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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Study on air flow dynamic characteristic of mechanical ventilation of a lung simulator显示文摘As an important life support treatment, mechanical ventilation is usually adopted in clinics. With the development of the res-piratory diagnostic and treatment technologies, air flow dynamics of mechanical ventilation is usually referenced in the evaluation of pulmonary status and assessment of respiratory therapy. In order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, in this paper, a new mathematical model of mechanical ventilation system was set up. Furthermore, a prototype mechanical ventilation system for an artificial simulating lung was designed and experimentally studied. Lastly, in order to improve the ventilation efficiency and provide a reference for pulmonary diagnostics, the air flow dynamics of the mechanical ventilation system was illustrated through simulation and experimental studies. The study can be helpful to the optimization of the mechanical ventilation system. | NIU JingLong SHI Yan CAO ZhiXin CAI MaoLin CHEN Wei ZHU Jian XU WeiQing | 2017 | Science China(Technological Sciences)2017，60，2： | 8 |
| 3 | Signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong'显示文摘For the first time in the world,underwater acoustic transmission of images,human voice,data and texts between vehicle under 7000 m depth and surface ship was accomplished by underwater acoustic communication system of manned deep submersible 'Jiaolong'.In this paper,signal processing in underwater acoustic communication system for manned deep submersible 'Jiaolong' is introduced.(1) Four communication methods are integrated to meet different needs:1) coherent underwater acoustic communication,with a variable transmission rate from 5 kbps to 15 kbps,to transmit images.2) Non-coherent underwater acoustic communication, with a transmission rate 300 bps,to transmit texts,instructions,and sensor data. 3) Spread spectrum underwater acoustic communication,with a transmission rate 16 bps,to transmit instructions.4) Underwater voice communication,using single sideband modulation to transmit human voice.(2) Signal processing method in coherent communication mainly consists of concatenation of decision feedback equalizer and Turbo decoder,and wavelet based image compression with fixed length coding.In the equalizer,Doppler compensation,multichannel combining and equalizer coefficients updating are all using fast self-optimized adaptive algorithm.(3) A linear hydrophone array is lowered from the mother ship to certain depth, and spatial diversity combining technology is adopted.(4) Diving trials of 'Jiaolong' were carried out in Pacific Ocean.The communication range can cover nearly all ocean depth.One optical/acoustic image can be transmitted in 7 or 14 seconds. | ZHU Weiqing ZHU Min WU Yanbo YANG Bo XU Lijun FU Xiang PAN Feng | 2013 | Chinese Journal of Acoustics2013，32，1： | 7 |
| 4 | Energy conversion characteristics of reciprocating piston quasi- isothermal compression systems using water sprays显示文摘Air compressors are vital and have numerous industrial applications. Approximately 8% of the annual operating electricity consumption in industrial countries is constituted by due to the use of air compressors. Because the poor heat transfer to the environment in the rapid compression process, the compression is non-isothermal, the efficiency of compressors is restricted. To improve their efficiency and achieve isothermal compression, this study proposes energy conversion reciprocating piston quasiisothermal compression using a water spray. First, a mathematical model of a reciprocating piston compressor with water sprays was established. Through experimental investigation and simulations, the mathematical model was validated. The energy conversion characteristics of the reciprocating piston compressor were then studied. To reduce compression power and enhance compression efficiency, it was first discovered that the critical parameters were the input pressure of the driving chamber, water spray mass, and compression volume ratio, which were then evaluated thoroughly. The higher the inlet pressure of the driving chamber, the faster the air compression velocity. Additionally, the compression efficiency was elevated as the water spray mass was gradually increased for a given compression volume ratio. When the compression volume ratio was increased from 2 to 3,the compression power increased from 172.7 J/stroke to 294.2 J/stroke and the compression efficiency was enhanced from 37.3%(adiabatic) to 80.6%. This research and its performance analysis can be referred to during the parameter design optimisation of reciprocating piston quasi-isothermal compression systems using water sprays. | jia guanwei cai maolin xu weiqing shi yan | 2018 | Science China(Technological Sciences)2018，61，2： | 6 |
| 5 | Therapeutic effect of electroacupuncture,massage,and blocking therapy on external humeral epicondylitis显示文摘OBJECTIVE:To compare two therapeutic methods:electroacupuncture + massage + blocking therapy,and blocking therapy alone in the treatment of external humeral epicondylitis.METHODS:Eighty-six patients were randomized into two groups with 43 in each. The treatment group received electroacupuncture + massage +blocking therapy, while the control group received blocking therapy only. A course of electroacupuncture treatment included therapy once a day for 10days. There were 10 treatments in a massage course and massage was given once a day, with a1-week interval given before the next course. A course of blocking treatment included therapy once a week, for twototaltreatments,andgenerallyno more than three times. The therapeutic effects were evaluated with the visual analog scale(VAS),grip strength index(GSI) score, and Mayo elbow performance score(MEPS) before treatment and at0, 6, 12, and 24 months after treatment to observe thetotaleffectiverate.RESULTS: In the treatment and control groups before treatment and at 0, 6, 12, and 24 months after treatment, the VAS scores were: 6.5±1.9 and 6.4±1.6; 4.6±1.3 and 4.6±1.7; 4.8±1.3 and 4.8±1.2; 4.6±1.2 and 6.6±1.6; and 6.5±1.6 and 6.5±1.3, respectively. The GSI scores were 63±8 and 63±8; 84±6and82±7;82±7and82±6;84±6and62±8;and64±6 and 64±7, respectively.The MEPS of both groups were65±7and66±8;85±6and84±7;84±5and84±7;80±7and66±6;and65±6and65±7,respectively.The total effective rates of the treatment and control groups at 0, 6, 12, and 24 months after treatment were 87.5% and 85.0%; 85.0% and 82.5%;80.0% and 12.5%; and 2.5% and 5.0%, respectively.Compared with the treatment group, the control group had greater joint function, better the rapeutic effect, and lower pain intensity(P<0.01), indicating a high recurrence rate in the 12th month after treatment.There were no differences inVAS, GSI, or MEPS at 0, 6, and 24 months after treatment(P>0.05)betweenthetwogroups.CONCLUSION: We found that both methods were effective for external humeral epicondylitis. After 6months of treatment,the effects were good in both groups. However, in the 12th month, the control group had a relatively severe relapse. After 24months, both groups relapsed. The effect of electroacupuncture, massage, and blocking therapy used in combination lasted longer, delaying the recurrence of the disease. | Xinjian Li Kun Zhou Enming Zhang Zhen xiQi Weiqing Sun Liangfu Xu Jianfeng Xu Youzhi Cai Ronghui Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 6 |
| 6 | Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays显示文摘 | Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li Weiqing Xu Zijian Wu Wei Hu Yanqing Lu Lifeng Chi | 2013 | Nano Research2013，6，3： | 6 |
| 7 | MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。 | Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 6 |
| 8 | Sensory and chemical assessment of silver pomfret (Pampus argenteus) treated with Ginkgo biloba leaf extract treatment during storage in ice显示文摘This study investigated the physical(L*,a*,b*,texture profile analyses,pH),chemical(TVB-N,K value and TBA),microbiological,amino acid content,and flavor effects that Gingko biloba leaf extract(GBLE)had on silver pomfret(Pampus argenteus)stored at 4±1C in ice for 18 days.Fresh pomfret samples were obtained directly from the local fish market and transported to the laboratory with ice immediately.After being gutted,washed,filleted and trimmed in a water-ice mixture,samples were treated with different concentrations of GBLE(0.0 mg/mL,2.5 mg/mL,5.0 mg/mL,10.0 mg/mL)and packaged in Polyethylene bag,then stored in a refrigerator at 4±1C with ice.The results show that the shelf-life of untreated(0.0 mg/mL)pomfret samples was 8e9 days compared to 14e15 days for the GBLE1(2.5 mg/mL)treated group.The assessment results showed that different concentrations of GBLE had variable effects on preserving the texture parameters of acceptability limit,inhibit lipid oxidation,protein degradation,and microorganism growth.2.5 mg/mL of GBLE was the best for the preservation of pomfret during storage in ice.Therefore,there is potential use for GBLE as a preservative to extend the shelf-life of pomfret during chilled storage in ice. | Weiqing Lan Xu Che Qiaoling Xu Ting Wang Ruoyuan Du Jing Xie Min Hou Han Lei | 2018 | Aquaculture and Fisheries2018，3，1： | 5 |
| 9 | Methods to Evaluate and Measure Power of Pneumatic System and Their Applications显示文摘Pneumatic system has been widely used throughout industry, and it consumes more than billions kW h of electricity one year all over the world. So as to improve the efficiency of pneumatic system, its power evaluation as well as measurement methods should be proposed, and their applicability should be validated. In this paper, firstly, power evaluation and measurement methods of pneumatic system were introduced for the first time. Secondly, based on the proposed methods, power distributions in pneumatic system was analyzed. Thirdly, through the analysis on pneumatic efficiencies of typical compressors and pneumatic components, the applicability of the proposed methods were validated. It can be concluded that, first of all, the proposed methods to evaluation and measurement the power of pneumatic system were efficient. Furthermore, the pneumatic power efficiencies of pneumatic system in the air production and cleaning procedure are respectively about 35%–75% and 85%–90%. Moreover, the pneumatic power efficiencies of pneumatic system in the transmission and consumption procedures are about 70%–85% and 10%–35%. And the total pneumatic power efficiency of pneumatic system is about 2%–20%, which varies largely with the system configuration. This paper provides a method to analyze and measure the power of pneumatic system, lay a foundation for the optimization and energy-saving design of pneumatic system. | Yan Shi Maolin Cai Weiqing Xu Yixuan Wang | 2019 | Chinese Journal of Mechanical Engineering2019，32，3： | 4 |
| 10 | Tuning Atomically Dispersed Fe Sites in Metal–Organic Frameworks Boosts Peroxidase‑Like Activity for Sensitive Biosensing显示文摘Although nanozymes have been widely developed,accurate design of highly active sites at the atomic level to mimic the electronic and geometrical structure of enzymes and the exploration of underlying mechanisms still face significant challenges.Herein,two functional groups with opposite electron modulation abilities(nitro and amino)were introduced into the metal–organic frameworks(MIL-101(Fe))to tune the atomically dispersed metal sites and thus regulate the enzymelike activity.Notably,the functionalization of nitro can enhance the peroxidase(POD)-like activity of MIL-101(Fe),while the amino is poles apart.Theoretical calculations demonstrate that the introduction of nitro can not only regulate the geometry of adsorbed intermediates but also improve the electronic structure of metal active sites.Benefiting from both geometric and electronic effects,the nitro-functionalized MIL-101(Fe)with a low reaction energy barrier for the HO*formation exhibits a superior POD-like activity.As a concept of the application,a nitro-functionalized MIL-101(Fe)-based biosensor was elaborately applied for the sensitive detection of acetylcholinesterase activity in the range of 0.2–50 mU mL−1 with a limit of detection of 0.14 mU mL−1.Moreover,the detection of organophosphorus pesticides was also achieved.This work not only opens up new prospects for the rational design of highly active nanozymes at the atomic scale but also enhances the performance of nanozyme-based biosensors. | Weiqing Xu Yikun Kang Lei Jiao Yu Wu Hongye Yan Jinli Li Wenling Gu Weiyu Song Chengzhou Zhu | 2020 | Nano-Micro Letters2020，12，12： | 4 |
| 11 | Efficiency optimized fuel supply strategy of aircraft engine based on air-fuel ratio control显示文摘Accurate fuel injection control of aircraft engine can optimize the energy efficiency of UAV power system while meeting the propeller speed requirement. Traditional injection control method such as open-loop calibration causes instability of fuel supply which brings the risk of power loss of UAV. Considering that the closed-loop control of AFR can ensure a stable fuel feeding, this paper proposes an AFR control based fuel supply strategy in order to improve the efficiency of fuel-powered UAV while obtaining the required engine speed. According to the optimum fuel injection results, we implement fuzzy-PID method to control the set AFR in different situations. Through simulation and experiment studies, the results indicate that, to begin with, the calibrated mathematical model of the aircraft engine is effective. Next, this fuel supply strategy based on AFR control can normally realize the engine speed regulation, and the applied control algorithm can eliminate the overshoot of AFR throughout all the working progress. What is more,the fuel supply strategy can averagely shorten the response time of the engine speed by about two seconds. In addition, compared with the open-loop calibration, in this work the power efficiency is improved by 9% to 33%. Last but not the least, the endurance can be improved by 30 min with a normal engine speed. This paper can be a reference for the optimization of UAV aircraft engine. | Yixuan WANG Yan SHI Maolin CAI Weiqing XU Qihui YU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 3 |
| 12 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 13 | MXene based mechanically and electrically enhanced film for triboelectric nanogenerator显示文摘The development of triboelectric nanogenerator(TENG)technology which can directly convert ambient mechanical energy into electric energy may affect areas from green energy harvesting to emerging wearing electronics.And,the material of triboelectric layer is critical to the mechanical robustness and electrical output characteristics of the TENGs.Herein,a MXene enhanced electret polytetrafluoroethylene(PTFE)film with a high mechanical property and surface charge density is developed.The MXene/PTFE composite film was synthesized by spraying and annealing treatment.With the doping of MXene,the crystallinity of composite film could be tuned,leading to an enhancement in the tensile property of 450%and reducing the wear volume about 80%in the friction test.Furthermore,the as-fabricated TENG with this composite film outputs 397 V of open-circuit voltage,21µA of short-circuit current,and 232 nC of transfer charge quantity,which are 4,6,and 6 times higher than that of the TENG made by pure PTFE film,respectively.Therefore,this work provides a creative strategy to simultaneously improve the mechanical property and electrical performance of the TENGs,which have great potential in improving device stability under a complex mechanical environment. | Yuyu Gao Guoxu Liu Tianzhao Bu Yaoyao Liu Youchao Qi Yanting Xie Shaohang Xu Weili Deng Weiqing Yang Chi Zhang | 2021 | Nano Research2021，14，12： | 2 |
| 14 | Quantitative Determination of Urine Glucose: Combination of Laminar Flow in Microfluidic Chip with SERS Probe Technique显示文摘 | SUN Dan LIU Xiangyuan XU Shuping TIAN Yu XU Weiqing TAO Yanchun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 2 |
| 15 | Self-sustained Oscillation Pulsed Air Blowing System for Energy Saving显示文摘Currently, many studies have been made for years on dimensions of pneumatic nozzle, which influence the flow characteristic of blowing system. For the purpose of outputting the same blowing force, the supply pressure could be reduced by decreasing the ratio of length to diameter of nozzle. The friction between high speed air and pipe wall would be reduced if the nozzle is designed to be converging shape comparing with straight shape. But the volume flow and pressure, discussed in these studies, do not describe energy loss of the blowing system directly. Pneumatic power is an innovative principle to estimate pneumatic system’s energy consumption directly. Based on the above principle, a pulse blowing method is put forward for saving energy. A flow experiment is carried out, in which the high speed air flows from the pulse blowing system and continuous blowing system respectively to a plate with grease on top. Supply pressure and the volume of air used for removing the grease are measured to calculate energy consumption. From the experiment result, the pulse blowing system performs to conserve energy comparing with the continuous blowing system. The frequency and duty ratio of pulse flow influence the blowing characteristic. The pulse blowing system performs to be the most efficient at the specified frequency and duty ratio. Then a pneumatic self-oscillated method based on air operated valve is put forward to generate pulse flow. A simulation is made about dynamic modeling the air operated valve and calculating the motion of the valve core and output pressure. The simulation result verifies the system to be able to generate pulse flow, and predicts the key parameters of the frequency and duty ratio measured by experiment well. Finally, on the basis of simplifying and solution of the pulse blowing system’s mathematic model, the relationship between system’s frequency duty ratio and the dimensions of components is simply described with four algebraic equations. The system could be designed with specified frequency and duty ratio according to the four equations. This study provides theoretical basis for designing energy-saving air blowing system. | CAI Maolin XU Weiqing | 2010 | Chinese Journal of Mechanical Engineering2010，23，3： | 2 |
| 16 | Preparation of Surface-enhanced Raman Scattering(SERS)-active Optical Fiber Sensor by Laser-induced Ag Deposition and Its Application in Bioidentification of Biotin/Avidin显示文摘 | LIU Chunyu WANG Shaoyan FU Cuicui LI Haibo XU Shuping XU Weiqing | 2015 | Chemical Research in Chinese Universities2015，31，1： | 2 |
| 17 | Signal processing for high speed underwater acoustic transmission of image显示文摘一个信号处理方法为高速度在水下图象的声学的传播被介绍。它有二部分。第 1 部分介绍信号处理为在水下声学的协调通讯。第 1 部分包括 3 个技术的点。(1 ) Doppler 移动 compensation.Chirp 信号在数据包裹之间被插入。在二个拷贝关联函数之间的关联进程给吝啬的 Doppler 移动的更多的精确评价。然后,它能被采样补偿数据。在适应决定反馈均衡器(DFE ) 一个适应阶段赔偿者与快,自我优化的最不吝啬的广场(FOLMS ) 改编算法被利用与第二顺序阶段锁环算法比赔偿者导致更好的运动忍耐。吝啬的 Doppler 移动赔偿和适应阶段赔偿者的联合的表演相当好。(2 ) 差异 combiner (DC ) 在均衡器之前使用了。combiner 和适应 DFE 基于 FOLMS 改编算法。这导致减少的计算复杂性和更好的性能。(3 ) 串联了均衡器,涡轮架子编码了调整(TCM ) 解码器和重复算法。一个新 bitsymbol 变换器基于软产量 Viterbi 算法(SOVA ) 被学习。与传统的决定作比较,编码并且印射算法,在将近 2 的新变换器罐头还原剂小点错误率(BER ) 订。第 2 部分主要在一个柔韧的图象压缩算法附近。基于分离小浪变换并且修理了长度编码,为声学的图象的一个柔韧的压缩算法被学习。算法包括 4 个技术的点。(1 ) 利用小浪基于转变图象的 CDF9/7。(2 ) 分析 subband 系数的精力分发。合适的转变层数字是 3。(3 ) 根据他们的精力分发把不同量子化步用于不同 subbands。(4 ) 使用修理了长度编码阻止错误繁殖。结果证明算法在图象质量,压缩率,和大多数之中完成平衡重要,坚韧性到 BER。灰色的规模的压缩的位率声学的图象是 0.85 小点 / 象素。当 BER 比 10-3 低时,图象质量仍然保持好。当 BER 起床到 10-2 时,在那里削减一些小脏点。基于提及的上面的信号处理技术,一在水下声学的通讯系统是运作的频率乐队是的 built.Its (7.5-12.5 ) kHz。它的收到的数组是 8 元素制服线性数组。为串联均衡器和 Turbo-TCM 解码器的 QPSK 和 8PSK 调整和重复算法基于难 SOVA 被使用。系统在卡恩道·莱克被测试了。当数据率是 10 kbps 时,低 BER 在 5.5 km 范围被完成。一幅灰色的规模图象能在 7 s 被播送。它的通讯距离和数据率的产品是 55 km kbps。 | ZHU Weiqing ZHU Min WANG Junwei HUANG Haiyun YANG Bo XU Lijun ZHAO Liang | 2009 | Chinese Journal of Acoustics2009，28，1： | 2 |
| 18 | The ChinaMAP reference panel for the accurate genotypeimputation in Chinese populations显示文摘Dear Editor,The genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism(SNP)genotyping arrays or whole-genome sequencing(WGS).The fine mapping of variants in the genome-wide association study(GWAS)could be critically improved by the imputation with an optimal reference panel based on the population-specific haplotypes. | Lin Li Peide Huang Xiaohui Sun Siyu Wang Min Xu Sha Liu Zhimin Feng Qing Zhang Xiaoji Wang Xiaole Zheng Mengyao Dai Yufang Bi Guang Ning Yanan Cao Weiqing Wang | 2021 | Cell Research2021，31，12： | 2 |
| 19 | Efficacy and safety of degarelix in patients with prostate cancer:Results from a phase III study in China显示文摘Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively. | Yinghao Sun Liping Xie Tao Xu Jorn S.Jakobsen Weiqing Han Per S.Sorensen Xiaofeng Wang | 2020 | Asian Journal of Urology2020，7，3： | 2 |
| 20 | Modulation of hot regions in waveguide-based evanescent-field-coupled localized surface plasmons for plasmon-enhanced spectroscopy显示文摘Coupling efficiency between the localized surface plasmons(LSPs) of metal nanoparticles(NPs) and incident light dominates the sensitivities of plasmon-based sensing spectroscopies and imaging techniques, e.g., surfaceenhanced Raman scattering(SERS) spectroscopy. Many endogenous features of metal NPs(e.g., size, shape,aggregation form, etc.) that have strong impacts on their LSPs have been discussed in detail in previous studies.Here, the polarization-tuned electromagnetic(EM) field that facilitates the LSP coupling is fully discussed.Numerical analyses on waveguide-based evanescent fields(WEFs) coupled with the LSPs of dispersed silver nanospheres and silver nano-hemispheres are presented and the applicability of the WEF-LSPs to plasmon-enhanced spectroscopy is discussed. Compared with LSPs under direct light excitation that only provide 3–4 times enhancement of the incidence field, the WEF-LSPs can amplify the electric field intensity about 30–90 times(equaling the enhancement factor of 10~6–10~8 in SERS intensity), which is comparable to the EM amplification of the SERS'hot spot' effect. Importantly, the strongest region of EM enhancement around silver nanospheres can be modulated from the gap region to the side surface simply by switching the incident polarization from TM to TE, which widely extends its sensing applications in surface analysis of monolayer of molecule and macromolecule detections. This technique provides us a unique way to achieve remarkable signal gains in many plasmon-enhanced spectroscopic systems in which LSPs are involved. | HAILONG WANG YUYANG WANG YI WANG WEIQING XU SHUPING XU | 2017 | Photonics Research2017，5，5： | 2 |
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