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| 1 | Global Dynamic Molecular Profiling of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing显示文摘The regulation of stomatal lineage cell development has been extensively investigated.However,a comprehensive characterization of this biological process based on single-cell transcriptome analysis has not yet been reported.In this study,we performed RNA sequencing on 12844 individual cells from the cotyledons of 5-day-old Arabidopsis seedlings.We identified 11 cell clusters corresponding mostly to cells at specific stomatal developmental stages using a series of marker genes.Comparative analysis of genes with the highest variable expression among these cell clusters revealed transcriptional networks that regulate development from meristemoid mother cells to guard mother cells.Examination of the developmental dynamics of marker genes via pseudo-time analysis revealed potential interactions between these genes.Collectively,our study opens the door for understanding how the identified novel marker genes participate in the regulation of stomatal lineage cell development. | Zhixin Liu Yaping Zhou Jinggong Guo Jiaoai Li Zixia Tian Zhinan Zhu Jiajing Wang Rui Wu Bo Zhang Yongjian Hu Yijing Sun Yan Shangguan Weiqiang Li Tao Li Yunhe Hu Chenxi Guo Jean-David Rochaix Yuchen Miao Xuwu Sun | 2020 | Molecular Plant2020，13，8： | 11 |
| 2 | Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters显示文摘In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of 2006.We tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological degradation.The taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological indicators.Further application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising. | ZHOU Hong HUA Er ZHANG Zhinan | 2010 | Journal of Ocean University of China2010，9，4： | 9 |
| 3 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 4 | Meiofauna Distribution in Intertidal Sandy Beaches Along China Shoreline(18?–40?N)显示文摘In this study,the distribution pattern of meiofauna from nine sandy beaches at six latitudinal gradients along Chinese coast between 18 and 40?N was studied on their meiofauna abundance to examine the effect of latitudinal gradients.In general,meiofauna abundance was lower in four subtropical beaches in Xiamen(24?N) and Zhoushan(29?N) than that in other beaches.Meiofauna abundance differed little between tropical and temperate beaches.The taxonomic structure of meiofauna showed a dominance of nematode in colder area.The relative composition of turbellarians and polychaetes increased in warmer area.In addition to latitudinal gradient,salinity,oxygenation,sediment grain size affect also the meiofauna latitudinal distribution.As for horizontal distribution,the highest meiofauna abundance was found in low tidal zone at tropical beaches,and in middle tidal zone at temperate beaches.The horizontal distribution of meiofauna was controlled by both physical and biotic factors including feeding and anthropogenic activities.Although meiofauna abundance exhibited a horizontal difference,the composition of meiofaunal main taxa was unanimous horizontally at all beaches at the same sampling latitude. | HUA Er ZHANG Zhinan ZHOU Hong MU Fanghong LI Jia ZHANG Ting CONG Bingqing LIU Xiaoshou | 2016 | Journal of Ocean University of China2016，15，1： | 7 |
| 5 | High activity of CeO2-TiO2 composites for deep oxidation of 1,2-dichloroethane显示文摘CeO2-TiO2 catalysts prepared by different methods were investigated for deep oxidation of 1,2-dichloroethane(DCE),as a typical representative of the chlorinated volatile organic compounds(CVOCs).Characterization analysis reveals that CeO2-TiO2 catalysts prepared by sol-gel and coprecipitation methods exhibit higher specific area,CeO2 and TiO2 particles are highly dispersed into each other and the reducibility and mobility of active oxygen species are obviously promoted due to the strong interaction between the two catalysts CeO2 and TiO2,resulting in higher catalytic activity for DCE oxidation to and less chlorinated byproduct.The high calcination temperature would lead to the formation of a new monoclinic phase Ce0.3Ti0.7O2 and sintering,which is the main reason for the catalytic activity for DCE oxidation markedly decreases. | Jialu Wang Zhinan Shi Renxian Zhou | 2020 | Journal of Rare Earths2020，38，8： | 5 |
| 6 | Sodium Danshensu promotes the healing of stage 2 pressure injury wounds in ischemia/reperfusion injury rat models:possible regulation of apoptosis and inflammatory response显示文摘OBJECTIVE:To investigate the protective effect and possible mechanism of sodium Danshensu(SDSS)against pressure injury caused by ischemia/reperfusion(I/R)injury.METHODS:Sprague-Dawley rats were randomly divided into five groups of eight rats each:control group,model group,10 mg/kg SDSS-treated group,20 mg/kg SDSS-treated group,and 40 mg/kg SDSS-treated group.We used two round ferrite magnetic plates of 15 mm diameter and 3 mm thickness to establish stage 2 pressure injury model rats.Each rat was subjected to five cycles of ischemia and reperfusion to induce pressure injury.One cycle consisted of 2 h of ischemia and 0.5 h of reperfusion,which meant that each cycle included2 h of pressure and 0.5 h of pressure relief.The outline of the wound was delineated by butter paper and marker pen,and histopathological changes were observed by hematoxylin and eosin staining.In addition,the number of apoptotic cells and the activity of caspase-3 were assessed by terminal deoxynucleotidyl transferase-mediated nick end labeling and caspase-3 assay kits,respectively.The expression of apoptosis-regulatory proteins and inflammatory mediators was investigated by enzyme-linked immunosorbent assay.RESULTS:Results showed that treatment with SDSS for 7 d after establishing the pressure injury model remarkably improved the healing rate of the wound.SDSS also inhibited the levels of tumor necrosis factor-α,myeloperoxidase,and intercellular cell adhesion molecule-1;decreased the number of apoptotic cells;increased the ratio of B-cell lymphoma-2(Bcl-2)/Bcl-2-associated X(Bax);and regulated the expression and activity of caspase-3.CONCLUSION:Our results suggest that SDSS exhibits a treatment efficacy for pressure injury caused by I/R injury possibly by inhibiting apoptosis and inflammatory response. | ZHANG Qiongzhi FU Tingting DAI Jianing ZHOU Zhinan SHEN Cuizhen | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 5 |
| 7 | Enoplus taipingensis,a new species of marine nematode from the rocky intertidal seaweeds in the Taiping Bay,Qingdao显示文摘One new species of free-living marine nematodes Enoplus taipingensis sp.nov.from the rocky intertidal seaweeds in the Taiping Bay,Qingdao is described and illustrated with scanning electron microscopy observation and 18S rRNA gene sequence analysis.Enoplus taipingensis is characterized by special arrangement of lateral setae on the tail,three cervical setae,distal structure on the supplement,and much longer body length with bigger De Man ratio 'a'.Type specimens are deposited in the College of Marine Life Science,Ocean University of China. | ZHANG Zhinan ZHOU Hong | 2012 | Acta Oceanologica Sinica2012，31，2： | 2 |
| 8 | Effects of Organic Enrichment on Sandy Beach Meiofauna:A Laboratory Microcosm Experiment显示文摘Meiofauna samples from intertidal sediments of Qingdao No.2 Bathing Beach, China, were collected for field study, and subjected to organic enrichment in a laboratory microcosm experiment for 21 d. There were three different treatments including non-organic addition as the control, low-organic enrichment (2 g DW green algae per 150 mL) and high-organic enrichment (10 g DW green algae per 150 mL). After 21 d, the meiofauna richness decreased in both organic enrichment treatments. Among the three treatments, total meiofauna abundance was significantly different, and the control groups had higher abundance than the other two treatment groups. However, the responses of the meiofauna abundance in the two organic enrichment treatments were non-significantly different. The relationship of meiofaunal abundance and nematode/copepod ratios to organic matter and oxygen level in the microcosm experiments were discussed. | WANG Jianing ZHOU Hong ZHANG Zhinan CONG Bingqing XU Shuhui | 2011 | Journal of Ocean University of China2011，10，3： | 2 |
| 9 | Eli mination of the Myeotoxin Citrinin Production in the Industrial Important Strain Monaseus purpureusSMOOl显示文摘 | JIA Xiaoqin XU Zhinan ZHOU Liping | 2010 | Metabolic Engineering2010，12，1： | 1 |
| 10 | GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis显示文摘 | Jinliang Xing Ronald E. Myers Xianli He Falin Qu Feng Zhou Xi Ma Terry Hyslop Guoqiang Bao Shaogui Wan Hushan Yang Zhinan Chen | 2011 | European Journal of Cancer2011，，11： | 1 |
| 11 | Changes in the shelf macrobenthic community over large temporal and spatial scales in the Bohai Sea, China 显示文摘 | ZHOU Hong ZHANG Zhinan LIU Xiaoshou | 2007 | Journal of Marine Systems2007，67，34： | 1 |
| 12 | Phytal meiofauna of a rocky shore at the cape d'Aguilar marine reserve,Hong Kong显示文摘 | Zhang Zhinan Zhou Hong | 1997 | The Marine Flora and Fauna of Hong Kong and Southern China1997，，： | 1 |
| 13 | Transition metaldoping effect and high catalytic activity of CeO_(2)-TiO_(2) for chlorinated VOCs degradation显示文摘A series of transition metals(Fe,Co,Ni,Cu,Cr and Mn)-doped CeO_(2)-TiO_(2) catalysts were prepared by the sol-gel method and applied for the catalytic removal of 1,2-dichloroethane(DCE) as a model for chlorinated VOCs(CVOCs).The various characterization methods including X-ray diffraction(XRD),N_(2) adsorption-desorption,UV-Raman,NH_(3) temperature-programmed desorption(NH_(3)-TPD) and H_(2) temperature-programmed reduction(H_(2)-TPR) were utilized to investigate the physicochemical properties of the catalysts.The results show that doping Fe,Co,Ni or Mn can obviously promote the activity of CeO_(2)-TiO_(2) mixed oxides for DCE degradation,which is related to their improved texture properties,acid sites(especially for strong acidity) and low-temperature reducibility.Particularly,CeTi-Fe doped with moderate Fe exhibits excellent activity for 1,2-dichloroethane(DCE) degradation,giving a T_(90%) value as low as 250℃.More importantly,only trace chlorinated byproducts were produced during the low-temperature degradation of various CVOCs(dichloromethane(DCM),trichloroethylene(TCE) and chlorobenzene(CB)) over CeTi-Fe1/9 catalyst with high durability. | Yijun Shi Xiaolin Guo Zhinan Shi Renxian Zhou | 2022 | Journal of Rare Earths2022，40，5： | 1 |
| 14 | Phytal meiofauna of a rocky shore at the cape d' A_guilar marine reserve, Hong Kong 显示文摘 | Zhang Zhinan Zhou Hong | 1997 | The Marine Flora and Fauna of Hong Kong and Southern China1997，，： | 1 |
| 15 | Water‑Dispersible CsPbBr_(3) Perovskite Nanocrystals with Ultra‑Stability and its Application in Electrochemical CO_(2) Reduction显示文摘Thanks to the excellent optoelectronic properties,lead halide perovskites(LHPs)have been widely employed in highperformance optoelectronic devices such as solar cells and lightemitting diodes.However,overcoming their poor stability against water has been one of the biggest challenges for most applications.Herein,we report a novel hot-injection method in a Pb-poor environment combined with a well-designed purification process to synthesize water-dispersible CsPbBr_(3) nanocrystals(NCs).The as-prepared NCs sustain their superior photoluminescence(91%quantum yield in water)for more than 200 days in an aqueous environment,which is attributed to a passivation effect induced by excess CsBr salts.Thanks to the ultra-stability of these LHP NCs,for the first time,we report a new application of LHP NCs,in which they are applied to electrocatalysis of CO_(2) reduction reaction.Noticeably,they show significant electrocatalytic activity(faradaic yield:32%for CH4,40%for CO)and operation stability(>350 h). | Keqiang Chen Kun Qi Tong Zhou Tingqiang Yang Yupeng Zhang Zhinan Guo Chang‑Keun Lim Jiayong Zhang Igor Zutic Han Zhang Paras N.Prasad | 2021 | Nano-Micro Letters2021，13，11： | 0 |
| 16 | Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI. | Hua Zhang Guodong Sun Xiaowei Li Zhen Fu Chengbin Guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao | 2019 | Science Bulletin2019，64，16： | 0 |
| 17 | Estimates of Autumntime Benthic Secondary Production in Laizhou Bay and Adjacent Bohai Sea Waters显示文摘The whole metazoan community inhabiting Laizhou Bay and adjacent Bohai Sea waters were sampled in late autumn,2006.Secondary production estimates for macrofauna and meiofauna were made separately.Total benthic secondary production was as high as 8.38 ± 4.08 g ash-free dry weight(AFDW) m-2 a-1,which represented the autumn production level.In general,macrofaunal secondary production in Laizhou Bay was much lower than that in adjacent Bohai Sea areas.In contrast,meiofaunal secondary production in Laizhou Bay was higher than that in adjacent Bohai Sea areas.Macrofauna contributed 61% to benthic secondary production(5.09 ± 3.26 g AFDW m-2 a-1),lower than the value in previous studies in Bohai Sea.Sediment granulometric characteristics and bottom-water salinity could explain the substantial variability in the macrofauna biomass and production.Meiofaunal production was an important component of benthic production and exceeded macrofauna production under exceptional conditions,e.g.in Laizhou Bay,where macrofauna was restricted.Chlorophyll pigments(Chl-a) concentrations in sediment explained the general meiofaunal biomass and production distribution here. | HUA Er ZHOU Hong ZHANG Zhinan YU Zishan | 2010 | Journal of Ocean University of China2010，9，3： | 0 |
| 18 | Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats显示文摘Cathepsin D(CTSD),the major lysosomal aspartic protease that is widely expressed in different tissues,potentially regulates the biological behaviors of various cells.Follicular granulosa cells are responsive to the increase of ovulation number,hence indirectly influencing litter size.However,the mechanism underlying the effect of CTSD on the behaviors of goat granulosa cells has not been fully elucidated.This study used immunohistochemistry to analyze CTSD localization in goat ovarian tissues.Moreover,western blotting was applied to examine the differential expression of CTSD in the ovarian tissues of monotocous and polytocous goats.Subsequently,the effects of CTSD knockdown on cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of the prolific traits,including bone morphogenetic protein receptor IB(BMPR-IB),follicle-stimulating hormone(FSHR),and inhibinα(INHA),were determined in granulosa cells.Results showed that CTSD was expressed in corpus luteum,follicle,and granulosa cells.Notably,CTSD expression in the monotocous group was significantly higher than that in the polytocous group.In addition,CTSD knockdown could improve granulosa cell proliferation,inhibit cell apoptosis,and significantly elevate the expression of proliferating cell nuclear antigen(PCNA)and B cell lymphoma 2(Bcl-2),but it lowered the expression of Bcl-2-associated X(Bax)and caspase-3.Furthermore,CTSD knockdown significantly reduced the ratios of cells in the G0/G1 and G2/M phases but substantially increased the ratio of cells in the S phase.The expression levels of cyclin D2 and cyclin E were elevated followed by the obvious decline of cyclin A1 expression.However,the expression levels of BMPR-IB,FSHR,and INHA clearly increased as a result of CTSD knockdown.Hence,our findings demonstrate that CTSD is an important factor affecting the litter size trait in goats by regulating the granulosa cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of the prolific trait. | Zhinan ZHOU Xiang CHEN Min ZHU Weiwei WANG Zheng AO Jiafu ZHAO Wen TANG Lei HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 0 |
| 19 | Superior performance for lithium-ion battery with organic cathode and ionic liquid electrolyte显示文摘Organic small structure quinones go with ionic liquids electrolytes would exhibit ultrastable electrochemical properties.In this study,calix[6]quinone(C6Q) cathode was matched with ionic liquid electrolyte Li[TFSI]/[PY13][TFSI](bis(trifluoromethane)sulfonimide lithium salt/N-methyl-N-pro pylpyrrolidinium bis(trifluoromethanesulfonyl)amide) to assemble lithium-ion batteries(LIBs).The electrochemical performance of LIBs was systematically studied.The capacity retention rates of C6Q through 1000 cycles at current densities of 0.2 C and 0.5 C were 70% and 72%,respectively.At 5 C, the capacity was maintained at 190 mAh g^(-1) after 1000 cycles,and 155 mAh g^(-1) even after 10,000 cycles,comparable to inorganic materials.This work would give a big push to the practical process of organic electrode materials in energy storage. | Xueqian Zhang Wenjun Zhou Meng Zhang Zhinan Yang Weiwei Huang | 2021 | Journal of Energy Chemistry2021，30，1： | 0 |
| 20 | A meso–molecular muscle based on copillar[5]arenes显示文摘A meso–molecular muscle was prepared by capping the[c2]daisy chain based on a mono-functionalized copillar[5]arene with an imidazolium group in its axle.From its crystal structure,we observed that it was a cyclic dimer composed of two mirror image subcomponents,a pR-and a pS-copillar[5]arene.Their conformations were fixed by the doubly interlocked mechanical bond.By comparison of the^1H NMR and COSY spectra,we found that the length of this meso–molecular muscle could be controlled not only by the solvents,but also by the counter anions. | Yu Yao Peiling Zhang Dan Zhou Zhinan Lai Shijun Li Feihe Huang Zibin Zhang | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
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