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| 1 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 2 | ESCRT-I Component VPS23A Is Targeted by E3 Ubiquitin Ligase XBAT35 for Proteasome-Mediated Degradation in Modulating ABA Signaling显示文摘A myriad of abiotic stress responses in plants are controlled by abscisic acid(ABA)signaling.ABA receptors can be degraded by both the 26S proteasome pathway and vacuolar degradation pathway after processing via the endosomal sorting complex required for transport(ESCRT)proteins.Despite being essential for ABA signaling,the upstream regulators of ESCRTs remain unknown.Here,we report that the ESCRT-I component VPS23A is an unstable protein that is degraded via the ubiquitin-proteasome system(UPS).The UEV domain of VPS23A physically interacts with the two PSAP motifs of XBAT35,an E3 ubiquitin ligase,and this interaction results in the deposition of K48 polyubiquitin chains on VPS23A,marking it for degradation by 26S proteasomes.We showed that XBAT35 in plants is a positive regulator of ABA responses that acts via the VPS23A/PYL4 complex,specifically by accelerating VPS23A turnover and thereby increasing accumulation of the ABA receptor PYL4.This work deciphers how an ESCRT component is regulated in plants and deepens our understanding of plant stress responses by illustrating a mechanism whereby crosstalk between the UPS and endosome-vacuole-mediated degradation pathways controls ABA signaling. | Feifei Yu Xiaoqiang Cao Guangchao Liu Qian Wang Ran Xia Xiangyun Zhang Qi Xie | 2020 | Molecular Plant2020，13，11： | 4 |
| 3 | Normalization cancer immunotherapy: blocking Siglec-15!显示文摘In a recent paper published in Nature medicine,Wang,J.,et al.identified Siglec-15 as a new candidate responsible for adaptive immune resistance and a potential target for normalization cancer immunotherapy.1 Cancer cells can develop various mechanisms to evade tumor-specific and non-specific attacks in the TME of solid tumors.2 Thus,systemic activation of immune systems or even increasing tumor-specific T cells in the peripheral does not necessarily lead to tumor regression.In fact,almost all the known strategies adopted by cancer for immune escape are also used for maintaining systemic homeostasis. | Guangchao Cao Zhiqiang Xiao Zhinan Yin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 4 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 5 | The Study of Vegetation Carbon Storage in Qinghai Lake Valley Based on Remote Sensing and CASA Model显示文摘 | Chen Kelong Han Yanli Cao Shengkui Ma Jin Cao Guangchao Lu Hui | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 6 | Yin Yang 1 Plays an Essential Role in Breast Cancer and Negatively Regulates p27显示文摘 | Meimei Wan Weiwei Huang Timothy E. Kute Lance D. Miller Qiang Zhang Heather Hatcher Jingxuan Wang Daniel B. Stovall Gregory B. Russell Paul D. Cao Zhiyong Deng Wei Wang Qingyuan Zhang Ming Lei Suzy V. Torti Steven A. Akman Guangchao Sui | 2012 | The American Journal of Pathology2012，，： | 1 |
| 7 | Spatio-temporal variation of water conservation and its impact factors on the southern slope of Qilian Mountains显示文摘The ecology of Qilian Mountains has been seriously threatened by uncontrolled grazing and wasteland reclamation. This study examined the ecological changes on the southern slope of Qilian Mountains in China from the perspective of water conservation by classifying different clusters of water conservation functional areas to efficiently use limited human resources to tackle the water conservation protection problem. In this study, we used Integrate Valuation of Ecosystem Services and Tradeoffs(InVEST) model to estimate water conservation and analyzed the factors that influence the function. The results of this study include:(1) from 2000 to 2015, the water conservation of the southern slope of Qilian Mountains generally showed an increasing trend, and the total water conservation in 2015 increased by 42.18% compared with that in 2000.(2) Rainfall, fractional vegetation cover(FVC), and evapotranspiration have the most significant influence on the water conservation of the study area. Among them, water conservation is positively correlated with rainfall and FVC(P<0.05) and negatively correlated with evapotranspiration(P<0.05).(3) The importance level of water conservation functional areas gradually increases from northwest to southeast, and the region surrounding Menyuan Hui Autonomous County in the southeast of the southern slope of Qilian Mountains is the core water conservation functional area. And(4) the study area was divided into five clusters(Cluster Ⅰ–Cluster Ⅴ) of water conservation, with the areas of Clusters Ⅰ through Ⅴ accounting for 0.58%, 13.74%, 41.23%, 32.43%, and 12.01% of the whole study area, respectively. | WEI Xingtao Oliver Valentine EBOY CAO Guangchao XU Lu | 2023 | Regional Sustainability2023，4，1： | 1 |
| 8 | The Study of Vegetation Carbon Storage in Qinghai Lake Valley Based on Remote Sensing and CASA Model显示文摘 | Chen Kelong Han Yanli Cao Shengkui Ma Jin Cao Guangchao Lu Hui | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 9 | Paleocurrent and fabric analyses of the imbricated fluvial gravel deposits in Huangshui Valley, the northeastern Tibetan Plateau, China 显示文摘 | Miao Xiaodong Lu Huayu Li Zhen Cao Guangchao | 2008 | Geomorphology2008，99，： | 1 |
| 10 | Soil microbial community diversity and distribution characteristics under three vegetation types in the Qilian Mountains, China显示文摘Qilian Mountains in Northwest China is a significant ecological security barrier due to its distinctive geographic setting,which has significant biological resource and gene pool.In order to assess the soil quality and ecosystem health in this area,we identified the structural characteristics and functional groups of soil microbial communities.This study focused on Amidongsuo,a typical watershed of the Qilian Mountains,and researched the vertical distribution and dominant populations of soil microorganisms in different habitats,and the relationship between soil microorganisms and environmental factors.Soil microorganisms from three grassland plots,five shrubland plots,and five forest plots in Amidongsuo were studied using high-throughput sequencing.The Venn diagram showed that the types of bacteria were fewer than those of fungi in Amidongsuo.Soil bacteria Acidobacteriota,Proteobacteria,and Methylomirabilota as well as fungi Basidiomycota,Ascomycota,and Mortierellomycota played dominant roles in Amidongsuo,according to the LEfSe(linear discriminant analysis(LDA)effect size)and community structure analyses.According to the ANOSIM(analysis of similarities)result,for both bacteria and fungi,R values of grassland and shrubland were small(R^(2)=0.045 and R^(2)=0.256,respectively),indicating little difference between these two ecosystems.RDA(redundancy analysis)showed a closer relationship between soil nutrients and fungi,and a gradually decreasing correlation between soil nutrients and microorganisms with increasing soil depth.Bacteria were mainly affected by pH,nitrogen(N),and potassium(K),while fungi were mainly affected by K.Overall,fungi had more effect on soil quality than bacteria.Therefore,adjustment of soil K content might improve the soil environment of Amidongsuo in the Qilian Mountains. | TONG Shan CAO Guangchao ZHANG Zhuo ZHANG Jinhu YAN Xin | 2023 | Journal of Arid Land2023，15，3： | 1 |
| 11 | Thoughts on Pairing Assistance to Tibet for Promoting Agricultural High-quality Development in Southern Tibet from the Perspective of Agricultural Power显示文摘In the new era,there is an urgent need to further promote pairing assistance to Tibet,promote the simultaneous construction of a strong agriculture in Tibet and the China's Mainland,and compose a Chinese-style modernization.Southern Tibet,located in the southeastern part of the Tibet Autonomous Region,includes Shannan City and Nyingchi City,is a region assisted by four provincial partners including Hubei Province.This paper introduces the agricultural environment in southern Tibet,studies its agricultural characteristics,and analyzes the main issues of its pairing assistance.Taking forging the strong consciousness of the Chinese national community as the main line,the paper explores strategies for promoting agricultural high-quality development in southern Tibet through pairing assistance to Tibet from the perspective of agricultural power,and proposes some strategies,such as inheriting agricultural cultural heritage,promoting the upgrading of modern seed industry,enhancing the characteristic advantages of highland barley(naked barley)and animal husbandry industries,and developing edible fungi and cold water fish industries. | Zhiguo SUN Li GAO Yuanpeng SUN Guangchao CAO Xinying ZHOU Xiaoqiang LI | 2024 | Asian Agricultural Research2024，16，3： | 0 |
| 12 | Nutrient status of Populus euphratica growing in desert riparian forests of northwestern China显示文摘Seasonal and microhabitat variations of chemical constituents of foliar organic carbon(C),total nitrogen(N),total phosphorus(P),and total potassium(K),in Populus euphratica growing in desert riparian forests in northwestern China and their correlations were studied.Results show that ranges of C,N,P and K contents in the leaves of P.euphratica were 39.08% 46.16%,0.28% 2.81%,0.05% 0.18% and 0.35% 2.03%,with means of 43.51%,1.49%,0.102% and 1.17%,respectively.The ratio of C/N,C/P and N/P changed from 16.26 to 146.61,from 258.08 to 908.67 and from 2.89 to 26.67;the mean was 37.24,466.27 and 15.14,respectively.The mean N content was significantly lower than of deciduous trees in China,but the mean P content was nearly equivalent.The ratio of C/N was remarkably higher than of global land plants.The ratio of N/P indicated that growth of P.euphratica was jointly limited by N and P nutrient deficiency.During the growth season,total trends of leaf C,N,P and K contents decreased.The maximum appeared in May,and the minimum in September.Among microhabitats,C,N and K contents gradually increased from riparian lowland,flatland,sandpile,Gobi and dune,but C/N ratio was opposite,and P content was not apparent.Foliar C content was extremely,significantly and positively correlated with N and K contents,respectively.The relationships of N-K and P-K were both significantly positive. | ShengKui Cao Qi Feng JianHua Si XiaoYun Zhang GuangChao Cao KeLong Chen JingFu Zhu | 2012 | Research in Cold and Arid Regions2012，4，4： | 0 |
| 13 | Metabolic Control ofγδT Cell Function显示文摘Metabolic change is associated with cell activities,such as signal transduction,cell differentiation,and cell cycle.In the pathogenesis of autoimmune diseases,abnormal activation of T cells is often accompanied by changes in their metabolism.Conversely,the changes of metabolites can also regulate the proliferation,differentiation,and function of T cells.As a bridge between innate and adaptive immune responses,γδT cells have unique biological characteristics and functions.However,the immunometabolic mechanism ofγδT cells has been a novel field for research in recent years.In this review,we summarize the influence of metabolic pathways and nutrients onγδT cell function,and metabolic features ofγδT cell subsets,which may provide new insights in interventions targetingγδT cells in disease control. | Ziyu Meng Guangchao Cao Quanli Yang Hengwen Yang Jianlei Hao Zhinan Yin | 2021 | Infectious Microbes & Diseases2021，3，3： | 0 |
| 14 | Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI. | Hua Zhang Guodong Sun Xiaowei Li Zhen Fu Chengbin Guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao | 2019 | Science Bulletin2019，64，16： | 0 |
| 15 | Palaeoclimatic evolution recorded by multidicipline in sediments in gahai lake, qaidam basin since late last deglacial显示文摘 | Chen Zhong Ma Haizhou Cao Guangchao Zhang Xiying Zhou Dujun Yao Yuan Yang Guangshu | 2010 | High Technology Letters2010，16，3： | 0 |
| 16 | CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity显示文摘CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer development.However,little is known about the effects of CFTR on the differentiation and function ofγδT cells.In this study,we observed that CFTR was functionally expressed on the cell surface ofγδT cells.Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.Interestingly,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)influx.CFTR was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun signaling.In addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT cells.Thus,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor immunity.Our investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer. | Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo Huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，8： | 0 |
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