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| 1 | Application and reliability analysis of DPM system in site investigation of HK weathered granite显示文摘A drilling process monitor (DPM) for ground characterization of weathered granite is presented. The monitor is portable and can be mounted on a hydraulic rotary drilling rig to record various drilling parameters in real time during normal subsurface in- vestigation. The identification method for dominative and subsidiary interfaces has been established. The study reveals that the monitored drilling parameters are dependent on geotechnical materials and can be further applied to characterize ground interfaces. The t-test between manual logging and DPM logging has been carried out. The results show that the DPM has high accuracy in inter- faces detection and well agreement with the manual logging. The findings show that the device and data analysis method are of po- tential application in subsurface drilling exploration in weathered granites. It also seems to have prospective uses in the determination of orebody boundary as well as in the detection of geohazards. | Zhuoying Tan Meifeng Cai Zhongqi Yue L.G. Tham C.F. Lee | 2005 | Journal of University of Science and Technology Beijing2005，12，6： | 12 |
| 2 | Transcriptional landscape of rice roots at the single-cell resolution显示文摘There are two main types of root systems in flowering plants,namely taproot systems of dicots and fibrous root systems found in monocots.Despite this fundamental split,our current knowledge of cellular and molecular mechanism driving root development is mainly based on studies of the dicot model Arabidopsis.However,the world major crops are monocots and little is known about the transcriptional programs underlying cell-type specification in this clade.Here,we report the transcriptomes of more than 20000 single cells derived from root tips of two agronomically important rice cultivars.Using combined computational and experimental analyses we were able to robustly identify most of the major cell types and define novel cell-type-specific marker genes for both cultivars.Importantly,we found divergent cell types associated with specific regulatory programs,including phytohormone biosynthesis,signaling,and response,which were well conserved between the two rice cultivars.In addition,we detected substantial differences between the cell-type transcript profiles of Arabidopsis and rice.These species-specific features emphasize the importance of analyzing tissues across diverse model species,including rice.Taken together,our study provides insight into the transcriptomic landscape of major cell types of rice root tip at single-cell resolution and opens new avenues to study cell-type specification,function,and evolution in plants. | Qing Liu Zhe Liang Dan Feng Sanjie Jiang Yifan Wang Zhuoying Du Ruoxi Li Guihua Hu Pingxian Zhang Yanfei Ma Jan ULohmann Xiaofeng Gu | 2021 | Molecular Plant2021，14，3： | 9 |
| 3 | LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway显示文摘In recent decades,the incidence rate of papillary thyroid carcinoma(PTC)has been rapidly increasing.However,the molecular mechanism of the physiological and pathological processes of PTC is still largely unknown.Phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)is a tum or suppressor and exerts anti-tumor effect in several human cancers,while the role and underlying mechanism of LHPP in PTC remain vague.In this study,we firstly evaluated the roles of LHPP in PTC and explored its underlying mechanism.Using clinical tissue samples,we detected the level of LHPP in PTC tissues and in matched adjacent normal tissues.Lower level of LHPP was found in PTC tissues than in matched adjacent normal tissues.Similar LHPP expression pattern was found in PTC cell lines when compared with that in normal human thyroid follicular epithelial cells.Then,we over-expressed LHPP in three PTC cell lines and results showed that ectopic LHPP expression consistently reduced cell viability,proliferation,and migration and triggered cell autophagy.Furthermore,over-expression of LHPP inhibited the activation of the AKT/mTOR pathway and promoted the AMPK signaling pathway.In addition,the activation of AKT/mTOR and inhibition of AMPK signaling pathways restored the role of ectopic LHPP expression in PTC cell lines,indicating that LHPP exerts its anti-tumor activity through regulating the AKT/AMPK/mTOR pathway.Ultimately,we illustrated that ectopic LHPP expression inhibited PTC tumor growth in vivo.In conclusion,we revealed that LHPP has an anti-tumor effect in PTC and indicated that LHPP might serve as an effective diagnostic and therapeutic target for PTC. | Wenyu Sun Kai Qian Kai Guo Lili Chen Jun Xiang Duanshu Li Yi Wu Qinghai Ji Tuanqi Sun Zhuoying Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 8 |
| 4 | Spatial and temporal variation of particulate organic carbon in the PN section of East China Sea显示文摘Variations of the particulate organic carbon and nitrogen (POC/PN) along the PN section in the East China Sea (ECS) were examined based on POC/PN data obtained in September 2002. A comparison with others work indicates that POC is the highest in summer, followed by autumn and spring, and the lowest in winter. Generally, POC concentration decreases seawards, and the in situ productivity in September plays an important role in POC distribution. POC in the PN section is composed of terrestrial, resuspended, in situ produced carbon and carbon originated from the Kuroshio waters. The Changjiang River effects the ECS in the PN section, but the influence is mainly minimiged beyond 123.5° E because of barrier effect. The impact of Kuroshio subsurface water (KSSW) over shelf break can also effect POC distribution, with high POC concentration there. | ZHU Zhuoy WU Ying ZHANG Jing WEI Hao | 2005 | Acta Oceanologica Sinica2005，24，5： | 5 |
| 5 | Fluid Property Discrimination in Dolostone Reservoirs Using Well Logs显示文摘The Ordovician Majiagou Formation is one of the main gas-producing strata in the Ordos Basin,China.The identification of hydrocarbon-bearing intervals via conventional well logs is a challenging task.This study describes the litholog of Ma 5(Member 5 of Majiagou Formation)dolostones,and then analyzes the responses of various conventional well logs to the presences of natural gas.The lithology of the gas bearing layers is dominantly of the dolomicrite to fine to medium crystalline dolomite.Natural gas can be produced from the low resistivity layers,and the dry layers are characterized by high resistivities.Neutron-density crossovers are not sensitive to the presences of natural gas.In addition,there are no significant increases in sonic transit times in natural gas bearing layers.NMR(nuclear magnetic resonance)logs,DSI(Dipole Sonic Imager)logs and borehole image logs(XRMI)are introduced to discriminate the fluid property in Majiagou dolostone reservoirs.The gas bearing intervals have broad NMR T2(transverse relaxation time)spectrum with tail distributions as well as large T2gm(T2 logarithmic mean values)values,and the T2 spectrum commonly display polymodal behaviors.In contrast,the dry layers and water layers have low T2gm values and very narrow T2 spectrum without tails.The gas bearing layers are characterized by low Vp/Vs ratios,low Poisson’s ratios and low P-wave impedances,therefore the fluid property can be discriminated using DSI logs,and the interpretation results show good matches with the gas test data.The apparent formation water resistivity(AFWR)spectrum can be derived from XRMI image logs by using the Archie’s formula in the flushed zone.The gas bearing layers have broad apparent formation water resistivity spectrum and tail distributions compared with the dry and water layers,and also the interpretation results from the image logs exhibit good agreement with the gas test data.The fluid property in Majiagou dolostone reservoirs can be discriminated through NMR logs,DSI logs and borehole image logs.This study helps establish a predictable model for fluid property in dolostones,and have implications in dolostone reservoirs with similar geological backgrounds worldwide. | WANG Guiwen LAI Jin LIU Bingchang FAN Zhuoying LIU Shichen SHI Yujiang ZHANG Haitao CHEN Jing | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 4 |
| 6 | Measurement and study of the distributing law of in-situ stresses in rock mass at great depth显示文摘To solve the technical cruxes of the conventional system in deep rock mass, an automatic testing system for hydraulic frac- turing that includes a single tube for hydraulic loop, a pressure-relief valve, central-tubeless packers, and a multichannel real-time data acquisition system was used for in-situ stresses measurement at great depths (over 1000 m) in a coalfield in Juye of Northern China. The values and orientations of horizontal principal stresses were determined by the new system. The virgin stress field and its dis- tributing law were decided by the linear regression from the logged 37 points in seven boreholes. Besides, the typical boreholes ar- ranged in both the adjacent zone and far away zone of the faults were analyzed, respectively. The results show that a stress concentra- tion phenomenon and a deflection in the orientation of the maximal horizontal stress exist in the adjacent zone of the faults, which further provides theoretical basis for design and optimization of mining. | Zhuoying Tan Meifeng Cai | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 4 |
| 7 | Responses of bacterial strains isolated from drinking water environments to N-acyI-L-homoserine lactones and their analogs during biofilm formation显示文摘 | Zhuoying WU1 Qing WANG, Feng GUO Shenghua ZHANG Qipei JIANG Xin YU | 2014 | Frontiers of Environmental Science & Engineering2014，8，2： | 3 |
| 8 | Phosphorus fractions and alkaline phosphatase activity in sediments of a large eutrophic Chinese lake (Lake Taihu)显示文摘 | Yiyong Zhou Chunlei Song Xiuyun Cao Jianqiu Li Guoyuan Chen Zhuoying Xia Pinghong Jiang | 2008 | Hydrobiologia2008，，1： | 1 |
| 9 | An IOanalysis of the trend in virtual water trade and the impacton water resources and uses in China 显示文摘 | ZHANG Zhuoying SHI Minjun YANG Hong | 2011 | EconomicSystems Research2011，23，4： | 1 |
| 10 | Dietary fat intake and liver cancer risk: A prospective cohort study in Chinese women显示文摘Objective:This study aimed to determine whether dietary fat intake increased liver cancer risk in Chinese women from a prospective population-based cohort.Methods:A total of 72,704 Chinese women were followed up from the time of baseline recruitment(1996–2000)to the end of 2016.Dietary fat intake was calculated using a validated food frequency questionnaire.The Cox regression model was used to assess the hazard ratio(HR)and 95%confidence intervals(CI)for dietary fat intake and liver cancer risk.Results:We identified 252 incident liver cancer cases out of 1,267,845 person-years during the overall follow-up time.Null associations,neither in quartiles nor per standard deviation(SD)increment,were detected between liver cancer risk and dietary total fat,fat subtypes and subtype ratios,and food sources.The HR(95%CI)of the 1-SD increment was 1.03(0.90–1.17)for total fat,1.06(0.93–1.20)for saturated fat,1.06(0.93–1.21)for monounsaturated fat,and 1.00(0.89–1.13)for polyunsaturated fat.Similar null associations were observed in stratification analyses according to body mass index and menopausal status.Conclusions:In our prospective cohort study,no significant association was observed in Chinese women between dietary fat and liver cancer risk,and in stratification and sensitivity analyses. | Xiaowei Ji Jing Wang Zhuoying Li Qiuming Shen Jiayi Tuo Jinghao Bi Yuting Tan Honglan Li Yongbing Xiang | 2022 | Cancer Biology & Medicine2022，19，3： | 1 |
| 11 | Instrumented borehole drilling for interface identification in intricate weathered granite ground engineering显示文摘The successful application in drilling for HK simple weathered granite foundation has revealed its further use in instru- mented drilling system as a ground investigation tool in the detection of other lithology formations, geohazards, underground water, and boundary of orebody. To expand the further use and test the accuracy in identification of formation, an R-20 rotary-hydraulic drill rig was instrumented with a digital drilling process monitoring system (DPM) for drilling in an intricate decomposed granite site. In this test ground, the boreholes revealed that the weathered granite alternately changes between moderate and strong. The qualitative and quantitative analysis of the penetrating parameters, indicates the effective thrust force, rotary speed, flushing pressure, penetrating rate, and displacement of the bit fluctuate at ground interfaces. It shows that the parameters get a good response with the change of rock strength at the interfaces, which can reveal the change of the intricate granite formation. Besides, a variable-slope method has been established, for identification of dominative and subsidiary interfaces in the granite site. The result from a t-test shows that the confi- dence of the instrumented drilling system in identification of the geotechnical interfaces is up to 99%. | Zhuoying Tan Meifeng Cai Z.Q. Yue L.G Tham C.F. Lee | 2007 | Journal of University of Science and Technology Beijing2007，14，3： | 1 |
| 12 | Understanding Beijing's water challenge: a decomposition analysis of changes in Beijing's water footprint between 1997 and 2007 显示文摘 | Zhang Zhuoying Shi Minjun Yang Hong | 2012 | Environmental Science & Technology2012，46，12： | 1 |
| 13 | Co-pyrolysis and cogasification of coal and biomass in bench-scale fixedbed and fluidised bed reactor 显示文摘 | Collot A G ZhuoY Dugwell D R | 1999 | Fuel1999，78，： | 1 |
| 14 | On the Application of the Lattice Boltzmann Method to Predict Soil Meso Seepage Characteristics显示文摘In this study,a two-dimensional approach is elaborated to study with the lattice Boltzmann method(LBM)the seepage of water in the pores of a soil.Firstly,the D2Q9 model is selected to account for the discrete velocity distribution of water flow.In particular,impermeability is considered as macroscopic boundary condition for the left and right domain sides,while the upper and lower boundaries are assumed to behave as pressure boundaries controlled by different densities.The micro-boundary conditions are implemented through the standard rebound strategy and a non-equilibrium extrapolation scheme.Matlab is used for the development of the related algorithm.Finally,the influence of porosity,permeability,osmotic pressure and other factors is assessed with regard to seepage characteristics and the ensuing results are compared with Darcy’s law.The computations show that,for fixed initial conditions,the pore structure has a certain influence on the local velocity of seepage,but the overall state is stable,and the average velocity of each layer is the same.The larger the pore passage is,the faster the flow velocity is,and vice versa.For low permeability,the numerical results are consistent with the Darcy's law.The greater the pressure difference between the inlet and outlet of seepage,the greater the seepage rate.The relationship between them is linear(yet in good agreement with Darcy’s law). | Dong Zhou Zhuoying Tan | 2020 | Fluid Dynamics & Materials Processing2020，16，5： | 1 |
| 15 | Clinical Pathologic Study on Effect of Qianggan Capsule (强肝胶囊) in Treating Patients of Chronic Hepatitis B with Liver Cirrhosis显示文摘Objective: To explore the clinical therapeutic effect of Qianggan Capsule (QGC) in treating chronic hepatitis B with liver fibrosis from the pathological aspect. Methods: Sixty three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group (n=45) and the control group (n=18). Both groups were treated with general liver protective drugs, such as Glucurone and vitamins B complex for 6 months. To the treated group, QGC was used additionally. The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid (HA), collagen type Ⅳ (C Ⅳ) and laminin (LN) as well as the pathological examination of liver biopsy were observed before and after treatment. Results: The liver cirrhosis indexes, HA, C Ⅳ and LN, were improved significantly in the treated group after treatment, P <0.05. The liver function improvement rate in the treated group and the control group was 90.3% and 66.7% respectively, comparison of the two groups showed insignificant difference, P >0.05. Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8% and that on liver fibrosis stage was 75.6%, which were significantly improved as compared with those before treatment ( P <0.05 and P <0.01), while in the control group, no significant improvement was found after treatment ( P >0.05). Conclusion: QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis, and could lower the serum liver fibrosis related indexes effectively. | YANG Liuming(杨柳明) ZHAO Yanlong(赵延龙) WU Zhirong(吴志荣) CHEN Dufang(陈杜芳) CHEN Zhuoying(岑卓英) XU Kecheng(徐克成) ZUO Jiansheng(左建生) WEI Beihai(危北海) ZHANG Wandai(张万岱) | 2002 | Chinese Journal of Integrative Medicine2002，8，2： | 1 |
| 16 | Multi-factor sensitivity analysis of shallow unsaturated clay slope stability 显示文摘 | Tan Zhuoying Cai Meifeng | 2005 | Journal of University of Science and Technology Beijing : Mineral Metallurgy Materials(Eng Ed)2005，12，3： | 1 |
| 17 | Targeting m6A modification inhibits herpes virus 1 infection显示文摘The latent infection by herpes virus type 1(HSV-1)may be lifelong in trigeminal ganglia and a suspected cause of Alzheimer's Disease(AD)and Amyotrophic lateral sclerosis(ALS).Whether and how N6-methyladenosine(m6A)modification of viral RNAs affects virus infection are poorly understood.Here,we report that HSV-1 infection enhanced the expression of m6A writers(METTL3,METTL14)and readers(YTHDF1/2/3)at the early infection stage and decreased their expression later on,while suppressed the erasers'(FTO,ALBKH5)expression immediately upon infection to facilitate viral replication.Inhibiting m6A modification by 3-deazaadenosine(DAA)significantly decreased viral replication and reduced viral reproduction over 1000 folds.More interestingly,depleting the writers and readers by siRNAs inhibited virus replication and reproduction;whereas depleting the erasers promoted viral replication and reproduction.Silencing YTHDF3 strikingly decreased viral replication by up to 90%,leading to reduction of up to 10-fold viral replication and over 100-fold virus reproduction,respectively.Depletion of m6A initiator METTL3(by 60%–70%)by siRNA correlatedly decreased viral replication 60%–70%,and reduced virus yield over 30-fold.Consistently,ectopic expression of METTL3 largely increased virus yield.METTL3 knockdown suppressed the HSV-1 intermediate early and early genes(ICP0,ICP8 and UL23)and late genes(VP16,UL44,UL49 and ICP47);while ectopic expression of METTL3 upregulated these gene expression.Results from our study shed the lights on the importance for m6A modification to initiate HSV-1 early replication.The components of m6A modification machinery,particularly m6A initiator METTL3 and reader YTHDF3,would be potential important targets for combating HSV-1 infections. | Zhuoying Feng Fanghang Zhou Miaomiao Tan Tingting Wang Ying Chen Wenwen Xu Bin Li Xin Wang Xin Deng Ming-Liang He | 2022 | Genes & Diseases2022，9，4： | 1 |
| 18 | Analyses of water footprint of Beijing in an interregional input–output framework显示文摘 | Zhuoying Zhang Hong Yang Minjun Shi | 2011 | Ecological Economics2011，，12： | 1 |
| 19 | Design of a novel chimeric peptide via dual blockade of CD47/SIRPαand PD-1/PD-L1 for cancer immunotherapy显示文摘Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types,only a small subset of patients can benefit from PD-1/PD-L1 blockade.CD47 expressed on tumor cells protects them from phagocytosis through interaction with SIRPαon macrophages,while PD-L1 dampens T cell-mediated tumor killing.Therefore,dual targeting PD-L1 and CD47 may improve the efficacy of cancer immunotherapy.A chimeric peptide Pal-DMPOP was designed by conjugating the double mutation of CD47/SIRPαblocking peptide(DMP)with the truncation of PD-1/PD-L1 blocking peptide OPBP-1(8-12)and was modified by a palmitic acid tail.Pal-DMPOP can significantly enhance macrophage-mediated phagocytosis of tumor cells and activate primary T cells to secret IFN-γin vitro.Due to its superior hydrolysis-resistant activity as well as tumor tissue and lymph node targeting properties,Pal-DMPOP elicited stronger anti-tumor potency than Pal-DMP or OPBP-1(8-12)in immune-competent MC38 tumor-bearing mice.The in vivo anti-tumor activity was further validated in the colorectal CT26 tumor model.Furthermore,Pal-DMPOP mobilized macrophage and T-cell anti-tumor responses with minimal toxicity.Overall,the first bispecific CD47/SIRPαand PD-1/PD-L1 dual-blockade chimeric peptide was designed and exhibited synergistic anti-tumor efficacy via CD8^(+)T cell activation and macrophage-mediated immune response.The strategy could pave the way for designing effective therapeutic agents for cancer immunotherapy. | Zheng Hu Wanqiong Li Shaomeng Chen Danhong Chen Ran Xu Danlu Zheng Xin Yang Shuzhen Li Xiuman Zhou Xiaoshuang Niu Youmei Xiao Zhuoying He Huihao Li Juan Liu Xinghua Sui Yanfeng Gao | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 20 | Development of pretreatment protocol for DNA extraction from biofilm attached to biologic activated carbon(BAC)granules显示文摘The biologic activated carbon(BAC)process is widely used in drinking water treatments.A comprehensive molecular analysis of the microbial community structure provides very helpful data to improve the reactor performance.However,the bottleneck of deoxyribonucleic acid(DNA)extraction from BAC attached biofilm has to be solved since the conventional procedure was unsuccessful due to firm biomass attachment and adsorption capacity of the BAC granules.In this study,five pretreatments were compared,and adding skim milk followed by ultrasonic vibration was proven to be the optimal choice.This protocol was further tested using the vertical BAC samples from the full-scale biofilter of Pinghu Water Plant.The results showed the DNAyielded a range of 40μg·g^(-1) BAC(dry weight)to over 100μg·g^(-1) BAC(dry weight),which were consistent with the biomass distribution.All results suggested that the final protocol could produce qualified genomic DNA as a template from the BAC filter for downstream molecular biology researches. | Shuting ZHANG Bo WEI Xin YU Bing LIU Zhuoying WU Li GU | 2010 | Frontiers of Environmental Science & Engineering2010，4，4： | 1 |
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