|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element显示文摘杀死肿瘤的基因的 Glioma 特定的抄写作为有希望的基因被利用了在 glioma 病人的治疗学的形式。Musashi1 (Msi1 ) 和 GFAP 基因倡导者两个都是癌症特定的倡导者。优化 HIF 有约束力的地点(optHBS ) 顺序最新象在癌症基因治疗用作 enhancer 的 EPO HRE 一样被发现有效。我们构造了 4optHBS-Msi1/GFAP 倡导者并且测试了他们的能力调停在 glioma 房间导致 apoptosis 的 BAX 表示排队。我们的结果证明 4optHBS-Msi1/GFAP 倡导者是有在指向的 glioma 基因治疗的潜在的申请的显然强壮、 glioma 选择的倡导者,并且 4optHBS-Msi1/GFAP-BAX 是为 glioma 基因治疗的珍贵工具。 | Jiwei Huang Jun Gao Xiang Lv Guilin Li Delong Hao Xiaoying Yao Liquan Zhou Depei Liu Renzhi Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 11 |
| 3 | Equilibrium dialysis study on the interaction between Cu(Ⅱ) and HSA or BSA显示文摘The interaction of Cu(Ⅱ) and human serum albumin (HSA) or bovine serum albumin (BSA) at physiological pH is studied by equilibrium dialysis. The successive stability constants are obtained by non-linear least square methods fitting Bjerrum formula. For both the Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA systems, the order of magnitude of K 1 and K 2 was found to be ≈10 4 mol -1·dm 3. There are about twenty stoichiometry binding sites found in one HSA or BSA molecule. They can be divided into two or three sets. Results of equilibrium dialysis experiments suggest that there exists one strong metal binding site in both Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA. It is the imidazol group nitrogen atoms of His 3 that are primarily concerned with copper binding site. After reaching dialysis equilibrium, there is the interaction among the different binding sites, the values of K all deviate from the simple statistical effect except for K-1 and K-2 in both Cu(Ⅱ)-HSA and Cu(Ⅱ)-BSA systems, and the positive cooperative effect is found. | LIANG Hong 1, XIN Bengang 1, WANG Xiujian 1, YUAN Yuzhou 1, ZHOU Yongqia 2 and SHEN Panwen 2 1. Department of Chemistry, Guangxi Normal University, Guilin 541004, China 2. Department of Chemistry, Nankai University, Tianjin 300071, China | 1998 | Chinese Science Bulletin1998，43，5： | 10 |
| 4 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 5 | Efficacy of Bushenjianpi prescription on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) and to investigate the mechanisms underlying the action.METHODS: After randomization, POF was induced in the model mice by immunization with ZP3. One week later, mice received low(8.1 mg/kg), moderate(16.2 mg/kg) and high(32.4 mg/kg) doses of BSJPP by gastrogavage once daily for 90 days. Premarin(0.03 mg/kg) served as the positive group. Serum samples were collected 1 week after the last dose and stored at-20 ℃ for analysis. After cervical dislocation, the uterus and ovaries were collected aseptically for evaluation by histological assessment, scanning electron microscopy, immunohistochemical staining, and Western blot and reverse transcription-polymerase chain reaction analyses.RESULTS: Serum E2 levels in POF model mice were decreased, whereas follicle-stimulating hormone(FSH) and luteinizing hormone(LH) levels were dramatically increased. Serum levels of E2,LH and FSH were reduced in POF model mice treated with BSJPP(moderate and high doses) and premarin. Anti-bone morphogenetic protein 15(BMP-15) and connexin 43(Cx43) were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with BSJPP(moderate and high doses)and premarin.CONCLUSION: BSJPP is effective in treating ZP3-induced POF in mice and the increase in the expression of BMP-15 and Cx43 may be implicated in the mechanism underpinning the action. | Feng Guilin Lin Meijiao Zhou Xiaolin Zhang Lihong Li Jing Ouyang Jingfeng | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 6 |
| 6 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 7 | Numerical and Experimental Investigations on Tunable Low-frequency Locally Resonant Metamaterials显示文摘In this paper,a tunable locally resonant metamaterial is proposed for low-frequency band gaps.The local resonator composed of two pairs of folded slender beams and a proof mass is designed based on the theory of compliant mechanism.The design optimization on geometric parameters is carried out to fulfil the quasi-zero-stiffness property.The locally resonant metamaterial is formed by periodically arranged unit cells,and the transmittance of longitudinal wave is studied through three aspects:numerical predictions,finite element simulations and experimental tests.The variation trends revealed by these three methods match well with one another:the band gap moves to lower frequency and both its depth and width get smaller and smaller with the increase of pre-compression(Δ).The band gap overlays the frequency range of 73.10–92.38 Hz and 16.78–19.49 Hz atΔ=0mm andΔ=10mm,respectively,providing a wide range of tunability.Besides,the ultralow-frequency band gap can be achieved asΔapproaches 10 mm.This study may provide an avenue for achieving the tunable ultralow-frequency locally resonant band gap. | Qida Lin Jiaxi Zhou Hongbin Pan Daolin Xu Guilin Wen | 2021 | Acta Mechanica Solida Sinica2021，34，5： | 4 |
| 8 | CAD/CAE OF THE WORKING CHARACTERISTICS OF A NEW TYPE OF FLUID COUPLING SHOCK ABSORBER显示文摘For purpose of simulation of the working characteristics of a new type of fluid coupling shock absorber for vibration protection of sensitive equipment, a physical model is presented by analyzing the internal fluid dynamic phenomenon with respect to the coupling shock absorber and implemented in MATLAB software package. Using the model it is possible to evaluate the importance of different factors for design of the shock absorber. In the meantime, the key-model machine is designed for coupling dynamic test. Comparisons with experimental results confirm the validity of the model. So the CAD/CAE software has been developed in MATLAB for design and experimental test of the new coupling shock absorber. | Yang Ping Zhong Yifang Zhou JiSchool of Mechanical Science and Engineering, Huazhong University of Science and Technology,Wuhan 430074, ChinaLiu Yong Guilin Institute of Electronic Technology | 2002 | Chinese Journal of Mechanical Engineering2002，15，3： | 4 |
| 9 | Preparation of microencapsulatedα-olefin drag reducing polymer used in oil pipeline transportation显示文摘包含油拖减少聚合物粒子的 Microcapsules 被融化散布准备并且聚乙烯蜡压缩,在原处脲和甲醛的聚合,和苯乙烯的界面的聚合分别地。相关过程被一个分子的动力学模拟方法学习,并且 microcapsule 隔离代理人的分子的设计根据模拟被执行。为准备 microencapsulated 油拖减少聚合物粒子的技术被比较并且发行量拖减少 microencapsulated 聚合物粒子的效率基于描述结果和他们的溶解性质被评估。一个 microcapsule 隔离代理人的分子的设计建议石蜡聚合物粒子能被使用能阻止石蜡聚合物粒子的凝块的长链的烷基钠盐表面活化剂稳定地在水里驱散。吸附的模拟的结果处理烷基钠盐表面活化剂的数量能直接影响的表演 microencapsulated 石蜡聚合物粒子的稳定性。并且一定有它的最小的批评数量。在由与不同的壳材料扫描电子显微镜学( SEM )和静态的压力稳定性,特别反应的条件和 microcapsules 的工艺的控制的比较的形态学的描述以后,有poly-(脲甲醛)的石蜡聚合物粒子的 microencapsulation 作为最佳计划作为壳材料被选择,因为它能在温和条件下面反应,它的工艺的过程能在一个大范围被控制。关系拖减少率和显示出的 microcapsules 的溶解时间 microcapsules 的形成没影响最大值拖减少减少每件样品的率的率,和drag 能与溶解时间一起到达大约35%,即 microencapsulation 没影响减少石蜡的性质的drag 聚合物。 | Li Bing Xing Wenguo Dong Guilin Chen Xiangjun Zhou Ningning Qin Zhanbo Zhang Changqiao | 2011 | Petroleum Science2011，8，1： | 3 |
| 10 | Dust storms in northern China during the last 500 years显示文摘The history and mechanisms of dust storms in northern China remain unclear owing to the paucity of reliable longterm,high-resolution geological records.In this study,we reconstructed the dust storm history of the last~500 years in northern China,based on sedimentary coarse fraction(>63μm)of a well-dated core from Lake Daihai,Inner Mongolia.The highresolution data reveal three intervals of frequent dust storms:AD 1520–1580,AD 1610–1720,and AD 1870–2000.The dust storm events in the Lake Daihai area were broadly synchronous with those inferred from other historical or geological records and generally occurred during cold intervals.Changes in the intensity of Siberian High and the westerlies modulated by temperature variations are the likely major factors controlling dust storm dynamics.An interesting feature is that although the intensities of dust storms have been systematically increased during the recent warming period,a clear decreasing trend within this period is evident.The recent increase in average dust storm intensity may be ascribed to an increase in particle supply resulting from a rapid increase in human activity,whereas the weakening trend was likely caused by decreases in average wind speed resulting from the recent global warming. | Shuang ZHANG Hai XU Jianghu LAN Yonaton GOLDSMITH Adi TORFSTEIN Guilin ZHANG Jin ZHANG Yunping SONG Kang’en ZHOU Liangcheng TAN Sheng XU Xiaomei XU Yehouda ENZEL | 2021 | Science China Earth Sciences2021，64，5： | 3 |
| 11 | A Method of Job Scheduling on SMEs' Key Equipments Based on Hybrid Multi-attribute Decision Making显示文摘An analysis of the key factors affecting on the single production process job scheduling of the parts waiting for be- ing processed on the key equipments for SMEs (Small Manufacturing Enterprises) is given in this paper,which include interval number,real number and uncertain linguistic value.A kind of hybrid multi-attribute decision making method for the single pro- duction process job scheduling is presented in this paper,that the parts are firstly sorted about each factor,and then the total evalu- ative attributive value of each part is calculated with the method of weighted arithmetic average,and thus the part with the highest total evaluative attributive value is chosen for being processed firstly.The mathematic model corresponding to the method is set up in this paper.An example is studied in this paper,and the results of the example testify the correctness of this model. | LIU Dianting~(1,2) ZHOU Dejian~2 1.School of Mechano-Electronic Engineering,Xidian University,Xi’an 710071,China 2.Guilin University of Technology,Guilin 541004 ,China | 2006 | 武汉理工大学学报2006，28，S2： | 2 |
| 12 | WiSH:WiFi-Based Real-Time Human Detection显示文摘Sensorless sensing using wireless signals has been rapidly conceptualized and developed recently. Among numerous applications of WiFi-based sensing, human presence detection acts as a primary and fundamental function to boost applications in practice. Many complicated approaches have been proposed to achieve high detection accuracy, but they frequently omit various practical constraints such as real-time capability, computation efficiency, sampling rates, deployment efforts, etc. A practical detection system that works in realworld applicati ons is lacki ng. In this paper, we design and implement WiSH, a real-time system for con tactless human detection that is applicable for whole-day usage. WiSH employs lightweight yet effective methods and thus enables detection under practical conditions even on resource-limited devices with low signal sampling rates. We deploy WiSH on commodity desktops and customized tiny no des in different everyday scenarios. The experimental results dem on strate the superior performance of WiSH, which has a detection accuracy of >98% using a sampling rate of 20 Hz with an average detection delay of merely 1.5 s. Thus, we believe WiSH is a promising system for real-world deployment. | Tianmeng Hang Yue Zheng Kun Qian Chenshu Wu Zheng Yang Xiancun Zhou Yunhao Liu Guilin Chen | 2019 | Tsinghua Science and Technology2019，24，5： | 2 |
| 13 | Components in Antineoplastic Actinomycete Strain (N2010-37) of Bottom Mud in Mangrove显示文摘Objective To study the antitumor components from an actinomycete strain(N2010-37) of bottom mud in Zhanjiang Mangrove,South China Sea.Methods The components were isolated and purified by chromatographic techniques and recrystallization,and the structures were identified by spectral methods together with physicochemical analyses.The antitumor effects of these components were tested in vitro by MTT method.Results Three compounds were identified including two anthrones and one novel lactone.They are(3S,4R,7R,8R,9S)-3,8-dihydroxy-4,7,9-trimethyl-2,6-cyclononanediolacetone(1) ,2-hydroxy-1-methoxy-3-methylanthraquinone(2) ,and 1,6,8-thihydroxy-3-methylanthraquinone(3) .Conclusion Compound 1 is a new compound,and compounds 1 and 3 show the favorable cytotoxic activities against human chronic granulocytic leukemia cell line K562 strain by MTT method in vitro. | ZHOU Zhong-liu1,2,JIN Bei1,YIN Wen-qing2,FU Chun-yan2,FENG Hua-fen2 1.Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang 524048,China 2.Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education,School of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin 541004,China | 2011 | Chinese Herbal Medicines2011，3，3： | 2 |
| 14 | A limb-inspired bionic quasi-zero stiffness vibration isolator显示文摘Vibration reduction has always been one of hot and important topics in mechanical engineering,especially for the special measurement instrument.In this paper,a novel limb-inspired bionic structure is proposed to generate negative stiffness and design a new quasi-zero stiffness isolator via torsion springs,distinguishing from the existing tension spring structures in the literature.The nonlinear mathematical model of the proposed structure is developed and the corresponding dynamic properties are further investigated by using the Harmonic Balance method and ADAMS verification.To evaluate the vibration isolation performance,typical three-springs quasi-zero stiffness(TS QZS)system is selected to compare with the proposed bionic structure.And the graphical processing unit(GPU)parallel technology is applied to perform necessary two-parameter analyses,providing more insights into the effects of parameters on the transmissibility.It is shown that the proposed structure can show advantages over the typical TS QZS system in a wider vibration isolation range for harmonic excitation case and shorter decay time for the impact excitation case. | Rong Zeng Guilin Wen Jiaxi Zhou Gang Zhao | 2021 | Acta Mechanica Sinica2021，37，7： | 2 |
| 15 | A Novel Driving and Control System for Direct-wheel- driven Electric Vehicle显示文摘 | Guilin Tao Zhiyum Ma Libing Zhou Langru Li | 2005 | IEEE Transactions on Magnetics (S0018-9464)2005，41，1： | 1 |
| 16 | Polyacrylate- core/TiO-shellnanocomposite particles prepared by in situ emulsion polymerization显示文摘 | Zhaoquan Ai Guilin Sun Qilong Zhou | 2006 | Appl Polym Sci2006，，102： | 1 |
| 17 | Research on the new performance model for low light level imaging system 显示文摘 | Ai Kecong Zhou Liwei Zeng Guilin Liang Yanxi | 2002 | SPIE2002，4925，： | 1 |
| 18 | Polyaerylate-core/TiOz-shell nanocomposite particles prepared by in situ emulsion polymerization 显示文摘 | Ai Zhaoquan Sun Guilin Zhou Qilong | 2006 | Journal of Applied Polymer Science2006，102，： | 1 |
| 19 | Comments on aPractical(t,n)Threshold Proxy Signature Scheme Based on theRSA Cryptosystem显示文摘 | Wang Guilin Feng Bao Zhou Jianying | 2004 | IEEE Transactions on Knowledge and DataEngineering2004，16，10： | 1 |
| 20 | Fine mapping a major QTL for flag leaf size and yield-related traits in rice显示文摘 | Peng Wang Guilin Zhou Huihui Yu Sibin Yu | 2011 | Theoretical and Applied Genetics2011，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员