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您的检索式：作者名="Zhenyin Wang"
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| 1 | Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells显示文摘An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%–18.5%of hospitalized adults,calling for an urgent investigation to determine the role of smoking in SARS-CoV-2 infection.Here,we show that cigarette smoke extract(CSE)and carcinogen benzo(a)pyrene(BaP)increase ACE2 mRNA but trigger ACE2 protein catabolism.BaP induces an aryl hydrocarbon receptor(AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination.ACE2 in lung tissues of non-smokers is higher than in smokers,consistent with the findings that tobacco carcinogens downregulate ACE2 in mice.Tobacco carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the cells.Given that tobacco smoke accounts for 8 million deaths including 2.1 million cancer deaths annually and Skp2 is an oncoprotein,tobacco use should not be recommended and cessation plan should be prepared for smokers in COVID-19 pandemic. | Guizhen Wang Qun Zhao Hui Zhang Fan Liang Chen Zhang Jun Wang Zhenyin Chen Ran Wu Hong Yu Beibei Sun Hua Guo Ruie Feng Kaifeng Xu Guangbiao Zhou | 2021 | Frontiers of Medicine2021，15，2： | 1 |
| 2 | Economic Analysis and Research of New Energy Vehicle Promotion Model显示文摘New energy vehicles represent the inevitable trend of future development.Compared to traditional fuel vehicles,they are more energy-saving and environmentally friendly,effectively reducing air pollution and mitigating excessive exploitation of oil resources,a stance strongly supported by governments.However,new energy vehicles possess certain drawbacks in terms of price and usability compared to traditional counterparts.Therefore,external support is imperative for their development.This paper delineates four main sections:the background of new energy vehicle promotion and application,a comparative analysis of domestic and foreign promotion models,specific promotion suggestions,and future development prospects.By leveraging insights from economic analysis,the optimal promotion model for new energy vehicles is elucidated. | Zihang Wang Xudong Wang Zhenyin Zhang Shaolong Wang Chenyang Xu | 2024 | Proceedings of Business and Economic Studies2024，7，1： | 0 |
| 3 | Preparation of safe water-lipid mixed electrolytes for application in ion capacitor显示文摘Aqueous electrolytes are safe,economic,and environmentally friendly.However,they have a narrow potential window.On the other hand,organic electrolytes exhibit good thermodynamic stability but are inflammable and moisture sensitive.In this study,we prepared water-PEG-lipid ternary electrolytes(TEs).To combine the advantages of water,polyethylene glycol(PEG)and propylene carbonate(PC).The nonflammable mixed electrolytes exhibited a wide potential window of about 2.8 V due to the beneficial effects of PEG and PC.Using these TEs,a lithium manganate-active carbon ion capacitor could be operated at 2.4 V with an energy density of 32 Wh/kg,based on the total active electrode material(current density of 3.3 m A/cm^(2)).This value was significantly higher than that achieved using an aqueous electrolyte,thereby rationalizing the higher energy density. | Miaofeng Huang Aihua Tang Zhenyin Wang Jingkun Shi Xiaoping Jiang Chubin Wan Xin Ju | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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