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| 1 | Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘 | Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu | 2018 | Cell Research2018，28，8： | 9 |
| 2 | Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration显示文摘Necroptosis 是词法上类似于坏死的规划、 caspase 独立的房间死亡。导致 TNF 的 necroptosis 被交往受体的蛋白质调停 kinases, RIP1 和 RIP3,和混合的系 kinase 像域(MLKL ) 。在是由 RIP3 的 phosphorylated 以后, MLKL 是到血浆膜的 translocated 并且调停 necroptosis。然而, necroptosis 的实行和它在发炎和另外的细胞的回答的角色留下大部分逃犯。在这研究,我们报导房间表面朊酶的那调停 MLKL 的激活 disintegrin 和 metalloprotease (ADAM ) 家庭支持 necroptosis,发炎和房间移植。当 MLKL 是 phosphorylated 和 translocated 到房间血浆膜时,亚当斯明确地在 necroptosis 的早阶段被激活。亚当斯的激活导致包括粘附分子,受体,生长因素和 cytokines 多样的房间表面蛋白质流的 ectodomain。重要地,流房间表面蛋白质破坏房间粘附并且加速 necroptosis,当劈开的蛋白质的可溶的碎片触发煽动性的回答时。我们也证明从 necroptotic 房间流 E-cadherin ectodomain 支持房间移植。因此,我们的学习提供导致 necroptosis 的发炎和新卓见的新奇机制进房间死亡的这种唯一的形式的生理、病理学的功能。 | Zhenyu Cai Anling Zhang Swati Choksi Weihua Li Tao Li Xue-Min Zhang Zheng-Gang Liu | 2016 | Cell Research2016，26，8： | 5 |
| 3 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 4 | Methodology of drug screening and target identification for new necroptosis inhibitors显示文摘Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus,the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed. | Pengchao Pan Zhenyu Cai Chunlin Zhuang Xiaofei Chen Yifeng Chai | 2019 | Journal of Pharmaceutical Analysis2019，9，2： | 3 |
| 5 | Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury显示文摘The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used computer simulation of molecular docking to predict that S1P might be a ligand for triggering receptor expressed on myeloid cells 2(TREM2).Next,microscale thermophoresis(MST),surface plasmon resonance(SPR)and liquid chromatography–tandem mass spectrometry(LC–MS/MS)were performed to reveal that S1P was a novel TREM2 ligand.Then,we confirmed the pro-phagocytosis of S1P targeting in Trem2-Dap12 transfected CHO cells and TREM2 knockdown microglia.Point mutation analysis showed that D104 was the critical binding residue.Trem2^(−/−)mice were used to demonstrate the role of S1P-induced phagocytosis targeting on TREM2 in protecting against ischemic brain injury.Finally,further studies revealed that apolipoprotein E(APOE)loaded with S1P was released by microglia and bound to apoptotic neurons via LDL receptor related protein 1B(LRP1B)and thereby induced microglia to phagocytose apoptotic neurons.Overall,the present work reveals for the first time that S1P acts as a novel endogenous ligand of TREM2 to effectively promote microglial phagocytosis.Our findings provide a new lead compound for developing immunomodulator targeting on TREM2. | Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 6 | Experimental and numerical analysis of the heat flux characteristic of the plume of a 120-N thruster显示文摘The convective heat transfer of the plume of a 120-N thruster is investigated experimentally and numerically. Numerical results agree well with experimental results in that there is a nonlinear decrease in convective heat transfer with an increasing cone angle. It is also found that convective heat transfer decreases with increasing distance from the thruster outlet. Furthermore, the convective heat transfer of the plume mainly concentrates within a 35° cone angle and the heat flux decreases to the same order as solar radiation at the Earth’s surface when the cone angle exceeds 60°. The results of the study will help improve spacecraft design. | ZHANG MingXing CAI GuoBiao HE BiJiao TANG ZhenYu ZHOU Hao | 2019 | Science China(Technological Sciences)2019，62，10： | 3 |
| 7 | Smart ring resonator–based sensor for multicomponent chemical analysis via machine learning显示文摘We demonstrate a smart sensor for label-free multicomponent chemical analysis using a single label-free ring resonator to acquire the entire resonant spectrum of the mixture and a neural network model to predict the composition for multicomponent analysis. The smart sensor shows a high prediction accuracy with a low rootmean-squared error ranging only from 0.13 to 2.28 mg/m L. The predicted concentrations of each component in the testing dataset almost all fall within the 95% prediction bands. With its simple label-free detection strategy and high accuracy, the smart sensor promises great potential for multicomponent analysis applications in many fields. | ZHENYU LI HUI ZHANG BINH THI THANH NGUYEN SHAOBO LUO PATRICIA YANG LIU JUN ZOU YUZHI SHI HONG CAI ZHENCHUAN YANG YUFENG JIN YILONG HAO YI ZHANG AI-QUN LIU | 2021 | Photonics Research2021，9，2： | 3 |
| 8 | Mineralogical Characteristics of Exsolved Spinel in the Panzhihua V-Ti Magnetite Deposit, Sichuan: Implications for the Mineralization Process显示文摘Spinel exsolution is widespread in titanomagnetite from the Fe-Ti oxide gabbro of the Panzhihua intrusion, Emeishan Large Igneous Province, SW China. However, little research has been conducted into the implications of patterns in the mineralogical characteristics of the spinel for spatial variation in the controls on the exsolution mechanism and, hence, the formation process of the ore deposit. This study selected the Lanjiahuoshan Ore Block in the Panzhihua V-Ti magnetite deposit to explore this issue, systematically studying exsolution textures in the titanomagnetite through petrographic observation and the integrated use of in-situ microanalysis. The results show that the exsolved spinel gradually becomes finer-grained and less abundant from the center to edge and the bottom to top of the ore bodies. Compositionally, there is an inverse correlation between the size of exsolved spinel grains and their Mg# value. In addition, there is compositional zonation in the spinel interiors, with a gradual increase in the Mg content and decrease in Fe content from the core to the rim. The analysis suggests that fractional crystallization of ferrotitanium magma with a high oxygen fugacity in a shallow magma chamber caused compositional differences in the primary magnetite solid solution in different parts of the Panzhihua intrusion. Additionally, the thermal evolution of the magnetite solid solution differed in different parts of orebody, bringing about variations in spinel development. Together, these effects resulted in spatial variation in the abundance, grain size, and morphology of spinel in different parts of the orebody and intrusion that follows an identifiable distribution law. Furthermore, the compositional zonation of exsolved spinels reflects the rapid growth of exsolution features in a high-temperature environment. Thus, the size, morphology, abundance, and composition of spinel exsolution features in titanomagnetite provide a valuable petrogenetic tool for estimating the maturity and formational environment of the deposit. | ZHANG Zhibin HUANG Fei XING Miaomiao WAN Quan GAO Wenyuan GAO Shang CHEN Zhenyu CAI Jianhui | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 9 | Purification, characterization and anticancer activity of a polysaccharide from Panax ginseng显示文摘 | Cong Li Jianping Cai Jingshu Geng Yinghong Li Zhenyu Wang Rui Li | 2012 | International Journal of Biological Macromolecules2012，，5： | 2 |
| 10 | Superelasticity of NiTi Shape Memory Alloy Thin Films显示文摘The superelastic properties of NiTi thin films prepared with sputtering were studied. To characterize their superelasticity, tensile and bulging and indentation tests were performed. The measured mechanisms using these three methods were compared, and the factors that influence superelasticity were described. | Zhenyu YUAN, Dong XU, Zhican YE and Bingchu CAI Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, Research Institute of Micro/Nanometer Science and Technology, Shanghai Jiao Tong University, Shanghai 200030, China | 2005 | Journal of Materials Science & Technology2005，21，3： | 1 |
| 11 | Multi- objective community detection in complex networks 显示文摘 | SHI Chuan YAN Zhenyu CAI Yanan | 2012 | Applied Soft Computing2012，12，2： | 1 |
| 12 | Genetic diversity and population structure of an endangered Orchid ( Dendrobium lod- dlgesii Rolfe) from China revealed by SRAP markers 显示文摘 | Xianyan Cai Zhenyu Feng Xiaoxiao Zhang | 2011 | Seientia Horticulmrae2011，129，： | 1 |
| 13 | Measurement and Promotion Strategy of Poverty Alleviation Effect through Ecological Tourism in Huanggang City显示文摘Huangang City is rich in ecotourism resources,in which more than 80%of ecotourism resources concentrate in poor countryside.According to the statistics,there are 4 tourism counties,15 famous tourism villages and 115 rural tourist attractions.But economic development in ecotourism scenic spots of Huanggang City is relatively backward,and the development of ecological economy is imminent,especially ecological tourism.Based on research results on poverty alleviation effect through ecological tourism at home and abroad,Huanggang City is taken as research object,and two input indexes(per capita comprehensive tourism income and per capita tourist reception)and three output indexes(per capita GDP,per capita net income of farmers,and per capita disposable income of urban residents)are used to establish evaluation index system of poverty alleviation effect through ecological tourism.Based on DEA-BCC model,11 counties(cities and districts)in Huanggang City are taken as decision-making units,and empirical analysis on poverty alleviation effect through tourism is conducted from three aspects:comprehensive efficiency,technical efficiency and scale efficiency. | Li Pingheng Ke Chenglong Cai Zhenyu Fang Ping | 2019 | Meteorological and Environmental Research2019，10，6： | 1 |
| 14 | Current Status and Experience of WAMS Implementation in North America 显示文摘 | Jim Y Cai Zhenyu Huang John Hauer | 2005 | IEEE/PES Transmission and Distribution Conference2005，，： | 1 |
| 15 | An ecological assessment of the vernacular architecture and of its embodied energy in Yunnan, China显示文摘 | Wang Renping Cai Zhenyu | 2006 | Building and Enviranment2006，41，5： | 1 |
| 16 | An ecological assessment of the vemacular architecture and of its embodied energy in Yunnan,China 显示文摘 | Wang Renping Cai Zhenyu | 2006 | Building and Environment2006，41，： | 1 |
| 17 | Bi/BiVO_(4)/NiFe-LDH heterostructures with enhanced photoelectrochemical performance for streptomycin detection显示文摘Streptomycin(STR)plays an essential role in bacterial infection treatments.Selectivity and sensitivity of photoelectrochemical(PEC)sensors are the two most important parameters,which can be measured using the photosensitivity of its active material.We prepared a novel PEC sensor to detect STR using Bi/BiVO4/LDH(layered double hydroxides)heterostructures as an active material,which is photoactive in the visible light wavelength range.The simultaneous presence of LDH and Bi/BiVO4 enhanced the material photocurrent response,which was linear to the STR concentrations in the 0.01–500 nmol/L range.The STR detection limit by this sensor was 0.0042 nmol/L.Our novel PEC-based sensing strategy includes using an ultra-sensitive and highly selective sensor for STR detection.Additionally,the two-pot synthesis of Bi/BiVO4/LDH developed in this work is environmentally friendly. | Liqin Yang Jun Zhao Caijun Wang Zheng Wang Cuijuan Xing Hao Guo Yuman Wang Zhiju Zhao Zhangji Hu Zhenyu Cai | 2021 | Journal of Environmental Sciences2021，33，11： | 1 |
| 18 | Overexpression of GsZFP1 enhances salt and drought tolerance in transgenic alfalfa ( Medicago sativa L.)显示文摘 | Lili Tang Hua Cai Wei Ji Xiao Luo Zhenyu Wang Jing Wu Xuedong Wang Lin Cui Yang Wang Yanming Zhu Xi Bai | 2013 | Plant Physiology and Biochemistry2013，，： | 1 |
| 19 | Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer显示文摘The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical trials.Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to drug resistance.However,the underlying mechanism is still unclear.In this study,we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation.Super-enhancers(SEs),crucial regulatory elements,have been shown to be associated with drug resistance in various cancers.Our analysis of SEs in metformin-resistant(MetR)PCa cells revealed a correlation with Prostaglandin Reductase 1(PTGR1)expression,which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome sequencing.Our functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases,resulting in reduced sensitivity to metformin.Additionally,we identified key transcription factors that significantly increase PTGR1 expression,such as SRF and RUNX3,providing potential new targets to address metformin resistance in PCa.In conclusion,our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis,offering potential avenues to enhance metformin’s therapeutic efficacy in PCa. | Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 20 | Erratum to:Borates as a new direction in the design of oxide ion conductors(vol 65,issue 10,page 2737,2022)显示文摘In the version of the article originally published in the volume 62,issue 10,2022 of Sci.china Mater.(page 2737-2745,http://gffzzd3cc09b8251d45dfs9x66qc0wobxx6opu.ffgz.tsg.suse.edu.cn/10.1007/s40843-022-2044-3).The chemical shift reported in Figure 5f for the^(11)B solid-state NMR spectra is incorrect because no parameter correction was performed during data processing. | Xiaohui Li Li Yang Zhenyu Zhu Xiaoge Wang Bohua Chen Senchuan Huang Xianyi Wei Guohong Cai Pascal Manuel Sihai Yang Jianhua Lin Xiaojun Kuang Junliang Sun | 2022 | Science China Materials2022，65，11： | 0 |
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