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| 1 | Gas Hydrates in the Qilian Mountain Permafrost, Qinghai, Northwest China显示文摘Qilian Mountain permafrost, with area about 10×104 km2, locates in the north of Qinghai-Tibet plateau. It equips with perfect conditions and has great prospecting potential for gas hydrate. The Scientific Drilling Project of Gas Hydrate in Qilian Mountain permafrost, which locates in Juhugeng of Muri Coalfield, Tianjun County, Qinghai Province, has been implemented by China Geological Survey in 2008–2009. Four scientific drilling wells have been completed with a total footage of 2059.13 m. Samples of gas hydrate are collected separately from holes DK-1, DK-2 and DK-3. Gas hydrate is hosted under permafrost zone in the 133–396 m interval. The sample is white crystal and easily burning. Anomaly low temperature has been identified by the infrared camera. The gas hydrate-bearing cores strongly bubble in the water. Gas-bubble and water-drop are emitted from the hydrate-bearing cores and then characteristic of honeycombed structure is left. The typical spectrum curve of gas hydrate is detected using Raman spectrometry. Furthermore, the logging profile also indicates high electrical resistivity and sonic velocity. Gas hydrate in Qilian Mountain is characterized by a thinner permafrost zone, shallower buried depth, more complex gas component and coal-bed methane origin etc. | ZHU Youhai ZHANG Yongqin WEN Huaijun LU Zhenquan JIA Zhiyao LI Yonghong LI Qinghai LIU Changling WANG Pingkang GUO Xingwang | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 19 |
| 2 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 3 | Identification of the starting reaction position in the hydrogenation of (N-ethyl)carbazole over Raney-Ni显示文摘Hydrogenation of carbazole and N-ethylcarbazole over Raney-Ni catalyst were realized in the temperature range of 393-503 K. 4[H] adduct dominated the hydrogenation products and the formation of 2[H] adduct was the rate-limiting step during the period, in which the conversion of carbazole was less than 40%. The hydrogenation process followed pseudo-first-order kinetics and the hydrogenation activation energies of carbazole and N-ethylcarbazole were 90 k J/mol and 115 k J/mol, respectively. The reaction starting position as well as the pathway of the hydrogenation of(N-ethyl)carbazole were investigated by comparing the kinetic characteristics of hydrogen uptake of carbazole and Nethylcarbazole. The results showed that the reaction was a stepwise hydrogenation process and the first H2 was added to the C1 = C10 double bond in the hydrogenation. | Feifei Sun Yue An Lecheng Lei Fuying Wu Jingke Zhu Xingwang Zhang | 2015 | Journal of Energy Chemistry2015，24，2： | 4 |
| 4 | Design of Fault Detection Observer Based on Hyper Basis Function显示文摘In this paper, we propose the Hyper Basis Function(HBF) neural network on the basis of Radial Basis Function(RBF) neural network. Compared with RBF, HBF neural networks have a more generalized ability with different activation functions. A decision tree algorithm is used to determine the network center. Subsequently, we design an adaptive observer based on HBF neural networks and propose a fault detection and diagnosis method based on the observer for the nonlinear modeling ability of the neural network. Finally, we apply this method to nonlinear systems. The sensitivity and stability of the observer for the failure of the nonlinear systems are proved by simulation, which is beneficial for real-time online fault detection and diagnosis. | Xin Wen Xingwang Zhang Yaping Zhu | 2015 | Tsinghua Science and Technology2015，20，2： | 4 |
| 5 | Photocatalytic degradation of methyl orange using ZnO/TiO_(2) composites显示文摘ZnO/TiO_(2)composites were synthesized by using the solvothermal method and ultrasonic precipitation followed by heat treatment in order to investigate their photocatalytic degradation of methyl orange(MO)in aqueous suspension under UV irradiation.The composition and surface structure of the catalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscope(FE-SEM),and transmission electron microscopy(TEM).The degradation efficiencies of MO at various pH values were obtained.The highest degradation efficiencies were obtained before 30 min and after 60 min at pH 11.0 and pH 2.0,respectively.A sample analysis was conducted using liquid chromatography coupled with electrospray ionization ion-trap mass spectrometry.Six intermediates were found during the photocatalytic degradation process of quinonoid MO.The degradation pathway of quinonoid MO was also proposed. | Ming GE Changsheng GUO Xingwang ZHU Lili MA Zhenan HAN Wei HU Yuqiu WANG | 2009 | Frontiers of Environmental Science & Engineering2009，3，3： | 3 |
| 6 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 7 | Texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr dual-phase alloy during cold rolling based on multiscale crystal plasticity finite element model显示文摘The complex micromechanical response among grains remains a persistent challenge to understand the deformation mechanism of titanium alloys during cold rolling.Therefore,in this work,a multiscale crystal plasticity finite element method of dual-phase alloy was proposed and secondarily developed based on LS-DYNA software.Afterward,the texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr alloy,based on the realistic 3D microstructure,during cold rolling(20%thickness reduction)were systematically investigated.The relative activity of the■slip system in theαphase gradually increased,and then served as the main slip mode at lower Schmid factor(<0.2).In contrast,the contribution of the■slip system to the overall plastic deformation was relatively limited.For theβphase,the relative activity of the<111>{110}slip system showed an upward tendency,indicating the important role of the critical resolved shear stress relationship in the relative activity evolutions.Furthermore,the abnormally high strain of very fewβgrains was found,which was attributed to their severe rotations compelled by the neighboring pre-deformedαgrains.The calculated pole figures,rotation axes,and compelled rotation behavior exhibited good agreement to the experimental results. | Duoduo Wang Qunbo Fan Xingwang Cheng Yu Zhou Ran Shi Yan Qian Le Wang Xinjie Zhu Haichao Gong Kai Chen Jingjiu Yuan Liu Yang | 2022 | Journal of Materials Science & Technology2022，，16： | 2 |
| 8 | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population显示文摘 | Jixia Liu Yongyong Shi Wei Tang Tingwei Guo Dawei Li Yifeng Yang Xinzhi Zhao Hongsheng Wang Xingwang Li Guoyin Feng Niufan Gu Shaomin Zhu Huijun Liu Yangling Guo Jianguo Shi Hong Sang Lijuan Yan Lin He | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 9 | Synchronous activation of Ag nanoparticles and BiOBr for boosting solar-driven CO_(2)reduction显示文摘Artificial photosynthesis of valuable chemicals from CO_(2)is a potential way to achieve sustainable carbon cycle.The CO_(2)conversion activity is still inhibited by the sluggish charge kinetics and poor CO_(2)activation.Herein,Ag nanoparticles coupled Bi OBr have been constructed by in-situ photoreduction strategy.The crafting of interface between Ag nanoparticles and Bi OBr nanosheets,achieving an ultra-fast charge transfer.The Bi OBr semiconductor excited electrons and plasmonic Ag nanoparticles generated high-energy hot electrons synchronous accelerates the C=O double bond activation.Thus,the optimized Ag/BiOBr-2 heterostructure shows excellent CO_(2)photoreduction activity with CO production of 133.75 and 6.83μmol/g under 5 h of 300 W Xe lamp and visible light(λ>400 nm)irradiation,which is 1.51 and 2.81 folds versus the pristine Bi OBr,respectively.The mechanism of CO_(2)photoreduction was in-depth understood through in-situ FT-IR spectrum and density functional theory calculations.This study provides some new perspectives into efficient photocatalytic CO_(2)reduction. | Gaopeng Liu Lin Wang Bin Wang Xingwang Zhu Jinman Yang Pengjun Liu Wenshuai Zhu Ziran Chen Jiexiang Xia | 2023 | Chinese Chemical Letters2023，34，6： | 1 |
| 10 | OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice显示文摘Meiotic recombination is essential for reciprocal exchange of genetic information between homologous chromosomes and their subsequent proper segregation in sexually reproducing organisms. MLH1 and MLH3 belong to meiosis-specific members of the Mut L-homolog family, which are required for normal level of crossovers(COs) in some eukaryotes. However, their functions in plants need to be further elucidated.Here, we report the identification of Os MLH1 and reveal its functions during meiosis in rice. Using CRISPRCas9 approach, two independent mutants, Osmlh1-1 and Osmlh1-2, are generated and exhibited significantly reduced male fertility. In Osmlh1-1, the clearance of PAIR2 is delayed and partial ZEP1 proteins are not loaded into the chromosomes, which might be due to the deficient in resolution of interlocks at late zygotene. Thus, Os MLH1 is required for the assembly of synapsis complex. In Osmlh1-1, CO number is dropped by ~53% and the distribution of residual COs is consistent with predicted Poisson distribution,indicating that Os MLH1 is essential for the formation of interference-sensitive COs(class I COs). Os MLH1 interacts with Os MLH3 through their C-terminal domains. Mutation in Os MLH3 also affects the pollen fertility. Thus, our experiments reveal that the conserved heterodimer Mut Lg(Os MLH1-Os MLH3) is essential for the formation of class I COs in rice. | Xiaodong Xin Xingwang Li Junkai Zhu Xiaobin Liu Zhenghu Chu Jiali Shen Changyin Wu | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 11 | Interface-engineered MoS_(2)/CoS/NF bifunctional catalysts for highly-efficient water electrolysis显示文摘The utilization of non-noble metal catalysts with robust and highly efficient electrocatalytic activity for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)are extremely important for the large-scale implementation of renewable energy devices.Integration of bifunctional electrocatalysts on both anode and cathode electrodes remains a significant challenge.Herein,we report on a novel and facile strategy to construct the ordered and aligned MoS_(2)nanosheet-encapsulated metal–organic frameworks(MOFs)derived hollow CoS polyhedron,in-situ grown on a nickel foam(NF).The starfish-like MoS_(2)/CoS/NF heterojunctions were formed due to the ordered growth of the material caused by NF substrate.The optimized 2-MoS_(2)/CoS/NF heterojunction exhibits robust bifunctional electrocatalytic activity with a low overpotential of 67 and 207 m V toward the HER and OER at 10 mA cm^(-2),and the long-term stability,which exceeds most of the reported bifunctional electrocatalysts.Such high electrocatalytic performance arises due to the synergistic effect between the MoS_(2)and CoS phases across the interface,the abundant active sites,as well as the hierarchical pore framework,which collectively enhance the mass and electron transfer during the reactions.The work provides a promising approach to fabricating bifunctional catalysts with custom-designed heterojunctions and remarkable performance for applications in electrochemical energy devices and related areas. | Wenxia Chen Xingwang Zhu Rui Wang Wei Wei Meng Liu Shuai Dong Kostya Ken Ostrikov Shuang-Quan Zang | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 12 | Downregulation of cancer stem cell properties via mTOR signaling pathwayinhibition by rapamycin in nasopharyngeal carcinoma显示文摘 | Chunguang Yang Yue Zhang Yu Zhang Ziheng Zhang Jianhua Peng Zhi Li Liang Han Quanjie You Xiaoyu Chen Xingwang Rao Yi Zhu Zhisu Liao | 2015 | International Journal of Oncology2015，，3： | 1 |
| 13 | Geological features and hydrocarbon accumulation in the Xinken oil field,Tarim Basin显示文摘Recently,a large-scale Ordovician oil and gas pool has been discovered in Xinken,north of the Tarim Basin,and it has strongly heterogeneous reservoirs and complicated fluid distribution.Through analyzing oil,gas and water samples collected from this area,in combination of field production and testing data,this study reveals that the Xinken oil pool contains dominantly normal oil characterized by low viscosity,low sulphur,and high wax.It has a low content of natural gas,which presents typical characteristics of wet gas and is oil-associated gas.Oil-gas correlation shows that the oil was from the Middle-Upper Ordovician source rocks and the charge and accumulation of oil and gas took place in the Late Hercynian Period.Controlled by paleogeomorphology,sedimentary facies,ancient karstification,faults,and other factors in the Caledonian Period,the Ordovician carbonate reservoirs are dominated by dissolved pores,cavities and fractures.The reservoir body of fractures and cavities is distributed in the shape of strip and laminate along faults and excellent reservoirs are mostly in the range of 70–100 m below the top of the Yijianfang Formation.As a whole,the Xinken oil pool is a fracture-cavity pool controlled by interbedded karst reservoirs and is a complex composed of stacked karst fractures and cavities of various sizes.It contains oil in large areas horizontally,which is quasi-laminated in distribution,and the accumulation of oil and gas is controlled by the distribution and development degree of the Ordovician carbonate reservoirs.The study shows that this area has abundant resources and a great exploration potential for oil and gas. | SONG Lichen ZHU Guangyou LIU Xingwang ZHU Yongfeng SU Jin WANG Kai | 2013 | Chinese Journal Of Geochemistry2013，32，4： | 1 |
| 14 | A candy-like photocatalyst by wrapping Co, N-co-doped hollow carbon sphere with ultrathin mesoporous carbon nitride for boosted photocatalytic hydrogen evolution显示文摘Hierarchical carbon material is used as a star cocatalyst in the field of photocatalysis due to its excellent catalytic properties. In this work, mesoporous carbon nitride sheet(MCNS) photocatalyst introduced nitrogen-doped hollow carbon spheres assembled with cobalt nanoparticles(Co@NHC) is synthesized by electrostatic adsorption. A series of characterizations are analyzed to display the structures, morphologies and optical properties of as-prepared materials. The photocatalytic activity of Co@NHC/MCNS material is evaluated with hydrogen evolution under visible light irradiation. The results indicate that 5 wt%Co@NHC/MCNS material reveals higher photocatalytic activity of hydrogen evolution rate of 3675 μmol/g with 4 h reaction time, which is 159 times than that of pure MCNS material. The carbon material with excellent charge transport properties can effectively accelerate the charge transfer from ultrathin MCNS to cobalt nanoparticles. The goal of improving the photocatalytic performance of Co@NHC/MCNS material is achieved. As a result, it provides a feasible and promised approach for doping transition metals to enhance photocatalytic activity. | Jinyuan Liu Shumin Zhu Bin Wang Ruizhe Yang Rong Wang Xingwang Zhu Yanhua Song Junjie Yuan Hui Xu Huaming Li | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 15 | Unraveling the role of phase engineering in tuning photocatalytic hydrogen evolution activity and stability显示文摘In this work,taking NiSe_(2)as a prototype to be used as cocatalyst in photocatalytic hydrogen evolution,we demonstrate that the crystal phase of NiSe_(2)plays a vital role in determining the catalytic stability,rather than activity.Theoretical and experimental results indicate that the phase structure shows negligible influence to the charge transport and hydrogen adsorption capacity.When integrating with carbon nitride(CN)photocatalyst forming hybrids(m-NiSe_(2)/CN and p-NiSe_(2)/CN),the hybrids show comparable photocatalytic hydrogen evolution rates(3.26μmol/h and 3.75μmol/h).Unlike the comparable catalytic activity,we found that phase-engineered NiSe_(2)exhibits distinct stability,i.e.,m-NiSe_(2)can evolve H_(2) steadily,but p-NiSe_(2)shows a significant decrease in catalytic process(∼57.1%decrease in 25 h).The factor leading to different catalytic stability can be ascribed to the different surface conversion behavior during photocatalytic process,i.e.,chemical structure of m-NiSe_(2)can be well preserved in catalytic process,but partial p-NiSe_(2)tends to be converted to NiOOH. | Jianjian Yi Zhou Zhou Yu Xia Ganghua Zhou Guoxiang Zhang Li Li Xuyu Wang Xingwang Zhu Xiaozhi Wang Huan Pang | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 16 | Synthesis of carbon nitride in moist environments:A defect engineering strategy toward superior photocatalytic hydrogen evolution reaction显示文摘Intimate understanding of the synthesis-structure-activity relationships is an accessible pathway to overcome the intrinsic challenges of carbon nitride(g-C_(3)N_(4))photocatalysts.This work looks in the effects of humidity of the synthesis process to the morphology,chemical structure,band structure as well as the photocatalytic activity of g-C_(3)N_(4) materials.Four g-C_(3)N_(4) samples were prepared by heating melem in four gas environments:dry Ar,dry Air,moist Ar and moist Air.The photocatalytic activity measurements revealed that the samples synthesized in moist inert and oxidic gases environments displayed 20 and 10 times the photocata lytic H_(2) evolution activity of the samples synthesized in dry inert and oxidic gases environments,respectively.The reasons for this remarkable variety in photocata lytic activities had been through investigated.After all,the terminations of the carbon vacancies were identified as the dominant factor in enhancing H_(2) evolution performance.The work here thus demonstrating an example of defect engineering. | Shuquan Huang Feiyue Ge Jia Yan Hongping Li Xingwang Zhu Yuanguo Xu Hui Xu Huaming Li | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
| 17 | Ti, Zn co-doped hematite photoanode for solar driven photoelectrochemical water oxidation显示文摘Although there have been many reports of metal doping to ameliorate the drawbacks of hematite as the photoanode for water oxidation, most of them focused on monometallic doping, and only a few of them payed attention to bimetallic doping. What is worse, the synergetic mechanism between two metal dopants was not sufficiently studied, especially the density functional theory(DFT) calculation. In this work, the n-type hematite was synthesized by introducing Ti dopant into hematite through the hydrothermal method, and dipping-sintering treatment was employed to further introduce homogeneously dispersed Zn dopant into that, forming the Ti, Zn co-doped hematite. Under the optimal condition, Tidoped hematite photoanode reached approximately 2-times enhancement of the photocurrent density compared with the pristine one at 1.23 V vs. RHE, while Ti, Zn co-doped hematite anode obtained another25% elevation. UV–Vis spectroscopy, Mott–Schottky plots, EIS analysis, photo-oxidation of hole scavenger(H2O2), and DFT calculation were employed to understand the role of Ti, Zn dopant. Based on the obtained results, the synergetic mechanism of two dopants was discussed, i.e., the improvement of PEC performance of Ti, Zn co-doped hematite photoanode was possibly attributed to greater carrier density and improved charge separation efficiency at the surface of hematite. This work provides new strategy and understanding of the improvement of PEC performance of hematite by doping engineering. | Quansong Zhu Chunlin Yu Xingwang Zhang | 2019 | Journal of Energy Chemistry2019，28，8： | 0 |
| 18 | Crafting of plasmonic Au nanoparticles coupled ultrathin BiOBr nanosheets heterostructure: steering charge transfer for efficient CO_(2) photoreduction显示文摘Integrating semiconductor photocatalysts with outstanding visible light absorption and fast surface/interface charge transfer kinetics is still an enormous challenge for efficient CO_(2)photoreduction.In this work,the Au nanoparticles have been coupled with ultrathin BiOBr nanosheets,the formed heterostructure(Au/BiOBr)pos-sesses a localized surface plasmon resonance(LSPR)and enhances the visible light absorption ability,as well as forms a fast charge transport channel on the interface between Au and BiOBr.Thus,the heterostructure photo-catalyst exhibits higher photocatalytic CO_(2)to CO performance(135.3/16.43μmol g^(-1))than that of BiOBr(89.0/6.46μmol g^(-1))under 300 W Xe lamp and visible light(λ>400 nm)irradiation for 5 h,respectively.Finally,the in situ FT-IR spectroscopy revealed CO_(2)photoreduction process and found that the*COOH is the key intermediate for CO_(2)to CO.This work provides an effective method to construct multielectron transfer scheme for efficient photocatalytic CO_(2)reduction. | Gaopeng Liu Lin Wang Xin Chen Xingwang Zhu Bin Wang Xinyuan Xu Ziran Chen Wenshuai Zhu Huaming Li Jiexiang Xia | 2022 | Green Chemical Engineering2022，3，2： | 0 |
| 19 | Application of machine learning to process simulation of n-pentane cracking to produce ethylene and propene显示文摘Modeling light olefin production was one of the main concerns in chemical engineering field.In this paper,machine learning model based on artificial neural networks(ANN)was established to describe the effects of temperature and catalyst on ethylene and propene formation in n-pentane cracking.The establishment procedure included data pretreatment,model design,training process and testing process,and the mean square error(MSE)and regression coefficient(R2)indexes were employed to evaluate model performance.It was found that the learning algorithm and ANN topology affected the calculation accuracy.GD24223,CGB2423,and LM24223 models were established by optimally matching the learning algorithm with ANN topology,and achieved excellent calculation accuracy.Furthermore,the stability of GD24223,CGB2423 and LM24223 models was investigated by gradually decreasing training data and simultaneously transforming data distribution.Compared with GD24223 and LM24223 models,CGB2423 model was more stable against the variations of training data,and the MSE values were always maintained at the magnitude of 10^-3-10^-4,confirming its applicability for simulating light olefin production in n-pentane cracking. | Weijun Zhu Xingwang Liu Xu Hou Jiayao Hu Zhenheng Diao | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 0 |
| 20 | Selenized liposomes with ameliorative stability that achieve sustained release of emodin but fail in bioavailability显示文摘Stability of liposomes plays a crucial role in drug delivery,especially in oral aspect.The structural modification of liposomes has been the orientation of efforts to improve their stability and enable the controllability of payload release.This study reported a selenylation strategy to optimize the liposomal structure in an attempt to enhance the nanocarrier’s stability,hence the bioavailability of emodin(EM),an active compound with poor water-solubility.EM-loaded selenized liposomes(EM-Se@LPs)were prepared by thin film dispersion followed by in situ reduction technique.The results showed that EM-Se@LPs were provided with enhancive gastrointestinal stability and exhibited sustained release of drug compared with EM-loaded liposomes(EM-LPs).However,the modified liposomes with Se depositing onto the interior and exterior bilayers did not substantially facilitate absorption of EM.The reinforced structure of liposomes irrelevant to absorption was affirmed to be due to good stability and absorbability of EM itself.Nevertheless,the present work provides an alternative option for stabilization of liposomes instead of conventional methods,which may be promising for oral delivery of physiologically unstable and/or poorly absorbed drugs and systemic drug delivery. | Mujuan Zhu Shiping Zhu Qiubo Liu Yuehong Ren Zhiguo Ma Xingwang Zhang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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