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| 1 | Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy显示文摘Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not satisfactory.Nanomaterial-mediated therapy targeting SSTR2 in NETs is very promising.This study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared light.AuNRs@mSiO_(2)@DOTA-TATE showed good photothermal conversion efficiency.In vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with light.In vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other groups.There was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other groups.No significant inflammatory lesions or cell necrosis was found in the main organs.In summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications. | Qichen Chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao | 2022 | Nano Research2022，15，10： | 0 |
| 2 | Tunable compact asynchronous optical sampling system using Er-doped fiber laser显示文摘We report a compact,tunable,self-starting,all-fiber laser-based asynchronous optical sampling(ASOPS)system.Two Er-doped fiber oscillators were used as the pulsed-laser source,whose repetition rate could be set at 100 MHz with a tuning range of 1.25 MHz through a fiber delay line.By employing phase-locked and temperature control loops,the repetition rate offset of the two lasers was stabilized with 7.13×10^(−11)fractional instability at an average time of 1 s.Its capabilities in the terahertz regime were demonstrated by terahertz time-domain spectroscopy,achieving a spectral bandwidth of 3 THz with a dynamic range of 30 dB.The large range of repetition rate adjustment in our ASOPS system has the potential to be a powerful tool in the terahertz regime. | Zilin Zhao Daping Luo Yang Liu Zejiang Deng Lian Zhou Gehui Xie Chenglin Gu Yanzhao Yang BinWu Wenxue Li | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
| 3 | Shanghai Autism Early Development:An Integrative Chinese ASD Cohort显示文摘Why Was the Cohort Set Up?Autism spectrum disorder(ASD)is a child neurodevelopmental disorder,the onset of which is generally within 3 years of age,and often leads to lifelong impaired social and cognitive functions,which impose significant mental pressure and economic burdens on the family and society. | Yuan Dai Yuqi Liu Lingli Zhang Tai Ren Hui Wang Juehua Yu Xin Liu Zilin Chen Lin Deng Minyi Tao Hangyu Tan Chu‑Chung Huang Jiaying Zhang Qiang Luo Jianfeng Feng Miao Cao Fei Li | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
| 4 | Fair hierarchical clustering of substations based on Gini coefficient显示文摘For the load modeling of a large power grid,the large number of substations covered by it must be segregated into several categories and,thereafter,a load model built for each type.To address the problem of skewed clustering tree in the classical hierarchical clustering method used for categorizing substations,a fair hierarchical clustering method is proposed in this paper.First,the fairness index is defined based on the Gini coefficient.Thereafter,a hierarchical clustering method is proposed based on the fairness index.Finally,the clustering results are evaluated using the contour coefficient and the t-SNE two-dimensional plane map.The substations clustering example of a real large power grid considered in this paper illustrates that the proposed fair hierarchical clustering method can effectively address the problem of the skewed clustering tree with high accuracy. | Dajun Si Wenyue Hu Zilin Deng Yanhui Xu | 2021 | Global Energy Interconnection2021，4，6： | 0 |
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