|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 2 | Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer显示文摘Dear Editor,Lung cancer is the predominant cause of cancer-related death worldwide[1].Non-small cell lung cancer accounts for 80%-85%and small cell lung cancer(SCLC)accounts for 15%-20%of all lung cancer cases[2].Patients with SCLC,a highly aggressive and poorly differentiated malignancy,have an alarming average 5-year overall sur-vival rate of less than 10%[3].Most patients with SCLC already show clinically detectable metastases at diag-nosis and have extremely poor prognoses,even when treated with multimodality therapy[4].Before the addi-tion of atezolizumab to chemotherapy became the first-line treatment of extensive-stage SCLC,chemotherapy is the primary treatment of SCLC[5]. | Jie Zhang Chen Tian Fang Lv Jianfei Wang Wenbo Han Jun Nie Ling Dai Weiheng Hu Xiaoling Chen Xiangjuan Ma Guangming Tian Di Wu Sen Han Yang Wang Jieran Long Ziran Zhang Jian Fang Henghui Zhang | 2019 | Cancer Communications2019，39，1： | 2 |
| 3 | Synchronous activation of Ag nanoparticles and BiOBr for boosting solar-driven CO_(2)reduction显示文摘Artificial photosynthesis of valuable chemicals from CO_(2)is a potential way to achieve sustainable carbon cycle.The CO_(2)conversion activity is still inhibited by the sluggish charge kinetics and poor CO_(2)activation.Herein,Ag nanoparticles coupled Bi OBr have been constructed by in-situ photoreduction strategy.The crafting of interface between Ag nanoparticles and Bi OBr nanosheets,achieving an ultra-fast charge transfer.The Bi OBr semiconductor excited electrons and plasmonic Ag nanoparticles generated high-energy hot electrons synchronous accelerates the C=O double bond activation.Thus,the optimized Ag/BiOBr-2 heterostructure shows excellent CO_(2)photoreduction activity with CO production of 133.75 and 6.83μmol/g under 5 h of 300 W Xe lamp and visible light(λ>400 nm)irradiation,which is 1.51 and 2.81 folds versus the pristine Bi OBr,respectively.The mechanism of CO_(2)photoreduction was in-depth understood through in-situ FT-IR spectrum and density functional theory calculations.This study provides some new perspectives into efficient photocatalytic CO_(2)reduction. | Gaopeng Liu Lin Wang Bin Wang Xingwang Zhu Jinman Yang Pengjun Liu Wenshuai Zhu Ziran Chen Jiexiang Xia | 2023 | Chinese Chemical Letters2023，34，6： | 1 |
| 4 | Finite Element Simulation of Radial Tire Building and Shaping Processes Using an Elasto-Viscoplastic Model显示文摘The comprehensive tire building and shaping processes are investigated through the finite element method(FEM)in this article.The mechanical properties of the uncured rubber from different tire components are investigated through cyclic loading-unloading experiments under different strain rates.Based on the experiments,an elastoviscoplastic constitutive model is adopted to describe themechanical behaviors of the uncured rubber.The distinct mechanical properties,including the stress level,hysteresis and residual strain,of the uncured rubber can all be well characterized.The whole tire building process(including component winding,rubber bladder inflation,component stitching and carcass band folding-back)and the shaping process are simulated using this constitutive model.The simulated green tire profile is in good agreement with the actual profile obtained through 3D scanning.The deformation and stress of the rubber components and the cord reinforcements during production can be obtained fromthe FE simulation,which is helpful for judging the rationality of the tire construction design.Finally,the influence of the parameter“drum width”is investigated,and the simulated result is found to be consistent with the experimental observations,which verifies the effectiveness of the simulation.The established simulation strategy provides some guiding significance for the improvement of tire design parameters and the elimination of tire production defects. | Yinlong Wang Zhao Li Ziran Li Yang Wang | 2023 | Computer Modeling in Engineering & Sciences2023，，5： | 1 |
| 5 | Long-term warming does not affect soil ecoenzyme activity and original microbial nutrient limitation on the Qinghai-Tibet Plateau显示文摘Microbes play an important role in the carbon cycle and nutrient flow of the soil ecosystem.However,the response of microbial activities to long-term warming over decades is poorly understood.To determine how warming changes ecoenzyme activity and microbial nutrient limitation,we conducted a long-term,21 years,experiment,on the Qinghai–Tibet Plateau.We selected typical grass-and shrub-covered plots,used fiberglass open-top chambers(OTCs)to raise the temperature,conducted soil sampling at different depths,studied the response of nutrient-acquiring enzyme activity and stoichiometry,and conducted vector analysis of stoichiometry.Our results showed that long-term warming did not have a notable effect on the activity of nutrient-acquiring enzymes or enzymatic stoichiometry.However,Spearman correlation analysis indicated a significant and positive correlation between ecoenzyme activity and the available nutrients and microbial biomass in soil.Vector analysis of stoichiometry showed phosphorus limitation for all soil microbes at different depths,regardless of whether the soil experienced warming.These changes in enzymatic stoichiometry and vector analysis suggested that microbial nutrient limitation was not alleviated substantially by long-term warming,and warming did not considerably affect the stratification of microbial nutrient limitation.Our research has also shown that long-term warming does not significantly change soil ecoenzyme activity and original microbial nutrient limitation at different soil depths within the OTUsʼimpact range.These results could help improve understanding of microbial thermal acclimation and response to future long-term global warming. | Yuanze Li Huakun Zhou Wenjing Chen Yang Wu Lei Lei Qiao ZiRan Yan GuoBin Liu Sha Xue | 2022 | Soil Ecology Letters2022，4，4： | 0 |
| 6 | Genome-wide selection and introgression of Chinese rice varieties during breeding显示文摘China is the largest rice-producing country,but the genomic landscape of rice diversity has not yet been clarified.In this study,we re-sequence 1070 rice varieties collected from China(400)and other regions in Asia(670).Among the six major rice groups(aus,indica-I,indica-II,aromatic,temperate japonica,and tropical japonica),almost all Chinese varieties belong to the indica-II or temperate japonica group.Most Chinese indica varieties belong to indica-II,which consists of two subgroups developed during different phases of rice breeding.The genomic segments underlying the differences between these subgroups span36.32 Mb.The Chinese japonica rice varieties fall into the temperate japonica group,consisting of two subgroups based on their geographical distribution.The genomic segments underlying the differences between these subgroups span 27.69 Mb.These differentiated segments in the Chinese indica varieties span 45 genes with nonsynonymous mutations that are closely related to variations in plant height and grain width.Fifty-four genes with nonsynonymous mutations are associated with the differences in heading date between the two Chinese japonica subgroups.These findings provide new insights into rice diversity in China that will facilitate the molecular breeding. | Jinyue Ge Junrui Wang Hongbo Pang Fei Li Danjing Lou Weiya Fan Ziran Liu Jiaqi Li Danting Li Baoxuan Nong Zongqiong Zhang Yanyan Wang Jingfen Huang Meng Xing Yamin Nie Xiaorong Xiao Fan Zhang Wensheng Wang Jianlong Xu Sung Ryul Kim Ajay Kohli Guoyou Ye Weihua Qiao Qingwen Yang Xiaoming Zheng | 2022 | Journal of Genetics and Genomics2022，49，5： | 0 |
| 7 | LncPheDB:a genome-wide lncRNAs regulated phenotypes database in plants显示文摘LncPheDB(http://gffzzc7260c3d948c41d8s96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/)is a systematic resource of genome-wide long non-coding RNAs(lncRNAs)-phenotypes associations for multiple species.It was established to display the genome-wide lncRNA annotations,target genes prediction,variant-trait associations,gene-phenotype correlations,lncRNA-phenotype correlations,and the similar non-coding regions of the queried sequence in multiple species.LncPheDB sorted out a total of 203,391 lncRNA sequences,2000 phenotypes,and 120,271 variants of nine species(Zea mays L.,Gossypium barbadense L.,Triticum aestivum L.,Lycopersicon esculentum Mille,Oryza sativa L.,Hordeum vulgare L.,Sorghum bicolor L.,Glycine max L.,and Cucumis sativus L.).By exploring the relationship between lncRNAs and the genomic position of variants in genome-wide association analysis,a total of 68,862 lncRNAs were found to be related to the diversity of agronomic traits.More importantly,to facilitate the study of the functions of lncRNAs,we analyzed the possible target genes of lncRNAs,constructed a blast tool for performing similar fragmentation studies in all species,linked the pages of phenotypic studies related to lncRNAs that possess similar fragments and constructed their regulatory networks.In addition,LncPheDB also provides a user-friendly interface,a genome visualization platform,and multi-level and multi-modal convenient data search engine.We believe that LncPheDB plays a crucial role in mining lncRNA-related plant data. | Danjing Lou Fei Li Jinyue Ge Weiya Fan Ziran Liu Yanyan Wang Jingfen Huang Meng Xing Wenlong Guo Shizhuang Wang Weihua Qiao Zhenyun Han Qian Qian Qingwen Yang Xiaoming Zheng | 2022 | aBIOTECH2022，3，3： | 0 |
| 8 | Integrative analysis of the transcriptome and metabolome reveals the response mechanism to tomato spotted wilt virus显示文摘Tomato spotted wilt virus(TSWV)is an important virus that has rapidly spread throughout the world.TSWV seriously hinders the production of tomato(Solanum lycopersicum)and other plants.In order to discover more new genes and metabolites related to TSWV resistance in tomato plants,the genes and metabolites related to the resistance of tomato plants inoculated with TSWV were identified and studied herein.The tomato TSWV-resistance line YNAU335(335)and TSWV-susceptible lines NO5 and 96172I(961)were used as the transcriptome and metabolome research materials.Transcriptomic and metabolomic techniques were used to analyze the gene and metabolite response mechanisms to TSWV inoculation.A total of 3566,2951,and 2674 differentially expressed genes(DEGs)were identified in lines 335,NO5,and961,respectively.Meanwhile,208,228,and 273 differentially accumulated metabolites(DAMs)were identified in lines 335,NO5,and 961,respectively.In line 335,the number of DEGs was the highest,but the number of DAMs was lowest.Furthermore,903 DEGs and 94 DAMs were common to the response to TSWV in the three inbred lines.The 903 DEGs and 94 DAMs were mainly enriched in the plant hormone signal transduction and flavonoid synthesis pathways.In addition,many nucleotide-binding site-leucine-rich repeat genes and transcription factors were found that might be involved in the TSWV response.These results provide new insights into TSWV resistance mechanisms. | Junheng Lv Minghua Deng Zuosen Li Haishan Zhu Ziran Wang Yanling Yue Zhengan Yang Junqiang Xu Shurui Jiang Wei Zhao Jing Li Kai Zhao | 2023 | Horticultural Plant Journal2023，9，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员