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| 1 | Studies on aeroservoelasticity semi-physical simulation test for missiles显示文摘Missiles may be damaged when aeroservoelastic problem occurs,which is caused by the interaction of structure flexibility and flight control system.Because of the limit of wind tunnel test condition,numerical methods are mostly used in previous aeroservoelastic studies.However,series of assumptions and simplification on structures,aerodynamics and flight control systems are unavoidably introduced,and various nonlinear factors are also ignored,therefore,they result in considerable errors.A novel method called aeroservoelasticity semi-physical simulation test is proposed in this paper,which takes the flexible missile with control system as the test object.Vibration signals at several locations of the missile are measured by accelerometers,then corresponding unsteady aerodynamics is computed based on the fact that airflow at high Mach is nearly quasi-steady,and finally unsteady aerodynamics is exerted simultaneously by shakers at certain locations of the missile.The aeroservoelasticity semi-physical simulation test system can be constructed after the control system is closed.Open loop transfer function test and closed loop stability test are carried out in sequence.The test principle and method proposed in this paper are verified by the concordance between the results of numerical simulation and experiment. | WU ZhiGang CHU LongFei YUAN RuiZhi YANG Chao TANG ChangHong | 2012 | Science China(Technological Sciences)2012，55，9： | 14 |
| 2 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 3 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 4 | Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine(5hmC)显示文摘As a dioxygenase, Ten-Eleven Translocation 2(TET2) catalyzes subsequent steps of 5-methylcytosine(5 mC) oxidation. TET2 plays a critical role in the self-renewal, proliferation,and differentiation of hematopoietic stem cells, but its impact on mature hematopoietic cells is not well-characterized. Here we show that Tet2 plays an essential role in osteoclastogenesis. Deletion of Tet2 impairs the differentiation of osteoclast precursor cells(macrophages) and their maturation into bone-resorbing osteoclasts in vitro. Furthermore, Tet2^(-/-) mice exhibit mild osteopetrosis, accompanied by decreased number of osteoclasts in vivo. Tet2 loss in macrophages results in the altered expression of a set of genes implicated in osteoclast differentiation, such as Cebpa, Mafb, and Nfkbiz. Tet2 deletion also leads to a genome-wide alteration in the level of 5-hydroxymethylcytosine(5 hmC) and altered expression of a specific subset of macrophage genes associated with osteoclast differentiation. Furthermore, Tet2 interacts with Runx1 and negatively modulates its transcriptional activity. Our studies demonstrate a novel molecular mechanism controlling osteoclast differentiation and function by Tet2, that is, through interactions with Runx1 and the maintenance of genomic 5 hmC. Targeting Tet2 and its pathway could be a potential therapeutic strategy for the prevention and treatment of abnormal bone mass caused by the deregulation of osteoclast activities. | Yajing Chu Zhigang Zhao David Wayne Sant Ganqian Zhu Sarah M. Greenblatt Lin Liu Jinhuan Wang Zeng Cao Jeanette Cheng Tho Shi Chen Xiaochen Liu Peng Zhang Jaroslaw P. Maciejewski Stephen Nimer Gaofeng Wang Weiping Yuan Feng-Chun Yang Mingjiang Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 2 |
| 5 | A Microsatellite Genetic Linkage Map of Black Rockfish(Sebastes schlegeli)显示文摘Ovoviviparous black rockfish(Sebastes schlegeli) is an important marine fish species for aquaculture and fisheries in China. Genetic information of this species is scarce because of the lack of microsatellite markers. In this study, a large number of microsatellite markers of black rockfish were isolated by constructing microsatellite-enriched libraries. Female- and male-specific genetic linkage maps were constructed using 435 microsatellite markers genotyped in a full-sib family of the fish species. The female linkage map contained 140 microsatellite markers, in which 23 linkage groups had a total genetic length of 1334.1 c M and average inter-marker space of 13.3 c M. The male linkage map contained 156 microsatellite markers, in which 25 linkage groups had a total genetic length of 1359.6 c M and average inter-marker distance of 12.4 c M. The genome coverage of the female and male linkage maps was 68.6% and 69.3%, respectively. The female-to-male ratio of the recombination rate was approximately 1.07:1 in adjacent microsatellite markers. This paper presents the first genetic linkage map of microsatellites in black rockfish. The collection of polymorphic markers and sex-specific linkage maps of black rockfish could be useful for further investigations on parental assignment, population genetics, quantitative trait loci mapping, and marker-assisted selection in related breeding programs. | CHU Guannan JIANG Liming HE Yan YU Haiyang WANG Zhigang JIANG Haibin ZHANG Quanqi | 2014 | Journal of Ocean University of China2014，13，6： | 2 |
| 6 | Anti-Phase Relationship Between the East Asian Winter Monsoon and Summer Monsoon During the Holocene?显示文摘The relationship between the East Asian winter monsoon(EAWM) and East Asian summer monsoon(EASM) during the Holocene is complicated and remains controversial.In this study,analysis of grain size and benthic foraminiferal oxygen isotope,as well as accelerator mass spectrometry ^(14)C dating was performed on a sediment core retrieved from the newly revealed muddy deposit on the northern South China Sea continental shelf.The history of the EAWM and EASM were reconstructed for the last 8200 a BP.Further analysis in conjunction with previously published paleo-climate proxies revealed that the relationship between the EAWM and EASM during the Holocene is more complex than a simple and strict anti-phase one-both negative and positive correlations were identified.The EAWM and EASM are negatively correlated around 7500,4800,4200,3200,and 300 a BP(cooling periods),while positively correlated around 7100,3700,and 2100 a BP(warm periods).In particular,both the EAWM and EASM intensified during the three positive correlation periods.However,we also found that the relationship between these two sub-monsoons is anti-phase during the final phase of particularly hot periods like Holocene Optimum and Medieval warm period.The possible impact from variations of solar irradiance on the relationship between the EAWM and EASM was also discussed. | GE Qian XUE Zuo YAO Zhigang ZANG Zhengchen CHU Fengyou | 2017 | Journal of Ocean University of China2017，16，2： | 2 |
| 7 | Comparison of deconvolution methods for the visualization of acoustic sources based on cross-spectral imaging functionbeamforming显示文摘 | CHU Zhigang YANG Yang | 2014 | Mechanical Systems and Signal Processing2014，48，12： | 1 |
| 8 | Hepatic stellate cells activated by acidic tumor microenvironment promote the metastasis of hepatocellular carcinoma via osteopontin显示文摘 | Jin Song Zhouhong Ge Xinrong Yang Qin Luo Cun Wang Haiyan You Tianxiang Ge Yun Deng Hechun Lin Yongqi Cui Wei Chu Ming Yao Zhigang Zhang Jianren Gu Jia Fan Wenxin Qin | 2014 | Cancer Letters2014，，： | 1 |
| 9 | PCPD:Plant cytochrome P450 database and web-based tools for structural construction and ligand docking显示文摘Plant cytochrome P450s play key roles in the diversification and functional modification of plant natural products.Although over 200,000 plant P450 gene sequences have been recorded,only seven crystalized P450 genes severely hampered the functional characterization,gene mining and engineering of important P450s.Here,we combined Rosetta homologous modeling and MD-based refinement to construct a high-resolution P450 structure prediction process(PCPCM),which was applied to 181 plant P450s with identified functions.Furthermore,we constructed a ligand docking process(PCPLD)that can be applied for plant P450s virtual screening.10 examples of virtual screening indicated the process can reduce about 80%screening space for next experimental verification.Finally,we constructed a plant P450 database(PCPD:http://gffzz90f9b80da1174166hkvxnn699b9bo6vow.ffgz.tsg.suse.edu.cn/),which includes the sequences,structures and functions of the 181 plant P450s,and a web service based on PCPCM and PCPLD.Our study not only developed methods for the P450-specific structure analysis,but also introduced a universal approach that can assist the mining and functional analysis of P450 enzymes. | Hui Wang Qian Wang Yuqian Liu Xiaoping Liao Huanyu Chu Hong Chang Yang Cao Zhigang Li Tongcun Zhang Jian Cheng Huifeng Jiang | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 1 |
| 10 | Distribution and conservation of Sino-Mongolian beaver,Castor fiber Birulai显示文摘 | CHU Hongjun JIANG Zhigang | | 0，，： | 1 |
| 11 | Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications:Concept and proof显示文摘Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion resistance.However,the high complex RE addition accompanied with multiple second phases may bring the concern of biological hazards.Single-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance”.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased microstructure.The bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to<1 wt%,without losing mechanical properties.The single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based implants.They exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity magnesium.In addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on organs.The novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored. | Dong Bian Xiao Chu Jin Xiao Zhipei Tong He Huang Qinggong Jia Jianing Liu Wenting Li Hui Yu Yue He Limin Ma Xiaolan Wang Mei Li Tao Yang Wenhan Huang Chi Zhang Mengyu Yao Yu Zhang Zhigang Xu Shaokang Guan Yufeng Zheng | 2023 | Bioactive Materials2023，，4： | 1 |
| 12 | Identification of Crack in Functionally Graded Material Beams Using the p-Version of Finite Element Method 显示文摘 | Zhigang Yu Fulei Chu | 2009 | Journal of Sound and Vibration2009，325，12： | 1 |
| 13 | Melphalan-loaded methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer nanomicelles in the treatment of multiple myeloma显示文摘Multiple myeloma(MM)is the second most common hematological tumor characterized by the proliferation of monoclonal plasma cells.Melphalan(MEL)is commonly used in the treatment of MM and is especially essential for patients undergoing autologous stem cell transplantation(ASCT).Although many drugs for MM have been developed in recent years,chemotherapy followed by ASCT remains the optimal option.Melphalan,the backbone of the conditioning regimen,brings severe toxicities at a high dose.Nanodrug delivery systems enable drugs to be highly effective and have low toxicity.In this study,methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(MPEG-PDLLA)was chosen to encapsulate melphalan,and the characteristics,effectiveness,and safety of MEL/MPEG-PDLLA in vitro and in vivo were investigated.MEL/MPEG-PDLLA showed slow release and was easily engulfed by MM cells despite a result of the antitumor assay comparable to that of free melphalan in vitro.The in vivo results showed that MEL/MPEG-PDLLA could significantly alleviate tumor burden and prolong survival time without increasing the toxicity to vital organs.In addition,MEL/MPEG-PDLLA could significantly reduce the damage to the intestinal mucosa caused by melphalan.In conclusion,MEL/MPEG-PDLLA shows improved antitumor activity and has the potential to alleviate pains of MM patients undergoing ASCT. | Yingying Chen Qiang Zeng Bingyang Chu Zhigang Liu Xue Wei Mengran Chen Peipei Yang Minghai Tang Ting Niu Yongqian Jia Ying Qu Zhiyong Qian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 14 | Bipolarized intrinsic faradaic layer on a semiconductor surface under illumination显示文摘Interface charge transfer plays a key role in the performance of semiconductors for different kinds of solar energy utilization,such as photocatalysis,photoelectrocatalysis,photochromism and photo-induced superhydrophilicity.In previous studies,different mechanisms have been used to understand interface charge transfer processes.However,the charge transfer mechanism at the solid/liquid interface remains a controversial topic.Here,taking TiO_(2) as a model,we find and prove,via experiments,the new characteristic of photo-induced bipolarity of the surface layer(reduction faradaic layer and oxidation faradaic layer)on a semiconductor for the first time.Different from energy level positions in the classic surface states transfer mechanism,the potential window of a surface faradaic layer is located out of the forbidden band.Moreover,we find that the reduction faradaic layer and oxidation faradaic layer serve as electron and hole transfer mediators in photocatalysis,while the bipolarity or mono-polarity of the surface layer on a semiconductor depends on the applied potential in photoelectrocatalysis.The new characteristic of bipolarity can also offer new insights into the charge transfer process at the semiconductor/liquid interface for solar energy utilization. | Mengfan Xue Zhiqiang Chu Dongjian Jiang Hongzheng Dong Pin Wang Gengzhi Sun Yingfang Yao Wenjun Luo Zhigang Zou | 2023 | National Science Review2023，10，4： | 0 |
| 15 | Fault Diagnosis of the LAMOST Fiber Positioner Based on a Long Short-term Memory(LSTM)Deep Neural Network显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST)has been in normal operation for more than 10 yr,and routine maintenance is performed on the fiber positioner every summer.The positioning accuracy of the fiber positioner directly affects the observation performance of LAMOST,and incorrect fiber positioner positioning accuracy will not only increase the interference probability of adjacent fiber positioners but also reduces the observation efficiency of LAMOST.At present,during the manual maintenance process of the positioner,the fault cause of the positioner is determined and analyzed when the positioning accuracy does not meet the preset requirements.This causes maintenance to take a long time,and the efficiency is low.To quickly locate the fault cause of the positioner,the repeated positioning accuracy and open-loop calibration curve data of each positioner are obtained in this paper through the photographic measurement method.Based on a systematic analysis of the operational characteristics of the faulty positioner,the fault causes are classified.After training a deep learning model based on long short-term memory,the positioner fault causes can be quickly located to effectively improve the efficiency of positioner fault cause analysis.The relevant data can also provide valuable information for annual routine maintenance methods and positioner designs in the future.The method of using a deep learning model to analyze positioner operation failures introduced in this paper is also of general significance for the maintenance and design optimization of fiber positioners using a similar double-turn gear transmission system. | Yihu Tang Yingfu Wang Shipeng Duan Jiadong Liang Zeyu Cai Zhigang Liu Hongzhuan Hu Jianping Wang Jiaru Chu Xiangqun Cui Yong Zhang Haotong Zhang Zengxiang Zhou | 2023 | Research in Astronomy and Astrophysics2023，23，12： | 0 |
| 16 | A New Fiber Detection Method for LAMOST Based on the Front-illuminated Method显示文摘The double revolving fiber positioning technology is one of the key technologies for the success of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST).The accuracy of fiber positioning will directly affect the observation efficiency of LAMOST.To achieve higher fiber positioning accuracy,the original open-loop controlled fiber positioning system urgently needs to be upgraded into a closed-loop control system.The fiber detection is the most important part of the closed-loop controlled fiber positioning system.The back-illuminated detection method is usually used to detect the fiber position by directly detecting the light spot generated at the fiber end in the multi-fiber spectral surveys.In this paper,we introduce a new method to measure the fiber position based on the image of the front-illuminated LAMOST focal plane.The front-illuminated image does not require lighting devices inside the spectrograph,and it could reduce the instability and light pollution in the spectrograph end.Our method measures the fiber position by fitting the profile of the fiber pinhole with a 2D Gaussian function.A series of tests show that the relative position measurement precision of the front-illuminated method is about 012,and the method could have the same accuracy as the back-illuminated method once the system bias is calibrated by a simple radial correction function.The required fiber positioning accuracy of LAMOST is 04,and the new method satisfies the requirement of LAMOST fiber detection accuracy and could be used in the closed-loop fiber control system. | Ming Zhou Yong Zhang Guanru Lv Jian Li Zengxiang Zhou Zhigang Liu Jianping Wang Zhongrui Bai Yuan Tian Mengxin Wang Shuqing Wang Hongzhuan Hu Chao Zhai Jiaru Chu Zhijie Han Mingxu Liu Yiqiao Dong Hailong Yuan Yongheng Zhao Yaoquan Chu Haotong Zhang | 2022 | Research in Astronomy and Astrophysics2022，22，6： | 0 |
| 17 | Isolation and Identification of Bacterial Pathogens of Proteus vulgaris and Chryseobacterium meningosepticum from Peodiscus sinensis and Observation on the Histopathology显示文摘Two dominant strains of bacteria Lb18-01 and Lb18-02 were isolated and purified from scabies,liver and intestine of diseased Peodiscus sinensis.By artificial infection test,the two strains were verified as pathogenic strains with similar characters to that of natural infectious cases.The strains Lb18-01 and Lb18-02 showed strong pathogenicity to healthy P.sinensis in the artificial infection experiment,so they were the pathogenic strain of the disease.According to the morphology,physicochemical characteristics,16 S rDNA sequence analysis and phylogenetic tree clustering,the pathogenic strains Lb18-01 and Lb18-02 were identified as Proteus vulgaris and Chryseobacterium meningosepticum which were tolerant to 20 drugs such as penicillin,tetracycline and ampicillin.Histopathological observation on diseased P.sinensis showed the pathological symptoms of sepsis such as hemorrhage and congestion of liver,spleen and intestine,and glomerular disintegration. | Guomin JIANG Li LIU Wuying CHU Zhigang HE Li ZOU Dongwu WANG Shiming DENG | 2021 | Agricultural Biotechnology2021，10，2： | 0 |
| 18 | Distribution Patterns of Major and Trace Elements and Provenance of Surface Sediments on the Continental Shelf off Western Guangdong Province and Northeastern Hainan Island显示文摘A coupled approach based on grain size and geochemical elements is used to trace the provenance of surface sediments and to confirm the distribution patterns of grain size and elements on the continental shelf off western Guangdong Province and northeastern Hainan Island. The mean grain size ranges from 0.05 φ to 7.28 φ with a mean value of 5.60 φ. The average concentra- tions of major elements descend in the order of SiO2 > Al2O3 > CaO > Fe2O3 > K2O > MgO > Na2O > TiO2 > P2O5 > MnO, while those of trace elements exhibit a descending order of Sr > Rb > Zn > V > Cr > Pb > Ni > Cu > As > Cd. On the basis of the distribution patterns of elements and results of statistical analysis, the study area is classified into three zones. Zone I locates on the continental shelf off western Guangdong Province, and the sediments are mainly from Pearl River, Taiwan Residents rivers, and small rivers nearby. Zone II locates in the eastern exit of Qiongzhou Strait and the coastal area off Leizhou Peninsula, and the sediments are mainly from the ero- sion products of Qiongzhou Strait and Hainan Island. Zone III locates off the eastern Hainan Island and the continental shelf deeper than 50 m isobaths, and the sediments are mainly from Hainan Island and coral reef. The influence from open water should also be considered. Results indicate that the grain size is the main controlling factor for major and trace element contents and that anthropo- genic impact and biological activity also play an important role in the distribution of these elements. | GE Qian XUE Z. George YE Liming XU Dong YAO Zhigang CHU Fengyou | 2019 | Journal of Ocean University of China2019，18，4： | 0 |
| 19 | Electricity-driven ammonia oxidation and acetate production in microbial electrosynthesis systems显示文摘Microbial electrosynthesis(MES)is an emerging technology for producing chemicals,and coupling MES to anodic waste oxidation can simultaneously increase the competitiveness and allow additional functions to be explored.In this study,MES was used for the simultaneous removal of ammonia from synthetic urine and production of acetate from CO_(2).Using graphite anode,83.2%±5.3%ammonia removal and 28.4%±9.9%total nitrogen removal was achieved,with an energy consumption of 1.32 kWh/g N for total nitrogen removal,0.45 kWh/g N for ammonia nitrogen removal,and 0.044 kWh/g for acetate production.Using boron-doped diamond(BDD)anode,70.9%±12.1%ammonia removal and 51.5%±11.8%total nitrogen removal was obtained,with an energy consumption of 0.84 kWh/g N for total nitrogen removal,0.61 kWh/g N for ammonia nitrogen removal,and 0.043 kWh/g for acetate production.A difference in nitrate accumulation explained the difference of total nitrogen removal efficiencies.Transport of ammonia and acetate across the membrane deteriorated the performance of MES.These results are important for the development of novel elcctricity-driven technologies for chemical production and pollution removal. | Qinjun Liang Yu Gao Zhigang Li Jiayi Cai Na Chu Wen Hao Yong Jiang Raymond Jianxiong Zeng | 2022 | Frontiers of Environmental Science & Engineering2022，16，4： | 0 |
| 20 | Consistency correction of echo intensity data for multiple radar systems and its application in quantitative estimation of typhoon precipitation显示文摘Calibration error is one of the primary sources of bias in echo intensity measurements by ground-based radar systems.Calibration errors cause data discontinuity between adjacent radars and reduce the effectiveness of the radar system.The Global Precipitation Measurement Kuband Precipitation Radar(GPM KuPR)has been shown to provide stable long-term observations.In this study,GPM KuPR observations were converted to S-band approximations,which were then matched spatially and temporally with ground-based radar observations.The measurements of stratiform precipitation below the melting layer collected by the KuPR during Typhoon Ampil were compared with those of multiple radar systems in the Yangtze River Delta to determine the deviations in the echo intensity between the KuPR and the ground-based radar systems.The echo intensity data collected by the ground-based radar systems was corrected using the KuPR observations as reference,and the correction results were verified by comparing them with rain gauge observations.It was found that after the correction,the consistency of the echo intensity measurements of the multiple radar systems improved significantly,and the precipitation estimates based on the revised ground-based radar observations were closer to the rain gauge measurements. | Shuai ZHANG Jing HAN Bingke ZHAO Zhigang CHU Jie TANG Limin LIN Xiaoqin LU Jiaming YAN | 2022 | Frontiers of Earth Science2022，16，1： | 0 |
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