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| 1 | Time resource management of OAR based on fuzzy logic priority for multiple target tracking显示文摘For coping with the multiple target tracking in the presence of complex time-varying environments and unknown target information, a time resource management scheme based on chance-constraint programming(CCP) employing fuzzy logic priority is proposed for opportunistic array radar(OAR). In this scheme,the total beam illuminating time is minimized by effective time resource allocation so that the desired tracking performance is achieved. Meanwhile, owing to the randomness of radar cross section(RCS), the CCP is used to balance tracking accuracy and time resource conditioned on the specified confidence level. The adaptive fuzzy logic prioritization, imitating the human decision-making process for ranking radar targets, can realize the full potential of radar. The Bayesian Crame ′r-Rao lower bound(BCRLB) provides us with a low bound of localization estimation root-mean-square error(RMSE), and equally important, it can be calculated predictively. Consequently, it is employed as an optimization criterion for the time resource allocation scheme. The stochastic simulation is integrated into the genetic algorithm(GA) to compose a hybrid intelligent optimization algorithm to solve the CCP optimization problem. The simulation results show that the time resource is saved strikingly and the radar performance is also improved. | HAN Qinghua PAN Minghai ZHANG Wucai LIANG Zhiheng | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 2 |
| 2 | Author Correction:Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsponwv0wbwwpq6ov9.ffgz.tsg.suse.edu.cn/10.1038/s41422-022-00635-9,published online 10 March 2022 We found that the information in the original Supplementary Figs.S2–S4 was not fully displayed due to an error in the image upload.The correct images are shown below for better display.These corrections do not affect the description of the results or the conclusion of this work.No change of the original figure legends is needed.We apologize for the mistake.The original article has been corrected. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2023 | Cell Research2023，33，7： | 1 |
| 3 | A Perspective on Rhythmic Gymnastics Performance Analysis Powered by Intelligent Fabric显示文摘Performance analysis is an important tool for gymnasts and coaches to assess the techniques,strengths,and weaknesses of rhythmic gymnasts during training.To have an accurate insight about the motion and postures can help the optimization of their performance and offer personalized suggestions.However,there are three primary limitations of traditional perfor-mance analysis systems applied in rhythmic gymnastics:(1)Inability to quantify anthropometric data in an imperceptible way,(2)labor-intensive nature of data labeling and analysis,and(3)lack of monitoring of all-round and multi-dimensional perspectives of the target.Thus,an advanced performance analysis system for rhythmic gymnastics is proposed in this paper,powered by intelligent fabric.The system uses intelligent fabric to detect the physiological and anthropometric data of the gymnasts.After a variety of data are collected,the analysis component is implemented by artificial intelligence techniques resulting in behavior recognition,decision-making,and other functions assisting performance improvement.A feasible solution to implementing the analysis component is the use of the hyperdimensional computing technique.In addition,four typical applications are presented to improve training performance.Powered by intelligent fabric,the proposed advanced performance analysis system exhibits the potential to promote innovative technologies for improving training and competi-tive performance,prolonging athletic careers,as well as reducing sports injuries. | Dan Zhu Zhenyu Zhang Min Chen Pan Li Yuanzhuo Xiang Jingyu Ouyang Zhiheng Huang Xiaojuan Liu Fuhong Wang Maiping Yang Hongtao Zeng Ping Hong Lei Wei Chong Hou Guangming Tao | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 4 | Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry显示文摘The outbreak of coronavirus disease 2019(COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the existence of alternative viral entry pathways. Here, we performed a genome-wide barcoded-CRISPRa screen to identify novel host factors that enable SARS-CoV-2 infection. Beyond known host proteins, i.e., ACE2, TMPRSS2, and NRP1, we identified multiple host components,among which LDLRAD3, TMEM30A, and CLEC4G were confirmed as functional receptors for SARS-CoV-2. All these membrane proteins bind directly to spike’s N-terminal domain(NTD). Their essential and physiological roles have been confirmed in either neuron or liver cells. In particular, LDLRAD3 and CLEC4G mediate SARS-CoV-2 entry and infection in an ACE2-independent fashion. The identification of the novel receptors and entry mechanisms could advance our understanding of the multiorgan tropism of SARS-CoV-2, and may shed light on the development of COVID-19 countermeasures. | Shiyou Zhu Ying Liu Zhuo Zhou Zhiying Zhang Xia Xiao Zhiheng Liu Ang Chen Xiaojing Dong Feng Tian Shihua Chen Yiyuan Xu Chunhui Wang Qiheng Li Xuran Niu Qian Pan Shuo Du Junyu Xiao Jianwei Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 1 |
| 5 | Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘The differences in size and function between primate and rodent brains,and the association of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight the importance to study primate ganglionic eminences(GEs)development.Here we used single-cell RNA and ATAC sequencing to characterize the emergence of cell diversity in monkey and human GEs where most striatal and cortical interneurons are generated.We identified regional and temporal diversity among progenitor cells which give rise to a variety of interneurons.These cells are specified within the primate GEs by well conserved gene regulatory networks,similar to those identified in mice.However,we detected,in human,several novel regulatory pathways or factors involved in the specification and migration of interneurons.Importantly,comparison of progenitors between our human and published mouse GE datasets led to the discovery and confirmation of outer radial glial cells in GEs in human cortex.Our findings reveal both evolutionarily conservative and nonconservative regulatory networks in primate GEs,which may contribute to their larger brain sizes and more complex neural networks compared with mouse. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2022 | Cell Research2022，32，5： | 1 |
| 6 | Intelligent Fast Cell Association Scheme Based on Deep Q-Learning in Ultra-Dense Cellular Networks显示文摘To support dramatically increased traffic loads,communication networks become ultra-dense.Traditional cell association(CA)schemes are timeconsuming,forcing researchers to seek fast schemes.This paper proposes a deep Q-learning based scheme,whose main idea is to train a deep neural network(DNN)to calculate the Q values of all the state-action pairs and the cell holding the maximum Q value is associated.In the training stage,the intelligent agent continuously generates samples through the trial-anderror method to train the DNN until convergence.In the application stage,state vectors of all the users are inputted to the trained DNN to quickly obtain a satisfied CA result of a scenario with the same BS locations and user distribution.Simulations demonstrate that the proposed scheme provides satisfied CA results in a computational time several orders of magnitudes shorter than traditional schemes.Meanwhile,performance metrics,such as capacity and fairness,can be guaranteed. | Jinhua Pan Lusheng Wang Hai Lin Zhiheng Zha Caihong Kai | 2021 | China Communications2021，18，2： | 0 |
| 7 | Geochemical evaluation of phaeozem quality in Northeast China: A case of Dehui County, Jilin Province显示文摘 | Jilong LU Zhiheng PAN Xinmin YU Libo HAO Rongjie BAI Yuyan ZHAO | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 8 | Unambiguous evidence of brilliant iridescent feather color from hollow melanosomes in an Early Cretaceous bird显示文摘Various plumage colors are roughly produced by pigment-based colors and structural colors[1,2].Brilliant iridescent plumage colors(in which the color changes depending on the reflectance spectra of sunlight at different viewing angles)greatly expand the range of plumage colors and create colors unachievable by plants or other animals[1]. | Yanhong Pan Zhiheng Li Min Wang Tao Zhao Xiaoli Wang Xiaoting Zheng | 2022 | National Science Review2022，9，2： | 0 |
| 9 | HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation显示文摘Ultra-stable fibrous structure is a hallmark of amyloids.In contrast to canonical disease-related amyloids,emerging research indicates that a significant number of cellular amyloids,termed‘functional amyloids’,contribute to signal transduction as temporal signaling hubs in humans.However,it is unclear how these functional amyloids are effectively disassembled to terminate signal transduction.RHIM motif-containing amyloids,the largest functional amyloid family discovered thus far,play an important role in mediating necroptosis signal transduction in mammalian cells.Here,we identify heat shock protein family A member 8(HSPA8)as a new type of enzyme—which we name as‘amyloidase’—that directly disassembles RHIM-amyloids to inhibit necroptosis signaling in cells and mice.Different from its role in chaperone-mediated autophagy where it selects substrates containing a KFERQ-like motif,HSPA8 specifically recognizes RHIM-containing proteins through a hydrophobic hexapeptide motif N(X_(1))φ(X_(3)).The SBD domain of HSPA8 interacts with RHIM-containing proteins,preventing proximate RHIM monomers from stacking into functional fibrils;furthermore,with the NBD domain supplying energy via ATP hydrolysis,HSPA8 breaks down pre-formed RHIM-amyloids into non-functional monomers.Notably,HSPA8’s amyloidase activity in disassembling functional RHIM-amyloids does not require its co-chaperone system.Using this amyloidase activity,HSPA8 reverses the initiator RHIM-amyloids(formed by RIP1,ZBP1,and TRIF)to prevent necroptosis initiation,and reverses RIP3-amyloid to prevent necroptosis execution,thus eliminating multi-level RHIM-amyloids to effectively prevent spontaneous necroptosis activation.The discovery that HSPA8 acts as an amyloidase dismantling functional amyloids provides a fundamental understanding of the reversibility nature of functional amyloids,a property distinguishing them from disease-related amyloids that are unbreakable in vivo. | Erpeng Wu Wenyan He Chenlu Wu Zhangcheng Chen Shijie Zhou Xialian Wu Zhiheng Hu Kelong Jia Jiasong Pan Limin Wang Jie Qin Dan Liu Junxia Lu Huayi Wang Jixi Li Sheng Wang Liming Sun | 2023 | Cell Research2023，33，11： | 0 |
| 10 | 青蒿不同溶剂萃取粗提物对结肠癌HT-29、Lovo细胞NF-κB活性的影响(英文)显示文摘Objective: To study changes of NF-κB activity in colon carcinoma cell lines treated with different crude extracts of abrotani herba obtained through solvent extraction methods. Methods: Crude extracts of abrotani herba were extracted with ligarine, chloroform, acetoacetate and n-butanol in separating funnel. Exposure concentration of crude extracts were obtained through detecting viability of HT-29 cells by MTT. Then HT-29 cells and Lovo cells were treated with different crude extracts respectively. Changes of NF-κB activity in HT-29 cells and Lovo cells using different crude extracts were observed by EMSA. Results: Successfully extracted different crude extracts of abrotani herba and called them ligarine extract, chloroform extract, acetoacetate extract, n-butanol extract and remaining extract for short. NF-κB activity was significantly inhibited in HT-29 cells treated with chloroform extract, there were no significant differences in other groups compared with the control. The same change of NF-κB activity was observed in Lovo cells using different crude extracts of abrotani herba. Conclusion: NF-κB activity can be inhibited in colon carcinoma HT-29 cells and Lovo cells treated with chloroform extract obtained from abrotani herba through the method of solvent extraction. | Feng Pan Yuying Chen Li Yang Zhiheng Bian Houjie Liang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，8： | 0 |
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