尺寸的声学的压力测量。 | WANG Junjie JIANG Desheng XIE Guanmo: LIANG Yufei HUANG Junbin | 2008 | Chinese Journal of Acoustics2008，27，1： | 1 |
| 9 | Fast Bezier interpolator with realtime lookahead function for high-accuracy machining显示文摘 | Yau Hongtzong Wang Junbin | 2007 | International Journal of Machine Tools & Manufacture2007，47，10： | 1 |
| 10 | Mass customization: apparel supply chain optimization 显示文摘 | MENG Zimin WANG Yiqiao LIU Junbin | 2012 | China Marketing2012，，3： | 1 |
| 11 | Study of the planar optical fiber Bragg grating hydrophone probe with acceleration compensation显示文摘自从一个平面光 FBG 水中听音器的探查加速反应,是很明显的并且在正常上有不利影响在水下声学的压力察觉,采用一项加速赔偿措施的一个加速不敏感性方法这里被介绍。结果显示由利用这个方法,相等的压力产量适用由当结构的敏感从 28 fm/Pa 减少到 20 fm/Pa 时,然而,回声频率从 6.2 kHz 稍微增加到 6.5 kHz。改进动态频率特征的增加的回声频率帮助,并且当结构的敏感被减少时,它能被补偿由改进光 FBG 动态波长讯问敏感。光 FBG 水中听音器的系统敏感被它的波长讯问敏感和并非探查结构敏感主要决定。因此,加速赔偿方法将有宽广实际应用。 | WANG Junjie DING Tengjiao JIANG Desheng XIE Guanmo HUANG Junbin | 2011 | Chinese Journal of Acoustics2011，30，2： | 1 |
| 12 | Real-time NURBS interpolator :application to short linear segments显示文摘 | WANG Junbin YAU H T | 2009 | The International Journal of Advanced Manufacturing Technology2009，41，1112： | 1 |
| 13 | Real-time NURBS Inter- polator:Application to Short Linear Segments显示文摘 | Wang Junbin Yau H T | 2009 | International Journal Advanced Manufacturing Technology2009，41，： | 1 |
| 14 | Fast Bezier Interpolator with Real-time Look-ahead Function for High-ac- curacy Machining显示文摘 | Yau H T Wang Junbin | 2007 | International Journal of Ma- chine Tools Manufacture2007，47，1： | 1 |
| 15 | Real-time NURBS interpola tor: application to short linear segments显示文摘 | Wang Junbin Yau H T | 2009 | The In ternational Journal of Advanced Manufacturing Tech nology2009，41，1112： | 1 |
| 16 | Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats显示文摘Excessive theta(θ)frequency oscillation and synchronization in the basal ganglia(BG)has been reported in elderly parkinsonian patients and animal models of levodopa(L-dopa)-induced dyskinesia(LID),particularly theθoscillation recorded during periods when L-dopa is withdrawn(the off L-dopa state).To gain insight into processes underlying this activity,we explored the relationship between primary motor cortex(M1)oscillatory activity and BG output in LID.We recorded local field potentials in the substantia nigra pars reticulata(SNr)and M1 of awake,inattentive resting rats before and after L-dopa priming in Sham control,Parkinson disease model,and LID model groups.We found that chronic L-dopa increasedθsynchronization and information flow between the SNr and M1 in off L-dopa state LID rats,with a SNr-to-M1 flow directionality.Compared with the on state,θoscillational activity(θsynchronization and informationflow)during the off state were more closely associated with abnormal involuntary movements.Our findings indicate thatθoscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1θoscillation may participate in the induction of dyskinesia. | Jiazhi Chen Qiang Wang Nanxiang Li Shujie Huang Min Li Junbin Cai Yuzheng Wang Huantao Wen Siyuan Lv Ning Wang Jinyan Wang Fei Luo Wangming Zhang | 2021 | Neuroscience Bulletin2021，37，3： | 1 |
| 17 | Real-time NURBS interpolator:application to short linear segments显示文摘 | Wang Junbin Yau H T | 2009 | The International Journal of Advanced Manufacturing Technology2009，41，11： | 1 |
| 18 | Fast Bezier interpolator with real-time look-ahead function for high-accuracy machining显示文摘 | YAU H T WANG Junbin | 2007 | International Journal of Machine Tools and Manufacture2007，47，10： | 1 |
| 19 | Real-time NURBS interpolator: application to short linear segments显示文摘 | WANG Junbin YAU H T | 2009 | The International Journal of Advanced Manufacturing Technology2009，41，1112： | 1 |
| 20 | Sm-MnO_(x)catalysts for low-temperature selective catalytic reduction of NO_(x)with NH_(3):Effect of precipitation agent显示文摘A series of Sm-Mn mixed oxide catalysts were prepared via precipitation using various precipitants,namely Na_(2)CO_(3)(NH_(4))_(2)CO_(3),and NH_(3)·H_(2)O,and evaluated for the selective catalytic reduction(SCR)of NO_(x)with NH_(3)at low temperatures.Various characterisation techniques were used to determine the physicochemical properties of the catalysts,and it is found that their catalytic performance is greatly influenced by the nature of the precipitation agent used.It is found that Sm_(0.1)Mn-Na_(2)CO_(3)and Sm_(0.1)Mn-(NH_(4))_(2)CO_(3)exhibit superior catalytic performance in the SCR reaction to that of Sm_(0.1)Mn-NH_(3)·H_(2)O due to an abundance of surface acid sites,high surface concentration of Mn^(4+),and high NO oxidation capacity.From in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFT)analysis,we conclude that the Sm-Mn catalysts follow both Eley-Rideal and Langmuir-Hinshelwood mechanisms,and that the Eley-Rideal mechanism is dominant at elevated temperatures. | Junbin Ding Xinwei Yang Aiyong Wang Can Yang Yanglong Guo Yun Guo Li Wang Wangcheng Zhan | 2022 | Journal of Rare Earths2022，40，8： | 1 |
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