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您的检索式：作者名="Zhoufang Li"
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| 1 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 2 | Self-generating nanogaps for highly effective surface-enhanced Raman spectroscopy显示文摘The fabrication of surface enhanced Raman spectroscopy(SERS)substrates with controlled high density hot spots still remains challenging.Herein,we report highly effective SERS substrates containing the self-generating(SG)nanogaps from polystyrene nanosphere monolayer through isotropic plasma etching.The emergence of multimode hot spots,i.e.,metal film over nanosphere(MFON)-like hot spots(closed gaps,0 nm),individual self-aligned hot spots(discrete gaps,>20 nm)and threedimensional(3D)hot spots(nanogaps,1-10 nm),makes the SG SERS substrates superior as compared to the traditional MFON or the well-ordered self-aligned SERS substrates in terms of enhancement,uniformity,and reproducibility.The SG SERS substrates can function as the excellent SERS platforms for trace molecule detection in the practical application fields. | Yangkai Chen Huan Li Jianmei Chen Dong Li Mengyuan Zhang Guanghua Yu Lin Jiang Yi Zong Bin Dong Zhoufang Zeng Yandong Wang Lifeng Chi | 2022 | Nano Research2022，15，4： | 1 |
| 3 | Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing显示文摘 | Zhoufang Li Guangjie Liu Yin Tong | 2015 | Scientific Reports2015，5，10： | 1 |
| 4 | T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients显示文摘Type 1 diabetes mellitus(T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors(TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual T1D patients and controls.We sequenced the T cell repertoire of nine T1D patients, four type 2 diabetes(T2D) patients,and six nondiabetic controls. The diversity of the T cell repertoire in T1D patients was significantly decreased in comparison with T2 D patients(P = 7.0E 08 for CD4^+T cells, P = 1.4E 04 for CD8^+T cells) and nondiabetic controls(P = 2.7E 09 for CD4^+T cells, P = 7.6E 06 for CD8^+T cells). Moreover, T1D patients had significantly more highly-expanded T cell clones than T2D patients(P = 5.2E 06 for CD4+T cells, P = 1.9E 07 for CD8^+T cells) and nondiabetic controls(P = 1.7E 07 for CD4^+T cells, P = 3.3E 03 for CD8^+T cells). Furthermore, we identified a group of highly-expanded T cell receptor clones that are shared by more than two T1D patients. Although further validation in larger cohorts is needed, our data suggest that T cell receptor diversity measurements may become a valuable tool in investigating diabetes, such as using the diversity as an index to distinguish different types of diabetes. | Yin Tong Zhoufang Li Hua Zhang Ligang Xia Meng Zhang Ying Xu Zhanhui Wang Michael W.Deem Xiaojuan Sun Jiankui He | 2016 | Genomics, Proteomics & Bioinformatics2016，14，6： | 0 |
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