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| 1 | Weekly albumin-bound paclitaxel/cisplatin versus gemcitabine/cisplatin as first-line therapy for patients with advanced non-small-cell lung cancer:A phase II open-label clinical study显示文摘Objective: The aim of this trial was to compare both the efficacy and the safety of a weekly nanoparticle albumin-bound paclitaxel(nab-paclitaxel) plus cisplatin vs. gemcitabine plus cisplatin in patients with advanced non-small-cell lung cancer(NSCLC).Methods: A total of 84 participants received either 100 mg/m^2 nab-paclitaxel each week on d 1, 8 and 15 of a 28 day cycle, as well as cisplatin 75 mg/m^2 on d 1 every three weeks(nab-TP arm); or gemcitabine 1,000 mg/m^2 on d 1 and 8, plus cisplatin 75 mg/m^2 on d 1 every three weeks(GP arm). The primary end point was progression-free survival(PFS). The secondary end points were overall response rate(ORR) and overall survival(OS).Results: According to our analysis, the median PFS was 4.8 months for the nab-TP arm vs. 5.2 months for the GP arm(P=0.55). Analysis showed the median OS was 14.6 months for participants who were in the nab-TP arm vs. 15.1 months for those in the GP arm(P=0.94). Besides, nab-TP showed OS advantages over GP in patients harboring epidermal growth factor receptor(EGFR) mutation(26.7 vs. 15.3 months, P=0.046) and patients with a performance status of 0(23.5 vs. 14.7 months, P=0.020). It was found that incidences of drug-related grade 3 or 4 toxicities were comparable between the two treatment arms.Conclusions: Therefore, it can be seen that weekly nab-TP treatment has a similar efficacy and tolerability to GP treatment for patients who are undergoing their first-line treatment for NSCLC. It could be that survival differences among platinum doublets in the context of both EGFR mutation and performance status have the potential to be the basis for our further clinical trials. | Shanshan Qin Hui Yu Xianghua Wu Zhiguo Luo Huijie Wang Si Sun Mingzhu Huang Jia Jin Zhonghua Tao Jie Qiao Yu Feng Jialei Wang Jianhua Chang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 9 |
| 2 | Development and experimental validation of a novel hybrid powertrain with dual planetary gear sets for transit bus applications显示文摘Given that energy conservation and environmental protection are two important goals for the automotive industry, the application of a hybrid electric powertrain can improve vehicle energy efficiency while decreasing fuel consumption and engine emissions. Planetary gear-based power-split hybrid powertrains have become widely used in passenger vehicles, but remain rarely employed on transit buses. This study proposes a novel hybrid powertrain based on two planetary gear sets(CHS) and presents its operating principles along with development of a control strategy for the powertrain. The CHS hybrid powertrain operates in electric mode when the driving power demand is low, and changes to a hybrid electric mode according to the power-split principle of the planetary gear set. To validate the feasibility of the designed CHS hybrid powertrain, a prototype transit bus equipped with the designed hybrid powertrain system was built, and the operating characteristics of the system were analyzed through a performance test conducted on a chassis dynamometer. Compared with a conventional powertrain, the CHS hybrid powertrain can reduce fuel consumption by 39%. Thus, the CHS hybrid powertrain is a good solution for heavy-duty applications such as hybrid transit buses because of its simple structure and excellent fuel efficiency. | QIN KongJian WANG EnHua ZHAO Hang SHI GuangKui WANG RenGuang KONG ZhiGuo WANG Wei | 2015 | Science China(Technological Sciences)2015，58，12： | 5 |
| 3 | Recent progress in stability of perovskite solar cells显示文摘Perovskite solar cells have attracted significant attention in just the past few years in solar cell research fields,where the power conversion efficiency was beyond 22.1%.Now,the most important challenge for perovskite solar cells in practical applications is the stability issue.In this mini-review,we will summarize the degradation mechanism of perovskite solar cells,including the perovskite material itself and also the interfaces.While we also provide our opinion on improving the stability of perovskite solar cells. | Xiaojun Qin Zhiguo Zhao Yidan Wang Junbo Wu Qi Jiang Jingbi You | 2017 | Journal of Semiconductors2017，38，1： | 4 |
| 4 | Multi-dimensional overall regulatory modes and threshold values for water cycle of the Haihe River Basin显示文摘In this study, a multi-dimensional critical regulatory criteria and decision-making mechanism based on the scientific cognition of multi-dimensional attributes and characteristics of the water cycle was proposed. This system was functioned by deeply discriminating the nature-society binary characteristics of the five-dimensional characteristics of the water cycle system of the Haihe River Basin (water resources, economy, society, ecology, and environment) under the influence of high-intensity human activities and hydrological changes and by analyzing the organic interactive relationships between the five dimensions and their overall effect on the water cycle. A GDP calculation model was constructed in this study by adjusting the water environment for water resources, after which five-dimensional normalization objective functions were established for multi-objective analysis to carry out trade-off analysis of multi-dimensional regulatory indexes. In addition, synergetic theory, entropy theory and dissipation structure theory were introduced to construct an evaluation model for multi-dimensional regulatory schemes. A water cycle multi-dimensional critical overall regulatory model system was also established. This system consisted of a multi-objective macroeconomic model (DAMOS), water resource allocation model based on rules (ROWAS), evaluation model for WEDP (EMW) and multi-dimensional regulatory scheme evaluation model (SEAMUR) as the main body. To address the national demands faced by the Haihe River Basin as a result of combinatorial schemes for different hydrological series and water amounts diverted by the south-to-north water diversion project, this study adopted a hierarchy progression method to set up the technologies, investigated multi-dimensional overall regulatory methods, proposed an overall regulation threshold value for the water cycle of the Haihe River Basin, and recommended corresponding five-dimensional regulatory schemes. | GAN Hong WANG Lin CAO YinBai YOU JinJun GAN ZhiGuo QIN ChangHai HE Shan XU Kai | 2013 | Chinese Science Bulletin2013，58，27： | 4 |
| 5 | All-silica zeolites screening for capture of toxic gases from molecular simulation显示文摘The exhaust gases, including SO_2,NH_3, H_2S, NO_2, NO, and CO, are principal air pollutants due to their severe harms to the ecological environment.Zeolites have been considered as good absorbent candidates to capture the six exhaust gases.In this work, we performed grand canonical ensemble Monte Carlo(GCMC) simulations to examine the capability of 95 kinds of all-silica zeolites in the removal of the six toxic gases, and to predict the adsorption isotherms of the six gases on all the zeolites.The simulation results showed that, H_2S, NO, NO_2, CO and NH_3 are well-captured by zeolite structures with accessible surface area of 1600–1800 m^2·g^(-1) and pore diameter of 0.6–0.7 nm, such as AFY and PAU, while SO_2 is well-adsorbed by zeolites containing larger accessible surface area(1700–2700 m^2·g^(-1)) and pore diameter(0.7–1.4 nm) at room temperature and an atmospheric pressure.However, at saturated adsorption, zeolites RWY, IRR, JSR, TSC, and ITT are found to exhibit better abilities to capture these gases.Our study provides useful computational insights in choosing and designing zeolite structures with high performance to remove toxic gases for air purification, thereby facilitating the development and application of exhaust gas-processing technology in green industry. | Zhiguo Yan Sai Tang Xumiao Zhou Li Yang Xingqing Xiao Houyang Chen Yuanhang Qin Wei Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 4 |
| 6 | Robust key point descriptor for multi-spectral image matching显示文摘Histogram of collinear gradient-enhanced coding(HCGEC), a robust key point descriptor for multi-spectral image matching, is proposed. The HCGEC mainly encodes rough structures within an image and suppresses detailed textural information,which is desirable in multi-spectral image matching. Experiments on two multi-spectral data sets demonstrate that the proposed descriptor can yield significantly better results than some state-ofthe-art descriptors. | Yueming Qin Zhiguo Cao Wen Zhuo Zhenghong Yu | 2014 | Journal of Systems Engineering and Electronics2014，25，4： | 3 |
| 7 | Large-scale preparation of black phosphorus by molten salt method for energy storage显示文摘Black phosphorus(BP)is a new layered material in concept,which has attracted great interest due to its fascinat-ing optical and electrochemical properties.Here,we report the large scale synthesis of BP(20 g)by reducing PCl 5 with metallic Al in melt AlCl 3 at 300°C.X-ray diffraction indicates the orthorhombic structure of BP and Raman spectrum shows that there is no obvious impurities.BP samples consist of micron-sized clusters of about 2μm aggregated by flake-like nanoparticles with 20-100 nm.When used as anode materials for lithium ion battery,it exhibits a high specific capacity of 1610 m Ah g−1 at a current density of 0.1C,and cycle life up to 1000 cycles at a current density of 5C.In addition,through gradient centrifugation of as-prepared BP samples,gram-scale BP quantum dots can be obtained. | Shaojie Zhang Zili Qin Zhiguo Hou Jiajia Ye Zhibin Xu Yitai Qian | 2022 | ChemPhysMater2022，1，1： | 1 |
| 8 | A New Solar Broadband Radio Spectrometer (SBRS) in China显示文摘 | Qijun Fu Huirong Ji Zihai Qin Zhicai Xu Zhiguo Xia Hongao Wu Yuying Liu Yihua Yan Guangli Huang Zhijun Chen Zhenyu Jin Qijun Yao Congling Cheng Fuying Xu Min Wang Libei Pei Shanhuai Chen Guo Yang Chenming Tan Suobiao Shi | 2004 | Solar Physics2004，，1： | 1 |
| 9 | Automatic image-based detection technology for two critical growth stages of maize: Emergence and three-leaf stage显示文摘 | Zhenghong Yu Zhiguo Cao Xi Wu Xiaodong Bai Yueming Qin Wen Zhuo Yang Xiao Xuefen Zhang Hongxi Xue | 2013 | Agricultural and Forest Meteorology2013，，： | 1 |
| 10 | Two-photon absorption in V-type chromophores with electron-rich heterocyclevinylene bridges显示文摘A series of V-type chromophores with electron-rich heterocyclevinylene bridges have been synthesized via Wittig-Horner-Emmons and Vilsmeier reactions.All the target chromophores showed strong one-photon and two-photon excited emission,and their electron properties could be tuned by using different heterocycles such as furan,thiophene and pyrrole moieties in I-III.The maximum two-photon absorption (TPA) cross sections occurred at 760 nm and were measured to be in the range of 400-800 GM. | LI QianQian ZHONG AoShu LIU HaiJie PENG Ming LIU Jun PEI ZhiGuo HUANG ZhenLi QIN JinGui LI Zhen | 2011 | Science China Chemistry2011，54，4： | 1 |
| 11 | Opening the calcium-activatedpotassium channel participates in the cardioprotective effect of puer-arin显示文摘 | Gao Qin Yang Bo Ye Zhiguo | 2007 | European Journal of Pharmacology2007，，574： | 1 |
| 12 | PDE- based unsupervised repair of hair-occluded information in dermoscopy images of melanoma显示文摘 | Xie Fengying Qin Shiyin Jiang Zhiguo | 2009 | Computerized Medi- cal Imaging and Graphics2009，33，： | 1 |
| 13 | Interaction of dietary Bacillus subtilis and fructooligosaccharide on the growth performance, non-specific immunity of sea cucumber, Apostichopus japonicus显示文摘 | Qin Zhang Hongming Ma Kangsen Mai Wenbing Zhang Zhiguo Liufu Wei Xu | 2010 | Fish and Shellfish Immunology2010，，2： | 1 |
| 14 | Interaction of dietary Bacillus subtilis and fructooligosaccharide on the growth performance, non-specific immunity of sea cucumber, Apostichopus japonicus显示文摘 | Qin Zhang Hongming Ma Kangsen Mai Wenbing Zhang Zhiguo Liufu Wei Xu | 2010 | Fish and Shellfish Immunology2010，，2： | 1 |
| 15 | Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice显示文摘 | Haiyan Cheng Jianchun Yu Zhiguo Jiang Xuezhu Zhang Cunzhi Liu Yingmei Peng Fuyan Chen You Qu Yujie Jia Qingfei Tian Chuan Xiao Qin Chu Kun Nie Bohong Kan Xiaolin Hu Jingxian Han | 2007 | Neuroscience Letters2007，，2： | 1 |
| 16 | Polysaccharide hemostatic system for hemostasis management in colorectal endoscopic mucosal resection显示文摘 | Rui Huang Yanglin Pan Na Hui Xuegang Guo Linhui Zhang Xiangping Wang Rongchun Zhang Hui Luo Xiong Zhou Qin Tao Zhiguo Liu Kaichun Wu | 2014 | Digestive Endoscopy2014，，1： | 1 |
| 17 | Characterization of the Convoluted 3D Internetallic Phases in a Recycled Al Alloy by Synchrotron X-ray Tomography and Machine Learning显示文摘Fe-rich intermetallic phases in recycled Al alloys often exhibit complex and 3D convoluted structures and morphologies.They are the common detrimental intermetallic phases to the mechanical properties of recycled Al alloys.In this study,we used synchrotron X-ray tomography to study the true 3D morphologies of the Ferich phases,Al_(2)Cu phases and casting defects in an ascast Al-5Cu-1.5Fe-1Si alloy.Machine learning-based image processing approach was used to recognize and segment the diff erent phases in the 3D tomography image stacks.In the studied condition,theβ-Al_(9)Fe_(2)Si_(2)andω-Al_(7)Cu_(2)Fe are found to be the main Fe-rich intermetallic phases.Theβ-Al_(9)Fe_(2)Si_(2)phases exhibit a spatially connected 3D network structure and morphology which in turn control the 3D spatial distribution of the Al_(2)Cu phases and the shrinkage cavities.The Al_(3)Fe phases formed at the early stage of solidification aff ect to a large extent the structure and morphology of the subsequently formed Fe-rich intermetallic phases.The machine learning method has been demonstrated as a powerful tool for processing big datasets in multidimensional imaging-based materials characterization work. | Zhenhao Li Ling Qin Baisong Guo Junping Yuan Zhiguo Zhang Wei Li Jiawei Mi | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 0 |
| 18 | Impaction of Aggregated Network Traffic on Queueing Performance显示文摘The impaction of aggregated network traffic on queueing system is studied in this paper. It shows that the network traffic stayed in buffer has different impaction on queueing performance when it is aggregated at different scales. And its influence is related not only to traffic parameters but also to system parameter, such as buffer size. The increased buffer size can absorb the effect of short-range dependence (SRD) in network traffic and only the effect of long-range dependence (LRD) is expressed. The queueing length is asymptotic Weibull distribution with increasing buffer size, which is irrespective with the effect of short-range dependence character. Monte-Carlo based simulation confirmed the validity of these results. | RAO Yunhua WEI Cui QIN Ming SUN Lijun ZHAO Cuncheng WANG Zhiguo | 2007 | Wuhan University Journal of Natural Sciences2007，12，2： | 0 |
| 19 | Corrigendum to“Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment”[Bioact.Mater.18C(2022)1-14]显示文摘 | Lei Zhang Zhiguo Qin Han Sun Xiang Chen Jian Dong Siyu Shen Liming Zheng Ning Gu Qing Jiang | 2023 | Bioactive Materials2023，，1： | 0 |
| 20 | Amplitude variation characteristics of active source airgun signals at Qilian Mountain显示文摘In this study,Qilian Mountain active source airgun signals recorded at 79 stations were obtained after stacking waveforms from July 2015 to December 2016.Based on analysis of the amplitude variation characteristics of the airgun signals,the following conclusions were drawn:along the NW-SE fault distribution direction of the Qilian Mountain area,the decrease in amplitude of airgun signals was relatively slow in relation to the epicentral distance,while the decrease in amplitude in the direction perpendicular to the fault was relatively fast.This difference may be related to the energy loss of seismic waves reflecting and scattering by the regional faults mainly distributed along the NW-SE direction,which are caused by tectonic compression of the QinghaiTibet and Alxa blocks. | Xuzhou Liu Yuansheng Zhang Zhiguo Liu Manzhong Qin Rui Zou Xiao Guo | 2021 | Earthquake Science2021，34，2： | 0 |
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