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| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Metal-organic framework-derived porous shuttle-like vanadium oxides for sodium-ion battery application显示文摘有分层的结构的钒氧化物为锂离子电池和钠离子电池(亲族) 正在答应候选人。自我模板途径,从金属器官的框架(MOF ) 包含转变进多孔的金属氧化物,是完成理想的电气化学的性能的一个新奇、有效的方法。在这研究,多孔的像梭的钒氧化物(即, V 2 O 5, V 2 O 3/C) 被与一个特定的锻烧过程把 MIL-88B (V) 用作先锋成功地准备。作为 proof-of-concept 应用, asprepared 多孔的像梭的 V 2 O 3/C 为亲族被用作阳极材料。多孔的像梭的 V 2 与金属性的行为有固有的分层的结构的 O 3/C, ,展出优秀电气化学的性质。417, 247, 202, 176, 164,和 149 mAhants 的显著的率能力,仅仅 CC 一?? | Yangsheng Cai Guozhao Fang Jiang Zhou Sainan Liu Zhigao Luo Anqiang Pan Guozhong Cao I Shuquan Liang | 2018 | Nano Research2018，11，1： | 12 |
| 3 | Nitrogen/sulfur co-doped hollow carbon nanofiber anode obtained from polypyrrole with enhanced electrochemical performance for Na-ion batteries显示文摘Polypyrrole and sulfur derived hollow carbon nanofibers co-doped with nitrogen/sulfur are synthesized and applied as the anode for Na-ion batteries(NIBs). Successful doping of hollow carbon nanofiber with nitrogen and sulfur is confirmed by X-ray photoelectron spectroscopy, scanning and tunneling electron microscopy. Further analysis certifies that sulfur doping has a significant impact in improving the elecctrochemical performance of the carbon-based anodes for NIBs. The obtained N-doped hollow carbon nanofiber and N/S co-doped hollow carbon nanofiber exhibit similar morphologies but different electrochemical behavior. As expected, the N/S co-doped hollow carbon nanofiber anode exhibits enhanced electrochemical performance, including high specific capacity, outstanding long-term stability, and good rate stability. | Zhigao Luo Sainan Liu Yangshen Cai Shi Li Anqiang Pan Shuquan Liang | 2018 | Science Bulletin2018，63，2： | 4 |
| 4 | Flower-like ZnO modified with BiOI nanoparticles as adsorption/catalytic bifunctional hosts for lithium–sulfur batteries显示文摘Due to the high specific capacity and energy density, lithium–sulfur battery is regarded as a potential energy storage conversion system. However, the serious shuttle effect and the sluggish electrochemical reaction kinetics impede the practical use of lithium–sulfur battery. In the interests of breaking through the above knotty problems, herein we propose to use the polar flower-like Zn O modified by Bi OI nanoparticles as bifunctional host with catalytic and adsorption ability for polysulfides in lithium–sulfur battery.It can be found that this adsorption/catalytic host integrates the functions of adsorption and mutual catalytic conversion of polysulfides, in which the polar flower-like Zn O can effectively capture the polysulfides through strong polar-polar interaction, simultaneously the BiOI nanoparticles can accelerate the mutual conversion of polysulfides to Li2 S through reducing the activation energy and conversion energy barrier required for the electrochemical reaction. As a result, under a sulfur loading of 2.5 mg cm^(-2), the lithium–sulfur battery with Zn O/Bi OI/CNT/S as cathode reveals a considerable initial specific capacity of1267 mAh g^(-1) at a current density of 0.1 C. Even the current density increased to 1 C, the capacity can reach as 873.4 mAh g^(-1), together with a good capacity retention of 67.1% after 400 cycles. Therefore,after systematically study the positive effects of the flower-like ZnO modified by catalytic BiOI nanoparticles on the adsorption and catalytic conversion of polysulfides, this work provides a new idea for the development and application of high-performance lithium–sulfur batteries. | Peng Zeng Hao Yu Manfang Chen Wensheng Xiao Yongfang Li Hong Liu Jing Luo Jiao Peng Dingsheng Shao Ziyi Zhou Zhigao Luo Ying Wang Baobao Chang Xianyou Wang | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 5 | Fault identification and classification of rolling element bearing based on time- varying autoregressive spectrum 显示文摘 | Wang Guofeng Luo Zhigao | 2008 | Mechanical Systems and Signal Progressing2008，22，4： | 1 |
| 6 | Combating the Coronavirus Pandemic:Early Detection,Medical Treatment,and a Concerted Effort by the Global Community显示文摘The World Health Organization(WHO)has declared the outbreak of 2019 novel coronavirus,known as 2019-nCoV,a pandemic,as the coronavirus has now infected over 2.6 million people globally and caused more than 185,000 fatalities as of April 23,2020.Coronavirus disease 2019(COVID-19)causes a respiratory illness with symptoms such as dry cough,fever,sudden loss of smell,and,in more severe cases,difficulty breathing.To date,there is no specific vaccine or treatment proven effective against this viral disease.Early and accurate diagnosis of COVID-19 is thus critical to curbing its spread and improving health outcomes.Reverse transcription-polymerase chain reaction(RT-PCR)is commonly used to detect the presence of COVID-19.Other techniques,such as recombinase polymerase amplification(RPA),loopmediated isothermal amplification(LAMP),clustered regularly interspaced short palindromic repeats(CRISPR),and microfluidics,have allowed better disease diagnosis.Here,as part of the effort to expand screening capacity,we review advances and challenges in the rapid detection of COVID-19 by targeting nucleic acids,antigens,or antibodies.We also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression. | Zichao Luo Melgious Jin Yan Ang Siew Yin Chan Zhigao Yi Yi Yiing Goh Shuangqian Yan Jun Tao Kai Liu Xiaosong Li Hongjie Zhang Wei Huang Xiaogang Liu | 2020 | Research2020，，1： | 1 |
| 7 | Mating Ethogram of a Video-aided Study of Mating and Parturition in Captive Chinese Crocodile Lizards (Shinisaurus crocodilurus)显示文摘Mating behavior and parturition are important components in the life history of any species. The endangered Chinese crocodile lizard(Shinisaurus crocodilurus) is suffering dramatic population decreases in the wild. Successful captive breeding can provide individuals to be reintroduced into their natural habitat and help to restore the wild populations. Studying the mating behavior and parturition of these lizards in captivity will enable us understand how is this ancient species reproduction and optimize artificial reproduction protocol. We studied the mating behavior and parturition of Chinese crocodile lizards in captivity using video recordings at the Daguishan National Nature Reserve, China, from 2015 to 2017. We analyzed pre-copulation and copulation, which occurred in mid-March to late May from all studied years. Pre-copulation and copulation lasted on average 7.51(n=11) and 27.45(n=11) minutes, respectively. We found that large-bodied male lizards have longer copulation periods, a pattern seen in other lizard species. In the mating event, males always initiated sex, while the females were passive. The duration of parturition lasted 153.8 ± 26.8(n=46) minutes, and larger females had heavier clutches. In addition, even though Chinese crocodile lizards represent an ancient lizard clade with primitive characteristics, they still abide by the reproduction patterns seen in most other lizard species. | Chengming HUANG Zhengjun WU Shuyi LUO Jiasong HE Chunsheng YANG Meng MENG Lu YAO Zhigao ZENG | 2019 | Asian Herpetological Research2019，10，4： | 1 |
| 8 | Reconstructing interfacial manganese deposition for durable aqueous zinc-manganese batteries显示文摘Low-cost,high-satety,and broad-prospect aqueous zinc-manganese batteries(ZMBs)are limited by complex interracial reactions.The solid-liquid interfacial state of the cathode dominates the Mn dissolution/deposition process of aqueous ZMBs,especially the important influence on the mass and charge transfer behavior of Zn2+and Mn2+.We proposed a quasi-eutectic electrolyte(QEE)that would stabilize the reversible behavior of interracial deposition and favorable interracial reaction kinetic of manganese-based cathodes in a long cycle process by optimizing mass and charge transfer.We emphasize that the initial interfacial reaction energy barrier is not the main factor affecting cycling performance,and the good reaction kinetics induced by interfacial deposition during the cycling process is more conducive to the stable cycling of the battery,which has been confirmed by theoretical analysis,quartz crystal microbalance with dissipation monitoring,depth etching X-ray photon-electron spectroscopy,etc.As a result,the QEE electrolyte maintained a stable specific capacity of 250 mAh g-1 at 0.5 A g-1 after 350 cycles in zinc-manganese batteries.The energy density retention rate of the ZMB with QEE increased by 174%compared to that of conventional aqueous electrolyte.Furthermore,the multi-stacked soft-pack battery with a cathodic mass load of 54.4 mg maintained a stable specific capacity of 200 mAh g-1 for 100 cycles,demonstrating its commercial potential.This work proves the feasibility of adapting lean-water QEE to the stable aqueous ZMBs. | Yida Hu Zhexuan Liu Lanyan Li Shan Guo Xuefang Xie Zhigao Luo Guozhao Fang Shuquan Liang | 2023 | National Science Review2023，10，10： | 0 |
| 9 | Boosting high initial coulombic efficiency of hard carbon by in-situ electrochemical presodiation显示文摘Hard carbon(HC)is a promising anode material for sodium ion batteries(SIBs),whereas inferior initial coulombic efficiency(ICE)severely limits its practical application.In the present work,we propose an in situ electrochemical presodiation approach to improve ICE by mixing sodium biphenyl(Na-Bp)dimethoxyethane(DME)solution with DME-based ether electrolyte.A solid electrolyte interface(SEI)could be formed beforehand on the HC electrode and Na^(+)was absorbed to nanopores and graphene stacks,compensating for the sodium loss and preventing electrolyte decomposition during the initial charge and discharge cycle.By this way,the ICE of half-cells was increased to nearly 100%and that of full-cells from 45%to 96%with energy density from 132.9 to 230.5 W h kg^(-1).Our work provides an efficient and facile method for improving ICE,which can potentially promote the practical application of HCbased materials. | Nannan Qin Yanyan Sun Chao Hu Sainan Liu Zhigao Luo Xinxin Cao Shuquan Liang Guozhao Fang | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 10 | Single cell RNA and immune repertoire prowling of COVID-19 patients reveal novel neutralizing antibody显示文摘There is no doubt that COVID-19 outbreak is currently the biggest public health threat,which has caused catastrophic con sequences in many countries and regions.As host immunity is key to fighting against virus infection,it is important to characterize the immunologic changes in the COVID-19 patients,and to explore potential therapeutic candidates.The most efficient ways to end this pandemic are to vaccinate the susceptible population,and to use specific drugs,such as monoclonal antibodies against the viral spike protein(S protein),to treat the affected individuals.Several promising neutralizing antibodies have recently been reported(Cao et al.,2020;Lv et al.,2020). | Fang Li Meng Luo Wenyang Zhou Jinliang Li Xiyun Jin Zhaochun Xu Liran Juan Zheng Zhang Yuou Li Renqiang Liu Yiqun Li Chang Xu Kexin Ma Huimin Cao Jingwei Wang Pingping Wang Zhigao Bu Qinghua Jiang | 2021 | Protein & Cell2021，12，10： | 0 |
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