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| 1 | Evaluation of contrast-enhanced ultrasound for diagnosis of dysplastic nodules with a focus of hepatocellular carcinoma in liver cirrhosis patients显示文摘Objective: To compare the enhancement features of dysplastic nodules with a focus of hepatocellular carcinoma(DN-HCC) versus HCC and regenerative nodules(RN) in cirrhotic patients.Methods: One hundred and ninety-three cirrhotic patients were enrolled in this study; they had 215 focal liver lesions, 1.0-3.5 cm in size, which were examined using contrast-enhanced ultrasound(CEUS) with Sono Vue?and diagnosed as HCC, RN or DN-HCC by biopsy. Samples were obtained using 18-gauge needles in the different enhanced areas. The enhancement features of DN-HCC, HCC and RN were evaluated.Results: There were 86 HCC lesions, 102 RN lesions, and 27 DN-HCC lesions diagnosed by biopsy. Of 86 HCC lesions, 87.2%(75/86) showed complete enhancement during the arterial phase, and 12.8%(11/86) had inhomogeneous enhancement, with no enhancement in the central area during the arterial phase; 100%(86/86) exhibited washout during the late phase. Of 102 RN lesions, 95.1%(97/102) had delayed or simultaneous enhancement during the arterial phase, and 4.9%(5/102) displayed slight enhancement during the arterial phase; 26.5%(27/102) exhibited washout and 73.5%(75/102) exhibited no washout during the late phase. In 27 DN-HCC lesions, only part of the lesions enhanced during the arterial phase and washed out during the late phase; the other areas had delayed or simultaneous enhancement during the arterial phase, and 29.6%(8/27) exhibited slight washout in the late phase. In 86 HCCs, the pathological feature was HCC in the enhanced area of 75 lesions, hepatocellular fatty degeneration in the slightly enhanced area of 7 lesions, and hepatocellular necrosis in the unenhanced area and HCC in the enhanced area of 4 lesions. In 102 RNs, the pathological diagnosis was hepatocyte proliferation with or without fatty degeneration. In 27 DN-HCCs, the pathological feature was HCC in the enhanced area and hepatocyte regeneration in the unenhanced area.Conclusions: CEUS is useful for the diagnosis of focal liver lesions in cirrhotic patients. CEUS can help determine the progression from RN to DN-HCC to HCC by analyzing the hemodynamics. CEUS can promote the diagnostic accuracy of a biopsy by providing more accurate information on the site of the biopsy. | Wei Wu Minhua Chen Kun Yan Yin Dai Shanshan Yin Wei Yang Zhihui Fan | 2015 | Chinese Journal of Cancer Research2015，27，1： | 15 |
| 2 | Effect of Zn addition on microstructure and mechanical properties of an Al–Mg–Si alloy显示文摘In the present work, an Al–0.66Mg–0.85Si–0.2Cu alloy with Zn addition was investigated by electron back scattering diffraction(EBSD), high resolution electron microscopy(HREM), tensile and Erichsen tests. The mechanical properties of the alloy after pre-aging met the standards of sheet forming. After paint baking, the yield strength of the alloy was improved apparently. GP(Ⅱ) zones and η'phases were formed during aging process due to Zn addition. With the precipitation of GP zones, β″ phases, GP(Ⅱ) zones and η'phases, the alloys displayed excellent mechanical properties. | Lizhen Yan Yongan Zhang Xiwu Li Zhihui Li Feng Wang Hongwei Liu Baiqing Xiong | 2014 | Progress in Natural Science:Materials International2014，24，2： | 13 |
| 3 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 4 | Analysis of the dynamic performance of an electro-hydrostatic actuator and improvement methods显示文摘As a kind of actuation mechanism for power-by-wire(PBW) actuation systems of more/all electrical aircraft, an electro-hydrostatic actuator(EHA) is a highly integrated local hydraulic actuation system. It is a volume control system consisting of a motor, a pump, an actuator, etc.,which has features of high efficiency and reliability. However, the poor dynamic characteristic is one of the main factors restricting its wide application in aircraft. In this paper, the reason for the poor dynamic characteristic of an EHA is revealed from the perspectives of the natural frequency characteristic and the power requirement, respectively. In other words, the insufficiency of the motor output power at a high frequency is the main factor causing the poor dynamic characteristic of the system, and methods which include increasing the maximum output torque of the motor, reducing the rotational inertia of the motor-pump group, and adopting a double-motorpump group configuration are proposed in this paper, by which the dynamic characteristic of the system can be improved. The feasibility of those methods are verified by simulations. Finally, the dynamic characteristic is tested on an EHA prototype, and results show that saturation of the output torque of the motor is the main factor restricting the dynamic characteristic of the EHA system. | Zhihui LI Yaoxing SHANG Zongxia JIAO Yan LIN Shuai WU Xiaobin LI | 2018 | Chinese Journal of Aeronautics2018，31，12： | 9 |
| 5 | Generation of seed lipoxygenase-free soybean using CRISPR-Cas9显示文摘Beany flavor induced by three lipoxygenases(LOXs, including LOX1, LOX2, and LOX3)restricts human consumption of soybean. It is desirable to generate lipoxygenase-free new mutant lines to improve the eating quality of soybean oil and protein products. In this study, a pooled clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPRassociated protein 9(Cas9) strategy targeting three GmLox genes(GmLox1, GmLox2, and GmLox3) was applied and 60 T_0 positive transgenic plants were generated, carrying combinations of sg RNAs and mutations. Among them, GmLox-28 and GmLox-60 were gmlox1 gmlox2 gmlox3 triple mutants and GmLox-40 was a gmlox1 gmlox2 double mutant.Sequencing of T_1 mutant plants derived from GmLox-28, GmLox-60, and GmLox-40 showed that mutation in the GmLox gene was inherited by the next generation. Colorimetric assay revealed that plants carrying different combinations of mutations lost the corresponding lipoxygenase activities. Transgene-free mutants were obtained by screening the T_2 generation of lipoxygenase-free mutant lines(GmLox-28 and GmLox-60). These transgeneand lipoxygenase-free mutants could be used for soybean beany flavor reduction without restriction by regulatory frameworks governing transgenic organisms. | Jie Wang Huaqin Kuang Zhihui Zhang Yongqing Yang Long Yan Mengchen Zhang Shikui Song Yuefeng Guan | 2020 | The Crop Journal2020，8，3： | 9 |
| 6 | Research progress of gut flora in improving human wellness显示文摘Human wellness is the ultimate goal of our efforts in improving the human life.Special foods are undoubtedly important in achieving human wellness.However,overeating significantly leads to obesity and diabetes.These chronic diseases will in turn affect the human wellness.Therefore,“dietary restriction and proper exercise”were introduced in the human daily life.Different foods cause various effects on the human health.The diversification of diet is a priority for nutritionists to keep our body healthy.To avoid diabetes mellitus,special foods for ketogenic diet,low-carbon diet,and low-calorie intake are also gradually attracting attention.In addition,the hypothesis that“hunger sensation comes from gut flora”brings new light to the research on the biological motivation for humans to eat food.This hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods,such as plant polysaccharides and dietary fibers.The response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human wellness.The gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our body.Therefore,“gut flora priority principle”is developed to guarantee human wellness.The 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora,which may guide us to a new era of human wellness based on gut flora wellness. | Chenggang Zhang Wenjing Gong Zhihui Li Dawen Gao Yan Gao | 2019 | Food Science and Human Wellness2019，8，2： | 8 |
| 7 | The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients显示文摘 | Lihong Cui Chao Li Xiaohui Wang Zhihui Yan Xing He Sandong Gong | 2015 | Chinese Journal of Traumatology2015，18，1： | 7 |
| 8 | Imaging and clinical properties of inflammatory demyelinating pseudotumor in the spinal cord显示文摘Inflammatory demyelinating pseudotumor usually occurs in the brain and rarely occurs in the spinal cord.On imaging,inflammatory demyelinating pseudotumor appears very similar to intramedullary tumors such as gliomas.It is often misdiagnosed as intramedullary tumor and surgically resected.In view of this,the clinical and magnetic resonance imaging manifestations and the pathological features of 36 cases of inflammatory demyelinating pseudotumor in the spinal cord were retrospectively analyzed and summarized.Most of these cases suffered from acute or subacute onset and exhibited a sensorimotor disorder.Among them,six cases were misdiagnosed as having intramedullary gliomas,and inflammatory demyelinating pseudotumor was only identified and pathologically confirmed after surgical resection.Lesions in the cervical and thoracic spinal cord were common.Magnetic resonance imaging revealed edema and space-occupying lesions to varying degrees at the cervical-thoracic junction,with a predominant feature of non-closed rosette-like reinforcement(open-loop sign).Pathological examination showed perivascular cuffing of predominantly dense lymphocytes,and demyelination was observed in six of the misdiagnosed cases.These results suggest that tumor-like inflammatory demyelinating disease in the spinal cord is a kind of special demyelinating disease that can be categorized as inflammatory pseudotumor.These solitary lesions are easily confused with intramedullary neoplasms.Patchy or non-closed reinforcement(open-ring sign)on magnetic resonance imaging is the predominant property of inflammatory demyelinating pseudotumor,and inflammatory cell infiltration and demyelination are additional pathological properties. | Ying Wang Min Wang Hui Liang Quntao Yu Zhihui Yan Min Kong | 2013 | Neural Regeneration Research2013，8，26： | 5 |
| 9 | Biofilm structure and its influence on clogging in drip irrigation emitters distributing reclaimed wastewater显示文摘Using reclaimed wastewater for crop irrigation is a practical alternative to discharge wastewater treatment plant effluents into surface waters.However,biofouling has been identified as a major contributor to emitter clogging in drip irrigation systems distributing reclaimed wastewater.Little is known about the biofilm structure and its influence on clogging in the drip emitter flow path.This study was first to investigate the microbial characteristics of mature biofilms present in the emitters and the effect of flow path structures on the biofilm microbial communities.The analysis of biofilm matrix structure using a scanning electron microscopy(SEM) revealed that particles in the matrix of the biofilm coupled extracellular polysaccharides(EPS) and formed sediment in the emitter flow path.Analysis of biofilm mass including protein,polysaccharide,and phospholipid fatty acids(PLFAs) showed that emitter flow path style influenced biofilm community structure and diversity.The correlations of biofilm biomass and discharge reduction after 360 h irrigation were computed and suggest that PFLAs provide the best correlation coeffcient.Comparatively,the emitter with the unsymmetrical dentate structure and shorter flow path(Emitter C) had the best anti-clogging capability.By optimizing the dentate structure,the internal flow pattern within the flow path could be enhanced as an important method to control the biofilm within emitter flow path.This study established electron microscope techniques and biochemical microbial analysis methods that may provide a framework for future emitter biofilm studies. | YAN Dazhuang BAI Zhihui Mike Rowan GU Likun Ren Shumei YANG Peiling | 2009 | Journal of Environmental Sciences2009，21，6： | 4 |
| 10 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 11 | Experimental and numerical simulation of bird-strike performance of lattice-material-infilled curved plate显示文摘The anti-bird-strike performance of a lattice-material-infilled curved plate is investigated herein.Since automatically filling the curved structure by classical lattice material filling methods will cause a large number of manufacturing defects,a space-dependent lattice material filling method for the curved plate is firstly proposed in this paper Next,using a face-centered cubic lattice,a lattice-material-infilled test piece with a hollow ratio of 40.8%is built.The test pieces are manufactured via additive manufacturing using titanium alloy.In bird-strike experimental tests,the test pieces are crashed against gelatin birds at an impact velocity of 200 m/s.Dynamic strain gauges are used to record the crash history and the results are discussed.Furthermore,a numerical analysis to simulate the bird-strike experiment is performed.The results from the experimental tests and numerical simulation agree well.This work shows that the lattice-material-infilled curved plate yields promising bird-strike resistance.Therefore,lattice-infilled materials are feasible for protecting aerospace components against bird-strike as well as for reducing the component weight. | Jun YAN Chenguang ZHANG Sixu HUO Xianghai CHAI Zhihui LIU Kun YAN | 2021 | Chinese Journal of Aeronautics2021，34，8： | 4 |
| 12 | Pre-aging on early-age behavior and bake hardening response of an Al-0.90Mg-0.80Si-0.64Zn-0.23Cu alloy显示文摘Pre-aging on early-age behavior and bake hardening response of an Al-0.90Mg-0.80Si-0.64 Zn alloy was investigated by differential scanning calorimetry(DSC), high resolution transmission electron microscopy(HRTEM), 3-dimensional atom probe(3DAP), Erichsen test and tensile test. The results indicated that pre-aged alloy exhibited excellent formability and bake-hardening response, while bake hardening response was poor in samples with natural aging. Clustering behavior during natural aging was inhibited by pre-aging. Numerous GP zones formed in pre-aged samples. GP zones were the nuclei of β′′ precipitates or directly transformed β′′ phases during paint baking process. A large number of β′′ phases were observed in pre-aged samples after paint bake treatment. There was no sign to indicate that β′′phase precipitated in natural aged samples after bake hardening treatment. | Lizhen Yan Zhihui Li Yong-an Zhang Baiqing Xiong Xiwu Li Hongwei Liu Shuhui Huang Hongwei Yan | 2016 | Progress in Natural Science:Materials International2016，26，4： | 4 |
| 13 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 14 | Quantum network based on non-classical light显示文摘Quantum network enables quantum communication among quantum nodes and provides advantages that are unavailable in any classical network.Based on rapidly developing science and technology in quantum communication,the studies on quantum network have also made important progresses recent years.In this study,we briefly review the experimental progresses in building quantum network based on optical field and discuss the challenges toward a quantum Internet. | Xiaolong SU Meihong WANG Zhihui YAN Xiaojun JIA Changde XIE Kunchi PENG | 2020 | Science China(Information Sciences)2020，63，8： | 3 |
| 15 | Magnetic coupling engineered porous dielectric carbon within ultralow filler loading toward tunable and high-performance microwave absorption显示文摘Developing microwave absorption(MA)materials with satisfied comprehensive performance is a great challenge for tackling severe electromagnetic pollution.In particular,the magnetic component/carbon hybrids absorbers always suffer from high filler loading.Herein,we propose a feasible strategy to construct hierarchical porous carbon with tightly embedded Ni nanoparticles(Ni@NPC).These highly dispersed Ni nanoparticles produce strong magnetic coupling networks to enhance magnetic loss abilities.Moreover,the interconnected hierarchical dielectric carbon network affords favorable dipolar/interfacial polarization,conduction loss,multiple reflection and scattering.Impressively,with an ultralow filler loading of 5 wt.%,the resultant Ni@NPC/paraffin composite achieves an excellent MA performance with a minimum reflection loss of as high as-72.4 dB and a broad absorption bandwidth of 5.0 GHz.This capability outperforms most current magnetic-dielectric hybrids counterparts.Furthermore,the MA capacity can be easily tuned with adjustments in thickness,content and type of magnetic material.Thus,this work opens up new avenues for the development of high-performance and lightweight MA materials. | Wang Yang Bo Jiang Zhihui Liu Rui Li Liqiang Hou Zhengxuan Li Yongli Duan Xingru Yan Fan Yang Yongfeng Li | 2021 | Journal of Materials Science & Technology2021，，11： | 3 |
| 16 | Modulating effects of RAMPs on signaling profiles of the glucagon receptor family显示文摘Receptor activity-modulating proteins(RAMPs)are accessory molecules that form complexes with specific G protein-coupled receptors(GPCRs)and modulate their functions.It is established that RAMP interacts with the glucagon receptor family of GPCRs but the underlying mechanism is poorly understood.In this study,we used a bioluminescence resonance energy transfer(BRET)approach to comprehensively investigate such interactions.In conjunction with c AMP accumulation,Gaqactivation andβ-arrestin1/2 recruitment assays,we not only verified the GPCR-RAMP pairs previously reported,but also identified new patterns of GPCR-RAMP interaction.While RAMP1 was able to modify the three signaling events elicited by both glucagon receptor(GCGR)and glucagon-like peptide-1 receptor(GLP-1 R),and RAMP2 mainly affectedβ-arrestin1/2 recruitment by GCGR,GLP-1 R and glucagon-like peptide-2 receptor,RAMP3 showed a widespread negative impact on all the family members except for growth hormone-releasing hormone receptor covering the three pathways.Our results suggest that RAMP modulates both G protein dependent and independent signal transduction among the glucagon receptor family members in a receptor-specific manner.Mapping such interactions provides new insights into the role of RAMP in ligand recognition and receptor activation. | Lijun Shao Yan Chen Shikai Zhang Zhihui Zhang Yongbing Cao Dehua Yang Ming-Wei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 17 | Wind power time series simulation model based on typical daily output processes and Markov algorithm显示文摘The simulation of wind power time series is a key process in renewable power allocation planning,operation mode calculation,and safety assessment.Traditional single-point modeling methods discretely generate wind power at each moment;however,they ignore the daily output characteristics and are unable to consider both modeling accuracy and efficiency.To resolve this problem,a wind power time series simulation model based on typical daily output processes and Markov algorithm is proposed.First,a typical daily output process classification method based on time series similarity and modified K-means clustering algorithm is presented.Second,considering the typical daily output processes as status variables,a wind power time series simulation model based on Markov algorithm is constructed.Finally,a case is analyzed based on the measured data of a wind farm in China.The proposed model is then compared with traditional methods to verify its effectiveness and applicability.The comparison results indicate that the statistical characteristics,probability distributions,and autocorrelation characteristics of the wind power time series generated by the proposed model are better than those of the traditional methods.Moreover,modeling efficiency considerably improves. | Zhihui Cong Yuecong Yu Linyan Li Jie Yan | 2022 | Global Energy Interconnection2022，5，1： | 2 |
| 18 | Thermal Cycling Effect on the Wear Resistance of Bionic Laser Processed Gray Iron显示文摘 | Hong Zhou Peng Zhang Zhihui Zhang Wenjun Qiu Yan Liu Luquan Ren | 2014 | Journal of Bionic Engineering2014，11，2： | 2 |
| 19 | The salt-activated CBF1/CBF2/CBF3-GALS1 module fine-tunes galactan-induced salt hypersensitivity in Arabidopsis显示文摘Plant growth and development are significantly hampered in saline environments,limiting agricultural productivity.Thus,it is crucial to unravel the mechanism underlying plant responses to salt stress.β-1,4-Galactan(galactan),which forms the side chains of pectic rhamnogalacturonan I,enhances plant sensitivity to high-salt stress.Galactan is synthesized by GALACTAN SYNTHASE1(GALS1).We previously showed that Na Cl relieves the direct suppression of GALS1 transcription by the transcription factors BPC1 and BPC2 to induce the excess accumulation of galactan in Arabidopsis(Arabidopsis thaliana).However,how plants adapt to this unfavorable environment remains unclear.Here,we determined that the transcription factors CBF1,CBF2,and CBF3 directly interact with the GALS1 promoter and repress its expression,leading to reduced galactan accumulation and enhanced salt tolerance.Salt stress enhances the binding of CBF1/CBF2/CBF3 to the GALS1 promoter by inducing CBF1/CBF2/CBF3 transcription and accumulation.Genetic analysis suggested that CBF1/CBF2/CBF3 function upstream of GALS1 to modulate salt-induced galactan biosynthesis and the salt response.CBF1/CBF2/CBF3 and BPC1/BPC2 function in parallel to regulate GALS1 expression,thereby modulating the salt response.Our results reveal a mechanism in which salt-activated CBF1/CBF2/CBF3 inhibit BPC1/BPC2-regulated GALS1 expression to alleviate galactan-induced salt hypersensitivity,providing an activation/deactivation fine-tune mechanism for dynamic regulation of GALS1 expression under salt stress in Arabidopsis. | Jingwei Yan Ya Liu Jiawen Yan Zhihui Liu Heqiang Lou Jiasheng Wu | 2023 | Journal of Integrative Plant Biology2023，65，8： | 2 |
| 20 | Vibration con- trol in thin slab hot strip mills显示文摘 | Yan Xiaoqiang Sun Zhihui Chen Wei | 2011 | Iron Making and Steelmaking2011，38，4： | 1 |
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