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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis显示文摘The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer.However,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal tissues.Here,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer. | Xiaobo Zheng Jinen Song Chune Yu Zongguang Zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 3 | A 12-bit 250-MS/s Charge-Domain Pipelined Analog-to-Digital Converter with Feed-Forward Common-Mode Charge Control显示文摘A feed-forward Common-Mode(CM) charge control circuit for a high-speed Charge-Domain(CD)pipelined Analog-to-Digital Converter(ADC) is presented herein.This study aims at solving the problem whereby the precision of CD pipelined ADCs is restricted by the variation in input CM charge,which can compensate for CM charge errors caused by a variation in CM charge input in real time.Based on the feed-forward CM charge control circuit,a 12-bit 250-MS/s CD pipelined ADC is designed and realized using a 1 P6 M 0.18-μm CMOS process.The ADC achieved a Spurious Free Dynamic Range(SFDR) of 78.1 d B and a Signal-to-Noise-and-Distortion Ratio(SNDR) of 64.6 d B for a 20.1-MHz input:a SFDR of 74.9 d B and SNDR of 62.0 d B were achieved for a 239.9-MHz input at full sampling rate.The variation in signal-to-noise ratio was less than 3 d B over a 0–1.2 V input CM voltage range.The power consumption of the prototype ADC is only 85 m W at 1.8 V supply,and it occupies an active die area of 2.24 mm^2. | Zongguang Yu Xiaobo Su Zhenhai Chen Jiaxuan Zou Jinghe Wei Hong Zhang Yan Xue | 2018 | Tsinghua Science and Technology2018，23，1： | 2 |
| 4 | A Novel Boosted Charge Transfer Circuit for High Speed Charge Domain Pipelined ADC显示文摘 | CHEN Zhenhai YU Zongguang HUANG Songren JI Huicai ZHANG Hong | 2012 | Chinese Journal of Electronics2012，21，4： | 2 |
| 5 | A simple cost-effective PSR LED driver without auxiliary winding显示文摘 | Nie Weidong Wu Jin Yu Zongguang | 2013 | IEICE Elec- tronics Express2013，10，23： | 1 |
| 6 | Patterns of neoplastic foci and lymph node micrometastasis within the mesorectum显示文摘 | Cun Wang Zongguang Zhou Zhao Wang Yangchun Zheng Gaoping Zhao Yongyang Yu Zhong Cheng Daiyun Chen Weiping Liu | 2005 | Langenbeck’s Archives of Surgery2005，，4： | 1 |
| 7 | Design of Low-Power Modern Radar SoC Based on ASIX显示文摘With the rapid development in spaceflights and aeroplanes,the demand for low-power and miniaturization techniques has become insistent in modern radar systems. A new framework for low-power modern radar System on a Chip(SoC) based on ASIX core is presented. Pivotal modules and low-power design flows are described in detail. The dynamic clock-distribution mechanism of the power management module and the influence of the chip power are both stressed. This design adopts the SMIC 0.18-?m 1P6M Salicide CMOS process,the area is 7.825mm 7.820 mm,there are approximately 2 million gates and the frequency is 100 MHz. The results show that the modern radar SoC passes the test on modern radar application system and meets the design requirements. The chip incurs power savings of 42.79% during the fore-end phase and 12.77% during the back-end phase. The total power is less than 350 mW for a 100-MHz operating environment. | Bing Yang Zongguang Yu Jinghe Wei | 2014 | Tsinghua Science and Technology2014，19，2： | 0 |
| 8 | A 4 Gbps current-mode transmitter for 12-bit 250 MSPS ADC显示文摘A 4 Gbps transmitter for a 12-bit 250 MSPS pipelined ADCs is presented.A low power current mode(CM) output driver with reverse scaling technique is proposed.A high speed,low power combined serializer is implemented to convert 12 bit parallel data into a serial data stream.The whole transmitter is used in a 12-bit250 MSPS pipelined ADC for the digital output buffer and fabricated in 180 nm 1.8 V 1P5M CMOS technology.Test results show that the transmitter provides an eye height greater than 800 mV for data rates of both 2 Gbps and 4 Gbps,the 12-bit 250 MSPS ADC achieves the SNR of 69.92 dBFS and SFDR of 81.17 dB with 20.1 MHz input at full sampling speed.The ADC with the 4 Gbps transmitter consumes the power consumption of 395 mW,where the power consumption of transmitter is 75 mW.The ADC occupies an area of 2.5×3.2 mm^2,where the active area of the transmitter block is 0.5×1.2 mm^2. | Zhenhai Chen Zongguang Yu Jinghe Wei Dejin Zhou Xiaobo Su Jiaxuan Zou | 2017 | Journal of Semiconductors2017，38，8： | 0 |
| 9 | Boundedness of some integral operators and commutators on homogeneous Herz spaces with three variable exponents显示文摘We obtain the boundedness of some integral operators and commutators on homogeneous Herz spaces with three variable exponents K^(˙α(⋅))_(p(⋅),q(⋅)),such as some sublinear operators,the fractional integral and its commutator. | Xia YU Zongguang LIU | 2021 | Frontiers of Mathematics in China2021，16，1： | 0 |
| 10 | High Precision Mix-Signal Capacitor Mismatch Error Calibration Method for Charge-Domain Pipelined ADC显示文摘A mix-signal high precision capacitor mismatch error calibration method for charge domain pipelined ADCs is proposed. The calibration method calibrates the capacitors one by one based on binary search.Charge errors caused by the capacitor mismatch in and between pipelined sub-stage circuits can be compensated by the proposed calibration method. Based on the proposed calibration method, a 14 bit 250 MS/s charge domain pipelined Analog-to-digital converter(ADC) is designed and realized in a 1P6M 0.18 m CMOS process.Test results show the 14 bit 250 MS/s ADC achieves the signal-to-noise ratio of 70.7 dBFS and the spurious free dynamic range of 84.6 dB, with 70.1 MHz single-tone sine wave input at 250 MS/s, while the ADC core consumes the power consumption of 235 mW and occupies an area of 3.2 mm^2. | YU Zongguang ZOU Jiaxuan CHEN Zhenhai WEI Jinghe SU Xiaobo ZHANG Hong | 2019 | Chinese Journal of Electronics2019，28，2： | 0 |
| 11 | Neurons generated from carcinoma stem cells support cancerprogression显示文摘Recent evidences show that nervous system acts as a crucial part of cancer microenvironment.Infiltration of nerve fibers into cancer microenvironment has an important active role in cancer progression.The stimulations of both cancer growth and metastasis by members of nervous system such as neurons and glial cells have been demonstrated.However,how the nervous system is built in cancer is largely unknown.Here we show that a fraction of cancer stem cells(CSCs)derived from patients with gastric carcinoma and colorectal carcinoma are capable of producing neurons that are involved in tumor neurogenesis and tumor growth.Cancer stem cell monoclone derived from a single cancer stem cell was able to generate neurons including sympathetic and parasympathetic neurons to take part in the nervous system in cancer tissues.Knocking down the neural cell generating capability of the human CSCs inhibited the growth of xenograft tumors in mouse model.Our data demonstrate that human CSCs are able to produce one of most important components in the cancer microenvironment that are required for cancer development and progression. | Ran Lu Chuanwen Fan Wenqi Shangguan Yuan Liu Yu Li Yanna Shang Dongqin Yin Shengliang Zhang Qiaorong Huang Xue Li Wentong Meng Hong Xu Zongguang Zhou Jiankun Hu Weimin Li Lunxu Liu Xianming Mo | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 12 | Design of GGNMOS ESD protection device for radiationhardened 0.18 μm CMOS process显示文摘In this paper,the ESD discharge capability of GGNMOS(gate grounded NMOS)device in the radiation-hardened 0.18μm bulk silicon CMOS process(Rad-Hard by Process:RHBP)is optimized by layout and ion implantation design.The effects of gate length,DCGS and ESD ion implantation of GGNMOS on discharge current density and lattice temperature are studied by TCAD and device simulation.The size of DCGS,multi finger number and single finger width of ESD verification structures are designed,and the discharge capacity and efficiency of GGNMOS devices in ESD are characterized by TLP test technology.Finally,the optimized GGNMOS is verified on the DSP circuit,and its ESD performance is over 3500 V in HBM mode. | Jianwei Wu Zongguang Yu Genshen Hong Rubin Xie | 2020 | Journal of Semiconductors2020，41，12： | 0 |
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