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| 1 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 2 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 3 | COVID-19: a new challenge for human beings显示文摘Since December 2019,just a month before the Chinese Spring Festival,multiple cases of pneumonia of unknown etiology appeared in Wuhan,Hubei Province,China.Later,a novel coronavirus was identified in a bronchoalveolar lavage fluid sample from the Wuhan Seafood Market using metagenomic next-generation sequencing technology.1 On February 11,2020,the virus was named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by the International Committee on Taxonomy of Viruses(ICTV).SARS-CoV-2 is the seventh member of the coronavirus family that can infect humans after the emergence of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV). | Penghui Yang Xiliang Wang | 2020 | Cellular & Molecular Immunology2020，17，5： | 9 |
| 4 | Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2显示文摘Single-cell RNA sequencing(scRNA-seq)is generally used for profiling transcriptome of individual cells.The droplet-based 10X Genomics Chromium(10X)approach and the plate-based Smart-seq2 full-length method are two frequently used scRNA-seq platforms,yet there are only a few thorough and systematic comparisons of their advantages and limitations.Here,by directly comparing the scRNA-seq data generated by these two platforms from the same samples of CD45cells,we systematically evaluated their features using a wide spectrum of analyses.Smart-seq2 detected more genes in a cell,especially low abundance transcripts as well as alternatively spliced transcripts,but captured higher proportion of mitochondrial genes.The composite of Smart-seq2 data also resembled bulk RNA-seq data more.For 10X-based data,we observed higher noise for mRNAs with low expression levels.Approximately 10%30%of all detected transcripts by both platforms were from non-coding genes,with long non-coding RNAs(lncRNAs)accounting for a higher proportion in 10X.10X-based data displayed more severe dropout problem,especially for genes with lower expression levels.However,10X-data can detect rare cell types given its ability to cover a large number of cells.In addition,each platform detected distinct groups of differentially expressed genes between cell clusters,indicating the different characteristics of these technologies.Our study promotes better understanding of these two platforms and offers the basis for an informed choice of these widely used technologies. | Xiliang Wang Yao He Qiming Zhang Xianwen Ren Zemin Zhang | 2021 | Genomics, Proteomics & Bioinformatics2021，19，2： | 4 |
| 5 | Experiment study of a quartz tube falling particle receiver显示文摘这篇论文论述特殊设计的掉落的粒子接收装置的试验性的评估。一个石英试管在设计,粒子没被风与征服被使用。集中的太阳的放射被吸收并且由稳固的粒子变换成热精力流动里面石英试管。几个实验被进行在太阳的炉子系统上测试接收装置的动态热表演。在实验期间,最大的粒子温度上升是 212C,与 61.2% 的效率,它在小规模粒子接收装置与 0.2 m 的掉落的距离显示出好热表演。平均插头粒子温度被直接正常的发光(DNI ) 影响,象风那样的另外的因素加速。当更小的稳固的粒子更容易在螺旋石英试管困住时,稳固的粒子与更高的温度获得更大的粘性。,当稳固的粒子的温度增加,硅碳化物的热能力与粒子温度的上升变得更大,硅碳化物的温度上升减少。 | Tianjian WANG Fengwu BAI Shunzhou CHU Xiliang ZHANG Zhifeng WANG | 2017 | Frontiers in Energy2017，11，4： | 3 |
| 6 | Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils显示文摘Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the world.IAV infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully elucidated.In this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and mice.FGF2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling pathway.FGF2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and activation.More importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected mice.Based on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting neutrophils.Thus,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection. | Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia Chengyu Jiang Xiliang Wang Penghui Yang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 7 | Response of BALB/c mice to a monovalent influenza A (H1N1) 2009 split vaccine显示文摘新奇流行性感冒 A (H1N1 ) 2009 病毒出现了到原因第一第二十一个世纪流行。流行性感冒 A (H1N1 ) 病毒引起的疾病爆发关于潜力推动了担心为一流行并且对流行性感冒 A 的这种子类型驾驶了疫苗的发展。在这研究,我们开发了一支一价的流行性感冒 A (H1N1 ) 裂口疫苗并且在 BALB/c 老鼠评估了它的效果。老鼠与包含红血球凝聚素的疫苗的 2 剂量皮下地被使免疫(哈) 独自一个或哈加铝氢氧化物(艾尔(哦) 3 ) 助手。有改变剂量的免疫哈(3.75, 7.5, 15, 30, 45 或 60 渭 g ) 被执行导致抵销抗体的生产。疫苗的得到的强壮的红血球凝聚抑制(嗨) 并且助手的 microneutralization,和增加扩充了抗体反应。初步的安全评估证明疫苗不是有毒的逍遥法外剂量(包含 60 渭 g HA+600 渭 g 艾尔的 0.5 ml (哦) 3 或 60 渭 g 哈) 。而且,疫苗被发现在 120 渭 g HA+1200 渭 g 艾尔的剂量安全(哦) 3 或 120 渭 g 哈在在老鼠的 1.0 ml。在结论,现在的学习作为公共健康干预为流行性感冒 A (H1N1 ) 种痘的临床的评估提供支持减轻一可能流行。另外,我们疫苗的进一步的评估在首领或人在这研究使用了的调查结果支持。 | Penghui Yang Li Xing Chong Tang Weihong Jia Zhongpeng Zhao Kun Liu Xiao Gao Xiliang Wang | 2010 | Cellular & Molecular Immunology2010，7，2： | 2 |
| 8 | Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy——lysosomal pathway显示文摘Nonalcoholic fatty liver disease(NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment.Hyperactivation of mTOR complex1(mTORCl) and subsequent impairment of the transcription factor EB(TFEB)-mediated autophagy-lysosomal pathway(ALP) are implicated in the development of NAFLD.Accordingly,agents that augment hepatic TFEB transcriptional activity may have therapeutic potential against NAFLD.The objective of this study was to investigate the effects of nuciferine,a major active component from lotus leaf,on NAFLD and its underlying mechanism of action.Here we show that nuciferine activated ALP and alleviated steatosis,insulin resistance in the livers of NAFLD mice and palmitic acid-challenged hepatocytes in a TFEB-dependent manner.Mechanistic investigation revealed that nuciferine interacts with the Ragulator subunit hepatitis B X-interacting protein and impairs the interaction of the Ragulator complex with Rag GTPases,thereby suppressing lysosomal localization and activity of mTORC1,which activates TFEB-mediated ALP and further ameliorates hepatic steatosis and insulin resistance.Our present results indicate that nuciferine may be a potential agent for treating NAFLD and that regulation of the mTORCl-TFEB-ALP axis could represent a novel pharmacological strategy to combat NAFLD. | Xiliang Du Chiara Di Malta Zhiyuan Fang Taiyu Shen Xiaodi Niu Meng Chen Bo Jin Hao Yu Lin Lei Wenwen Gao Yuxiang Song Zhe Wang Chuang Xu Zhijun Cao Guowen Liu Xinwei Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 9 | A Rate of Convergence of Physics Informed Neural Networks for the Linear Second Order Elliptic PDEs显示文摘In recent years,physical informed neural networks(PINNs)have been shown to be a powerful tool for solving PDEs empirically.However,numerical analysis of PINNs is still missing.In this paper,we prove the convergence rate to PINNs for the second order elliptic equations with Dirichlet boundary condition,by establishing the upper bounds on the number of training samples,depth and width of the deep neural networks to achieve desired accuracy.The error of PINNs is decomposed into approximation error and statistical error,where the approximation error is given in C2 norm with ReLU^(3)networks(deep network with activation function max{0,x^(3)})and the statistical error is estimated by Rademacher complexity.We derive the bound on the Rademacher complexity of the non-Lipschitz composition of gradient norm with ReLU^(3)network,which is of immense independent interest. | Yuling Jiao Yanming Lai Dingwei Li Xiliang Lu Fengru Wang Yang Wang Jerry Zhijian Yang | 2022 | Communications in Computational Physics2022，31，4： | 2 |
| 10 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 11 | Tensile mechanical properties of greenhouse cucumber cane显示文摘To obtain the mechanical properties of greenhouse cucumber cane,tensile and shear properties of the greenhouse cucumber cane were studied by using computer-controlled electronic universal testing machine and homemade cutting test bench,respectively.Firstly,the root,middle and head of cucumber cane were subjected for tensile tests.The tensile stress-strain curves showed that the root of cumber cane presented the characteristics of plastic material,while the middle and head showed the characteristics of brittle material.The average tensile strength of root,middle and head of fresh cucumber cane were 7.35 MPa,6.30 MPa and 4.68 MPa,respectively.The average elastic modulus of root of fresh cucumber cane was 280.58 MPa,which was much greater than the middle and head with average elastic modulus of 198.81 MPa and 137.22 MPa,respectively.A pendulum impact cutting test-rig and a cutting force measurement system composed of a cantilever weigh sensor,a high frequency DAQ card and motion control card were developed.The cutting mechanical property experiments of different parts of greenhouse cucumber cane were carried out,and the continuous curves of cutting force were measured.The single factor test for cross-sectional area,cutting speed,cutting tool type and manner were analyzed.The results indicated that the peak cutting force increased approximately linearly with the increasing of cutting sectional area,but decreased gradually with the increasing of cutting speed.In the same conditions,the cutting force could be reduced by using straight blade cutting tool and ramp cutting way.Through the multifactor interaction impact test of the cutting way,the blade type and the cutting speed,it was found that the corresponding F-value of the three factors were 21.316,49.141 and 0.222,which suggests that the blade type is the most significant factor for the cutting force. | Xu Yunfeng Zhang Xiliang Sun Xiaojia Wang Jizhang Liu Jizhan Li Zhiguo Guo Qian Li Pingping | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 2 |
| 12 | A Study of The role played by renewable energies in China's sustainable energy supply 显示文摘 | Zhang Xiliang Wang Ruoshui Huo Molin | 2010 | Energy2010，，35： | 1 |
| 13 | Development and application of lateral flow test strip technology for detection of infectious agents and chemical contaminants: a review显示文摘 | NGOM B GUO Yaneheng WANG Xiliang | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 14 | Research on Causality Relationship of Low-Carbon Development and Industrial Structure显示文摘 | Liu Chunmei Duan Maosheng Zhang Xiliang Zhou Jieting Zhang Tianhou Yang Guang Ou Xunmin Wang Enchuang Dai Chunyan Guo Shiyi Hu Guangping Zhou Lingling Qi Tianyu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 15 | Affinity and Specificity of Levamlodipine-Human Serum Albumin Interactions: Insights into Its Carrier Function显示文摘 | Zuojia Liu Xiliang Zheng Xiurong Yang Erkang Wang Jin Wang | 2009 | Biophysical Journal2009，，10： | 1 |
| 16 | Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles显示文摘 | WANG Xiliang LI Kui SHI Deshi | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 17 | Enhanced Influenza VLP vaccines comprising matrix-2 ectodomain and nucleoprotein epitopes protects mice from lethal challenge显示文摘 | Xiao Gao WenJuan Wang YuFeng Li ShaoGeng Zhang YueQiang Duan Li Xing ZhongPeng Zhao PeiRui Zhang ZhiWei Li RuiSheng Li Xiliang Wang PengHui Yang | 2013 | Antiviral Research2013，，1： | 1 |
| 18 | The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation显示文摘Acetaminophen(APAP)overdose is a major cause of liver injury.Neural precursor cell expressed developmentally downregulated 4—1(NEDD4-1)is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases;however,its role in APAP-induced liver injury(AILI)is unclear.Thus,this study aimed to investigate the role of NEDD4-1 in the pathogenesis of AILI.We found that NEDD4-1 was dramatically downregulated in response to APAP treatment in mouse livers and isolated mouse hepatocytes.Hepatocyte-specific NEDD4-1 knockout exacerbated APAP-induced mitochondrial damage and the resultant hepatocyte necrosis and liver injury,while hepatocyte-specific NEDD4-1 overexpression mitigated these pathological events both in vivo and in vitro.Additionally,hepatocyte NEDD4-1 deficiency led to marked accumulation of voltage-dependent anion channel 1(VDAC1)and increased VDAC1 oligomerization.Furthermore,VDAC1 knockdown alleviated AILI and weakened the exacerbation of AILI caused by hepatocyte NEDD4-1 deficiency.Mechanistically,NEDD4-1 was found to interact with the PPTY motif of VDAC1 through its WW domain and regulate K48-linked ubiquitination and degradation of VDAC1.Our present study indicates that NEDD4-1 is a suppressor of AILI and functions by regulating the degradation of VDAC1. | Yiwei Zhu Lin Lei Xinghui Wang Linfang Chen Wei Li Jinxia Li Chenchen Zhao Xiliang Du Yuxiang Song Wenwen Gao Guowen Liu Xinwei Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 19 | Development and application of lateral flow test strip technology for detection of infectious agents and chemical contaminants: a review显示文摘 | Babacar Ngom Yancheng Guo Xiliang Wang Dingren Bi | 2010 | Analytical and Bioanalytical Chemistry2010，，3： | 1 |
| 20 | Projection of energy use and greenhouse gas emissions by motor vehicles in China: Policy options and impacts显示文摘 | Hong Huo Michael Wang Xiliang Zhang Kebin He Huiming Gong Kejun Jiang Yuefu Jin Yaodong Shi Xin Yu | 2011 | Energy Policy2011，，： | 1 |
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