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| 1 | New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。 | Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 45 |
| 2 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 3 | Adoptive cell transfer therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma? Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research. | Renyu Zhang Zhao Zhang Zekun Liu Ding Wei Xiaodong Wu Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 17 |
| 4 | Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy显示文摘Lung cancer is the most common incident cancer and the leading cause of cancer death. In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-T) cell has shown a promising future. Epidermal growth factor receptor variant III (EGFRvlll) is a tumor-specific mutation expressed in various types of tumors and has been detected in non-small cell lung cancer with a mutation rate of 10%. Thus, EGFRvIII is a potential antigen for targeted lung cancer therapy. In this study, CAR vectors were constructed and transfected into virus-packaging cells. Then, activated T cells were infected with retrovirus harvested from stable virus-producing single clone cell lines. CAR expression on the surfaces of the T cells was detected by flow cytometry and Western blot. The function of CAR-T targeting EGFRvIII was then evaluated. The EGFRvIII-CAR vector was successfully constructed and confirmed by DNA sequencing. A stable virus-producing cell line was produced from a single clone by limited dilution. The culture conditions for the cell line, including cell density, temperature, and culture medium were optimized. After infection with retrovirus, CAR was expressed on more than 90% of the T cells. The proliferation of CAR-T cells were induced by cytokine and specific antigen in vitro. More importantly, EGFRvIII-CART specifically and efficiently recognized and killed A549-EGFRvIII cells with an effector/target ratio of 10:1 by expressing and releasing cytokines, including perforin, granzyme B, IFN-γ, and TNF-α. The in vivo study indicated that the metastasis of A549-EGFRvIII cells in mice were inhibited by EGFRvIII-CART cells, and the survival of the mice was significantly prolonged with no serious side effects. EGFRvIII-CART showed significantly efficient antitumor activity against lung cancer cells expressing EGFRvlll in vivo and in vitro. Therefore, CAR-T targeting EGFRvIII is a potential therapeutic strategy in preventing recurrence and metastasis of lung cancer after surgery. | Zhao Zhang Jun Jiang Xiaodong Wu Mengyao Zhang Dan Luo Renyu Zhang Shiyou Li Youwen He Huijie Bian Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 11 |
| 5 | reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs显示文摘气喘的发炎被一种类型调停 2 助手 T 房间(Th2 ) cytokine 反应,和堵住的 Th2 cytokine 生产被证明有一个有势力治疗学对气喘的发炎的效果。用 IL-4-green 荧光灯蛋白质(GFP ) 记者老鼠,我们表明了那 Bavachinin,从中国植物孤立的单个混合物,显著地禁止的 Th2 cytokine 生产包括 IL-4, IL-5 和 IL-13。尤其是,在 ovalbumin (卵) 的这复合几乎完全堵住的发炎敏化动物气喘模型。而且,我们证明这化学药品有选择地影响 GATA-3 的水平,由影响 GATA-3 mRNA 的稳定性最可能。第一次,我们的结果证明这单个混合物的潜在的治疗学的价值源于中国植物。 | Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang Richard Flavell Shumei Gao Min Wang Zhinan Yin | 2013 | Cellular & Molecular Immunology2013，10，6： | 9 |
| 6 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 7 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 8 | Tribo-informatics:Concept,architecture,and case study显示文摘Friction plays a vital role in energy dissipation,device failure,and even energy supply in modern society.After years of research,data and information on tribology research are becoming increasingly available.Because of the strong systematic and multi-disciplinary coupling characteristics of tribology,tribology information is scattered in various disciplines with different patterns,e.g.,technical documents,databases,and papers,thereby increasing the information entropy of the system,which is inconducive to the preservation and circulation of research information.With the development of computer and information science and technology,many subjects have begun to be combined with information technology,and multi-disciplinary informatics has been born.This paper describes the combination of information technology with tribology research,presenting the connotation and architecture of tribo-informatics,and providing a case study on implementing the proposed concept and architecture.The proposal and development of tribo-informatics described herein will improve the research efficiency and optimize the research process of tribology,which is of considerable significance to the development of this field. | Zhinan ZHANG Nian YIN Shi CHEN Chengliang LIU | 2021 | Friction2021，9，3： | 5 |
| 9 | Deformation mode-determined misorientation and microstructural characteristics in rolled pure Zr sheet显示文摘In this work, commercially pure Zr sheets were subjected to β air cooling and then rolled to different reductions(10% and 50%)at room temperature. Microstructures of both the β-air-cooled and the rolled specimens were well characterized by electron channelling contrast imaging and electron backscatter diffraction techniques, with special attentions paid to their misorientation characteristics. Results show that the β-air-cooled specimen owns a Widmanst?tten structure featured by lamellar grains with typical phase transformation misorientations. The 10% rolling allows prismatic slip and tensile twinning({11-21}<11-2-6> and{10-12}<10-11>) to be activated profusely, which produce new low-angle(~3°–5°) and high-angle(~35° and ~85°) misorientation peaks, respectively. After increasing the rolling reduction to 50%, twinning is suppressed and dislocation slip becomes the dominant deformation mode, with the lamellar grains highly elongated and aligned towards the rolling direction.Meanwhile, only one strong low-angle misorientation peak related to the prismatic slip is presented in the 50%-rolled specimen,with all other peaks disappeared. Analyses on local misorientations reveal that hardly any residual strains exist in the β-air-cooled specimen, which should be related to their sufficient relaxation during slow cooling. Residual strains introduced by 10% rolling are heterogeneously distributed near grain/twin boundaries while heavier deformation(50% rolling) produces much larger residual strains pervasively existing throughout the specimen microstructure. | CHAI LinJiang XIA JiYing ZHI Yan GOU YinNing CHEN LiangYu YANG ZhiNan GUO Ning | 2018 | Science China(Technological Sciences)2018，61，9： | 3 |
| 10 | Application of microcalorimetry of Escherichia coli growth and discrimin antanalysis to the quality assessment of a Chinese herbal injection(Yinzhihuang)显示文摘This paper describes a novel approach to the quality control of a Chinese herbal injection based on microca lorimetric determination of its effect on the biothermal active fingerprint(BTAF)of Escherichia coli(E.coli)growth.Yinzhihuang Injection(YZHI)was selected for this proof of concept study.Reference samples of Y ZHI were collected and compared with test(stressed)samples prepared under different stress conditions.The BTAF of E.coli growth was found to be affected by YZHI and the changes were analyzed on the basis of eleven biothermokinetic parameters.Similarity and multivariate statistical analysis were used to investi-gate the differences between reference and test samples and discriminant analysis was used to delineate the altered samples.Reference samples were found to have coincident BTAFs with similarity index>0.99.Stressed samples showed differences in the BTAF which increased in line with decreased quality.Discriminant formulae were developed based on a sensitivity parameter which could identify all altered samples.In conclusion,BTAF can be used to assess the quality of YZHI both qualitatively and quantitatively and has the potential to provide a sensitive method for quality control of Chinese herbal injections. | Yongshen Ren Ping Zhang Dan Yan Yan Yan Longhu Chen Lingling Qiu Zhinan Mei Xiaohe Xiao | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 3 |
| 11 | Spatial variations in the trophic status of Favia palauensis corals in the South China Sea:Insights into their different adaptabilities under contrasting environmental conditions显示文摘Scleractinian corals exhibit a dual trophic pattern of autotrophic photosynthesis and heterotrophic predation.However,whether corals can adjust their trophic status under contrasting environmental conditions remains unclear.In our study,70 scleractinian corals(Favia palauensis)were collected from Sanya and the Xisha and Nansha Islands in the South China Sea.We measured the zooxanthellae density(ZD)andδ^(13)C of zooxanthellae(δ^(13)C_(z))and host tissue(δ^(13)C_(h))and analyzed the difference betweenδ^(13)C_(h) andδ^(13)C_(z)(i.e.,△^(h-z)^(13)C).The relatively high ZD andδ^(13)C_(z) values in the samples from Sanya indicate that these corals might have higher photosynthetic rates and autotrophic abilities than those from Xisha and Nansha.In contrast,the relatively lowδ^(13)C_(h) and△^(h-z)^(13)C values in the samples from Xisha and Nansha suggest that these corals might have a higher heterotrophic ability than those from Sanya.In addition,we tested the coral tissue biomass and skeletalδ^(13)C(δ^(13)C_(s))in the samples from Sanya and examined their correlations with△^(h-z)^(13)C.The results showed a negative correlation,indicating that the more the organic material produced by the coral,the stronger its heterotrophic ability.Our results show that corals can adjust their trophic status under different environmental and physiological conditions,which is essential for increasing their adaptability to different environmental conditions. | Shendong XU Zhinan ZHANG Kefu YU Xueyong HUANG Hanji CHEN Zhenjun QIN Risheng LIANG | 2021 | Science China Earth Sciences2021，64，6： | 2 |
| 12 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 13 | Biologically Inspired Design of Context-Aware Smart Products显示文摘The rapid development of information and communication technologies(ICTs)and cyber-physical systems(CPSs)has paved the way for the increasing popularity of smart products.Context-awareness is an important facet of product smartness.Unlike artifacts,various bio-systems are naturally characterized by their extraordinary context-awareness.Biologically inspired design(BID)is one of the most commonly employed design strategies.However,few studies have examined the BID of context-aware smart products to date.This paper presents a structured design framework to support the BID of context-aware smart products.The meaning of context-awareness is defined from the perspective of product design.The framework is developed based on the theoretical foundations of the situated function-behavior-structure ontology.A structured design process is prescribed to leverage various biological inspirations in order to support different conceptual design activities,such as problem formulation,structure reformulation,behavior reformulation,and function reformulation.Some existing design methods and emerging design tools are incorporated into the framework.A case study is presented to showcase how this framework can be followed to redesign a robot vacuum cleaner and make it more context-aware. | Ang Liu Ivan Teo Diandi Chen Stephen Lu Thorsten Wuest Zhinan Zhang Fei Tao | 2019 | Engineering2019，5，4： | 2 |
| 14 | Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients显示文摘Immunotherapy has limited efficacy against locally advanced pancreatic cancer(LAPC)due to the presence of an immunosuppressive microenvironment(ISM).Irreversible electroporation(IRE)can not only induce immunogenic cell death,but also alleviate immunosuppression.This study aimed to investigate the antitumor efficacy of IRE plus allogeneicγδT cells in LAPC patients.A total of 62 patients who met the eligibility criteria were enrolled in this trial,then randomized into two groups(A:n=30 and B:n=32).All patients received IRE therapy and after receiving IRE,the group A patients received at least two cycles ofγδT-cell infusion as one course continuously.Group A patients had better survival than group B patients(median OS:14.5 months vs.11 months;median PFS:11 months vs.8.5 months).Moreover,the group A patients treated with multiple courses ofγδT-cell infusion had longer OS(17 months)than those who received a single course(13.5 months).IRE combined with allogeneicγδT-cell infusion is a promising strategy to enhance the antitumor efficacy in LAPC patients,yielding extended survival benefits. | Mao Lin Xiaoyan Zhang Shuzhen Liang Haihua Luo Mohammed Alnaggar Aihua Liu Zhinan Yin Jibing Chen Lizhi Niu Yong Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 15 | Adsorption and desorption behaviors of S-adenosyl-L-methionine in a fixedbed ion-exchange column显示文摘 | Xu Zhinan Chen Yong Shen Wenhe | 2006 | The Korean Journal of Chemical Engineering2006，23，1： | 1 |
| 16 | Solid lipid nanoparticle and microemulsion for topical delivery of triptolide显示文摘 | Zhinan Mei Huabing Chen Ting Weng Yajiang Yang Xiangliang Yang | 2003 | European Journal of Pharmaceutics and Biopharmaceutics2003，，2： | 1 |
| 17 | GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis显示文摘 | Jinliang Xing Ronald E. Myers Xianli He Falin Qu Feng Zhou Xi Ma Terry Hyslop Guoqiang Bao Shaogui Wan Hushan Yang Zhinan Chen | 2011 | European Journal of Cancer2011，，11： | 1 |
| 18 | Iteration framework for solving mixed lubrication computation problems显示文摘The general discrete scheme of time-varying Reynolds equation loses the information of the previous step,which makes it unreasonable.A discretization formula of the Reynolds equation,which is based on the Crank-Nicolson method,is proposed considering the physical message of the previous step.Gauss-Seidel relaxation and distribution relaxation are adopted for the linear operators of pressure during the numerical solution procedure.In addition to the convergent criteria of pressure distribution and load,an estimation framework is developed to investigate the relative error of the most important term in the Reynolds equation.Smooth surface with frill contacts and mixed elastohydrodynamic lubrication is tested for validation.The asperity contact and sinusoidal wavy surface are examined by the proposed discrete scheme.Results show the precipitous decline in the boundary of the contact area.The relative error suggests that the pressure distribution is reliable and reflects the accuracy and effectiveness of the developed method. | Shi CHEN Nian YIN Zhinan ZHANG Xiaojiang CAI | 2021 | Frontiers of Mechanical Engineering2021，16，3： | 1 |
| 19 | Solid lipid nanoparticle and microemulsion for topical delivery of triptolide显示文摘 | Mei Zhinan Chen Huabing Weng Ting | 2003 | Eur J Pharm Biopharm2003，56，2： | 1 |
| 20 | Prospects of immunotherapy for cancer显示文摘Cancer is a significant global health problem and remains one of the most challenging threats to human health. Conventional cancer treatments may include surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Immunotherapy is still considered as a highly exciting field for new discoveries and treatments for cancer [1]. Immunotherapy was cited by Science as one of the top 10 breakthroughs in the world in 2013. | Zhinan Chen | 2019 | Frontiers of Medicine2019，13，1： | 1 |
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